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Journal Articles

Safety of Caplacizumab in Patients Without Documented Severe ADAMTS13 Deficiency During the HERCULES Study

Javier De La Rubia, Flora Peyvandi, MD PhD, Marie Scully, Spero Cataland, MD, Paul Coppo, MD PhD, Johanna A. Kremer Hovinga, MD Prof, Paul Knoebl, MD, Ara Metjian, MD, Katerina Pavenski, MD, Hilde De Winter, MD, Rui de Passos Sousa, Filip Callewaert

Blood (2019) 134 (Supplement_1): 1093.

https://doi.org/10.1182/blood-2019-124004

Published: 2019

Journal Articles

Narratives of Patients with Fatal Outcomes During the Phase 2 TITAN and Phase 3 HERCULES Studies

Spero Cataland, MD, Marie Scully, Flora Peyvandi, MD PhD, Paul Knoebl, MD, Johanna A. Kremer Hovinga, MD Prof, Paul Coppo, MD PhD, Ara Metjian, MD, Javier De La Rubia, Katerina Pavenski, MD, Hilde De Winter, MD, Filip Callewaert

Blood (2019) 134 (Supplement_1): 4908.

https://doi.org/10.1182/blood-2019-123124

Published: 2019

Journal Articles

Acquired Hemophilia and Plasma Cell Neoplasms, a Rare Association

Katarzyna Aleksandra Jalowiec, Martin Andres, Behrouz Mansouri Taleghani, Anne Angelillo-Scherrer, MD PhD, Alicia Rovo, Johanna A. Kremer Hovinga, MD Prof

Blood (2019) 134 (Supplement_1): 4930.

https://doi.org/10.1182/blood-2019-128048

Published: 2019

Journal Articles

Efficacy of Caplacizumab in Patients with aTTP in the HERCULES Study According to Initial Immunosuppression Regimen

Katerina Pavenski, MD, Paul Knoebl, MD, Marie Scully, Johanna A. Kremer Hovinga, MD Prof, Paul Coppo, MD PhD, Flora Peyvandi, MD PhD, Spero Cataland, MD, Ara Metjian, MD, Javier De La Rubia, Hilde De Winter, MD, Rui de Passos Sousa, Filip Callewaert

Blood (2019) 134 (Supplement_1): 2365.

https://doi.org/10.1182/blood-2019-123126

Published: 2019

Journal Articles

Efficacy of Caplacizumab in Patients with aTTP in the HERCULES Study According to Baseline Disease Severity

Paul Coppo, MD PhD, Spero Cataland, MD, Flora Peyvandi, MD PhD, Paul Knoebl, MD, Marie Scully, Johanna A. Kremer Hovinga, MD Prof, Ara Metjian, MD, Javier De La Rubia, Katerina Pavenski, MD, Hilde De Winter, MD, Rui de Passos Sousa, Filip Callewaert

Blood (2019) 134 (Supplement_1): 2366.

https://doi.org/10.1182/blood-2019-123720

Published: 2019

Journal Articles

Safety of Caplacizumab for the Treatment of Patients with Acquired Thrombotic Thrombocytopenic Purpura - Results Normalized to Time of Exposure in a Double-Blind, Placebo-Controlled, Phase 3 Hercules Study

Johanna A. Kremer Hovinga, MD Prof, Marie Scully, MD MRCP, FRCPath, Spero R Cataland, MD, Flora Peyvandi, MD PhD, Paul Coppo, MD PhD, Paul Knöbl, MD PhD, Javier De La Rubia, MD, Katerina Pavenski, MD, Jessica Minkue, Rui Passos Sousa, MD MSc, Filip Callewaert, PhD, Hilde De Winter, MD, Ara Metjian, MD

Blood (2018) 132 (Supplement 1): 3744.

https://doi.org/10.1182/blood-2018-99-112177

Published: 2018

Journal Articles

Detection and Differential Diagnosis of Prekallikrein Deficiency: Genetic Study of New Families and Systematic Review of the Literature

