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Robert Z Orlowski
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Journal Articles

Dexamethasone dose intensity does not impact outcomes in newly diagnosed multiple myeloma: a secondary SWOG analysis

Clinical Trials & Observations
Rahul Banerjee, Rachael Sexton, Andrew J. Cowan, Aaron S. Rosenberg, Sikander Ailawadhi, S. Vincent Rajkumar, Shaji K Kumar, Angela Dispenzieri, Sagar Lonial, Brian G.M. Durie, Paul G. Richardson, Saad Z Usmani, Antje Hoering, Robert Z Orlowski
Journal: Blood
Blood blood.2024025939.
https://doi.org/10.1182/blood.2024025939
Published: 2024
Includes: Supplemental data
Journal Articles

Inhibition of Rho-Associated Coiled-Coil Containing Protein Kinases with Belumosudil Mesylate Shows Anti-Tumor and Immune Modulatory Properties in Models of Multiple Myeloma

Pankaj Kumar Singh, Frances N. Cervoni Curet, Cody T. Clayhold, Isere Kuiatse, Wei Tan, Marco Meloni, Monsif Bouaboula, Kamlesh Bisht, Helgi J. Van de Velde, Marielle Chiron, Angela Virone-Oddos, Robert Z. Orlowski
Journal: Blood
Blood (2023) 142 (Supplement 1): 4689.
https://doi.org/10.1182/blood-2023-188317
Published: 2023
Journal Articles

Trends in Outcomes over Three Decades after Upfront Autologous Stem Cell Transplant for Multiple Myeloma at MD Anderson Cancer Center

Oren Pasvolsky, Curtis Marcoux, Jianliang Dai, Denái R. Milton, Mark R. Tanner, Naureen Syed, Qaiser Bashir, Samer A. Srour, Neeraj Y. Saini, Paul Lin, Jeremy Ramdial, Yago Nieto, Hans C. Lee, Krina K. Patel, Elisabet E. Manasanch, Partow Kebriaei, Sheeba K. Thomas, Donna M. Weber, Robert Z. Orlowski, Elizabeth J. Shpall, Richard E. Champlin, Muzaffar H. Qazilbash
Journal: Blood
Blood (2023) 142 (Supplement 1): 4962.
https://doi.org/10.1182/blood-2023-174479
Published: 2023
Journal Articles

Outcomes of Patients with Multiple Myeloma and 1q Gain/Amplification Receiving Autologous Hematopoietic Stem Cell Transplant: The MD Anderson Cancer Center Experience

Oren Pasvolsky, Sassine Ghanem, Denái R. Milton, Mikael Rauf, Mark R. Tanner, Qaiser Bashir, Samer A. Srour, Neeraj Y. Saini, Paul Lin, Jeremy Ramdial, Yago Nieto, Hina N. Khan, Partow Kebriaei, Hans C. Lee, Krina K. Patel, Sheeba K. Thomas, Donna M. Weber, Robert Z. Orlowski, Elizabeth J. Shpall, Richard E. Champlin, Muzaffar H. Qazilbash
Journal: Blood
Blood (2023) 142 (Supplement 1): 4963.
https://doi.org/10.1182/blood-2023-173697
Published: 2023
Journal Articles

Impact of Dexamethasone (Dex) Dose Strength on Outcomes in Newly Diagnosed Multiple Myeloma (NDMM): A Secondary Analysis of SWOG Studies S0777 and S1211

Rahul Banerjee, Rachael Sexton, Andrew J. Cowan, Sikander Ailawadhi, S. Vincent Rajkumar, Shaji Kunnathu Kumar, Sagar Lonial, Bart Barlogie, Brian GM Durie, Saad Z Usmani, Antje Hoering, Robert Z. Orlowski
Journal: Blood
Blood (2023) 142 (Supplement 1): 1066.
https://doi.org/10.1182/blood-2023-181744
Published: 2023
Journal Articles

Single Cell Multi-Omic Analysis of Neoplastic Plasma Cells across the Disease Spectrum Identifies Novel Pathobiologic Mediators and Potential Therapeutic Targets in Multiple Myeloma (MM)

