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Journal Articles

Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure

Blood (2016) 127 (13): 1656–1665.

https://doi.org/10.1182/blood-2015-10-676924

Published: 2016

Includes: Supplemental data

Journal Articles

Defibrotide for the Treatment of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome with Multi-Organ Dysfunction: Final Results from a Pivotal, Historically Controlled, Phase 3 Trial

Blood (2015) 126 (23): 737.

https://doi.org/10.1182/blood.V126.23.737.737

Published: 2015

Journal Articles

Intraoral Mitochondrial-Targeted GS Nitroxide JP4-039 Ameliorates Radiation-Induced Mucositis in Orthotopic Tumor-Bearing Fanconi Anemia (FA) ( Fancd2-/- ) Mice.

Ashwin Shinde, Byung Han Rhieu, Hebist Berhane, Eva C. Guinan, MD, Kalindi Parmar, PhD, Hong Wang, PhD, Darcy Franicola, Xichen Zhang, Song Li, Tracy M. Dixon, Joel S. Greenberger, MD

Blood (2014) 124 (21): 5961.

https://doi.org/10.1182/blood.V124.21.5961.5961

Published: 2014

Journal Articles

Chemotherapy-Only Preparative Regimen for T-Cell Depleted Hematopoietic Stem Cell Transplantation of Patients with Fanconi Anemia From Alternative Donors

Farid Boulad, MD, Stella M. Davies, MBBS, PhD, David A. Williams, MD, David A Margolis, MD, Elizabeth G Klein, Leslie E. Lehmann, MD, Christine Duncan, MD, MMSc, Eva C. Guinan, MD, Parinda A. Mehta

Blood (2012) 120 (21): 3471.

https://doi.org/10.1182/blood.V120.21.3471.3471

Published: 2012

Journal Articles

Meta-Analysis of Defibrotide (DF) In the Treatment of Severe Hepatic Veno-Occlusive Disease (VOD) with Multi-Organ Failure (MOF) with Comparison to a Historical Control (HC).

Blood (2010) 116 (21): 3481.

https://doi.org/10.1182/blood.V116.21.3481.3481

Published: 2010

Journal Articles

Leuprolide Acetate (GnRH Agonist) to Enhance Immune Function Post-Autologous Hematopoietic Stem Cell Transplantation (HSCT)

Richard Champlin, Eva C. Guinan, MD, Lee M. Nadler, MD, Patricia McAdams, RN, Lisa Brennan, RN, Christine Barbon, MS, Ping Jiang, MS, Kristof Chwalisz, MD, PhD, Cynthia Mattia-Goldberg, Karim Sajwani, MS, Richard Boyd, MD, Peter F. Thall, PhD, Robertson Parkman, MD

Blood (2010) 116 (21): 4292.

https://doi.org/10.1182/blood.V116.21.4292.4292

Published: 2010

Journal Articles

Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies

Joanne Kurtzberg, Vinod K. Prasad, Shelly L. Carter, John E. Wagner, Lee Ann Baxter-Lowe, Donna Wall, Neena Kapoor, Eva C. Guinan, Stephen A. Feig, Elizabeth L. Wagner, Nancy A. Kernan

Blood (2008) 112 (10): 4318–4327.

https://doi.org/10.1182/blood-2007-06-098020

Published: 2008

Journal Articles

Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies

Jeff K. Davies, John G. Gribben, Lisa L. Brennan, Dongin Yuk, Lee M. Nadler, Eva C. Guinan

Blood (2008) 112 (6): 2232–2241.

https://doi.org/10.1182/blood-2008-03-143636

Published: 2008

Journal Articles

Early Deficiency of Endogenous Proteins Inhibiting LPS-Induced TNF-α Production Correlates with Acute Graft vs Host Disease (aGVHD) after Myeloablative Stem Cell Transplantation (SCT).