Stefano Barco, Stefanie Sollfrank, Alice Trinchero, Luigi Tomao, Barbara Zieger, Johanna A. Kremer Hovinga, MD Prof, Laura Conti, Anke Adenäuer, Erwin Miloni, Karl J. Lackner, Heidi Rossmann, Bernhard Lammle, MD

Blood (2018) 132 (Supplement 1): 2496.

https://doi.org/10.1182/blood-2018-99-116030

Published: 2018

Journal Articles

Integrated Efficacy Results from the Phase II and Phase III Studies with Caplacizumab in Patients with Acquired Thrombotic Thrombocytopenic Purpura

Flora Peyvandi, MD PhD, Spero R Cataland, MD, Marie Scully, MD MRCP, FRCPath, Paul Coppo, MD PhD, Paul Knöbl, MD PhD, Johanna A. Kremer Hovinga, MD Prof, Ara Metjian, MD, Javier De La Rubia, MD, Katerina Pavenski, MD, Jessica Minkue, Filip Callewaert, PhD, Hilde De Winter, MD

Blood (2018) 132 (Supplement 1): 373.

https://doi.org/10.1182/blood-2018-99-112125

Published: 2018

Journal Articles

Risk Factors and Manageability of the Mainly Mild Mucocutaneous Bleeding Profile Observed in Attp Patients Treated with Caplacizumab during the Phase III Hercules Study

Spero R Cataland, MD, Marie Scully, MD MRCP, FRCPath, Flora Peyvandi, MD PhD, Paul Coppo, MD PhD, Paul Knöbl, MD PhD, Johanna A. Kremer Hovinga, MD Prof, Ara Metjian, MD, Javier De La Rubia, MD, Katerina Pavenski, MD, Jessica Minkue, Rui Passos Sousa, MD MSc, Filip Callewaert, PhD, Hilde De Winter, MD

Blood (2018) 132 (Supplement 1): 1142.

https://doi.org/10.1182/blood-2018-99-112179

Published: 2018

Journal Articles

Description of the First Cases with ADAMTS13 Mutations in Hungary

Marienn Réti, MD, György Sinkovits, MD, Orsolya Cseprekál, MD PhD, Dorottya Csuka, PhD, Ágnes Szilágyi, PhD, Zita Farkas, MD, Zsolt Klucsik, MD, Attila Szederjesi, MSC, László Wágner, MD Prof, György Reusz, MD Prof, Johanna A. Kremer Hovinga, MD Prof, János Rigó, MD Prof, Tamas Masszi, MD Prof., Zoltan Prohászka, MD Prof

Blood (2018) 132 (Supplement 1): 5003.

https://doi.org/10.1182/blood-2018-99-118327

Published: 2018

Journal Articles

Integrated Safety Results from the Phase II and Phase III Studies with Caplacizumab in Patients with Acquired Thrombotic Thrombocytopenic Purpura

Paul Knöbl, MD PhD, Marie Scully, MD MRCP, FRCPath, Spero R Cataland, MD, Flora Peyvandi, MD PhD, Paul Coppo, MD PhD, Johanna A. Kremer Hovinga, MD Prof, Ara Metjian, MD, Javier De La Rubia, MD, Katerina Pavenski, MD, Jessica Minkue, Filip Callewaert, PhD, Hilde De Winter, MD

Blood (2018) 132 (Supplement 1): 3739.

https://doi.org/10.1182/blood-2018-99-112174

Published: 2018

Journal Articles

Results of the Randomized, Double-Blind, Placebo-Controlled, Phase 3 Hercules Study of Caplacizumab in Patients with Acquired Thrombotic Thrombocytopenic Purpura

Marie Scully, MD, Spero R Cataland, MD, Flora Peyvandi, MD PhD, Paul Coppo, MD PhD, Paul Knöbl, MD PhD, Johanna A. Kremer Hovinga, MD, Ara Metjian, MD, Javier de la Rubia, MD, Katerina Pavenski, MD, Filip Callewaert, PhD, Debjit Biswas, PhD, Hilde De Winter, MD, Robert K. Zeldin, MD