Luz Yurany Moreno Rueda, Keiko Akagi, Amishi U. Vora, Hans C. Lee, Krina K. Patel, Pei Lin, Bo Jiang, Yang Song, Maura L. Gillison, Sheeba K. Thomas, Donna M. Weber, Lixia Diao, Jing Wang, Elisabet E. Manasanch, David E. Symer, Robert Z. Orlowski
Journal: Blood
Blood (2023) 142 (Supplement 1): 752.
https://doi.org/10.1182/blood-2023-188016
Published: 2023
Journal Articles

Initial Clinical Results and Immune Correlates of a Phase 2 Study of Daratumumab, Bortezomib, Dexamethasone Followed By a Proteasome Inhibitor in -Class Transition ( i CT) to Daratumumab, Ixazomib, Dexamethasone in Relapsed Refractory Multiple Myeloma

Hans C. Lee, June Li, Heather Lin, Astrid D. Murga, Gabriela M Rodriguez, Mostafa E. Mohamed, Jared Henderson, Sarah Rodriguez, Melody R. Becnel, Donna M. Weber, Swami P. Iyer, Gregory P. Kaufman, Sheeba K. Thomas, Elisabet E. Manasanch, Krina K. Patel, Stephen J. Noga, Michael R. Green, Robert Z. Orlowski, Cara L Haymaker
Journal: Blood
Blood (2023) 142 (Supplement 1): 4760.
https://doi.org/10.1182/blood-2023-188201
Published: 2023
Journal Articles

Daratumumab-Based Maintenance in Patients with Relapsed Multiple Myeloma after Salvage Autologous Hematopoietic Stem Cell Transplantation

Oren Pasvolsky, Krina K. Patel, Qaiser Bashir, Mikael Rauf, Dawen Sui, Samer A. Srour, Mark R. Tanner, Uday R. Popat, Neeraj Y. Saini, Chitra Hosing, Jeremy Ramdial, Elisabet E. Manasanch, Hans C. Lee, Gregory P. Kaufman, Sheeba K. Thomas, Donna M. Weber, Melody R. Becnel, Guilin Tang, Robert Z. Orlowski, Dipa Patel, Richard E. Champlin, Yago Nieto, Elizabeth J. Shpall, Muzaffar H. Qazilbash
Journal: Blood
Blood (2023) 142 (Supplement 1): 7070.
https://doi.org/10.1182/blood-2023-189109
Published: 2023
Journal Articles

Hdp-101, an Anti-BCMA Antibody-Drug Conjugate with a Novel Payload Amanitin in Patients with Relapsed Multiple Myeloma, Initial Findings of the First in Human Study

Marc S. Raab, Jonathan L. Kaufman, Shambavi Richard, Sebastian Grosicki, Istvan Takacs, Andras Strassz, Andreas Martin Pahl, Thorsten Michael, Anette Last, Hajnalka Szaboki, Garrit Jentsch, Oliver Schönborn-Kellenberger, Robert Z. Orlowski
Journal: Blood
Blood (2023) 142 (Supplement 1): 3334.
https://doi.org/10.1182/blood-2023-182480
Published: 2023
Journal Articles

Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit (CLPP) As a Novel Mediator of, and Target in High Risk Multiple Myeloma

Li Qin, Luz Yurany Moreno Rueda, Iqbal Mahmud, Isere Kuiatse, Wei Tan, Hans C. Lee, Krina K. Patel, David E. Symer, Elisabet E. Manasanch, Robert Z. Orlowski
Journal: Blood
Blood (2023) 142 (Supplement 1): 3302.
https://doi.org/10.1182/blood-2023-190766
Published: 2023
Journal Articles

Mezigdomide (MEZI) Plus Dexamethasone (DEX) and Daratumumab (DARA) or Elotuzumab (ELO) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Results from the CC-92480-MM-002 Trial

