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Simona Soverini, PhD
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Journal Articles

Detection of Actionable BCR-ABL1 Kinase Domain (KD) Mutations in Chronic Myeloid Leukemia (CML) Patients with Failure and Warning Response to Tyrosine Kinase Inhibitors (TKIs): Potential Impact of Next-Generation Sequencing (NGS) and Droplet Digital PCR (ddPCR) on Clinical Decision Making

Simona Soverini, PhD, Margherita Martelli, Dr, Luana Bavaro, Dr, Caterina De Benedittis, Alessandra Iurlo, MD PhD, Sara Galimberti, MD PhD, Patrizia Pregno, Massimiliano Bonifacio, MD, Francesca Lunghi, MD, Fausto Castagnetti, MD PhD, Gabriele Gugliotta, MD PhD, Gianantonio Rosti, MD, Mario Tiribelli, Vanessa Velotta, Fabio Stagno, MD, Antonella Russo Rossi, Mariella D'Adda, MD, Claudia Baratè, Monica Crugnola, MD, Luigiana Luciano, Maria Antonella Laginestra, PhD, Adam S Corner, PhD, Dianna Maar, PhD, Antonio Percesepe, MD PhD, Stefano Pileri, MD, Fabrizio Pane, MD, Giuseppe Saglio, MD, Michele Baccarani, MD, Giovanni Martinelli, MD, Michele Cavo
Journal: Blood
Blood (2019) 134 (Supplement_1): 661.
https://doi.org/10.1182/blood-2019-126767
Published: 2019
Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Can be Therapeutically Targeted Inducing Apoptotic Cell Death in a Caspase-Dependent Way

Manuela Mancini, PhD, Sara De Santis, Dr, Cecilia Monaldi, Dr, Luana Bavaro, Dr, Margherita Martelli, Dr, Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD PhD, Gianantonio Rosti, MD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Elisa Dan, PhD, Barbara Sinigaglia, Dr, Alessandra Iurlo, MD PhD, Nicola Orofino, MD, Elisabetta Abruzzese, MD, Marzia Salvucci, MD, Patrizia Pregno, Antonella Gozzini, MD, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, MD, Elisabetta Calistri, MD, Mario Tiribelli, Gianni Binotto, MD, Annalisa Imovilli, Elena Trabacchi, MD, Sara Galimberti, MD PhD, Claudia Baratè, Elena Tenti, Michele Baccarani, MD, Giovanni Martinelli, MD, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4142.
https://doi.org/10.1182/blood-2019-126500
Published: 2019
Journal Articles

Ten-Year Follow-up of Patients with Chronic Myeloid Leukemia Treated with Nilotinib in First-Line: Final Results of the Gimema CML 0307 Trial

Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD PhD, Massimo Breccia, MD, Luciano Levato, MD, Tamara Intermesoli, MD, Mariella D'adda, Marzia Salvucci, MD, Fabio Stagno, MD, Giovanna Rege Cambrin, MD PhD, Mario Tiribelli, Bruno Martino, MD, Monica Bocchia, Elena Trabacchi, MD, Francesco Cavazzini, MD, Ferdinando Porretto, Federica Sorà, MD, Giovanni Caocci, MD, Francesco Albano, MD, Giovanni Martinelli, MD, Simona Soverini, PhD, Robin Foà, MD, Fabrizio Pane, MD, Michele Cavo, Giuseppe Saglio, MD, Michele Baccarani, MD, Gianantonio Rosti, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4145.
https://doi.org/10.1182/blood-2019-126163
Published: 2019
Journal Articles

In Systemic Masocytosis, Midostaurin Targets Both Kit and Aurora Kinase a Reverting H3K36Me3 Deficiency and Synergizes with Second-Generation Tyrosine Kinase Inhibitors

Manuela Mancini, PhD, Cecilia Monaldi, Dr, Sara De Santis, Dr, Cristina Papayannidis, Michela Rondoni, MD, Luana Bavaro, Dr, Margherita Martelli, Dr, Antonio Curti, MD PhD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Roberta Zanotti, MD, Massimiliano Bonifacio, MD, Luigi Scaffidi, MD, Livio Pagano, MD, Marianna Criscuolo, MD, Francesco Albano, MD, Fabio Ciceri, MD, Chiara Elena, MD, Patrizia Tosi, Massimo Delledonne, Carla Avanzato, Luciano Xumerle, Peter Valent, MD, Giovanni Martinelli, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4204.
https://doi.org/10.1182/blood-2019-126538
Published: 2019
Journal Articles

