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Journal Articles

Prognostic value of premaintenance FDG PET/CT response in patients with newly diagnosed myeloma from the CASSIOPEIA trial

Free
CME Clinical Trials & Observations
Françoise Kraeber-Bodéré, Bastien Jamet, Sonja Zweegman, Aurore Perrot, Cyrille Hulin, Denis Caillot, Thierry Facon, Xavier Leleu, Karim Belhadj, Emmanuel Itti, Lionel Karlin, Clément Bailly, Mark-David Levin, Monique C. Minnema, Caroline Bodet-Milin, Bart de Keizer, Jill Corre, Pieter Sonneveld, Philippe Moreau, Thomas Carlier, Cyrille Touzeau
Journal: Blood
Blood (2025) 146 (25): 3050–3058.
https://doi.org/10.1182/blood.2025030084
Published: 2025
Includes: Supplemental data
Journal Articles

Favorable impact of patient's selection on outcome of Relapsed/Refractory multiple myeloma treated with idecabtagene vicleucel (Ide-cel) chimeric antigen receptor (CAR) T-cell therapy; Experience in french patients (Super-FENIX): An IFM study from the descar-T registry

Free
Bertrand Arnulf, Jerome Lambert, Lionel Karlin, Cyrille Touzeau, Olivier Decaux, Aurore Perrot, Marie-Odile Petillon, Denis Caillot, Salomon Manier, Jean Marc Schiano De Colella, Mohamad Mohty, Laure Vincent, Karim Belhadj Merzoug, Xavier Leleu, Cyrille Hulin, Michael Loschi, Lydia Montes, Thomas Chalopin, Carine Chateleix, Camille Bigenwald, Jean-Richard Eveillard, Yann Guillermin, Fabrice Jardin, Alexis Talbot, Anne Lazareth, Jean-Noel Bastie, Stephanie Harel, Jill Corre, Roch Houot, Niels Moya, Pierre Bories, Titouan Cazaubiel, Noemie Bigot, Thierry Facon, Herve Avet-Loiseau, Benoit Ferment, Philippe Moreau
Journal: Blood
Blood (2025) 146 (Supplement 1): 4076.
https://doi.org/10.1182/blood-2025-4076
Published: 2025
Journal Articles

A comparison between subcutaneous isa-vrd from the isasocut study and intravenous isa-vrd from the imroz study in patients with transplant- ineligible newly diagnosed multiple myeloma

Free
Arthur Bobin, Mohamad Mohty, Philippe Moreau, Hartmut Goldschmidt, Meletios Dimopoulos, Robert Orlowski, Cyrille Touzeau, Aurore Perrot, Thomas Chalopin, Mamoun Dib, Lydia Montes, Umer Khan, Mony Morisse, Rick Zhang, Corina Oprea, Florence Suzan Teisserenc, Thierry Facon, Xavier Leleu
Journal: Blood
Blood (2025) 146 (Supplement 1): 7566.
https://doi.org/10.1182/blood-2025-7566
Published: 2025
Journal Articles

A Phase 2/3, multicenter, randomized, open-label study evaluating the efficacy and safety of etentamig and daratumumab compared to daratumumab, lenalidomide, and dexamethasone in frailer transplant-ineligible patients with newly diagnosed multiple myeloma

Free
Salomon Manier, Noemí Puig, Xavier Leleu, Albert Oriol, Cyrille Hulin, Ramon García-Sanz, Jill Corre, Jesus San-Miguel, Thierry Facon, Hans Lee, Peter Forsberg, Kaustav Chatterjee, Anders Svensson, Chetasi Talati, Sunny He, Thomas Doerr, Emma Arriola, Myles Dillon, Jennifer Lin, Linh Nguyen, Fan Wang, María-Victoria Mateos
Journal: Blood
Blood (2025) 146 (Supplement 1): 2288.
https://doi.org/10.1182/blood-2025-2288
Published: 2025
Journal Articles

Relative mortality in elderly frail patients with newly diagnosed multiple myeloma: Ad-hoc analysis of the Phase 3 IFM 2017-03 trial compared to population-based data in France and implications for the functional cure concept

