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Massimo Iacobelli
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Journal Articles

The Influence of Coagulation Factor Biosimilars in Shortening the Activated Partial Thromboplastin Time in Patients with Hemophilia a

Kannan Meganathan, Chitrali Laha Roy, Fakiha Siddiqui, Massimo Iacobelli, Ravi Ranjan, Manoranjan Mahapatra, Renu Saxena, Jawed Fareed
Journal: Blood
Blood (2024) 144 (Supplement 1): 5492.
https://doi.org/10.1182/blood-2024-204967
Published: 2024
Journal Articles

Use of Defibrotide in Patients with COVID-19 Pneumonia; Results of the Defi-VID19 Phase 2 Trial

Annalisa Ruggeri, Antonio Voza, Carmine Liberatore, Gloria Catalano, Francesco Corrado, Luigi Di Filippo, Rosamaria Nitti, Carlo Fedeli, Alessandro Bruno, Eleonora Calabretta, Fabio Giglio, Fabio Sciutti, Francesca Lunghi, Giovanni Landoni, Paul G. Richardson, Massimo Iacobelli, Alessio Aghemo, Patrizia Rovere-Querini, Andrea A. Assanelli, Jacopo Peccatori, Fabio Ciceri, Carmelo Carlo-Stella
Journal: Blood
Blood (2021) 138 (Supplement 1): 672.
https://doi.org/10.1182/blood-2021-147784
Published: 2021
Journal Articles

Defibrotide for the Treatment of Endotheliitis Complicating Sars-Cov-2 Infection: Rationale and Ongoing Studies As Part of the International Defacovid Study Group

Jose M. Moraleda, MD, Carmelo Carlo-Stella, MD, David Garcia-Bernal, PhD, Ruben Jara Rubio, MD, Enriqueta Andreu, MD, Eleonora Calabretta, MD, Alessio Aghemo, MD, Maribel Diaz-Ricart, Marta Palomo, PhD, Enric Carreras, MD PhD, Israel Vlodavsky, PhD, Massimo Iacobelli, Jawed Fareed, PhD, Pedro Castro, MD PhD, Sara Fernandez, MD, Clifton C. Mo, MD, Gerald L. Weinhouse, MD, Kenneth R. Cooke, MD, Robert J. Soiffer, MD, Rebecca M. Baron, MD, Peter O'Gorman, MD PhD FRCP, FRCPath, Gregory Yanik, MD, Antonio Pagliuca, MBBS, MA, FRCP, FRCPath, Paul G. Richardson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–8.
https://doi.org/10.1182/blood-2020-141872
Published: 2020
Journal Articles

A Meta-Analysis Evaluating the Risk of Bleeding-Related Adverse Events with Defibrotide Treatment

William Tappe, Saurabh Aggarwal, Ozlem Topaloglu, Massimo Iacobelli
Journal: Blood
Blood (2019) 134 (Supplement_1): 2016.
https://doi.org/10.1182/blood-2019-123686
Published: 2019
Journal Articles

Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure

Clinical Trials & Observations
Paul G. Richardson, Marcie L. Riches, Nancy A. Kernan, Joel A. Brochstein, Shin Mineishi, Amanda M. Termuhlen, Sally Arai, Stephan A. Grupp, Eva C. Guinan, Paul L. Martin, Gideon Steinbach, Amrita Krishnan, Eneida R. Nemecek, Sergio Giralt, Tulio Rodriguez, Reggie Duerst, John Doyle, Joseph H. Antin, Angela Smith, Leslie Lehmann, Richard Champlin, Alfred Gillio, Rajinder Bajwa, Ralph B. D’Agostino, Sr, Joseph Massaro, Diane Warren, Maja Miloslavsky, Robin L. Hume, Massimo Iacobelli, Bijan Nejadnik, Alison L. Hannah, Robert J. Soiffer
Journal: Blood
Blood (2016) 127 (13): 1656–1665.
https://doi.org/10.1182/blood-2015-10-676924
Published: 2016
Includes: Supplemental data
Journal Articles

