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Journal Articles

Endogenous Ligands Selectively Stimulate Highly Avid Autoreactive Human Invariant Natural Killer T Cells with Distinctive T-Cell Receptor Vβ11 CDR3 Sequence Motifs

Osamu Imataki, Makito Tanaka, Alla Berezovskaya, Marcus O. Butler, Lee M. Nadler, Naoto Hirano

Blood (2011) 118 (21): 999.

https://doi.org/10.1182/blood.V118.21.999.999

Published: 2011

Journal Articles

A Series of Human Cell-Based Artificial APC Expands Long-Lived, Th1-Biased, Viral Antigen-Specific CD4 + T Cells with a Central/Effector Memory Phenotpype Restricted by Common HLA-DR Alleles

Marcus O. Butler, Sascha Ansén, Makito Tanaka, Osamu Imataki, Alla Berezovskaya, Mary M. Mooney, Genita Metzler, Matthew I. Milstein, Lee M. Nadler, Naoto Hirano

Blood (2010) 116 (21): 354.

https://doi.org/10.1182/blood.V116.21.354.354

Published: 2010

Journal Articles

CD8 Coreceptor-Independent T Cell Stimulation Induces High Avidity CTL In the Presence of IL-21

Osamu Imataki, Sascha Ansén, Makito Tanaka, Marcus O. Butler, Alla Berezovskaya, Kiyotaka Kuzushima, Lee M. Nadler, Naoto Hirano

Blood (2010) 116 (21): 2086.

https://doi.org/10.1182/blood.V116.21.2086.2086

Published: 2010

Journal Articles

Efficient Generation of HLA-A24-Restricted WT1-Specific Cytotoxic T Lymphocytes Using Gene-Engineered Artificial Antigen-Presenting Cells

Masahiro Ogasawara, MD, Ph.D, Tomohiro Yamakawa, MD, Yuki Katsura, MD, Kanako Shima, MD, Toshihiro Matsukawa, MD, Minoru Kanaya, MD, Koichiro Minauchi, MD, Masanobu Nakata, MD, Shuichi Ota, MD, PhD, Kiyotoshi Imai, MD, Ph.D, Teiichi Hirano, MD, Ph.D, Naoki Kobayashi, MD, Ph.D, Yoshio Kiyama, MD, Naoto Hirano, MD, Ph.D

Blood (2010) 116 (21): 2101.

https://doi.org/10.1182/blood.V116.21.2101.2101

Published: 2010

Journal Articles

Human CD4 + T Cells Help CD8 + T Cells Proliferate Ex Vivo by Secreting Both IL-2/IL-21 and Upregulating IL-21R

Marcus O. Butler, PhD, Osamu Imataki, Yoshihiro Yamashita, PhD, Makito Tanaka, Sascha Ansén, PhD, Alla Berezovskaya, PhD, Matthew I. Milstein, PhD, Genita Metzler, PhD, Mary M. Mooney, PhD, Andrew P. Murray, PhD, Hiroyuki Mano, Lee M. Nadler, Naoto Hirano

Blood (2010) 116 (21): 4284.

https://doi.org/10.1182/blood.V116.21.4284.4284

Published: 2010

Journal Articles

Establishing CD8 + T Cell Immunity by Adoptive Transfer of Autologous, IL-15 Expanded, Anti-Tumor CTL with a Central/Effector Memory Phenotype Can Induce Objective Clinical Responses.

Marcus Butler, Philip Friedlander, Mary Mooney, Linda Drury, Martha Metzler, Matthew Milstein, Alla Berezovskaya, Marisa Flavin, Osamu Imataki, Makito Tanaka, Heather Daley, F. Stephen Hodi, Lee Nadler, Naoto Hirano

Blood (2009) 114 (22): 782.

https://doi.org/10.1182/blood.V114.22.782.782

Published: 2009

Journal Articles

Immunogenicity of Artificial Dendritic Cells Is Upregulated by ROCK Inhibition-Mediated Dendrite Formation.

Makito Tanaka, Tetsuro Sasada, Tetsuya Nakamoto, Sascha Ansén, Osamu Imataki, Alla Berezovskaya, Marcus Butler, Lee Nadler, Naoto Hirano

Blood (2009) 114 (22): 3022.

https://doi.org/10.1182/blood.V114.22.3022.3022

Published: 2009

Journal Articles

Artificial APC-Based Generation of IL-21 Secreting CD4 + T Cells That Can Provide Help to CD8 + T Cells.