Free
Julie Castiaux, Noemie Bigot, Cyrille Hulin, Magaret Macro, Kamel Laribi, Carla Araujo, Gian Matteo Pica, Cyrille Touzeau, Pascal Godmer, Aurore Perrot, Jean-Yves Mary, Jill Corre, Herve Avet-Loiseau, Philippe Moreau, Xavier Leleu, Thierry Facon, Jerome Lambert, Salomon Manier
Journal: Blood
Blood (2025) 146 (Supplement 1): 498.
https://doi.org/10.1182/blood-2025-498
Published: 2025
Journal Articles

Longitudinal assessments of minimal residual disease in high-risk patients from benefit phase 3 randomized Study of isatuximab plus lenalidomide and dexamethasone with bortezomib (Isa-VRd) versus isard in newly diagnosed transplant ineligible multiple myeloma. (IFM 2020-05)

Free
Anais Schavgoulidze, Jerome Lambert, Arthur Bobin, Salomon Manier, Aurore Perrot, Lionel Karlin, Murielle Roussel, Noemie Bigot, Omar Benbrahim, Olivier Allangba, Philippe Rey, Veronique Dorvaux, Marguerite Vignon, Virginie Roland, Reda Garidi, Jean-Noel Bastie, Marie-Lorraine Chrétien, Sophie Godet, Lydia Montes, Cherel Brieuc, Ikhlef Souhila, Anne Vekkhof, Thomas Chalopin, Bohrane Slama, Laurent Frenzel, Emilie Chalayer, Helene Gardeney, Magaret Macro, Bruno Royer, Stephanie Harel, Olivier Decaux, Bertrand Arnulf, Karim Belhadj Merzoug, Cyrille Touzeau, Mohamad Mohty, Aurelie Gontier, Philippe Moreau, Thierry Facon, Jill Corre, Cyrille Hulin, Xavier Leleu
Journal: Blood
Blood (2025) 146 (Supplement 1): 497.
https://doi.org/10.1182/blood-2025-497
Published: 2025
Journal Articles

Multicenter phase 2 study of subcutaneous isatuximab plus bortezomib , lenalidomide and dexamethasone (Isa Sc-VRd) in transplant ineligible newly diagnosed multiple myeloma: Final analysis of the isasocut study (IFM 2022-05)

Free
Arthur Bobin, Rick Zhang, Mony Morisse, Anais Schavgoulidze, Stéphanie Ragot, Christophe Roul, Thomas Chalopin, Lydia Montes, Mamoun Dib, Mourad Tiab, Frederique Orsini Piocelle, Thorsten Braun, Julie Gay, Carla Araujo, Reza Tabrizi, Laure Vincent, Alberto Santagostino, karine Garnier, Douaa Dhahri, Mohamad Mohty, Magaret Macro, Murielle Roussel, Lionel Karlin, Philippe Moreau, Cyrille Touzeau, Aurore Perrot, Thierry Facon, Cyrille Hulin, Jill Corre, Salomon Manier, Xavier Leleu
Journal: Blood
Blood (2025) 146 (Supplement 1): 2275.
https://doi.org/10.1182/blood-2025-2275
Published: 2025
Journal Articles

Efficacy and safety of isa-vrd in elderly patients with or without frailty criteria: Pooled analysis of imroz and phase 1b studies in newly diagnosed multiple myeloma patients

Free
Enrique Ocio, Aurore Perrot, Jesus San-Miguel, Lionel Karlin, Joaquin Martinez-Lopez, Sara Bringhen, Paula Rodriguez-Otero, Mohamad Mohty, Robert Orlowski, Meletios Dimopoulos, Xavier Leleu, María-Victoria Mateos, Philippe Moreau, Sandrine Macé, Ecrem Kodas, Christine Tekle, Umer Khan, Corina Oprea, Thierry Facon
Journal: Blood
Blood (2025) 146 (Supplement 1): 2267.
https://doi.org/10.1182/blood-2025-2267
Published: 2025
Journal Articles

Sustained minimal residual disease (sMRD) negativity in transplant ineligible newly diagnosed multiple myeloma treated with isatuximab plus lenalidomide and dexamethasone with bortezomib (Isa-VRd) versus isa-rd: 12-24-month data from the phase 3 benefit trial (IFM 2020-05)

