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Journal Articles

Development of hyperdiploidy starts at an early age and takes a decade to complete

Mehmet K. Samur, Anil Aktas Samur, Parth Shah, Joseph Park, Mariateresa Fulciniti, Masood A Shammas, Jill Corre, Kenneth C. Anderson, Giovanni Parmigiani, Hervé Avet-Loiseau, Nikhil C. Munshi

Blood blood.2024025250.

https://doi.org/10.1182/blood.2024025250

Published: 2024

Includes: Supplemental data

Journal Articles

A Focused High Throughput Functional Screen Identifies Novel Targets for aggressive B-Cell Lymphoma

Chengcheng Liao, Sha He, Jie Sun, Qing Ke, Chao Rong, Baoping Guo, Xiaohong Tan, Srikanth Talluri, Masood A. Shammas, Nikhil C. Munshi, Hong Cen

Blood (2024) 144 (Supplement 1): 5758.

https://doi.org/10.1182/blood-2024-209515

Published: 2024

Journal Articles

Deciphering Drivers of Functional and Phenotypic Changes through Genome-Wide Screen (DRIVE-Genome) to Identify Genes Inducing Genomic Instability in Myeloma

Srikanth Talluri, Leutz Buon, Jiangning Zhao, Daniel Meglino, Chandraditya Chakraborty, Chengcheng Liao, Mehmet K. Samur, David E. Root, Masood A. Shammas, Nikhil C. Munshi

Blood (2024) 144 (Supplement 1): 4133.

https://doi.org/10.1182/blood-2024-210496

Published: 2024

Journal Articles

PKMYT1 Kinase Is an Actionable Synthetically Lethal Target for Del17p Myeloma

Anais Schavgoulidze, Mariateresa Fulciniti, Giulia Giorgetti, Sabrina Maheo, Shuhui Deng, Vanessa Favasuli, Srikanth Talluri, Masood A. Shammas, Luka Pavageau, Anil Aktas-Samur, Mehmet K. Samur, Herve Avet-Loiseau, Jill Corre, Nikhil C. Munshi

Blood (2024) 144 (Supplement 1): 764.

https://doi.org/10.1182/blood-2024-199692

Published: 2024

Journal Articles

ABL1 kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma

Subodh Kumar, Srikanth Talluri, Jiangning Zhao, Chengcheng Liao, Lakshmi B. Potluri, Leutz Buon, Shidai Mu, Jialan Shi, Chandraditya Chakraborty, Yu-Tzu Tai, Mehmet K. Samur, Nikhil C. Munshi, Masood A. Shammas

Blood (2024) 143 (11): 996–1005.

https://doi.org/10.1182/blood.2023021225

Published: 2024

Includes: Supplemental data

Journal Articles

Multi-Level Control of Myeloma Cell Proliferation and Genomic Instability By the PDZ Binding Kinase (PBK)

Lai Shi, Srikanth Talluri, Subodh Kumar, Jiangning Zhao, Chengcheng Liao, Leutz Buon, DeYao Shi, Shidai Mu, Lakshmi B. Potluri, Chandraditya Chakraborty, Jialan Shi, Mehmet K. Samur, Masood A. Shammas, Nikhil C Munshi

Blood (2023) 142 (Supplement 1): 6606.

https://doi.org/10.1182/blood-2023-188922

Published: 2023

Journal Articles

RAD51 Is Required for the Occupancy of Replication Licensing Factors on the Myeloma Genome

Jiangning Zhao, Srikanth Talluri, Subodh Kumar, Eugenio Morelli, Lakshmi B. Potluri, Masood A. Shammas, Nikhil C Munshi

Blood (2023) 142 (Supplement 1): 6587.

https://doi.org/10.1182/blood-2023-189307

Published: 2023

Journal Articles

Discovery of Mutated MUC3A Gene As a Novel Transcription Factor Exclusively Associated with Accelerated Phase Chronic Myeloid Leukemia: Hunt for Common Biomarker of Fatal CML Progression

Sameen Shahid, Muhammad Sabar, Abid Jamil, Muhammad Abbas Khokar, Muhammad Absar, Mudassar Iqbal, Masood A. Shammas, Giuseppe Saglio, Sulman Basit, Sibtain Afzal, Khushnooda Ramzan, Aamer Aleem, Amer Mahmood, Nawaf Alanzazi, Muhammad Javed Asif, Mahmood Rasool, Ahmad Khalid, Zafar Iqbal

Blood (2023) 142 (Supplement 1): 7429.

https://doi.org/10.1182/blood-2023-185547

Published: 2023

Journal Articles

Venetoclax Resistance Results in Broad Resistance to Majority of Anti-MM Agents Due to the Suppression of Apoptosis but Can be Overcome By BCMA-Targeted Immunotherapy