Paul G. Richardson, Irwindeep Sandhu, Craig C. Hofmeister, Robert Z. Orlowski, Darrell White, Angelo Belotti, Charlotte Toftmann Hansen, Noopur S. Raje, Tracy T. Chow, Zehua Zhou, Tiziana Civardi, Phillip Koo, Yue Zhu, Jessica Katz, Albert Oriol
Journal: Blood
Blood (2023) 142 (Supplement 1): 1013.
https://doi.org/10.1182/blood-2023-174443
Published: 2023
Journal Articles

Attrition after Referral for Chimeric Antigen Receptor T-Cell (CAR-T) Products in Multiple Myeloma (MM)

Naveen Subramanian, Ashwath Gurumurthi, Oren Pasvolsky, Christopher Ferreri, Hans C. Lee, Elisabet E. Manasanch, Sheeba K. Thomas, Donna M. Weber, Mahmoud Gaballa, Christen Dillard, Melody Becnel, Chitra Hosing, Pei Lin, Behrang Amini, Muzaffar H. Qazilbash, Nilesh Kalariya, Misha Hawkins, Sairah Ahmed, Robert Z. Orlowski, Krina K. Patel
Journal: Blood
Blood (2023) 142 (Supplement 1): 3794.
https://doi.org/10.1182/blood-2023-187583
Published: 2023
Journal Articles

Impact of Pre-Transplant Minimal Residual Disease in Patients with Multiple Myeloma with ≥ Very Good Partial Response Receiving Autologous Hematopoietic Stem Cell Transplantation

Oren Pasvolsky, Sarah Pasyar, Roland L. Bassett, Hina N. Khan, Mark R. Tanner, Qaiser Bashir, Samer A. Srour, Neeraj Y. Saini, Paul Lin, Jeremy Ramdial, Yago Nieto, Hans C. Lee, Krina K. Patel, Partow Kebriaei, Sheeba K. Thomas, Donna M. Weber, Robert Z. Orlowski, Elizabeth J. Shpall, Richard E. Champlin, Muzaffar H. Qazilbash
Journal: Blood
Blood (2023) 142 (Supplement 1): 2215.
https://doi.org/10.1182/blood-2023-173040
Published: 2023
Journal Articles

Single Cell Multi-Omic Analysis of Tumor Microenvironment Evolution across the Disease Spectrum of Multiple Myeloma Identifies Differential Mechanisms of Immune Suppression

Minghao Dang, Hima Bansal, Maria Jose Acevedo-Calado, Li Qin, Wei Tan, Luz Yurany Moreno Moreno Rueda, Mei Huang, David Berrios Nolasco, Hans C. Lee, Krina K. Patel, Pei Lin, Sheeba K. Thomas, Donna M. Weber, Linghua Wang, Elisabet E. Manasanch, Robert Z. Orlowski
Journal: Blood
Blood (2023) 142 (Supplement 1): 89.
https://doi.org/10.1182/blood-2023-182902
Published: 2023
Journal Articles

Safety and Efficacy Outcomes for Patients with High-Risk Multiple Myeloma Receiving Idecabtagene Vicleucel: The MD Anderson Experience

Oren Pasvolsky, Michelle Hildebrandt, Naveen Subramanian, Christopher Ferreri, Hans C. Lee, Elisabet E. Manasanch, Sheeba K. Thomas, Donna M. Weber, Mahmoud Gaballa, Christen Dillard, Melody Becnel, Chitra Hosing, Pei Lin, Behrang Amini, Muzaffar H. Qazilbash, Nilesh Kalariya, Robert Z. Orlowski, Krina K. Patel
Journal: Blood
Blood (2023) 142 (Supplement 1): 4712.
https://doi.org/10.1182/blood-2023-187854
Published: 2023
Journal Articles

Treatment Outcomes and Prognostic Factors with Lenalidomide, Bortezomib, and Dexamethasone (RVd) Alone Versus Rvd Plus Autologous Stem Cell Transplantation (ASCT) in African American (AA) Patients (Pts) with Newly Diagnosed Multiple Myeloma (NDMM) in the Determination Phase 3 Trial