Makito Tanaka, Marcus Butler, Sascha Ansén, Osamu Imataki, Alla Berezovskaya, Lee Nadler, Naoto Hirano

Blood (2009) 114 (22): 466.

https://doi.org/10.1182/blood.V114.22.466.466

Published: 2009

Journal Articles

Presence of HLA-DR15, a Minor PNH Clone, or an Aplastic Anemia - Associated Autoantibody Do Not Predict a Favorable Response to Immunosuppressive Therapy in Children with Aplastic Anemia.

Hiroshi Yagasaki, MD, PhD, Nao Yoshida, MD, Naoto Hirano, MD, PhD, Nobuhiro Nishio, MD, Asahito Hama, ND, Yue Wang, MD, PhD, Yoshiyuki Takahashi, MD, PhD, Seiji Kojima, MD, PhD

Blood (2006) 108 (11): 984.

https://doi.org/10.1182/blood.V108.11.984.984

Published: 2006

Journal Articles

Identification of an immunogenic CD8 + T-cell epitope derived from γ-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia

Naoto Hirano, Marcus O. Butler, Zhinan Xia, Alla Berezovskaya, Andrew P. Murray, Sascha Ansén, Seiji Kojima, Lee M. Nadler

Blood (2006) 108 (8): 2662–2668.

https://doi.org/10.1182/blood-2006-04-017566

Published: 2006

Journal Articles

Engagement of CD83 ligand induces prolonged expansion of CD8 + T cells and preferential enrichment for antigen specificity

Naoto Hirano, Marcus O. Butler, Zhinan Xia, Sascha Ansén, Michael S. von Bergwelt-Baildon, Donna Neuberg, Gordon J. Freeman, Lee M. Nadler

Blood (2006) 107 (4): 1528–1536.

https://doi.org/10.1182/blood-2005-05-2073

Published: 2006

Journal Articles

Highly Efficient Presentation of Endogenously Processed Class I Peptides by Artificial APC for the Generation of Effective Anti-Tumor Responses.

Naoto Hirano, MD. PhD, Marcus O. Butler, MD, Zhinan Xia, PhD, Lee M. Nadler, MD

Blood (2004) 104 (11): 1355.

https://doi.org/10.1182/blood.V104.11.1355.1355

Published: 2004

Journal Articles

4-1BB (CD137) or CD40 Signaling Fails To Improve the Expansion of Antigen Specific T Cells Demonstrated with Engagement of TCR, CD28 and CD83 Ligand.

Naoto Hirano, MD, PhD, Marcus O. Butler, MD, Lee M. Nadler, MD

Blood (2004) 104 (11): 2665.

https://doi.org/10.1182/blood.V104.11.2665.2665

Published: 2004

Journal Articles

Off the Shelf, GMP Grade Artificial APC Efficiently Generates Large Numbers of Antigen Specific CTLs Sufficient for the Treatment of Cancer and Infectious Disease.

Marcus O. Butler, MD, Naoto Hirano, MD/PhD, Jeng-Shin Lee, MD/PhD, E. Jeffrey Beecham, PhD, Mirra Chung, Robin Ripley, Andrew P. Murray, Richard C. Mulligan, PhD, Lee M. Nadler, MD

Blood (2004) 104 (11): 3172.

https://doi.org/10.1182/blood.V104.11.3172.3172

Published: 2004

Journal Articles

γ-Globin, a Tumor-Associated Antigen for Juvenile Myelomonocytic Leukemia (JMML): A Cell-Based Approach To Identify Tumor Antigenic Epitopes That Are Naturally Processed and Presented.

Naoto Hirano, MD, PhD, Marcus O. Butler, MD, Zhinan Xia, PhD, Seiji Kojima, MD3, Lee M. Nadler, MD

Blood (2004) 104 (11): 3418.

https://doi.org/10.1182/blood.V104.11.3418.3418

Published: 2004

Journal Articles

Autoantibodies frequently detected in patients with aplastic anemia

Naoto Hirano, Marcus O. Butler, Michael S. von Bergwelt-Baildon, Britta Maecker, Joachim L. Schultze, Kevin C. O'Connor, Peter H. Schur, Seiji Kojima, Eva C. Guinan, Lee M. Nadler

Blood (2003) 102 (13): 4567–4575.

