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Ugo Orfanelli
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Journal Articles

The Mitochondrial Protease Clpp Is a Metabolic Vulnerability and an Immunogenic Trigger Against Multiple Myeloma

Tommaso Perini, Paola Zordan, Rossella Del Pizzo, Massimo Resnati, Ugo Orfanelli, Davide Stefanoni, Laura Cassina, Laura Oliva, Mehmet K. Samur, Lisa Viviani, Maria Materozzi, Matteo Trudu, Alessandra Boletta, Enrico Milan, Fabio Ciceri, Nikhil C. Munshi, Matteo Bellone, Simone Cenci
Journal: Blood
Blood (2024) 144 (Supplement 1): 765.
https://doi.org/10.1182/blood-2024-201364
Published: 2024
Journal Articles

Targeting the Mitochondrial Protease Clpp Unveils Mitochondrial Vulnerabilities in Multiple Myeloma

Tommaso Perini, Laura Oliva, Maria Materozzi, Rossella Del Pizzo, Laura Cassina, Mehmet K. Samur, Ugo Orfanelli, Enrico Milan, Alessandra Boletta, Nikhil C Munshi, Simone Cenci
Journal: Blood
Blood (2022) 140 (Supplement 1): 7072–7073.
https://doi.org/10.1182/blood-2022-164536
Published: 2022
Journal Articles

Arginine Deprivation and Autophagy Sustain Bioenergetics in Multiple Myeloma

Alessandra Romano, MDPhD, Laura Oliva, PhD, Jose Manuel Manteiga, Todoerti Katia, Lorenzo Canziani, Matteo Trudu, Francesca Fontana, Michela Ghizzinardi, Ugo Orfanelli, Magda Marcatti, MD, Fabio Ciceri, MD, Giovanni Tonon, MD PhD, Antonino Neri, MD, Claudio Cerichione, MD PhD, Francesco Di Raimondo, MD, Simone Cenci, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3051.
https://doi.org/10.1182/blood.V130.Suppl_1.3051.3051
Published: 2017
Journal Articles

Arginine Deprivation Sustains Plasma Cell Fitness Via GCN2: A Novel Immuno-Metabolic Check-Point

Alessandra Romano, MDPhD, Ugo Orfanelli, Michela Ghizzinardi, Nunziatina Laura Parrinello, Piera La Cava, Todoerti Katia, Laura Oliva, PhD, Francesca Paradiso, Floriana Cremasco, Daniele Tibullo, Cesarina Giallongo, Concetta Conticello, MD, Magda Marcatti, MD, Fabio Ciceri, MD, Antonino Neri, MD, Claudio Cerichione, MD PhD, Francesco Di Raimondo, MD, Simone Cenci, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1752.
https://doi.org/10.1182/blood.V130.Suppl_1.1752.1752
Published: 2017
Journal Articles

The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity

Laura Oliva, Ugo Orfanelli, Massimo Resnati, Andrea Raimondi, Andrea Orsi, Enrico Milan, Giovanni Palladini, Paolo Milani, Fulvia Cerruti, Paolo Cascio, Simona Casarini, Paola Rognoni, Thierry Touvier, Magda Marcatti, Fabio Ciceri, Silvia Mangiacavalli, Alessandro Corso, Giampaolo Merlini, Simone Cenci
Journal: Blood
Blood (2017) 129 (15): 2132–2142.
https://doi.org/10.1182/blood-2016-08-730978
Published: 2017
Includes: Supplemental data