Christiane A. Houde, Abdullah Khan, Susanna J. Jacobus, Hani Hassoun, Larry D. Anderson, Jr., Lauren E. Merz, Rebecca L. Zon, Yvonne Efebera, Tondre Buck, Racquel D. Innis-Shelton, Monique A Hartley-Brown, Sagar Lonial, Erica L. Campagnaro, Peter M. Voorhees, Robert Z. Orlowski, Edward Libby, David Duane Hurd, Caitlin L. Costello, Noopur S. Raje, Eva Medvedova, Philip L. McCarthy, Carter P. Milner, Cristina Gasparetto, Mounzer E Agha, Krisstina Gowin, Rammurti T. Kamble, Sundar Jagannath, Nitya Nathwani, Melissa Alsina, Sergio A. Giralt, Jacob P. Laubach, Omar Nadeem, Irene M. Ghobrial, Clifton C. Mo, Mehmet K. Samur, Kenneth C. Anderson, Nikhil C Munshi, Paul G. Richardson
Journal: Blood
Blood (2023) 142 (Supplement 1): 4762.
https://doi.org/10.1182/blood-2023-181032
Published: 2023
Journal Articles

Phase 1/2 Trial to Jointly Optimize Dose and Administration Schedule of Evomela in Newly Diagnosed Multiple Myeloma Patients Undergoing Autologous Hematopoietic Cell Transplantation

Qaiser Bashir, Peter Thall, Dawen Sui, Jitesh Kawedia, Cristina Knape, Ruby Delgado, Jandi L Schindler, Uday R. Popat, Partow Kebriaei, Chitra Hosing, Issa F. Khouri, Yago Nieto, Betul Oran, Samer A. Srour, Neeraj Y. Saini, Amanda L. Olson, Sairah Ahmed, Gheath Alatrash, Gabriela Rondon, Hans C. Lee, Sheeba K. Thomas, Elisabet E. Manasanch, Krina K. Patel, Robert Z. Orlowski, Richard E. Champlin, Elizabeth J. Shpall, Muzaffar H. Qazilbash
Journal: Blood
Blood (2023) 142 (Supplement 1): 4972.
https://doi.org/10.1182/blood-2023-189844
Published: 2023
Journal Articles

Impact of Revised International Staging System 2 (R2-ISS) Risk Stratification on Outcomes of Patients with Multiple Myeloma Receiving Autologous Hematopoietic Stem Cell Transplantation

Kamal Alzahrani, Oren Pasvolsky, Zhongya Wang, Denái R. Milton, Mark R. Tanner, Qaiser Bashir, Samer A. Srour, Neeraj Y. Saini, Paul Lin, Jeremy Ramdial, Yago Nieto, Hans C. Lee, Krina K. Patel, Elisabet E. Manasanch, Partow Kebriaei, Sheeba K. Thomas, Donna M. Weber, Robert Z. Orlowski, Elizabeth J. Shpall, Richard E. Champlin, Muzaffar H. Qazilbash
Journal: Blood
Blood (2023) 142 (Supplement 1): 3356.
https://doi.org/10.1182/blood-2023-174558
Published: 2023
Journal Articles

Preclinical and Translational Biomarker Analyses to Inform Clinical Development of Mezigdomide (CC-92480) in Combination with Dexamethasone and Daratumumab in Multiple Myeloma

Tracy T. Chow, Michael Amatangelo, Peilin Ma, Chad C. Bjorklund, Krista Wollerman, Tiziana Civardi, Phillip Koo, Yue Zhu, Paulo Maciag, Jessica Katz, Aparna Raval, Albert Oriol, Robert Z. Orlowski, Darrell White, Paul G. Richardson, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3318.
https://doi.org/10.1182/blood-2023-178881
Published: 2023
Journal Articles

Lysosomal Associated Membrane Protein Family Member 5 (LAMP5) As a Novel Mediator of, and Target in High Risk Multiple Myeloma (MM)

Hua Wang, Luz Yurany Moreno Rueda, Minghao Dang, Luz Yurany Moreno Rueda, Hans C. Lee, Krina K. Patel, Sheeba K. Thomas, Donna M. Weber, Elisabet E. Manasanch, David E. Symer, Robert Z. Orlowski
Journal: Blood
Blood (2023) 142 (Supplement 1): 873.
https://doi.org/10.1182/blood-2023-189286
Published: 2023