Droplet Digital PCR Phasing (DROP-PHASE): A Novel Method for Straightforward Detection of BCR-ABL1 Compound Mutations in Tyrosine Kinase Inhibitors Resistant Chronic Myeloid Leukemia (CML) and Acute Lymphoblastic Leukemia (ALL)

Pascal Vannuffel, PhD, Luana Bavaro, Dr, Friedel Nollet, PhD, Asena Aynaci, Margherita Martelli, Dr, Helena Devos, Céline De Rop, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4660.
https://doi.org/10.1182/blood-2019-123409
Published: 2019
Journal Articles

Biology of Acute Myeloid Leukemia (AML) with Monosomy of Chromosome 7 or Loss of 7q. a Study on 487 Patients Analyzed By Gene Expression Profile (GEP), Single Nucleotide Polymorphism (SNP) Arrays and Metabolomics

Maria Chiara Fontana, MSc, Matteo Olivi, Giovanni Marconi, Mariachiara Abbenante, MD, Eugenio Fonzi, PhD, Stefania Paolini, MD PhD, Chiara Sartor, Sarah Parisi, Samantha Bruno, Martina Pazzaglia, Stefano De Polo, Jacopo Nanni, MD, Luca Bertamini, MD, Simone Ragaini, Annalisa Talami, Maria Teresa Bochicchio, Emanuela Ottaviani, Anna Ferrari, PhD, Carmen Baldazzi, Nicoletta Testoni, BSc, Torsten Haferlach, MD, Robert Kralovics, PhD, Jelena D. Milosevic Feenstra, PhD, Simona Soverini, PhD, Giovanni Martinelli, Antonio Curti, Michele Cavo, MD, Cristina Papayannidis, Giorgia Simonetti, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2748.
https://doi.org/10.1182/blood-2018-99-118183
Published: 2018
Journal Articles

Next Generation Sequencing-Based BCR-ABL1 Kinase Domain Mutation Screening in De Novo and Tyrosine Kinase Inhibitor-Resistant Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of a Prospective Study

Simona Soverini, PhD, Luana Bavaro, Margherita Martelli, Caterina De Benedittis, PhD, Cristina Papayannidis, Antonio Percesepe, MD PhD, Maria Antonella Laginestra, PhD, Simona Sica, MD, Federica Sorà, MD, Francesco Albano, MD, Livio Pagano, Marianna Criscuolo, Sara Galimberti, Marzia Salvucci, MD, Mario Annunziata, Giovanni Marconi, Antonio Curti, Sabina Russo, Annalisa Imovilli, Daniele Mannina, MD, Dario Ferrero, MD, Manuela Stulle, Claudia Basilico, MD, Elisabetta Abruzzese, Flavio Mignone, Stefano A. Pileri, MD PhD, Giovanni Martinelli, Michele Cavo, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4078.
https://doi.org/10.1182/blood-2018-99-117028
Published: 2018
Journal Articles

Compound BCR-ABL1 Kinase Domain Mutants: Prevalence, Spectrum and Correlation with Tyrosine Kinase Inhibitor Resistance in a Prospective Series of Philadelphia Chromosome-Positive Leukemia Patients Analyzed By Next Generation Sequencing

Simona Soverini, PhD, Luana Bavaro, Margherita Martelli, Caterina De Benedittis, PhD, Alessandra Iurlo, Nicola Orofino, MD, Livio Pagano, Marianna Criscuolo, Massimiliano Bonifacio, Luigi Scaffidi, MD, Simona Sica, MD, Federica Sorà, MD, Elena Maino, Michela Rondoni, MD, Maria Antonella Laginestra, PhD, Francesca Lunghi, Anna Ermacora, Mariella D'adda, MD, Gabriele Gugliotta, MD PhD, Fausto Castagnetti, Gianantonio Rosti, Cristina Papayannidis, Giovanni Marconi, Antonio Curti, Maria Cristina Miggiano, Sara Galimberti, Antonio Percesepe, MD PhD, Fabio Stagno, Rosaria Sancetta, MD, Mario Annunziata, Franca Falzetti, MD, Isabella Capodanno, Patrizia Pregno, Margherita Maffioli, MD, Tamara Intermesoli, MD, Eros Di Bona, MD, Giovanni Caocci, MD, Imma Attolico, MD, Gianni Binotto, Monica Bocchia, MD PhD, Emanuele Angelucci, MD, Nicola Sgherza, MD, Luigiana Luciano, Flavio Mignone, Stefano A. Pileri, MD PhD, Giovanni Martinelli, Michele Cavo, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 789.
https://doi.org/10.1182/blood-2018-99-117166
Published: 2018
Journal Articles