Ofer Levy, MD, PhD, Eugenie E. Suter, MA, Leslie A. Kalish, PhD, Patrick Scannon, MD, PhD, Jerrold P. Weiss, PhD, Athmane Teghanemt, MS, Janice D. Russell, BS, Leighanne C. Gallington, SB, Hoi M. Leung, PhD, Robert J. Soiffer, MD, Suganya Viriyakosol, PhD, Gregory Priebe, MD, Michael R. Wessels, MD, Eva C. Guinan, MD

Blood (2007) 110 (11): 1058.

https://doi.org/10.1182/blood.V110.11.1058.1058

Published: 2007

Journal Articles

Effective Control of Mismatched Alloreactivity Via Ex Vivo Alloantigen-Specific Co-Stimulatory Blockade Does Not Significantly Impact Pathogen-Specific Immunity.

Jeff K. Davies, BM, BCh, PhD, Gullu Gorgun, PhD, Lee M. Nadler, MD, Eva C. Guinan, MD

Blood (2006) 108 (11): 3177.

https://doi.org/10.1182/blood.V108.11.3177.3177

Published: 2006

Journal Articles

Potential Therapeutic Intervention Suggested by Profound Deficiency of Neutrophil-Derived Bactericidal/Permeability-Increasing Protein (BPI) and Other Alterations in LPS-Directed Innate Immunity after Myeloablative Hematopoietic Stem Cell Transplantation (HSCT).

Ofer Levy, MD, PhD, Eugenie E. Suter, MA, Leslie A. Kalish, ScD, Janice Russell, BS, Patrick Scannon, MD, PhD, Eva C. Guinan, MD

Blood (2006) 108 (11): 2856.

https://doi.org/10.1182/blood.V108.11.2856.2856

Published: 2006

Journal Articles

Antigen-Specific T Lymphocyte Function Following Unrelated Cord Blood Transplantation (UCBT).

Robertson Parkman, MD, Geoff Cohen, MSc, Shelley L. Carter, DSc, Kenneth I. Weinberg, MD, Bernadette Masinsin, BA, Eva C. Guinan, MD, Joanne Kurtzberg, MD, John E. Wagner, MD, Nancy A. Kernan, MD

Blood (2005) 106 (11): 3032.

https://doi.org/10.1182/blood.V106.11.3032.3032

Published: 2005

Journal Articles

Patients (Pts) Surviving Haploidentical Stem Cell Transplantation (SCT) after Ex Vivo Costimulatory Blockade To Induce Anergy Experience Few Long-Term Complications.

Eva C. Guinan, MD, John G. Gribben, MB, DSc, Lisa L. Brennan, RN, Lee M. Nadler, MD

Blood (2005) 106 (11): 599.

https://doi.org/10.1182/blood.V106.11.599.599

Published: 2005

Journal Articles

Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia

W. Nicholas Haining, Donna S. Neuberg, Heather L. Keczkemethy, John W. Evans, Stephen Rivoli, Rebecca Gelman, Howard M. Rosenblatt, William T. Shearer, Javier Guenaga, Daniel C. Douek, Lewis B. Silverman, Stephen E. Sallan, Eva C. Guinan, Lee M. Nadler

Blood (2005) 106 (5): 1749–1754.

https://doi.org/10.1182/blood-2005-03-1082

Published: 2005

Journal Articles

Herpes Zoster (HZ) Infection in the Post-Hematopoietic Stem Cell Transplant Pediatric Population May Be Preceded by Transaminitis.

Jason N. Berman, M.D., Winter Berry, Molin Wang, PhD., Donna S. Neuberg, ScD., Eva C. Guinan, M.D.

Blood (2004) 104 (11): 3167.

https://doi.org/10.1182/blood.V104.11.3167.3167

Published: 2004

Journal Articles

Autoantibodies frequently detected in patients with aplastic anemia

Naoto Hirano, Marcus O. Butler, Michael S. von Bergwelt-Baildon, Britta Maecker, Joachim L. Schultze, Kevin C. O'Connor, Peter H. Schur, Seiji Kojima, Eva C. Guinan, Lee M. Nadler

Blood (2003) 102 (13): 4567–4575.

