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Journal Articles

Poisoning of Healthy Hematopoiesis Is an Unanticipated Mechanism Driving Clonal Dominance in Vexas Syndrome

Blood (2024) 144 (Supplement 1): 4050.

https://doi.org/10.1182/blood-2024-207200

Published: 2024

Journal Articles

The Mitochondrial Protease Clpp Is a Metabolic Vulnerability and an Immunogenic Trigger Against Multiple Myeloma

Tommaso Perini, Paola Zordan, Rossella Del Pizzo, Massimo Resnati, Ugo Orfanelli, Davide Stefanoni, Laura Cassina, Laura Oliva, Mehmet K. Samur, Lisa Viviani, Maria Materozzi, Matteo Trudu, Alessandra Boletta, Enrico Milan, Fabio Ciceri, Nikhil C. Munshi, Matteo Bellone, Simone Cenci

Blood (2024) 144 (Supplement 1): 765.

https://doi.org/10.1182/blood-2024-201364

Published: 2024

Journal Articles

Unraveling Pathophysiology and Hematopoiesis of Vexas Syndrome By Multi-Omics Analyses and Targeted Gene Editing

Blood (2023) 142 (Supplement 1): 2692.

https://doi.org/10.1182/blood-2023-179749

Published: 2023

Journal Articles

Targeting the Mitochondrial Protease Clpp Unveils Mitochondrial Vulnerabilities in Multiple Myeloma

Tommaso Perini, Laura Oliva, Maria Materozzi, Rossella Del Pizzo, Laura Cassina, Mehmet K. Samur, Ugo Orfanelli, Enrico Milan, Alessandra Boletta, Nikhil C Munshi, Simone Cenci

Blood (2022) 140 (Supplement 1): 7072–7073.

https://doi.org/10.1182/blood-2022-164536

Published: 2022

Journal Articles

A FAM46C-Dependent Molecular Circuit Modulates Antibody Synthesis and Proliferation in Plasma Cell Dyscrasias

Enrico Milan, Massimo Resnati, Elena Riva, Mario Nuvolone, Simone Cenci

Blood (2022) 140 (Supplement 1): 857.

https://doi.org/10.1182/blood-2022-162234

Published: 2022

Journal Articles

Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease

Blood (2021) 138 (17): 1554–1569.

https://doi.org/10.1182/blood.2020009594

Published: 2021

Includes: Supplemental data

Journal Articles

Tryptophan Deprivation Promotes an Adaptive Response and Contributes to Bioenergetics in Multiple Myeloma

Alessandra Romano, MDPhD, Nunziatina Laura Parrinello, Katia Todoerti, PhD, Piera La Cava, Fabrizio Puglisi, Cesarina Giallongo, PhD, Daniele Tibullo, Giuseppina Camiolo, Giuseppe Sapienza, MD, Vittorio Del Fabro, MD, Concetta Conticello, Francesco Piazza, Marilena Carrino, PhD, Giuseppe A. Palumbo, MD, Simone Cenci, MD, Antonino Neri, MD, Francesco Di Raimondo, MD

Blood (2018) 132 (Supplement 1): 4511.

https://doi.org/10.1182/blood-2018-99-116447

Published: 2018

Journal Articles

Arginine Deprivation and Autophagy Sustain Bioenergetics in Multiple Myeloma

Alessandra Romano, MDPhD, Laura Oliva, PhD, Jose Manuel Manteiga, Todoerti Katia, Lorenzo Canziani, Matteo Trudu, Francesca Fontana, Michela Ghizzinardi, Ugo Orfanelli, Magda Marcatti, MD, Fabio Ciceri, MD, Giovanni Tonon, MD PhD, Antonino Neri, MD, Claudio Cerichione, MD PhD, Francesco Di Raimondo, MD, Simone Cenci, MD

Blood (2017) 130 (Supplement 1): 3051.

https://doi.org/10.1182/blood.V130.Suppl_1.3051.3051

Published: 2017

Journal Articles

Arginine Deprivation Sustains Plasma Cell Fitness Via GCN2: A Novel Immuno-Metabolic Check-Point

Alessandra Romano, MDPhD, Ugo Orfanelli, Michela Ghizzinardi, Nunziatina Laura Parrinello, Piera La Cava, Todoerti Katia, Laura Oliva, PhD, Francesca Paradiso, Floriana Cremasco, Daniele Tibullo, Cesarina Giallongo, Concetta Conticello, MD, Magda Marcatti, MD, Fabio Ciceri, MD, Antonino Neri, MD, Claudio Cerichione, MD PhD, Francesco Di Raimondo, MD, Simone Cenci, MD

Blood (2017) 130 (Supplement 1): 1752.

https://doi.org/10.1182/blood.V130.Suppl_1.1752.1752

Published: 2017

Journal Articles

The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity

Laura Oliva, Ugo Orfanelli, Massimo Resnati, Andrea Raimondi, Andrea Orsi, Enrico Milan, Giovanni Palladini, Paolo Milani, Fulvia Cerruti, Paolo Cascio, Simona Casarini, Paola Rognoni, Thierry Touvier, Magda Marcatti, Fabio Ciceri, Silvia Mangiacavalli, Alessandro Corso, Giampaolo Merlini, Simone Cenci

Blood (2017) 129 (15): 2132–2142.