The Use of EUTOS Long-Term Survival Score Instead of Sokal Score Is Strongly Advised in Elderly Chronic Myeloid Leukemia Patients

Fausto Castagnetti, MD PhD, Gabriele Gugliotta, MD PhD, Massimo Breccia, MD, Fabio Stagno, Giorgina Specchia, MD, Luciano Levato, Bruno Martino, MD, Mariella D'Adda, Elisabetta Abruzzese, Patrizia Pregno, Mario Tiribelli, Alessandra Iurlo, Tamara Intermesoli, MD, Anna Rita Scortechini, MD, Francesco Cavazzini, MD, Carmen Fava, Massimiliano Bonifacio, Marzia Salvucci, MD, Monica Bocchia, MD PhD, Giovanni Caocci, MD, Antonella Gozzini, MD, Micaela Bergamaschi, MD, Simona Soverini, PhD, Robin Foà, MD, Giovanni Martinelli, Michele Cavo, MD, Giuseppe Saglio, Fabrizio Pane, Michele Baccarani, MD, Gianantonio Rosti
Journal: Blood
Blood (2018) 132 (Supplement 1): 44.
https://doi.org/10.1182/blood-2018-99-117409
Published: 2018
Journal Articles

Outcome of 472 Chronic Myeloid Leukemia Patients Treated with Frontline Nilotinib: A Gimema CML WP Analysis

Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD PhD, Massimo Breccia, MD, Alessandra Iurlo, Mariella D'Adda, Fabio Stagno, Luciano Levato, Bruno Martino, MD, Francesca Lunghi, Mario Tiribelli, Giovanna Rege Cambrin, MD, Elisabetta Abruzzese, MD, Serena Rupoli, MD, Antonella Gozzini, Patrizia Pregno, Marzia Salvucci, MD, Elena Trabacchi, MD, Giovanni Caocci, MD, Anna Rita Scortechini, MD, Luigia Luciano, MD, Giuseppe Tagariello, Massimiliano Bonifacio, Simona Soverini, PhD, Robin Foà, MD, Giovanni Martinelli, MD, Michele Cavo, MD, Fabrizio Pane, Giuseppe Saglio, Michele Baccarani, MD, Gianantonio Rosti
Journal: Blood
Blood (2018) 132 (Supplement 1): 458.
https://doi.org/10.1182/blood-2018-99-119182
Published: 2018
Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Induces Genetic Instability and Can be Therapeutically Targeted

Manuela Mancini, PhD, Sara De Santis, Cecilia Monaldi, Luana Bavaro, Margherita Martelli, Fausto Castagnetti, Gabriele Gugliotta, MD PhD, Gianantonio Rosti, Maria Chiara Fontana, MSc, Elisa Dan, Barbara Sinigaglia, Alessandra Iurlo, Nicola Orofino, Elisabetta Abruzzese, Marzia Salvucci, Patrizia Pregno, Antonella Gozzini, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, Elisabetta Calistri, MD, Mario Tiribelli, Gianni Binotto, MD, Annalisa Imovilli, Elena Trabacchi, MD, Sara Galimberti, Claudia Baratè, Elena Tenti, Michele Baccarani, MD, Giovanni Martinelli, Michele Cavo, MD, Simona Soverini, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1726.
https://doi.org/10.1182/blood-2018-99-112908
Published: 2018
Journal Articles

Higher Expression of PALB2 Predict Poor Prognosis in AML Patients and Identifies Potential Targets of Synthetic Lethal Therapies