Free
Arthur Bobin, Jerome Lambert, Jill Corre, Salomon Manier, Aurore Perrot, Lionel Karlin, Murielle Roussel, Noemie Bigot, Kamel Laribi, Claire Dingremont, Christophe Roul, Valentine Richez, Clara Mariette, Sophie Rigaudeau, Claire Calmettes, Mamoun Dib, Mourad Tiab, Laure Vincent, Jacques Delaunay, Jean Pierre Marolleau, Pascal Godmer, Anaïs Schavgoulidze, Laurent Frenzel, Ronan Le Calloch, Emilie Chalayer, Helene Gardeney, Magaret Macro, Bruno Royer, Stephanie Harel, Olivier Decaux, Bertrand Arnulf, Karim Belhadj Merzoug, Cyrille Touzeau, Mohamad Mohty, Philippe Moreau, Thierry Facon, Cyrille Hulin, Xavier Leleu
Journal: Blood
Blood (2025) 146 (Supplement 1): 368.
https://doi.org/10.1182/blood-2025-368
Published: 2025
Journal Articles

A phase 2 Study of teclistamab in combination with daratumumab in elderly patients with newly diagnosed multiple myeloma: The IFM2021-01 teclille trial, cohort a

Free
Salomon Manier, Jerome Lambert, Magaret Macro, Thomas Chalopin, Mamoun Dib, Anne Rumpler, Julie Gay, Jean-Noel Bastie, Caroline Jacquet, Cecile Sonntag Mottier, Laure Vincent, Aurore Perrot, Clara Mariette, Lydia Montes, Sophie Rigaudeau, Noemie Bigot, Margaret Doyle, Diptendu Santra, Pavel Smirnov, Claire Albrecht, Cyrille Touzeau, Jill Corre, Philippe Moreau, Herve Avet-Loiseau, Cyrille Hulin, Xavier Leleu, Thierry Facon
Journal: Blood
Blood (2025) 146 (Supplement 1): 367.
https://doi.org/10.1182/blood-2025-367
Published: 2025
Journal Articles

Daratumumab-bortezomib-thalidomide-dexamethasone for newly diagnosed myeloma: CASSIOPEIA minimal residual disease results

Available to Purchase
Clinical Trials & Observations
Jill Corre, Laure Vincent, Philippe Moreau, Benjamin Hebraud, Cyrille Hulin, Marie C. Béné, Annemiek Broijl, Denis Caillot, Michel Delforge, Thomas Dejoie, Thierry Facon, Jérôme Lambert, Xavier Leleu, Margaret Macro, Aurore Perrot, Sonja Zweegman, Thomas Filleron, Bastien Cabarrou, Niels W. C. J. van de Donk, Sabrina Mahéo, Winnie Hua, Jianping Wang, Maria Krevvata, Véronique Vanquickelberghe, Carla de Boer, Alba Tuozzo, Fredrik Borgsten, Melissa Rowe, Robin Carson, Soraya Wuilleme, Pieter Sonneveld
Journal: Blood
Blood (2025) 146 (6): 679–692.
https://doi.org/10.1182/blood.2024027620
Published: 2025
Includes: Supplemental data
Journal Articles

High-Risk Multiple Myeloma in Benefit (IFM 2020-05) Phase 3 Randomized Study of Isatuximab (Isa) Plus Lenalidomide and Dexamethasone (Rd) with Bortezomib Versus Isard in Patients with Newly Diagnosed Transplant Ineligible Multiple Myeloma (NDMM TI)

Free
Jill Corre, Jérôme Lambert, Arthur Bobin, Salomon Manier, Aurore Perrot, Lionel Karlin, Murielle Roussel, Noemie Bigot, Omar Benbrahim, Olivier Thierry Allangba, Philippe Rey, Veronique Dorvaux, Marguerite Vignon, Virginie Roland, Reda Garidi, Jean-Noel Bastie, Marie-Lorraine Chrétien, Sophie Godet, Lydia Montes, Brieuc Cherel, Thomas Chalopin, Borhane Slama, Kamel Laribi, Claire Dingremont, Christophe Roul, Valentine Richez, Clara Mariette, Sophie Rigaudeau, Claire Calmettes, Mamoun Dib, Mourad Tiab, Laure Vincent, Jacques Delaunay, Jean Pierre Marolleau, Pascal Godmer, Laurent Frenzel, Ronan Le Calloch, Emilie Chalayer, Helene Gardeney, Margaret Macro, Bruno Royer, Olivier Decaux, Bertrand Arnulf, Karim Belhadj Merzoug, Cyrille Touzeau, Mohamad Mohty, Aurelie Gontier, Amine Kasmi, Philippe Moreau, Thierry Facon, Herve Avet Loiseau, Cyrille Hulin, Xavier Leleu
Journal: Blood
Blood (2024) 144 (Supplement 1): 4756.
https://doi.org/10.1182/blood-2024-210345
Published: 2024
Journal Articles

