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Journal Articles

Exploiting Induced Pluripotent Stem Cells to Unravel Mechanisms in Inherited Platelet/Megakaryocyte Disorders

Mortimer Poncz, MD

Blood (2020) 136 (Supplement 1): SCI3.

https://doi.org/10.1182/blood-2020-133062

Published: 2020

Journal Articles

Complement Regulates the Procoagulant Effects of HIT Immune Complexes

Sanjay Khandelwal, PhD, Lubica Rauova, MD PhD, Ayiesha Barnes, MS, Ann Rux, Serge Yarovoi, Sooho S Myoung, Alexandra Johnson, Grace M Lee, MD, Madelaine Duarte, BA, Mortimer Poncz, MD, Gowthami M. Arepally, MD, Douglas B. Cines, MD

Blood (2020) 136 (Supplement 1): 11–12.

https://doi.org/10.1182/blood-2020-138631

Published: 2020

Journal Articles

Utilizing CRISPR-CAS9 Gene Editing Technology in Human Pluripotent Stem Cells to Study Platelet Integrin αIIbβ3 Function

Karen Fong, MD PhD, Chintan Jobaliya, Jean Ann Maguire, PhD, Mortimer Poncz, MD, Deborah L French, PhD, Joel S. Bennett, MD

Blood (2020) 136 (Supplement 1): 3.

https://doi.org/10.1182/blood-2020-134268

Published: 2020

Journal Articles

The Inherited Platelet Disorder of RUNX1 Haploinsufficiency (Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM)) Has a Marked Deficiency of Megakaryocyte-Biased Hematopoietic Progenitor Cells: Mechanistic Studies and Drug Correction

Brian Estevez, PhD, Sara Borst, BS, Danuta Jadwiga Jarocha, PhD, Varun Sudunagunta, Michael Gonzalez, PhD, Peng Gao, Kai Tan, Deborah L French, PhD, Paul Gadue, PhD, Mortimer Poncz, MD

Blood (2019) 134 (Supplement_1): 220.

https://doi.org/10.1182/blood-2019-124851

Published: 2019

Journal Articles

A Novel Approach for Generating Platelet-Delivered FVIII: Role of Transient LRP1 Expression during Megakaryopoiesis

John Tkaczynski, BS, Randolph Lyde, PhD, Hyunsook Ahn, MSc, Francis Ayombil, PhD, Sara Borst, BS, Paul Gadue, PhD, Deborah L French, PhD, Denise Sabatino, PhD, Rodney M. Camire, PhD, Mortimer Poncz, MD

Blood (2019) 134 (Supplement_1): 1102.

https://doi.org/10.1182/blood-2019-124788

Published: 2019

Journal Articles

Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis

Kandace Gollomp, MD, Amrita Sarkar, PhD, Gowthami Arepally, MD, Douglas B. Cines, MD, M. Anna Kowalska, PhD, Lubica Rauova, MD PhD, Mortimer Poncz, MD

Blood (2019) 134 (Supplement_1): 10.

https://doi.org/10.1182/blood-2019-123132

Published: 2019

Journal Articles

A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in α-Granules and Is Functional In Vivo in a Murine Model of Thrombosis

Hyunsook Ahn, MSc, John Tkaczynski, BS, Khalil Bdeir, PhD, Victoria Stepanova, Douglas B. Cines, MD, Mortimer Poncz, MD, Sergei Zaitsev

Blood (2019) 134 (Supplement_1): 3627.

https://doi.org/10.1182/blood-2019-124501

Published: 2019

Journal Articles

A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice

Randolph Lyde, PhD, Hyunsook Ahn, Vincent Hayes, Sergei Zaistev, PhD, Shu-Wha Lin, PhD, Zaverio M. Ruggeri, MD, Renhao Li, PhD, Vladimir Muzykantov, Douglas B. Cines, MD, Mortimer Poncz, MD

Blood (2018) 132 (Supplement 1): 990.

https://doi.org/10.1182/blood-2018-99-115262

Published: 2018

Journal Articles

Analysis of the Frequency of Spontaneous, Functionally-Significant Mutations in Genes Associated with Platelet Disorders in >120,000 Healthy Individuals

Joseph H Oved, MD BA, MA, Michele P. Lambert, MD, M. Anna Kowalska, PhD, Mortimer Poncz, MD, Konrad Karczewski, PhD