Antonella Padella, Giovanni Marconi, Giorgia Simonetti, PhD, Andrea Ghelli Luserna Di Rora, Maria Chiara Fontana, MSc, Cristina Papayannidis, Emanuela Ottaviani, Michele Cavo, MD, Simona Soverini, PhD, Giovanni Martinelli
Journal: Blood
Blood (2018) 132 (Supplement 1): 1507.
https://doi.org/10.1182/blood-2018-99-118210
Published: 2018
Journal Articles

MDM2 and Aurora Kinase a Contribute to SETD2 Loss of Function in Advanced Systemic Mastocytosis: Implications for Pathogenesis and Treatment

Manuela Mancini, PhD, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, Michela Rondoni, MD, Luana Bavaro, Margherita Martelli, Abbenante Maria Chiara, Antonio Curti, Elisa Ficarra, Giulia Paciello, Maria Chiara Fontana, MSc, Roberta Zanotti, MD, Massimiliano Bonifacio, Luigi Scaffidi, MD, Livio Pagano, Marianna Criscuolo, Francesco Albano, MD, Fabio Ciceri, MD, Chiara Elena, MD, Patrizia Tosi, MD, Massimo Delledonne, Carla Avanzato, Luciano Xumerle, Peter Valent, Giovanni Martinelli, MD, Michele Cavo, MD, Simona Soverini, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1779.
https://doi.org/10.1182/blood-2018-99-113278
Published: 2018
Journal Articles

DNA Analysis of Mutations in the Kinase Domain of BCR-ABL1 By Allele-Specific Digital PCR Is Highly Sensitive and Refines Prediction of Kinetics of Resistant CML Clones

Vaclava Polivkova, Nikola Curik, Hana Zizkova, Adela Benesova, Pavel Burda, Pavla Pecherkova, Eliska Motlova, Jana Brezinova, Sarka Ransdorfova, Hana Klamova, Lenka Hovorkova, Jan Zuna, Thomas Ernst, Simona Soverini, PhD, Katerina Machova
Journal: Blood
Blood (2018) 132 (Supplement 1): 1743.
https://doi.org/10.1182/blood-2018-99-119710
Published: 2018
Journal Articles

International, Prospective Study Comparing Nilotinib Versus Imatinib with Early Switch to Nilotinib to Obtain Sustained Treatment-Free Remission in Patients with Chronic Myeloid Leukemia. a GIMEMA and HOVON Study

Fabrizio Pane, Luigia Luciano, MD, Novella Pugliese, MD, Juan Luis Steegman, Prof, Peter E. Westerweel, MD, Elisabetta Abruzzese, MD, Massimo Breccia, MD, Monica Bocchia, MD PhD, Simona Soverini, PhD, Fausto Castagnetti, MD PhD, Maria Monteverde, Gianantonio Rosti, Giuseppe Saglio, Jeroen J. Janssen, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1750.
https://doi.org/10.1182/blood-2018-99-118925
Published: 2018
Journal Articles

First Report of the Gimema LAL1811 Phase II Prospective Study of the Combination of Steroids with Ponatinib As Frontline Therapy of Elderly or Unfit Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Giovanni Martinelli, Alfonso Piciocchi, Cristina Papayannidis, MD PhD, Stefania Paolini, MD PhD, Valentina Robustelli, PhD, Simona Soverini, PhD, Carolina Terragna, Roberto M Lemoli, MD, Fabio Guolo, MD, Paolo Di Bartolomeo, MD, Monia Lunghi, Paolo de Fabritiis, Anna Candoni, MD, Carmine Selleri, MD, Federico Simonetti, MD, Monica Bocchia, Antonella Vitale, Luca Frison, Alessandra Tedeschi, Antonio Cuneo, MD, Massimiliano Bonifacio, MD, Brunangelo Falini, MD, Stefano D'Ardia, Silvia Trappolini, Patrizia Tosi, MD, Piero Galieni, MD, Francesco Fabbiano, MD, Maria Chiara Abbenante, Giovanni Marconi, Chiara Sartor, Michele Cavo, MD, Robin Foà, MD, Paola Fazi, Marco Vignetti, Michele Baccarani, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 99.
https://doi.org/10.1182/blood.V130.Suppl_1.99.99
Published: 2017
Journal Articles

SETD2 Non-Genomic Loss of Function and p53 Functional Inactivation in Advanced Systemic Mastocytosis (SM): Pathogenetic and Therapeutic Implications

