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Journal Articles

Somatic Mutations in Cancer-Related Genes Were Observed More Frequently in AYA CML Patients Compared to Elderly at Diagnosis, Whereas the Frequency Was Markedly Higher in Elderly Patients during TKI Treatment

Jitka Krizkova, Vaclava Polivkova, Nikola Curik, Adam Laznicka, Adela Benesova, Hana Klamova, Marketa Stastna Markova, Dana Srbova, Jan Zuna, Marketa Zaliova, Jan Trka, Pavel Semerak, Tomas Kalina, Cyril Salek, Katerina Machova Polakova

Blood (2023) 142 (Supplement 1): 4544.

https://doi.org/10.1182/blood-2023-189017

Published: 2023

Journal Articles

The Rate of Cellular Energy Production of Muscle Cells Is Attenuated By Carnitine Intracellular Deficiency Caused By Imatinib Treatment

Pavel Burda, Alzbeta Hlavackova, Vaclava Polivkova, Nikola Curik, Hana Klamová, Jitka Koblihova, Jiri Suttnar, Katerina Machova

Blood (2021) 138 (Supplement 1): 3609.

https://doi.org/10.1182/blood-2021-152516

Published: 2021

Journal Articles

Clonal Hematopoiesis with Somatic Mutations in "AYA" Generation of Patients with Chronic Myeloid Leukemia

Jitka Koblihova, Vaclava Polivkova, Adela Benesova, Hana Zizkova, Nikola Curik, Monika Pepek, Tomasz Stoklosa, MD PhD, Marketa Markova Stastna, Hana Klamová, Dana Srbova, Katerina Machova

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-140725

Published: 2020

Journal Articles

DNA Analysis of Mutations in the Kinase Domain of BCR-ABL1 By Allele-Specific Digital PCR Is Highly Sensitive and Refines Prediction of Kinetics of Resistant CML Clones

Vaclava Polivkova, Nikola Curik, Hana Zizkova, Adela Benesova, Pavel Burda, Pavla Pecherkova, Eliska Motlova, Jana Brezinova, Sarka Ransdorfova, Hana Klamova, Lenka Hovorkova, Jan Zuna, Thomas Ernst, Simona Soverini, PhD, Katerina Machova

Blood (2018) 132 (Supplement 1): 1743.

https://doi.org/10.1182/blood-2018-99-119710

Published: 2018

Journal Articles

Patients with Chronic Myeloid Leukemia Show Different Modulation of MYB-Dependent Oncogenic Pathway in the Course of Hematopoietic Differentiation upon Sensitivity to the TKI Treatment

Klara Srutova, Nikola Curik, Koblihova Jitka, Filipp Savvulidi, Hana Klamova, Danilo Perrotti, Tomas Stopka, Katerina Machova Polakova

Blood (2015) 126 (23): 1243.

https://doi.org/10.1182/blood.V126.23.1243.1243

Published: 2015

Journal Articles

SNPs in the Promoter of the Gene Encoding Transmembrane Transporter SLC22A4 (hOCTN1) Are Significantly Associated with an Alteration of Gene Expression and with Resistance to the Imatinib Treatment in Chronic Myeloid Leukemia

Monika Jaruskova, Rajna Hercog, Nikola Curik, Vladimir Benes, Hana Klamova, Katerina Machova Polakova

Blood (2015) 126 (23): 2463.

https://doi.org/10.1182/blood.V126.23.2463.2463

Published: 2015

Journal Articles

Azacitidine Blocks GATA-1-Mediated Repression of the PU.1 Gene in Human Leukemic Cells

Pavel Burda, PhD, Jarmila Vargova, MSc, Nikola Curik, John Strouboulis, PhD, Giorgio Lucio Papadopoulos, PhD, Anna Jonasova, MD PhD, Tomas Stopka, MD PhD

Blood (2015) 126 (23): 5220.

https://doi.org/10.1182/blood.V126.23.5220.5220

Published: 2015

Journal Articles

Erythroid Transcription Factor GATA-1 Binds and Represses PU.1 Gene – Candidate Mechanism Of Epigenetic Repression Of PU.1 and Inefficient Erythropoiesis In MDS

Pavel Burda, PhD, Nikola Curik, PhD, Nina Dusilkova, MD, Giorgio L Papadopoulos, Ph.D., John Strouboulis, PhD, Anna T Jonasova, MD, Tomas Stopka, MD, PhD

Blood (2013) 122 (21): 1558.

https://doi.org/10.1182/blood.V122.21.1558.1558

Published: 2013

Journal Articles

Mutation Of The Divalent Metal Transporter (Dmt1) Gene Results In Inefficient Induction Of The Erythroid Transcriptional Program Due To Latter Onset Of GATA-1 and Epor Expression

Nikola Curik, PhD, Pavel Burda, PhD, Tomas Zikmund, MSc., Filipp Savvulidi, Monika Horvathova, PhD, John Strouboulis, PhD, Vladimir Divoky, PhD, Tomas Stopka, MD, PhD