Mariateresa Fulciniti, Shuhui Deng, Sanika Dereibal, Vera Joy Weiler, Madhumouli Chatterjee, Jessica Ng Fong, Chandraditya Chakraborty, Rao Prabhala, Masood A. Shammas, Anil Aktas-Samur, Mehmet K. Samur, Annamaria Gulla, Kenneth C. Anderson, Nikhil C Munshi

Blood (2023) 142 (Supplement 1): 3311.

https://doi.org/10.1182/blood-2023-187374

Published: 2023

Journal Articles

High-dose melphalan treatment significantly increases mutational burden at relapse in multiple myeloma

Mehmet Kemal Samur, Marco Roncador, Anil Aktas Samur, Mariateresa Fulciniti, Abdul Hamid Bazarbachi, Raphael Szalat, Masood A. Shammas, Adam S. Sperling, Paul G. Richardson, Florence Magrangeas, Stephane Minvielle, Aurore Perrot, Jill Corre, Philippe Moreau, Anjan Thakurta, Giovanni Parmigiani, Kenneth C. Anderson, Hervé Avet-Loiseau, Nikhil C. Munshi

Blood (2023) 141 (14): 1724–1736.

https://doi.org/10.1182/blood.2022017094

Published: 2023

Includes: Supplemental data

Journal Articles

A MIR17HG-derived long noncoding RNA provides an essential chromatin scaffold for protein interaction and myeloma growth

Blood (2023) 141 (4): 391–405.

https://doi.org/10.1182/blood.2022016892

Published: 2023

Includes: Supplemental data

Journal Articles

Exonuclease 1 Drives Growth and Genomic Instability in Multiple Myeloma through Interaction with CAD, a Key Protein Involved in De Novo Pyrimidine Biosynthesis

Shidai Mu, Srikanth Talluri, Jiangning Zhao, Lai Shi, Hannah Seah, Lakshmi B. Potluri, Jialan Shi, Mehmet K. Samur, Masood A. Shammas, Nikhil C Munshi

Blood (2022) 140 (Supplement 1): 4196–4197.

https://doi.org/10.1182/blood-2022-169978

Published: 2022

Journal Articles

Bioprocessing of MIR17HG Results in Long and Short Noncoding RNAs with Targetable Tumor-Promoting Activity in Multiple Myeloma

Blood (2022) 140 (Supplement 1): 1551–1552.

https://doi.org/10.1182/blood-2022-167604

Published: 2022

Journal Articles

Flap Structure-Specific Endonuclease 1 Coordinates with a Helicase (ASCC3) to Drive Genomic Instability, Proliferation and Poor Clinical Outcome in Myeloma

Chengcheng Liao, Srikanth Talluri, Shidai Mu, Subodh Kumar, Lakshmi B. Potluri, Jialan Shi, Leutz Buon, Masood A. Shammas, Nikhil C Munshi

Blood (2022) 140 (Supplement 1): 9963.

https://doi.org/10.1182/blood-2022-169117

Published: 2022

Journal Articles

Somatic Changes Prior to the Development of Hyperdiploidy Expose Mutation Accumulation Rate and Activated Processes in Multiple Myeloma

Thomas C. Smits, Anil Aktas-Samur, Romain Lannes, Mariateresa Fulciniti, Masood A. Shammas, Jill Corre, Giovanni Parmigiani, Herve Avet-Loiseau, Nikhil C Munshi, Mehmet K. Samur

Blood (2022) 140 (Supplement 1): 7062–7063.

https://doi.org/10.1182/blood-2022-168837

Published: 2022

Journal Articles

Identifying Long Noncoding RNA Dependencies Using CRISPR Interference (CRISPRi)-Based Platform in Multiple Myeloma

Blood (2021) 138 (Supplement 1): 894.

https://doi.org/10.1182/blood-2021-151705

Published: 2021

Journal Articles

B Cell Transcriptional Coactivator POU2AF1 (BOB-1) Is an Early Transcription Factor Modulating the Protein Synthesis and Ribosomal Biogenesis in Multiple Myeloma: With Therapeutic Implication

Zuzana Chyra, Mehmet K. Samur, Anil Aktas-Samur, Yao Yao, Sanika Derebail, Tommaso Perini, Yan Xu, Eugenio Morelli, Sophia Adamia, Woojun D Park, Lin Charles, Ryosuke Shirasaki, Masood A. Shammas, Constantine S. Mitsiades, Roman Hajek, Mariateresa Fulciniti, Nikhil C. Munshi

Blood (2021) 138 (Supplement 1): 2670.

https://doi.org/10.1182/blood-2021-152121

Published: 2021

Journal Articles

Dysfunctional HDAC8 Impacts Genomic Integrity and Is a Novel Therapeutic Target in Multiple Myeloma