Defibrotide for the Treatment of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome with Multi-Organ Dysfunction: Final Results from a Pivotal, Historically Controlled, Phase 3 Trial

Paul G. Richardson, MD, Marcie Riches, MD, Nancy A. Kernan, MD, Joel A. Brochstein, MD, Shin Mineishi, MD, Amanda M. Termuhlen, MD, Sally Arai, MD, Stephan A. Grupp, MD PhD, Eva C. Guinan, MD, Paul L. Martin, MD PhD, Gideon Steinbach, MD PhD, Amrita Krishnan, Eneida R. Nemecek, MD, Sergio A. Giralt, MD, Tulio E. Rodriguez, MD, Reggie Duerst, MD, John J. Doyle, MD FRCPC, Joseph H. Antin, MD, Angela R. Smith, MD MS, Leslie E. Lehmann, MD, Richard E. Champlin, MD, Alfred Gillio, MD, Rajinder Bajwa, MBBS, MD MRCP, Ralph B. D'Agostino, PhD, Joseph Massaro, PhD, Maja Miloslavsky, PhD, Robin L. Hume, MS, Massimo Iacobelli, MD, Bijan Nejadnik, MD, Alison L. Hannah, MD, Robert J. Soiffer, MD
Journal: Blood
Blood (2015) 126 (23): 737.
https://doi.org/10.1182/blood.V126.23.737.737
Published: 2015
Journal Articles

Regulatory T Cells Enhance the Allogeneic Activity of Endothelial-Specific Cytotoxic T Lymphocytes – Protective Effect of Defibrotide

Guenther Eissner, PhD, Isabel Hartmann, Altug Kesikli, MD, Silvia Haffner, Tanja Sax, Ernst Holler, MD, PhD, Massimo Iacobelli, MD
Journal: Blood
Blood (2011) 118 (21): 4693.
https://doi.org/10.1182/blood.V118.21.4693.4693
Published: 2011
Journal Articles

Defibrotide (DF) in the Treatment of Hepatic Veno-Occlusive Disease (VOD) in Stem Cell Transplant (SCT) and Non-SCT Patients (Pts): Early Intervention Improves Outcome - Updated Results of a Treatment IND Expanded Access Protocol

Paul G. Richardson, MD, Angela R. Smith, MD, MS, Stephan A Grupp, MD, PhD, Nancy A. Kernan, MD, Sally Arai, MD, Paul R. Haut, MD, Brandon M. Triplett, MD, Alfred P. Gillio, III, MD, Heather J. Symons, Roberta H. Adams, MD, Biljana N. Horn, MD, Kenneth Lucas, MD, Paul L. Martin, MD, PhD, Shin Mineishi, MD, Edward D. Ball, M.D., Michael Boyer, MD, John Fort, MD, Ivan I. Kirov, MD, Leslie E. Lehmann, MD, Catherine Madigan, MD, Michelle E. Maglio, Joseph Massaro, Ph.D., Ralph B. D'Agostino, PhD, Alison L. Hannah, MD, Elena Tudone, Robin Hume, Massimo Iacobelli, MD, Robert J. Soiffer, MD, Defibrotide Study Group
Journal: Blood
Blood (2011) 118 (21): 487.
https://doi.org/10.1182/blood.V118.21.487.487
Published: 2011
Journal Articles

Meta-Analysis of Defibrotide (DF) In the Treatment of Severe Hepatic Veno-Occlusive Disease (VOD) with Multi-Organ Failure (MOF) with Comparison to a Historical Control (HC).

Paul G Richardson, Gideon Steinbach, M.D., Nancy Kernan, M.D., Eva C. Guinan, MD, Allen R. Chen, MD, PhD, MHS, Paul L Martin, MD, PhD, Amrita Krishnan, M.D., Sally Arai, MD, Joel A. Brochstein, MD, Stephan A. Grupp, M.D., Ph.D., Shin Mineishi, M.D., Amanda Termuhlen, MD, Marcie Tomblyn, MD, MS, Joseph H. Antin, MD, Carolyn Revta, Robin Hume, M.S., Joseph Massaro, Ph.D., Alison L. Hannah, MD, Massimo Iacobelli, MD, Robert J Soiffer, MD, Defibrotide Study Group
Journal: Blood
Blood (2010) 116 (21): 3481.
https://doi.org/10.1182/blood.V116.21.3481.3481
Published: 2010
Journal Articles

Safety of Defibrotide (DF) In Stem Cell Transplant (SCT) Patients (Pts).