Blood (2013) 122 (21): 2197.

https://doi.org/10.1182/blood.V122.21.2197.2197

Published: 2013

Journal Articles

Transcription Factor CTCF Inhibits Effects of 5-Azacitidine in MDS/AML Cells

Martina Kapalova, MSc., Pavel Burda, PhD, Karin Vargova, MSc., Filipp Savvulidi, Tomas Zikmund, MSc., Nikola Curik, PhD, Anna Jonasova, Tomas Stopka, MD, PhD

Blood (2012) 120 (21): 3848.

https://doi.org/10.1182/blood.V120.21.3848.3848

Published: 2012

Journal Articles

Divalent Metal Transporter 1 (DMT1) Regulates EPO Receptor Gene Expression Via GATA-1

Pavel Burda, PhD, Nikola Curik, PhD, Monika Horvathova, MSc, PhD, Vladimir Divoky, Ph.D., ass. prof., Tomas Stopka, MD, PhD

Blood (2012) 120 (21): 991.

https://doi.org/10.1182/blood.V120.21.991.991

Published: 2012

Journal Articles

Activation of Chromatin Structure Upstream PU.1 Gene and in Vitro Differentiation in High Risk Myelodysplastic Syndrome Following 5-Azacytidine,

Tomas Stopka, MD, PhD, Nikola Curik, Pavel Burda, PhD, Karin Vargova, Vit Pospisil, Petra Vlckova, Filipp Savvulidi, Emanuel Necas, Hana Hájková, Cedrik Haskovec, PhD, Monika Belickova, Jaroslav Cermak, MD, PhD, Marek Trneny, Anna Jonasova, MD

Blood (2011) 118 (21): 3791.

https://doi.org/10.1182/blood.V118.21.3791.3791

Published: 2011

Journal Articles

Pattern of Mir-155 and PU.1 Expression in CLL/SLL and Aggressive Lymphomas

Tomas Stopka, MD, PhD, Karin Vargova, Hana Huskova, Pavel Burda, PhD, Nikola Curik, Petra Vlckova, Vojtech Kulvait, Vit Pospisil, Filipp Savvulidi, Emanuel Necas, Marek Mraz, MD, Sarka Pospisilova, Dr, PhD, Jiri Mayer, MD, PhD, Josef Karban, Petra Obrtlikova, MD, PhD, Marek Trneny

Blood (2011) 118 (21): 4600.

https://doi.org/10.1182/blood.V118.21.4600.4600

Published: 2011

Journal Articles

MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia

Karin Vargova, Nikola Curik, Pavel Burda, Petra Basova, Vojtech Kulvait, Vit Pospisil, Filipp Savvulidi, Juraj Kokavec, Emanuel Necas, Adela Berkova, Petra Obrtlikova, Josef Karban, Marek Mraz, Sarka Pospisilova, Jiri Mayer, Marek Trneny, Jiri Zavadil, Tomas Stopka

Blood (2011) 117 (14): 3816–3825.

https://doi.org/10.1182/blood-2010-05-285064

Published: 2011

Includes: Supplemental data

Journal Articles

ISWI Chromatin Remodeling ATPase Smarca5 (Snf2h) Is Required for Murine Erythroid Development and Globin Gene Regulation

Juraj Kokavec, Romit Majumdar, PhD, Martina Kapalova, Nikola Curik, Filipp Savvulidi, Emanuel Necas, Arthur I. Skoultchi, PhD, Tomas Stopka, MD, PhD

Blood (2010) 116 (21): 2062.

https://doi.org/10.1182/blood.V116.21.2062.2062

Published: 2010

Journal Articles

5-Azacytidine and G-CSF Derepressed Chromatin Structure of PU.1 and Its Targets Cebpa and Cbfb In Myelodysplastic Syndrome (MDS)

Tomas Stopka, MD, PhD, Pavel Burda, Petra Basova, Karin Vargova, Nikola Curik, Anna Jonasova, MD, Marek Trneny, MD, PhD

Blood (2010) 116 (21): 124.

https://doi.org/10.1182/blood.V116.21.124.124

Published: 2010

Journal Articles

Active Chromatin Structure near MYB Occupancy at the Mir-155 Host Gene Promoter Coincides with Increased Mir-155 and MYB Levels In Chronic Lymphocytic Leukemia

Tomas Stopka, MD, PhD, Karin Vargova, Nikola Curik, Pavel Burda, Petra Basova, Vit Pospisil, Vojtech Kulvait, Filipp Savvulidi, Emanuel Necas, MD, PhD, Adela Berkova, MD, Petra Obrtlikova, MD, Josef Karban, MD, Marek Trneny, MD, PhD, Jiri Zavadil, PhD

Blood (2010) 116 (21): 3589.