Health-Related Quality of Life (HRQoL) in Patients with Newly Diagnosed Multiple Myeloma (NDMM) Ineligible for Transplantation and Treated with Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone (Isa-VRd) Vs. Vrd Alone: Results from the Imroz Study

Free
Meletios Dimopoulos, Thierry Facon, Meral Beksac, Ludek Pour, Roman Hajek, Zhuogang Liu, Jiri Minarik, Philippe Moreau, Joanna Romejko-Jarosinska, Ivan Špička, Vladimir I. Vorobyev, Britta Besemer, Tadao Ishida, Wojciech Janowski, Sevgi Kalayoglu Besisik, Gurdeep Parmar, Pawel Robak, Elena Zamagni, Hartmut Goldschmidt, Thomas Martin, Salomon Manier, Mohamad Mohty, Robert Z. Orlowski, Erin Comerford, Claire Tian, Jérôme Msihid, Feng Lin, Stephanie Rhoten, Xavier. P Leleu
Journal: Blood
Blood (2024) 144 (Supplement 1): 3352.
https://doi.org/10.1182/blood-2024-207087
Published: 2024
Journal Articles

Prognostic Value of Positron Emission Tomography/Computed Tomography in Multiple Myeloma Patients Treated with Ide-Cel CAR-T Cell Therapy: Preliminary Results of a Real-World IFM Study from the Descar-T Registry (CAR MY PET)

Free
Bertrand Arnulf, Laetitia Vercellino, Denis Caillot, Jérôme Lambert, Bastien Jamet, Aurore Perrot, Pierre Bories, Olivier Decaux, Lionel Karlin, Anne Lazareth, Laure Vincent, Christine Latry Kuhn, Cyrille Touzeau, Harel Stephanie, Mohamad Mohty, Florent Malard, Salomon Manier, Ibrahim Yakoub-Agha, Alexis Talbot, Niels Moya, Arthur Bobin, Marie-Odile Petillon, Noemie Bigot, Thierry Facon, Jill Corre, Herve Avet-Loiseau, Philippe Moreau, Françoise Kraeber-Bodéré
Journal: Blood
Blood (2024) 144 (Supplement 1): 4765.
https://doi.org/10.1182/blood-2024-206867
Published: 2024
Journal Articles

The IFM2017-03 Phase 3 Trial: A Dexamethasone Sparing-Regimen with Daratumumab and Lenalidomide for Frail Patients with Newly-Diagnosed Multiple Myeloma

Free
Salomon Manier, Jérome Lambert, Cyrille Hulin, Kamel Laribi, Carla Araujo, Gian Matteo Pica, Cyrille Touzeau, Pascal Godmer, Bohrane Slama, Lionel Karlin, Frederique Orsini Piocelle, Mamoun Dib, Magaret Macro, Laurence Sanhes, Lydia Montes, Abderrazak El Yamani, Mourad Tiab, Reza Tabrizi, Laurent Garderet, Bruno Royer, Benoit Bareau, Aurore Perrot, Jean Yves Mary, Jill Corre, Herve Avet Loiseau, Philippe Moreau, Xavier Leleu, Thierry Facon
Journal: Blood
Blood (2024) 144 (Supplement 1): 774.
https://doi.org/10.1182/blood-2024-203045
Published: 2024
Journal Articles

Phase 3 Randomized Study of Daratumumab (DARA) + Bortezomib, Lenalidomide and Dexamethasone (VRd) Versus Alone in Patients with Transplant-Ineligible Newly Diagnosed Multiple Myeloma or for Whom Transplant Is Not Planned As Initial Therapy: Analysis of Minimal Residual Disease in the Cepheus Trial