Blood (2017) 130 (Supplement 1): LBA-1.

https://doi.org/10.1182/blood.V130.Suppl_1.LBA-1.LBA-1

Published: 2017

Journal Articles

Blocking Protein S Improves Hemostasis in Hemophilia a and B

Luca Bologna, PhDstudent, Raja Prince, PhDstudent, Mirko Manetti, PhD, Daniela Melchiorre, MD, Irene Rosa, PhDstudent, Natacha Dewarrat, Poorya Amini, PhDstudent, Jose A Fernandez, Claudia Quarroz, Yasuhiro Matsumura, MD PhD, Johanna A Kremer Hovinga, MD PhD, Shida Yousefi, PhD, John H. Griffin, PhD, Simon Hans-Uwe, MD PhD, Lidia Ibba Manneschi, Francois Saller, PhD, Sara Calzavarini, PhD, Anne Angelillo-Scherrer, MD

Blood (2016) 128 (22): 79.

https://doi.org/10.1182/blood.V128.22.79.79

Published: 2016

Journal Articles

Pharmacodynamic Profile of a Recombinant ADAMTS13 (BAX930) in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome (USS))

Marie Scully, Paul Knoebl, MD, Karim Kentouche, Lawrence Rice, MD, Jerzy Windyga, MD, Reinhard Schneppenheim, Johanna A Kremer Hovinga, MD PhD, Michiko Kajiwara, Caterina Maggiore, Jennifer Doralt, Leah Martell, Bruce M. Ewenstein

Blood (2016) 128 (22): 135.

https://doi.org/10.1182/blood.V128.22.135.135

Published: 2016

Journal Articles

Severe Depression Following Recovery From Thrombotic Thrombocytopenic Purpura (TTP)

Cassandra C. Deford, MA, Lauren H. Schwartz, MD, Jedidiah J. Perdue, MD, Jessica A. Reese, MS, Johanna A. Kremer Hovinga, MD, Bernhard Lämmle, MD, Lauren M. Stewart, MPH, Zayd L. Al-Nouri, MD, MPH, Deirdra R. Terrell, PhD, James N. George, MD, Sara K. Vesely, PhD, MPH

Blood (2012) 120 (21): 366.

https://doi.org/10.1182/blood.V120.21.366.366

Published: 2012

Journal Articles

Mortality and Morbidities During Long-Term Follow-up After Recovery From Thrombotic Thrombocytopenic Purpura (TTP)

Jessica A. Reese, MS, Zayd L. Al-Nouri, MD, MPH, Cassandra C. Deford, MA, Lauren M. Stewart, MPH, Deirdra R. Terrell, PhD, Sara K. Vesely, PhD, MPH, Johanna A. Kremer Hovinga, MD, Bernhard Lämmle, MD, James N. George, MD

Blood (2012) 120 (21): 362.

https://doi.org/10.1182/blood.V120.21.362.362

Published: 2012

Journal Articles

Circulating Nucleosomes Reflect Disease Activity in Patients with Thrombotic Microangiopathies.

Tobias A. Fuchs, PhD, Johanna A. Kremer Hovinga, MD, Daphne Schatzberg, BS, Marc Monestier, MD, PhD, Denisa D. Wagner, PhD, Bernhard Lämmle, MD

Blood (2010) 116 (21): 1437.

https://doi.org/10.1182/blood.V116.21.1437.1437

Published: 2010

Journal Articles

A Randomized, Double-Blind, Placebo-Controlled, Clinical Outcome Study of ARC1779 In Patients with Thrombotic Thrombocytopenic Purpura (TTP)

Spero R Cataland, MD, Flora Peyvandi, MD, PhD, Pier M. Mannucci, MD, Bernhard Lämmle, Johanna A Kremer Hovinga, MD, Samuel J Machin, Marie Scully, Gail Rock, PhD, MD, FRCP, James Gilbert, MD, Paul Knoebl, Shangbin Yang, PhD, Haifeng Wu, M.D., Bernd Jilma, MD

Blood (2010) 116 (21): 726.

https://doi.org/10.1182/blood.V116.21.726.726

Published: 2010

Journal Articles

Values for ADAMTS-13 Activity, Antigen and Autoantibodies in Normal European Controls.