Manuela Mancini, PhD, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, MD, Michela Rondoni, MD, Maria Chiara Abbenante, MD, Luana Bavaro, Margherita Martelli, Elisa Ficarra, Giulia Paciello, Viviana Guadagnuolo, Maria Chiara Fontana, MSc, Marco Manfrini, Roberta Zanotti, MD, Livio Pagano, MD, Francesco Albano, MD, Fabio Ciceri, MD, Chiara Elena, Patrizia Tosi, MD, Massimo Delledonne, Peter Valent, MD, Michele Cavo, MD, Giovanni Martinelli, MD, Simona Soverini, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2944.
https://doi.org/10.1182/blood.V130.Suppl_1.2944.2944
Published: 2017
Journal Articles

First-Line Treatment with Nilotinib in Chronic Myeloid Leukemia Patients in Real-Life: Results of the Observational Study Gimema CML0912

Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD, Francesca Lunghi, MD, Serena Rupoli, MD, Elisabetta Abruzzese, MD, Massimo Breccia, MD PhD, Alessandra Iurlo, MD PhD, Bruno Martino, Patrizia Pregno, MD, Mario Tiribelli, MD, Giovanna Rege Cambrin, Giuseppe Tagariello, Laura Nocilli, Antonietta Pia Falcone, MD, Debora Luzi, Monica Crugnola, MD, Sara Barulli, MD, Massimiliano Bonifacio, MD, Sabina Russo, Delia Noli, MD, Simona Soverini, PhD, Robin Foà, MD, Michele Cavo, MD, Giovanni Martinelli, MD, Fabrizio Pane, MD, Giuseppe Saglio, MD PhD, Michele Baccarani, MD, Gianantonio Rosti, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5253.
https://doi.org/10.1182/blood.V130.Suppl_1.5253.5253
Published: 2017
Journal Articles

Polo-like Kinase-1 and Aurora Kinase A As Novel Therapeutic Targets in Neoplastic Mast Cells

Manuela Mancini, PhD, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, MD, Michela Rondoni, MD, Maria Chiara Abbenante, MD, Luana Bavaro, Margherita Martelli, Roberta Zanotti, MD, Livio Pagano, MD, Michele Cavo, MD, Peter Valent, MD, Giovanni Martinelli, MD, Simona Soverini, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5290.
https://doi.org/10.1182/blood.V130.Suppl_1.5290.5290
Published: 2017
Journal Articles

What's Next in CML - a Prospective Study Evaluating Sanger Sequencing and Next Generation Sequencing (NGS) for BCR-ABL1 Kinase Domain (KD) Mutation Screening

Simona Soverini, PhD, Luana Bavaro, Caterina De Benedittis, PhD, Margherita Martelli, Stefania Stella, PhD, Paolo Vigneri, MD PhD, Alessandra Iurlo, MD PhD, Nicola Orofino, MD, Simona Sica, MD, Federica Sorà, MD, Sara Galimberti, PhD MD, Claudia Baratè, MD PhD, Francesco Albano, MD, Antonella Russo Rossi, MD, Fabio Ciceri, MD, Francesca Lunghi, MD, Fausto Castagnetti, MD, Gabriele Gugliotta, MD PhD, Gianantonio Rosti, MD, Elena Tenti, PhD, Fabio Stagno, MD PhD, Elisabetta Novella, PhD, Eros Di Bona, MD, Massimiliano Bonifacio, MD, Elisabetta Abruzzese, MD PhD, Marzia Salvucci, MD, Mariella D'Adda, MD, Rosaria Sancetta, MD, Elisabetta Calistri, MD, Monica Bocchia, Isabella Capodanno, MD, Giuseppina Spinosa, MD, Maria Antonella Laginestra, PhD, Santa Errichiello, PhD, Anna Serra, Dr, Francesca Carnuccio, Dr, Sabrina Coluzzi, PhD, Mario Annunziata, MD, Caterina Musolino, MD, Fabrizio Pane, MD, Giuseppe Saglio, MD PhD, Michele Baccarani, MD, Michele Cavo, MD, Giovanni Martinelli, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 248.
https://doi.org/10.1182/blood.V130.Suppl_1.248.248
Published: 2017