https://doi.org/10.1182/blood-2002-11-3409

Published: 2003

Journal Articles

Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation

Deborah C. Molrine, Joseph H. Antin, Eva C. Guinan, Robert J. Soiffer, Kristin MacDonald, Richard Malley, Frank Malinoski, Susan Trocciola, Marjorie Wilson, Donna M. Ambrosino

Blood (2003) 101 (3): 831–836.

https://doi.org/10.1182/blood-2002-03-0832

Published: 2003

Journal Articles

Multi-institutional use of defibrotide in 88 patients after stem cell transplantation with severe veno-occlusive disease and multisystem organ failure: response without significant toxicity in a high-risk population and factors predictive of outcome

Blood (2002) 100 (13): 4337–4343.

https://doi.org/10.1182/blood-2002-04-1216

Published: 2002

Journal Articles

Treatment of Severe Veno-Occlusive Disease With Defibrotide: Compassionate Use Results in Response Without Significant Toxicity in a High-Risk Population

Paul G. Richardson, Anthony D. Elias, Amrita Krishnan, Catherine Wheeler, Raj Nath, Debra Hoppensteadt, Nancy M. Kinchla, Donna Neuberg, Edmund K. Waller, Joseph H. Antin, Robert Soiffer, James Vredenburgh, Michael Lill, Ann E. Woolfrey, Scott I. Bearman, Massimo Iacobelli, Jawed Fareed, Eva C. Guinan

Blood (1998) 92 (3): 737–744.

https://doi.org/10.1182/blood.V92.3.737

Published: 1998

NARROW

Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure

Defibrotide for the Treatment of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome with Multi-Organ Dysfunction: Final Results from a Pivotal, Historically Controlled, Phase 3 Trial

Intraoral Mitochondrial-Targeted GS Nitroxide JP4-039 Ameliorates Radiation-Induced Mucositis in Orthotopic Tumor-Bearing Fanconi Anemia (FA) ( Fancd2-/- ) Mice.

Chemotherapy-Only Preparative Regimen for T-Cell Depleted Hematopoietic Stem Cell Transplantation of Patients with Fanconi Anemia From Alternative Donors

Meta-Analysis of Defibrotide (DF) In the Treatment of Severe Hepatic Veno-Occlusive Disease (VOD) with Multi-Organ Failure (MOF) with Comparison to a Historical Control (HC).

Leuprolide Acetate (GnRH Agonist) to Enhance Immune Function Post-Autologous Hematopoietic Stem Cell Transplantation (HSCT)

Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies

Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies

Early Deficiency of Endogenous Proteins Inhibiting LPS-Induced TNF-α Production Correlates with Acute Graft vs Host Disease (aGVHD) after Myeloablative Stem Cell Transplantation (SCT).

Effective Control of Mismatched Alloreactivity Via Ex Vivo Alloantigen-Specific Co-Stimulatory Blockade Does Not Significantly Impact Pathogen-Specific Immunity.

Potential Therapeutic Intervention Suggested by Profound Deficiency of Neutrophil-Derived Bactericidal/Permeability-Increasing Protein (BPI) and Other Alterations in LPS-Directed Innate Immunity after Myeloablative Hematopoietic Stem Cell Transplantation (HSCT).

Antigen-Specific T Lymphocyte Function Following Unrelated Cord Blood Transplantation (UCBT).

Patients (Pts) Surviving Haploidentical Stem Cell Transplantation (SCT) after Ex Vivo Costimulatory Blockade To Induce Anergy Experience Few Long-Term Complications.

Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia

Herpes Zoster (HZ) Infection in the Post-Hematopoietic Stem Cell Transplant Pediatric Population May Be Preceded by Transaminitis.

Autoantibodies frequently detected in patients with aplastic anemia

Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation

Multi-institutional use of defibrotide in 88 patients after stem cell transplantation with severe veno-occlusive disease and multisystem organ failure: response without significant toxicity in a high-risk population and factors predictive of outcome

Treatment of Severe Veno-Occlusive Disease With Defibrotide: Compassionate Use Results in Response Without Significant Toxicity in a High-Risk Population

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American Society of Hematology

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American Society of Hematology

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