Sabine Geiter, Markus Graf, Elin Tschokert, Agnes Veyradier, Martine Wolf, Claudine Caron, Roberta Palla, PhD, Flora Peyvandi, MD, PhD, Johanna A Kremer Hovinga, MD, Irmela Sulzer, Helga Vetr, PhD

Blood (2009) 114 (22): 4199.

https://doi.org/10.1182/blood.V114.22.4199.4199

Published: 2009

Journal Articles

The Frequency of Rheumatic Disease Autoantibodies in Patients with ADAMTS13-Deficient Thrombotic Thrombocytopenia Purpura (TTP).

Karen K. Swisher, MD, Qurana F. Lewis, MPH, Judith A. James, MD, PhD, Johanna A. Kremer Hovinga, MD, Bernhard Lämmle, MD, Deirdra R. Terrell, MPH, Sara K. Vesely, PhD, James N. George, MD

Blood (2007) 110 (11): 2090.

https://doi.org/10.1182/blood.V110.11.2090.2090

Published: 2007

NARROW

Safety of Caplacizumab in Patients Without Documented Severe ADAMTS13 Deficiency During the HERCULES Study

Narratives of Patients with Fatal Outcomes During the Phase 2 TITAN and Phase 3 HERCULES Studies

Acquired Hemophilia and Plasma Cell Neoplasms, a Rare Association

Efficacy of Caplacizumab in Patients with aTTP in the HERCULES Study According to Initial Immunosuppression Regimen

Efficacy of Caplacizumab in Patients with aTTP in the HERCULES Study According to Baseline Disease Severity

Safety of Caplacizumab for the Treatment of Patients with Acquired Thrombotic Thrombocytopenic Purpura - Results Normalized to Time of Exposure in a Double-Blind, Placebo-Controlled, Phase 3 Hercules Study

Detection and Differential Diagnosis of Prekallikrein Deficiency: Genetic Study of New Families and Systematic Review of the Literature

Integrated Efficacy Results from the Phase II and Phase III Studies with Caplacizumab in Patients with Acquired Thrombotic Thrombocytopenic Purpura

Risk Factors and Manageability of the Mainly Mild Mucocutaneous Bleeding Profile Observed in Attp Patients Treated with Caplacizumab during the Phase III Hercules Study

Description of the First Cases with ADAMTS13 Mutations in Hungary

Integrated Safety Results from the Phase II and Phase III Studies with Caplacizumab in Patients with Acquired Thrombotic Thrombocytopenic Purpura

Results of the Randomized, Double-Blind, Placebo-Controlled, Phase 3 Hercules Study of Caplacizumab in Patients with Acquired Thrombotic Thrombocytopenic Purpura

Blocking Protein S Improves Hemostasis in Hemophilia a and B

Pharmacodynamic Profile of a Recombinant ADAMTS13 (BAX930) in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome (USS))

Severe Depression Following Recovery From Thrombotic Thrombocytopenic Purpura (TTP)

Mortality and Morbidities During Long-Term Follow-up After Recovery From Thrombotic Thrombocytopenic Purpura (TTP)

Circulating Nucleosomes Reflect Disease Activity in Patients with Thrombotic Microangiopathies.

A Randomized, Double-Blind, Placebo-Controlled, Clinical Outcome Study of ARC1779 In Patients with Thrombotic Thrombocytopenic Purpura (TTP)

Values for ADAMTS-13 Activity, Antigen and Autoantibodies in Normal European Controls.

The Frequency of Rheumatic Disease Autoantibodies in Patients with ADAMTS13-Deficient Thrombotic Thrombocytopenia Purpura (TTP).

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American Society of Hematology

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American Society of Hematology

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