Selim Corbacioglu, MD, Enric Carreras, MD, PhD, Dietger W Niederwieser, MD, Marco Sardella, PharmD, Margaret Hoyle, Robin Hume, M.S., Joseph Massaro, Ph.D., Alison L. Hannah, MD, Massimo Iacobelli, MD, Paul G Richardson, Defibrotide Study Group
Journal: Blood
Blood (2010) 116 (21): 3482.
https://doi.org/10.1182/blood.V116.21.3482.3482
Published: 2010
Journal Articles

Defibrotide (DF) In the Treatment of Severe Hepatic Veno-Occlusive Disease (VOD) with Multi-Organ Failure (MOF): Results of a Treatment IND Expanded Access Protocol

Paul Richardson, M.D., Angela Smith, MD, MS, Sally Arai, MD, Stephan A. Grupp, Nancy A Kernan, Roberta Adams, MD, Paul L Martin, MD, PhD, Sunil Abhyankar, MD, Alfred Gillio, III, MD, Michael Grimley, MD, Leslie E. Lehmann, MD, Paul Haut, MD, Amanda Termuhlen, MD, Joseph H. Antin, MD, Thomas Spitzer, MD, David Avigan, MD, Joseph Massaro, Ph.D., Alison L. Hannah, MD, Massimo Iacobelli, MD, Robert J Soiffer, MD, Defibrotide Study Group
Journal: Blood
Blood (2010) 116 (21): 906.
https://doi.org/10.1182/blood.V116.21.906.906
Published: 2010
Journal Articles

Defibrotide (DF) for the Prevention of Hepatic Veno-Occlusive Disease (VOD) in Pediatric Stem Cell Transplantion: Results of a Prospective Phase II/III Randomized, Multicenter Study.

Selim Corbacioglu, MD, Simone Cesaro, MD, Maura Faraci, MD, Dominique Valteau-Couanet, MD, PhD, Bernd Gruhn, MD, Jaap Jan Boelens, MD, PhD, Cornelio Uderzo, MD, Netty Hewitt, Johanna Schrum, MD, Ingo Mueller, MD, Ansgar S Schulz, MD, Jerry Stein, MD, Robert Wynn, MRCP, FRCPath, MD, Johann Greil, MD, Susanne Matthes, MD, Sykora Karl-Walter, MD, Monika Fuehrer, MD, Anne O'Meare, MD, Klaus-Michael Debatin, MD, Joseph Massaro, PhD, Ralph D'Agostino, PhD, Margeret Hoyle, Massimo Iacobelli, MD, Christina Peters, MD, Giorgio Dini, MD
Journal: Blood
Blood (2009) 114 (22): 653.
https://doi.org/10.1182/blood.V114.22.653.653
Published: 2009
Journal Articles

Defibrotide (DF) in the Treatment of Severe Hepatic Veno-Occlusive Disease (VOD) with Multi-Organ Failure (MOF) Following Stem Cell Transplantation (SCT): Results of a Phase 3 Study Utilizing a Historical Control.

Paul Richardson, M.D., Marcie Tomblyn, MD, MS, Nancy Kernan, M.D., Joel A. Brochstein, MD, Shin Mineishi, MD, Amanda Termuhlen, MD, Sally Arai, MD, Stephan A. Grupp, MD, PhD, Eva Guinan, M.D., Paul L. Martin, MD, PhD, Selim Corbacioglu, MD, Ernst Holler, M.D., Ralph D'Agostino, Ph.D., Joseph Massaro, Ph.D., Alison L. Hannah, MD, Massimo Iacobelli, M.D., Robert J Soiffer, MD
Journal: Blood
Blood (2009) 114 (22): 654.
https://doi.org/10.1182/blood.V114.22.654.654
Published: 2009
Journal Articles

Prolonged Administration of Defibrotide Is Non-Immunogenic in Rats and Dogs.