https://doi.org/10.1182/blood-2002-11-3409

Published: 2003

Journal Articles

The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells

Britta Maecker, David H. Sherr, Robert H. Vonderheide, Michael S. von Bergwelt-Baildon, Naoto Hirano, Karen S. Anderson, Zhinan Xia, Marcus O. Butler, Kai W. Wucherpfennig, Carl O'Hara, Geoffrey Cole, Silvia S. Kwak, Urban Ramstedt, Andy J. Tomlinson, Roman M. Chicz, Lee M. Nadler, Joachim L. Schultze

Blood (2003) 102 (9): 3287–3294.

https://doi.org/10.1182/blood-2003-05-1374

Published: 2003

Journal Articles

Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application

Michael S. von Bergwelt-Baildon, Robert H. Vonderheide, Britta Maecker, Naoto Hirano, Karen S. Anderson, Marcus O. Butler, Zhinan Xia, Wan Y. Zeng, Kai W. Wucherpfennig, Lee M. Nadler, Joachim L. Schultze

Blood (2002) 99 (9): 3319–3325.

https://doi.org/10.1182/blood.V99.9.3319

Published: 2002

Journal Articles

A Potential Molecular Approach to Ex Vivo Hematopoietic Expansion With Recombinant Epidermal Growth Factor Receptor-Expressing Adenovirus Vector

Tokiharu Takahashi, Kaoru Yamada, Tomoyuki Tanaka, Keiki Kumano, Mineo Kurokawa, Tsuyoshi Takahashi, Naoto Hirano, Hiroaki Honda, Shigeru Chiba, Kohichiro Tsuji, Yoshio Yazaki, Tatsutoshi Nakahata, Hisamaru Hirai

Blood (1998) 91 (12): 4509–4515.

https://doi.org/10.1182/blood.V91.12.4509

Published: 1998

NARROW

Endogenous Ligands Selectively Stimulate Highly Avid Autoreactive Human Invariant Natural Killer T Cells with Distinctive T-Cell Receptor Vβ11 CDR3 Sequence Motifs

A Series of Human Cell-Based Artificial APC Expands Long-Lived, Th1-Biased, Viral Antigen-Specific CD4 + T Cells with a Central/Effector Memory Phenotpype Restricted by Common HLA-DR Alleles

CD8 Coreceptor-Independent T Cell Stimulation Induces High Avidity CTL In the Presence of IL-21

Efficient Generation of HLA-A24-Restricted WT1-Specific Cytotoxic T Lymphocytes Using Gene-Engineered Artificial Antigen-Presenting Cells

Human CD4 + T Cells Help CD8 + T Cells Proliferate Ex Vivo by Secreting Both IL-2/IL-21 and Upregulating IL-21R

Establishing CD8 + T Cell Immunity by Adoptive Transfer of Autologous, IL-15 Expanded, Anti-Tumor CTL with a Central/Effector Memory Phenotype Can Induce Objective Clinical Responses.

Immunogenicity of Artificial Dendritic Cells Is Upregulated by ROCK Inhibition-Mediated Dendrite Formation.

Artificial APC-Based Generation of IL-21 Secreting CD4 + T Cells That Can Provide Help to CD8 + T Cells.

Presence of HLA-DR15, a Minor PNH Clone, or an Aplastic Anemia - Associated Autoantibody Do Not Predict a Favorable Response to Immunosuppressive Therapy in Children with Aplastic Anemia.

Identification of an immunogenic CD8 + T-cell epitope derived from γ-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia

Engagement of CD83 ligand induces prolonged expansion of CD8 + T cells and preferential enrichment for antigen specificity

Highly Efficient Presentation of Endogenously Processed Class I Peptides by Artificial APC for the Generation of Effective Anti-Tumor Responses.

4-1BB (CD137) or CD40 Signaling Fails To Improve the Expansion of Antigen Specific T Cells Demonstrated with Engagement of TCR, CD28 and CD83 Ligand.

Off the Shelf, GMP Grade Artificial APC Efficiently Generates Large Numbers of Antigen Specific CTLs Sufficient for the Treatment of Cancer and Infectious Disease.

γ-Globin, a Tumor-Associated Antigen for Juvenile Myelomonocytic Leukemia (JMML): A Cell-Based Approach To Identify Tumor Antigenic Epitopes That Are Naturally Processed and Presented.

Autoantibodies frequently detected in patients with aplastic anemia

The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells

Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application

A Potential Molecular Approach to Ex Vivo Hematopoietic Expansion With Recombinant Epidermal Growth Factor Receptor-Expressing Adenovirus Vector

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American Society of Hematology

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American Society of Hematology

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