https://doi.org/10.1182/blood.V116.21.3589.3589

Published: 2010

Journal Articles

Smarca5 Regulates Ctcf Recruitment to Chromatin, Including to Regulatory Loci Involved In Control of Globin Gene Expression In Erythroleukemia

Martina Kapalova, Juraj Kokavec, Nikola Curik, Pavel Burda, Arthur I. Skoultchi, PhD, Tomas Stopka, MD, PhD

Blood (2010) 116 (21): 5159.

https://doi.org/10.1182/blood.V116.21.5159.5159

Published: 2010

Journal Articles

PU.1 Relieves Its GATA-1-Mediated Repression near Cebpa and Cbfb During Transdifferentiation of Murine Erythroleukemia - Tool of Inducing Leukemic Blasts to Differentiate.

Pavel Burda, Nikola Curik, Juraj Kokavec, Dana Mikulenkova, MD, Arthur Skoultchi, PhD, Jiri Zavadil, PhD, Tomas Stopka, MD, PhD

Blood (2009) 114 (22): 547.

https://doi.org/10.1182/blood.V114.22.547.547

Published: 2009

Journal Articles

MicroRNA Mir-155 and Myb Proto-Oncogene Family Members Cooperate in Pathogenesis of Chronic Lymphocytic Leukemia.

Tomas Stopka, MD, PhD, Karin Vargova, Pavel Burda, Juraj Kokavec, Nikola Curik, Adela Berkova, MD, Marek Trneny, Arthur Skoultchi, PhD, Jiri Zavadil, PhD

Blood (2009) 114 (22): 58.

https://doi.org/10.1182/blood.V114.22.58.58

Published: 2009

NARROW

Somatic Mutations in Cancer-Related Genes Were Observed More Frequently in AYA CML Patients Compared to Elderly at Diagnosis, Whereas the Frequency Was Markedly Higher in Elderly Patients during TKI Treatment

The Rate of Cellular Energy Production of Muscle Cells Is Attenuated By Carnitine Intracellular Deficiency Caused By Imatinib Treatment

Clonal Hematopoiesis with Somatic Mutations in "AYA" Generation of Patients with Chronic Myeloid Leukemia

DNA Analysis of Mutations in the Kinase Domain of BCR-ABL1 By Allele-Specific Digital PCR Is Highly Sensitive and Refines Prediction of Kinetics of Resistant CML Clones

Patients with Chronic Myeloid Leukemia Show Different Modulation of MYB-Dependent Oncogenic Pathway in the Course of Hematopoietic Differentiation upon Sensitivity to the TKI Treatment

SNPs in the Promoter of the Gene Encoding Transmembrane Transporter SLC22A4 (hOCTN1) Are Significantly Associated with an Alteration of Gene Expression and with Resistance to the Imatinib Treatment in Chronic Myeloid Leukemia

Azacitidine Blocks GATA-1-Mediated Repression of the PU.1 Gene in Human Leukemic Cells

Erythroid Transcription Factor GATA-1 Binds and Represses PU.1 Gene – Candidate Mechanism Of Epigenetic Repression Of PU.1 and Inefficient Erythropoiesis In MDS

Mutation Of The Divalent Metal Transporter (Dmt1) Gene Results In Inefficient Induction Of The Erythroid Transcriptional Program Due To Latter Onset Of GATA-1 and Epor Expression

Transcription Factor CTCF Inhibits Effects of 5-Azacitidine in MDS/AML Cells

Divalent Metal Transporter 1 (DMT1) Regulates EPO Receptor Gene Expression Via GATA-1

Activation of Chromatin Structure Upstream PU.1 Gene and in Vitro Differentiation in High Risk Myelodysplastic Syndrome Following 5-Azacytidine,

Pattern of Mir-155 and PU.1 Expression in CLL/SLL and Aggressive Lymphomas

MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia

ISWI Chromatin Remodeling ATPase Smarca5 (Snf2h) Is Required for Murine Erythroid Development and Globin Gene Regulation

5-Azacytidine and G-CSF Derepressed Chromatin Structure of PU.1 and Its Targets Cebpa and Cbfb In Myelodysplastic Syndrome (MDS)

Active Chromatin Structure near MYB Occupancy at the Mir-155 Host Gene Promoter Coincides with Increased Mir-155 and MYB Levels In Chronic Lymphocytic Leukemia

Smarca5 Regulates Ctcf Recruitment to Chromatin, Including to Regulatory Loci Involved In Control of Globin Gene Expression In Erythroleukemia

PU.1 Relieves Its GATA-1-Mediated Repression near Cebpa and Cbfb During Transdifferentiation of Murine Erythroleukemia - Tool of Inducing Leukemic Blasts to Differentiate.

MicroRNA Mir-155 and Myb Proto-Oncogene Family Members Cooperate in Pathogenesis of Chronic Lymphocytic Leukemia.

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American Society of Hematology

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American Society of Hematology

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