Zuzana Chyra, Srikanth Talluri, Rao Prabhala, Mehmet K. Samur, Anil Aktas-Samur, Yan Xu, Aaron B. Beeler, Roman Hajek, Mariateresa Fulciniti, Masood A. Shammas, Nikhil C. Munshi

Blood (2021) 138 (Supplement 1): 1610.

https://doi.org/10.1182/blood-2021-153382

Published: 2021

Journal Articles

Presence of Extrachromosomal DNA (ecDNA) Impacts Both Progression Free and Overall Survival and Is an Independent Poor Prognostic Marker in Multiple Myeloma

Parth Shah, Anil Aktas-Samur, Mariateresa Fulciniti, Raphael Szalat, Masood A. Shammas, Paul G. Richardson, Florence Magrangeas, Stephane Minvielle, Aurore Perrot, Jill Corre, Philippe Moreau, Anjan Thakurta, Kenneth C. Anderson, Herve Avet-Loiseau, Nikhil C. Munshi, Mehmet K. Samur

Blood (2021) 138 (Supplement 1): 461.

https://doi.org/10.1182/blood-2021-151647

Published: 2021

Journal Articles

ABL1 Kinase Plays an Important Role in Spontaneous and Melphalan-Induced Genomic Instability in Multiple Myeloma: Potential Therapeutic Application

Subodh Kumar, PhD, Srikanth Talluri, PhD, Jiangning Zhao, PhD MD, Chengcheng Liao, PhD MD, Lakshmi B. Potluri, MBBS, Leutz Buon, Shidai Mu, Jialan Shi, MDPhD, Mychell Neptune-Buon, Chandraditya Chakraborty, PhD, Yu-Tzu Tai, PhD, Mehmet K. Samur, PhD, Mariateresa Fulciniti, PhD, Rao Prabhala, Masood A. Shammas, PhD, Nikhil C. Munshi, MD

Blood (2020) 136 (Supplement 1): 51.

https://doi.org/10.1182/blood-2020-142793

Published: 2020

NARROW

Development of hyperdiploidy starts at an early age and takes a decade to complete

A Focused High Throughput Functional Screen Identifies Novel Targets for aggressive B-Cell Lymphoma

Deciphering Drivers of Functional and Phenotypic Changes through Genome-Wide Screen (DRIVE-Genome) to Identify Genes Inducing Genomic Instability in Myeloma

PKMYT1 Kinase Is an Actionable Synthetically Lethal Target for Del17p Myeloma

ABL1 kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma

Multi-Level Control of Myeloma Cell Proliferation and Genomic Instability By the PDZ Binding Kinase (PBK)

RAD51 Is Required for the Occupancy of Replication Licensing Factors on the Myeloma Genome

Discovery of Mutated MUC3A Gene As a Novel Transcription Factor Exclusively Associated with Accelerated Phase Chronic Myeloid Leukemia: Hunt for Common Biomarker of Fatal CML Progression

Venetoclax Resistance Results in Broad Resistance to Majority of Anti-MM Agents Due to the Suppression of Apoptosis but Can be Overcome By BCMA-Targeted Immunotherapy

High-dose melphalan treatment significantly increases mutational burden at relapse in multiple myeloma

A MIR17HG-derived long noncoding RNA provides an essential chromatin scaffold for protein interaction and myeloma growth

Exonuclease 1 Drives Growth and Genomic Instability in Multiple Myeloma through Interaction with CAD, a Key Protein Involved in De Novo Pyrimidine Biosynthesis

Bioprocessing of MIR17HG Results in Long and Short Noncoding RNAs with Targetable Tumor-Promoting Activity in Multiple Myeloma

Flap Structure-Specific Endonuclease 1 Coordinates with a Helicase (ASCC3) to Drive Genomic Instability, Proliferation and Poor Clinical Outcome in Myeloma

Somatic Changes Prior to the Development of Hyperdiploidy Expose Mutation Accumulation Rate and Activated Processes in Multiple Myeloma

Identifying Long Noncoding RNA Dependencies Using CRISPR Interference (CRISPRi)-Based Platform in Multiple Myeloma

B Cell Transcriptional Coactivator POU2AF1 (BOB-1) Is an Early Transcription Factor Modulating the Protein Synthesis and Ribosomal Biogenesis in Multiple Myeloma: With Therapeutic Implication

Dysfunctional HDAC8 Impacts Genomic Integrity and Is a Novel Therapeutic Target in Multiple Myeloma

Presence of Extrachromosomal DNA (ecDNA) Impacts Both Progression Free and Overall Survival and Is an Independent Poor Prognostic Marker in Multiple Myeloma

ABL1 Kinase Plays an Important Role in Spontaneous and Melphalan-Induced Genomic Instability in Multiple Myeloma: Potential Therapeutic Application

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American Society of Hematology

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American Society of Hematology

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