Free
Sonja Zweegman, Thierry Facon, Vania Hungria, Nizar J. Bahlis, Christopher P. Venner, Marc Braunstein, Luděk Pour, Josep Marti Tutusaus, Supratik Basu, Yael C. Cohen, Morio Matsumoto, Kenshi Suzuki, Cyrille Hulin, Sebastian Grosicki, Wojciech Maciej Legiec, Meral Beksac, Angelo Maiolino, Hiroyuki Takamatsu, Aurore Perrot, Mehmet Turgut, Weiping Liu, Jianping Wang, Katherine Chastain, Jessica Vermeulen, Maria Krevvata, Lorena Lopez-Masi, Jodi Carey, Melissa Rowe, Robin Carson, Saad Z. Usmani
Journal: Blood
Blood (2024) 144 (Supplement 1): 362.
https://doi.org/10.1182/blood-2024-200871
Published: 2024
Journal Articles

Mezigdomide (MEZI) Plus Dexamethasone (DEX) and Bortezomib (BORT) or Carfilzomib (CFZ) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Updated Results from the CC-92480-MM-002 Trial

Free
Irwindeep Sandhu, Paul G. Richardson, Albert Oriol, Darrell White, Richard Leblanc, Noopur Raje, Enrique M. Ocio, Aurore Perrot, Thierry Facon, Cesar Rodriguez, Ralph Wäsch, Meletios A. Dimopoulos, Tracy T. Chow, Allison Gaudy, Jing Gong, Zehua Zhou, Tiziana Civardi, Joseph T. Hadala, Yue Zhu, Jessica Katz, Marc S. Raab
Journal: Blood
Blood (2024) 144 (Supplement 1): 1025.
https://doi.org/10.1182/blood-2024-198408
Published: 2024
Journal Articles

How I treat multiple myeloma in geriatric patients

Free
Thierry Facon, Xavier Leleu, Salomon Manier
Journal: Blood
Blood (2024) 143 (3): 224–232.
https://doi.org/10.1182/blood.2022017635
Published: 2024
Journal Articles

French Early Nationwide Idecabtagene Vicleucel (Ide-Cel) Chimeric Antigen Receptor (CAR) T-Cell Therapy Experience in Patients with Relapsed/Refractory Multiple Myeloma (FENIX): Update of the IFM Study from the Descar-T Registry

Free
Sarah Cayla, Benoit Ferment, Noemie Bigot, Denis Caillot, Ingrid Lafon, Lionel Karlin, Anne Lazareth, Cyrille Touzeau, Xavier Leleu, Niels Moya, Stephanie Harel, Aurore Perrot, Pierre Bories, Laure Vincent, Sylvain Lamure, Mohamad Mohty, Florent Malard, Salomon Manier, Ibrahim Yakoub-Agha, Anne-Marie Stoppa, Gabriel Brisou, Olivier Decaux, Roch Houot, Steven Le Gouill, Jerome Lambert, Thierry Facon, Herve Avet Loiseau, Philippe Moreau, Bertrand Arnulf
Journal: Blood
Blood (2023) 142 (Supplement 1): 2139.
https://doi.org/10.1182/blood-2023-188655
Published: 2023
Journal Articles

Multicenter Open Label Phase 3 Benefit Study of Isatuximab Plus Lenalidomide and Dexamethasone with/without Bortezomib in the Treatment of Newly Diagnosed Non-Frail Transplant Ineligible Multiple Myeloma Elderly Patients. IFM2020-05

Free
Arthur Bobin, Cyrille Hulin, Jerome Lambert, Aurore Perrot, Salomon Manier, Lydia Montes, Arnaud Jaccard, Lionel Karlin, Pascal Godmer, Denis Caillot, Thomas Chalopin, Christophe Roul, Clara Mariette, Sophie Rigaudeau, Jacques Delaunay, Claire Dingremont, Alberto Santagostino, Mamoun Dib, Margaret Macro, Mourad Tiab, Kamel Laribi, Emmanuelle Bourgeois Petit, Claire Calmettes, Frederique Orsini Piocelle, Benoit Bareau, Reza Tabrizi, Laure Vincent, Mohamad Mohty, Cyrille Touzeau, Jill Corre, Philippe Moreau, Thierry Facon, Herve Avet Loiseau, Xavier Leleu
Journal: Blood
Blood (2023) 142 (Supplement 1): 6741.
https://doi.org/10.1182/blood-2023-185699
Published: 2023