Blood (2018) 132 (Supplement 1): 2438.

https://doi.org/10.1182/blood-2018-99-115567

Published: 2018

Journal Articles

Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia

Amrita Sarkar, PhD, Gowthami Arepally, MD, M. Anna Kowalska, PhD, Douglas B. Cines, MD, Lubica Rauova, MD PhD, Mortimer Poncz, MD, Kandace Gollomp, MD

Blood (2018) 132 (Supplement 1): 271.

https://doi.org/10.1182/blood-2018-99-111381

Published: 2018

Journal Articles

Janus Kinase (Jak) 1 Inhibition Affects Both Megakaryopoiesis and Thrombopoiesis

Danuta Jadwiga Jarocha, PhD, Paul Gadue, PhD, Wei Tong, PhD, Robert C Newton, PhD, Mortimer Poncz, MD

Blood (2018) 132 (Supplement 1): 2559.

https://doi.org/10.1182/blood-2018-99-115407

Published: 2018

Journal Articles

Inhibition of Neutrophil Extracellular Trap Release through the Disruption of PAD4 Leads to Decreased Neutrophil and Platelet Accumulation at Sites of Venular Vascular Injury in a Murine Model of Heparin-Induced Thrombocytopenia

Kandace Gollomp, MD, Vincent Hayes, Ian Johnston, BS, Minna Kim, Guohua Zhao, Lubica Rauova, MD PhD, Mortimer Poncz, MD

Blood (2017) 130 (Supplement 1): 2268.

https://doi.org/10.1182/blood.V130.Suppl_1.2268.2268

Published: 2017

Journal Articles

In Vitro Complement Activation By PF4/Heparin Complexes Is Mediated By Plasma IgM

Sanjay Khandelwal, PhD, Lubica Rauova, MD PhD, Mortimer Poncz, MD, Michael Frank, MD, Douglas B. Cines, MD, Gowthami Arepally, MD

Blood (2017) 130 (Supplement 1): 3617.

https://doi.org/10.1182/blood.V130.Suppl_1.3617.3617

Published: 2017

Journal Articles

Platelet Factor 4 (PF4)-Mediated Neutrophil Extracellular Trap Compaction Limits Endothelial Injury and Promotes Survival Following Lipopolysaccharide Challenge

Kandace Gollomp, MD, Ian Johnston, BS, Minna Kim, Li Zhai, Guohua Zhao, M. Anna Kowalska, PhD, Mortimer Poncz, MD

Blood (2017) 130 (Supplement 1): 997.

https://doi.org/10.1182/blood.V130.Suppl_1.997.997

Published: 2017

Journal Articles

Platelet Factor 4 Binds to Released Von Willebrand Factor Strands from Injured Endothelium and Forms a Prothrombotic HIT Antigenic Complex

Ian Johnston, BS, Jose A. Lopez, MD, Douglas B. Cines, MD, Lubica Rauova, MD PhD, Mortimer Poncz, MD

Blood (2017) 130 (Supplement 1): 2310.

https://doi.org/10.1182/blood.V130.Suppl_1.2310.2310

Published: 2017

Journal Articles

Maternal Anti-αIIb Antibodies Target Fetal Hematopoietic Stem Cells and May Lead to Pancytopenia and Miscarriage in Fnait

Jade Sullivan, BSc, Brigitta Elaine Oswald, B.Sc, Brian Vadasz, BSc, June Li, MSc, Pingguo Chen, PhD, Mortimer Poncz, MD, John J. Freedman, MD, Heyu Ni, MD MSc, PhD

Blood (2017) 130 (Supplement 1): 233.

https://doi.org/10.1182/blood.V130.Suppl_1.233.233

Published: 2017

Journal Articles

A Special Role for Neutrophil Extracellular Traps (NETs) and Neutrophils in the Prothombotic Nature of Heparin-Induced Thrombocytopenia

Kandace Gollomp, MD, Ian Johnston, BS, Lubica Rauova, MD PhD, Douglas B. Cines, MD, M. Anna Kowalska, PhD, Mortimer Poncz, MD

Blood (2016) 128 (22): 1023.

https://doi.org/10.1182/blood.V128.22.1023.1023

Published: 2016

Journal Articles

Platelet Release from Infused CD34 + -Derived Human Megakaryocytes: Lessons from a Natural-Occurring Platelet Bioreactor