https://doi.org/10.1182/blood-2016-08-730978

Published: 2017

Includes: Supplemental data

Journal Articles

Immune Suppression By High-Density Neutrophils Predicts Short Progression-Free Survival in Multiple Myeloma

Alessandra Romano, MD PhD, Jose Manteiga, PhD, Vittorio Simeon, PhD, Nunziatina L Parrinello, Cesarina Giallongo, Piera La Cava, Concetta Conticello, MD, Daniele Tibullo, PhD, Francesca Fontana, Fabio Ciceri, MD, Floriana Cremasco, Monica Fabbri, Pellegrino Musto, Simone Cenci, MD, Francesco Di Raimondo, MD

Blood (2016) 128 (22): 4459.

https://doi.org/10.1182/blood.V128.22.4459.4459

Published: 2016

Journal Articles

Metabolomics Identifies Potential Biomarkers of Multiple Myeloma Development and Progression

Francesca Fontana, MD, PhD, Josè Manuel garcia Manteiga, PhD, Magda Marcatti, MD, Francesca Lorentino, MD, Giovanni Tonon, MD, PhD, Fabio Ciceri, MD, Roberto Sitia, MD, Simone Cenci, MD

Blood (2012) 120 (21): 3985.

https://doi.org/10.1182/blood.V120.21.3985.3985

Published: 2012

Journal Articles

Assessing Proteostasis and Proteasome Stress In Light Chain Amyloidosis

Laura Oliva, PhD, Giovanni Palladini, MD, Fulvia Cerruti, PhD, Niccolò Pengo, MS, Paolo Cascio, PhD, Giampaolo Merlini, MD, Roberto Sitia, MD, Simone Cenci, MD

Blood (2010) 116 (21): 3992.

https://doi.org/10.1182/blood.V116.21.3992.3992

Published: 2010

Journal Articles

The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition

Giada Bianchi, Laura Oliva, Paolo Cascio, Niccolò Pengo, Francesca Fontana, Fulvia Cerruti, Andrea Orsi, Elena Pasqualetto, Alexandre Mezghrani, Valeria Calbi, Giovanni Palladini, Nicola Giuliani, Kenneth C. Anderson, Roberto Sitia, Simone Cenci

Blood (2009) 113 (13): 3040–3049.

https://doi.org/10.1182/blood-2008-08-172734

Published: 2009

Includes: Supplemental data

Journal Articles

Proteasome Stress Causes Apoptotic Sensitivity of Multiple Myeloma Cells to Proteasome Inhibition

Giada Bianchi, Laura Oliva, Paolo Cascio, Niccolo’ Pengo, Andrea Orsi, Francesca Fontana, Elena Pasqualetto, Alexandre Mezghrani, Fulvia Cerruti, Valeria Calbi, Giovanni Palladini, Nicola Giuliani, Dharminder Chauhan, Kenneth C. Anderson, Roberto Sitia, Simone Cenci

Blood (2008) 112 (11): 247.

https://doi.org/10.1182/blood.V112.11.247.247

Published: 2008

Journal Articles

Direct Assessment of Proteasomal Degradation as a Potential Predictor of Responsiveness to Bortezomib in Multiple Myeloma.

Giada Bianchi, MD, Andrea Orsi, PhD, Simone Cenci, MD, Paolo Cascio, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD, Roberto Sitia, MD

Blood (2006) 108 (11): 3525.

https://doi.org/10.1182/blood.V108.11.3525.3525

Published: 2006

Journal Articles

Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines

M. Neale Weitzmann, Simone Cenci, Leonard Rifas, Christopher Brown, Roberto Pacifici

Blood (2000) 96 (5): 1873–1878.

https://doi.org/10.1182/blood.V96.5.1873

Published: 2000

NARROW

Poisoning of Healthy Hematopoiesis Is an Unanticipated Mechanism Driving Clonal Dominance in Vexas Syndrome

The Mitochondrial Protease Clpp Is a Metabolic Vulnerability and an Immunogenic Trigger Against Multiple Myeloma

Unraveling Pathophysiology and Hematopoiesis of Vexas Syndrome By Multi-Omics Analyses and Targeted Gene Editing

Targeting the Mitochondrial Protease Clpp Unveils Mitochondrial Vulnerabilities in Multiple Myeloma

A FAM46C-Dependent Molecular Circuit Modulates Antibody Synthesis and Proliferation in Plasma Cell Dyscrasias

Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease

Tryptophan Deprivation Promotes an Adaptive Response and Contributes to Bioenergetics in Multiple Myeloma

Arginine Deprivation and Autophagy Sustain Bioenergetics in Multiple Myeloma

Arginine Deprivation Sustains Plasma Cell Fitness Via GCN2: A Novel Immuno-Metabolic Check-Point

The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity

Immune Suppression By High-Density Neutrophils Predicts Short Progression-Free Survival in Multiple Myeloma

Metabolomics Identifies Potential Biomarkers of Multiple Myeloma Development and Progression

Assessing Proteostasis and Proteasome Stress In Light Chain Amyloidosis

The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition

Proteasome Stress Causes Apoptotic Sensitivity of Multiple Myeloma Cells to Proteasome Inhibition

Direct Assessment of Proteasomal Degradation as a Potential Predictor of Responsiveness to Bortezomib in Multiple Myeloma.

Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines

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American Society of Hematology

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American Society of Hematology

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