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Michael Kuehl
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Journal Articles

IMiDs Synergize with EP300 Inhibition to Disrupt the Ikzf/MYC/IRF4 Axis in Multiple Myeloma

Seth J Welsh, Benjamin G Barwick, Erin Meermeier, Daniel Riggs, Chang-Xin Shi, Yuan Xiao Zhu, Meaghen E Sharik, Megan T Du, Victoria Marie Garbitt, Caleb K Stein, Joachim L Petit, Nathalie Meurice, Rodrigo Fonseca, Kennedi Todd, Sochilt Brown, Yuliza Tafoya Alvarado, Zachary Hammond, Nicklus Cuc, Courtney Wittenberg, Camille Herzog, Lawrence H. Boise, Nizar J. Bahlis, Paola Neri, W. Michael Kuehl, Marta Chesi, P. Leif Bergsagel
Journal: Blood
Blood (2022) 140 (Supplement 1): 12997.
https://doi.org/10.1182/blood-2022-169920
Published: 2022
Journal Articles

Disrupting Ectopic Super-Enhancers to Treat Multiple Myeloma

Seth Welsh, Daniel Riggs, Erin Meermeier, Chang-Xin Shi, Victoria Garbitt, Meaghen E Sharik, Megan Du, Kennedi Todd, Zachary Hammond, Sochilt Brown, Caleb K Stein, Paola Neri, Nizar J. Bahlis, Benjamin G Barwick, Larry H. Boise, W. Michael Kuehl, Marta Chesi, P. Leif Bergsagel
Journal: Blood
Blood (2021) 138 (Supplement 1): 1593.
https://doi.org/10.1182/blood-2021-147551
Published: 2021
Journal Articles

Detailing the genomic landscape of myeloma

P. Leif Bergsagel, W. Michael Kuehl
Journal: Blood
Blood (2018) 132 (6): 554–555.
https://doi.org/10.1182/blood-2018-06-857508
Published: 2018
Journal Articles

Repair Of DNA Double Strand Breaks By Insertion Of Nucleotide Sequences Derived From Distant Regions Of The Genome

Masahiro Onozawa, MD, PhD., Zhenhua Zhang, Yoo Jung Kim, Liat Goldberg, PhD, Tamas Varga, PhD, Leif Bergsagel, M.D., Michael Kuehl, MD, Peter D Aplan, MD
Journal: Blood
Blood (2013) 122 (21): 1243.
https://doi.org/10.1182/blood.V122.21.1243.1243
Published: 2013
Journal Articles

Promiscuous Cryptic Rearrangements of the MYC Locus Cis-Dysregulate MYC Expression and Are Present in the Majority of Patients with Hyperdiploid Myeloma

P Leif Bergsagel, MD, Maurizio Affer, PhD, Oleg K Glebov, PhD, Wei-Dong D Chen, PhD, Jonathan J Keats, PhD, Leslie A Brents, Marta Chesi, PhD, Scott Van Wier, Sandra K Badar, Rafael Fonseca, MD, W Michael Kuehl, MD
Journal: Blood
Blood (2012) 120 (21): 724.
https://doi.org/10.1182/blood.V120.21.724.724
Published: 2012
Journal Articles

MYC addiction: a potential therapeutic target in MM

W. Michael Kuehl, P. Leif Bergsagel
Journal: Blood
Blood (2012) 120 (12): 2351–2352.
https://doi.org/10.1182/blood-2012-08-445262
Published: 2012
Journal Articles

Mouse models can predict cancer therapy

W. Michael Kuehl
Journal: Blood
Blood (2012) 120 (2): 238–240.
https://doi.org/10.1182/blood-2012-04-422501
Published: 2012
Journal Articles

A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression

Christina M. Annunziata, Lidia Hernandez, R. Eric Davis, Adriana Zingone, Laurence Lamy, Lloyd T. Lam, Elaine M. Hurt, Arthur L. Shaffer, W. Michael Kuehl, Louis M. Staudt
Journal: Blood
Blood (2011) 117 (8): 2396–2404.
https://doi.org/10.1182/blood-2010-04-278788
Published: 2011
Includes: Supplemental data
Journal Articles

Classical and/or alternative NF-κB pathway activation in multiple myeloma

Yulia N. Demchenko, Oleg K. Glebov, Adriana Zingone, Jonathan J. Keats, P. Leif Bergsagel, W. Michael Kuehl
Journal: Blood
Blood (2010) 115 (17): 3541–3552.
https://doi.org/10.1182/blood-2009-09-243535
Published: 2010
Journal Articles

Patterns of Monoclonal Immunoglobulins and Serum Free Light Chains Are Significantly Different in African-American Compared to Caucasian MGUS Patients.