Ian Johnston, BS, Vincent M Hayes, BS, Jing Dai, MD PhD, Danuta Jadwiga Jarocha, PhD, Paul Kubes, PhD, Mortimer Poncz, MD, Lubica Rauova, MD PhD

Blood (2016) 128 (22): 1375.

https://doi.org/10.1182/blood.V128.22.1375.1375

Published: 2016

Journal Articles

Infusion of Coagulation Factor VIII-Containing Induced Pluripotent Stem Cell (iPSC)-Derived Megakaryocytes (iMks) Shows Potential As Hemophilia a Treatment

Randolph B Lyde, Jr., BS, Hyunsook Ahn, Karen K Vo, BS, Danuta Jadwiga Jarocha, PhD, Li Zhai, BS, Spencer K. Sullivan, MD, Valder R Arruda, MD PhD, Denise E. Sabatino, PhD, Rodney M. Camire, PhD, Deborah French, PhD, Mortimer Poncz, MD

Blood (2016) 128 (22): 2559.

https://doi.org/10.1182/blood.V128.22.2559.2559

Published: 2016

Journal Articles

Fli1 Expression Level Affects Megakaryopoiesis and Thrombopoiesis: More Is Not Always a Bad Thing

Karen K Vo, BS, Danuta Jadwiga Jarocha, PhD, Randolph B Lyde, Jr., BS, Spencer K. Sullivan, MD, Deborah French, PhD, Mortimer Poncz, MD

Blood (2016) 128 (22): 3876.

https://doi.org/10.1182/blood.V128.22.3876.3876

Published: 2016

NARROW

Exploiting Induced Pluripotent Stem Cells to Unravel Mechanisms in Inherited Platelet/Megakaryocyte Disorders

Complement Regulates the Procoagulant Effects of HIT Immune Complexes

Utilizing CRISPR-CAS9 Gene Editing Technology in Human Pluripotent Stem Cells to Study Platelet Integrin αIIbβ3 Function

The Inherited Platelet Disorder of RUNX1 Haploinsufficiency (Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM)) Has a Marked Deficiency of Megakaryocyte-Biased Hematopoietic Progenitor Cells: Mechanistic Studies and Drug Correction

A Novel Approach for Generating Platelet-Delivered FVIII: Role of Transient LRP1 Expression during Megakaryopoiesis

Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis

A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in α-Granules and Is Functional In Vivo in a Murine Model of Thrombosis

A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice

Analysis of the Frequency of Spontaneous, Functionally-Significant Mutations in Genes Associated with Platelet Disorders in >120,000 Healthy Individuals

Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia

Janus Kinase (Jak) 1 Inhibition Affects Both Megakaryopoiesis and Thrombopoiesis

Inhibition of Neutrophil Extracellular Trap Release through the Disruption of PAD4 Leads to Decreased Neutrophil and Platelet Accumulation at Sites of Venular Vascular Injury in a Murine Model of Heparin-Induced Thrombocytopenia

In Vitro Complement Activation By PF4/Heparin Complexes Is Mediated By Plasma IgM

Platelet Factor 4 (PF4)-Mediated Neutrophil Extracellular Trap Compaction Limits Endothelial Injury and Promotes Survival Following Lipopolysaccharide Challenge

Platelet Factor 4 Binds to Released Von Willebrand Factor Strands from Injured Endothelium and Forms a Prothrombotic HIT Antigenic Complex

Maternal Anti-αIIb Antibodies Target Fetal Hematopoietic Stem Cells and May Lead to Pancytopenia and Miscarriage in Fnait

A Special Role for Neutrophil Extracellular Traps (NETs) and Neutrophils in the Prothombotic Nature of Heparin-Induced Thrombocytopenia

Platelet Release from Infused CD34 + -Derived Human Megakaryocytes: Lessons from a Natural-Occurring Platelet Bioreactor

Infusion of Coagulation Factor VIII-Containing Induced Pluripotent Stem Cell (iPSC)-Derived Megakaryocytes (iMks) Shows Potential As Hemophilia a Treatment

Fli1 Expression Level Affects Megakaryopoiesis and Thrombopoiesis: More Is Not Always a Bad Thing

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American Society of Hematology

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American Society of Hematology

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