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Len Neckers
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Journal Articles

Novel Mechanism of Activated FLT3-Associated Leukemogenisis: FLT3 Regulates Wnt Signaling by Phosphorylating β-Catenin and Promoting β-Catenin Nuclear Localization.

Tomohiro Kajiguchi, MD, PhD, Eun Joo Chung, PhD, Hitoshi Kiyoi, MD, PhD, Tomoki Naoe, MD, PhD, Len Neckers, PhD, Jane Trepel, PhD
Journal: Blood
Blood (2005) 106 (11): 2295.
https://doi.org/10.1182/blood.V106.11.2295.2295
Published: 2005
Journal Articles

Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation

Clinical Trials & Observations Brief Report
Jason Gotlib, Caroline Berubé, Joseph D. Growney, Ching-Cheng Chen, Tracy I. George, Christopher Williams, Tomohiro Kajiguchi, Jia Ruan, Stan L. Lilleberg, Jeffrey A. Durocher, Jack H. Lichy, Yanfeng Wang, Pamela S. Cohen, Daniel A. Arber, Michael C. Heinrich, Len Neckers, Stephen J. Galli, D. Gary Gilliland, Steven E. Coutré
Journal: Blood
Blood (2005) 106 (8): 2865–2870.
https://doi.org/10.1182/blood-2005-04-1568
Published: 2005
Journal Articles

A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib

Clinical Trials & Observations
Cem Akin, Gerard Fumo, Akif S. Yavuz, Peter E. Lipsky, Len Neckers, Dean D. Metcalfe
Journal: Blood
Blood (2004) 103 (8): 3222–3225.
https://doi.org/10.1182/blood-2003-11-3816
Published: 2004
Journal Articles

17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells

Gerard Fumo, Cem Akin, Dean D. Metcalfe, Len Neckers
Journal: Blood
Blood (2004) 103 (3): 1078–1084.
https://doi.org/10.1182/blood-2003-07-2477
Published: 2004