Jawed Fareed, Debra Hoppensteadt, Josephine Cunanan, Walter Jeske, Ph.D., Cafer Adiguzal, He Zhu, MD, Cinara Echart, Massimo Iacobelli
Journal: Blood
Blood (2009) 114 (22): 4180.
https://doi.org/10.1182/blood.V114.22.4180.4180
Published: 2009
Journal Articles

Defibrotide Augments the Anticoagulant Actions of Heparin and Low Molecular Weight Heparins

Jawed Fareed, Ph.D., Omer Iqbal, M.D., Debra Hoppensteadt, Ph.D., Cafer Adiguzel, M.D., Massimo Iacobelli, M.D., Jeanine M. Walenga, Ph.D.
Journal: Blood
Blood (2008) 112 (11): 4086.
https://doi.org/10.1182/blood.V112.11.4086.4086
Published: 2008
Journal Articles

Angiogenesis alteration by defibrotide: implications for its mechanism of action in severe hepatic veno-occlusive disease

Luba Benimetskaya, Sijian Wu, Anatoliy M. Voskresenskiy, Cinara Echart, Jin-Feng Zhou, Joongho Shin, Massimo Iacobelli, Paul Richardson, Kanyalakshmi Ayyanar, C. A. Stein
Journal: Blood
Blood (2008) 112 (10): 4343–4352.
https://doi.org/10.1182/blood-2008-04-149682
Published: 2008
Journal Articles

Reduced Fibrinolysis in the Hepatic Venous Occlusive Disease: Effect of Defibrotide on Plasmin Activity.

Cinara Echart, PhD, Cinzia Repice, Laura Ferro, MD, Kenneth Anderson, MD, Paul Richardson, MD, Anna Falanga, MD, Jawed Fareed, MD, Massimo Iacobelli, MD
Journal: Blood
Blood (2007) 110 (11): 1992.
https://doi.org/10.1182/blood.V110.11.1992.1992
Published: 2007
Journal Articles

Defibrotide Counteracts the Modifications of Anti-Thrombotic Phenotype of Endothelial Cells Induced by Thalidomide.

Cinara Echart, PhD, Barbara Graziadio, Cinzia Repice, Mario Boccadoro, MD, Antonio Palumbo, MD, Constantine Mitsiades, MD, Kenneth Anderson, MD, Paul Richardson, MD, Massimo Iacobelli, MD
Journal: Blood
Blood (2007) 110 (11): 2502.
https://doi.org/10.1182/blood.V110.11.2502.2502
Published: 2007
Journal Articles

Co-Culture of Myeloma and Endothelial Cells: Defibrotide Downregulates Heparanase and Pro-Angiogenic Growth Factors.

Cinara Echart, PhD, Maria Distaso, Laura Ferro, MD, Mario Boccadoro, MD, Antonio Palumbo, MD, Constantine Mitsiades, MD, Kenneth Anderson, MD, Paul Richardson, MD, Massimo Iacobelli, MD
Journal: Blood
Blood (2007) 110 (11): 2513.
https://doi.org/10.1182/blood.V110.11.2513.2513
Published: 2007
Journal Articles

A Phase I/II Trial on Melphalan, Prednisone, Thalidomide and Defribotide Combination in Relapsed/Refractory Multiple Myeloma Patients.

Antonio Palumbo, MD, Alessandra Larocca, MD, Cecilia Rus, MD, Francesca Gay, MD, Davide Rossi, MD, Patrizia Pregno, MD, Patrizia Falco, MD, Ilaria Avonto, MD, Valeria Magarotto, MD, Federica Cavallo, MD, Massimo Iacobelli, MD, Gianluca Gaidano, MD, Constantine Mitsiades, MD, Paul G. Richardson, MD, Kenneth C. Anderson, MD, Mario Boccadoro, MD
Journal: Blood
Blood (2007) 110 (11): 2715.
https://doi.org/10.1182/blood.V110.11.2715.2715
Published: 2007