Brendan Weiss, MD, Alex Minter, MD, Matthew Laquer, MD, Robin Howard, MA, Jude Abadie, PhD, Joao Ascencao, MD, PhD, Geraldine P. Schechter, MD, Michael Kuehl, MD, Ola Landgren, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 2838.
https://doi.org/10.1182/blood.V114.22.2838.2838
Published: 2009
Journal Articles

A monoclonal gammopathy precedes multiple myeloma in most patients

Clinical Trials & Observations
Brendan M. Weiss, Jude Abadie, Pramvir Verma, Robin S. Howard, W. Michael Kuehl
Journal: Blood
Blood (2009) 113 (22): 5418–5422.
https://doi.org/10.1182/blood-2008-12-195008
Published: 2009
Journal Articles

Genetic Origin of Myeloma.

Marta Chesi, Peter Leif Bergsagel, MD, Michael Kuehl, MD
Journal: Blood
Blood (2008) 112 (11): sci-5.
https://doi.org/10.1182/blood.V112.11.sci-5.sci-5
Published: 2008
Journal Articles

OH-2, a Hyperdiploid Myeloma Cell Line without An IGH Translocation, Has a Complex Translocation Juxtaposing MYC near MAFB and the IGK Locus

Thea Kristin Våtsveen, Erming Tian, Stine H Kresse, Leonardo A Meza-zepeda, Ana Gabrea, Hong Yan Dai, Michael Kuehl, MD, Anders Sundan, Magne Borset, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2736.
https://doi.org/10.1182/blood.V112.11.2736.2736
Published: 2008
Journal Articles

A Pre-Existing Plasma Cell Disorder Occurs in Most Patients with Multiple Myeloma.

Brendan M Weiss, MD, Pramvir Verma, MD, Jude Abadie, PhD, Robin Howard, MA, Michael Kuehl, MD
Journal: Blood
Blood (2008) 112 (11): 1693.
https://doi.org/10.1182/blood.V112.11.1693.1693
Published: 2008
Journal Articles

Loss of p53 Is a Marker of Progression in Plasma Cell Neoplasias and Is a Negative Prognostic Factor in Relapsed Disease.

Soledad Molnar, MD, Victor J Jimenez Zepeda, Scott Van Wier, Esteban Braggio, Jonathan Keats, Michael Kuehl, Tammy Price-Troska, Greg Ahmann, Rachel Rempel, Kim Henderson, MD, S. Vincent Rajkumar, MD, Philip. R Greipp, MD, Daniel Auclair, John Carpten, Angela Baker, Keith Stewart, MD, P. Leif Bergsagel, MD, Wee Joo Chng, MD, Rafael Fonseca, MD
Journal: Blood
Blood (2008) 112 (11): 1663.
https://doi.org/10.1182/blood.V112.11.1663.1663
Published: 2008
Journal Articles

WSU-WM and BCWM.1 should not be assumed to represent Waldenström macroglobulinemia cell lines

P. Leif Bergsagel, W. Michael Kuehl
Journal: Blood
Blood (2008) 112 (3): 917.
https://doi.org/10.1182/blood-2008-05-154831
Published: 2008
Journal Articles

A Simple and Reliable Method To Verify the Authenticity and Purity of Human Myeloma Cell Lines.

Jonathan J. Keats, PhD, Marta Chesi, PhD, W. Michael Kuehl, MD, P. Leif Bergsagel, MD
Journal: Blood
Blood (2007) 110 (11): 2485.
https://doi.org/10.1182/blood.V110.11.2485.2485
Published: 2007
Journal Articles

CKS1B , overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27 Kip1 -dependent and -independent mechanisms

Fenghuang Zhan, Simona Colla, Xiaosong Wu, Bangzheng Chen, James P. Stewart, W. Michael Kuehl, Bart Barlogie, John D. Shaughnessy, Jr
Journal: Blood
Blood (2007) 109 (11): 4995–5001.
https://doi.org/10.1182/blood-2006-07-038703
Published: 2007
Journal Articles

Methylation and expression of the p16INK4A tumor suppressor gene in multiple myeloma

Amel Dib, Bart Barlogie, John D. Shaughnessy, Jr, Walter Michael Kuehl
Journal: Blood
Blood (2007) 109 (3): 1337–1338.
https://doi.org/10.1182/blood-2006-09-049510
Published: 2007
Journal Articles

Aberrant Immunoglobulin Class Switch Recombination and Switch Translocations in Activated B Cell-Like Diffuse Large B-Cell Lymphoma.

Georg Lenz, MD, Inga Nagel, PhD, Reiner Siebert, MD, Warren Sanger, MD, George W. Wright, PhD, Hong Zhao, Andreas Rosenwald, MD, Hans-Konrad Muller-Hermelink, MD, Randy D. Gascoyne, MD, Elias Campo, MD, Elaine S. Jaffe, MD, Erlend B. Smeland, MD, Richard I. Fisher, MD, W. Michael Kuehl, MD, Wing C. Chan, MD, Louis M. Staudt, MD, PhD
Journal: Blood
Blood (2006) 108 (11): 356.
https://doi.org/10.1182/blood.V108.11.356.356
Published: 2006