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Journal Articles

Clinical and Immunological Characterisation of Coversin, a Novel Small Protein Inhibitor of Complement C5 with Potential As a Therapeutic Agent in PNH and Other Complement Mediated Disorders

Wynne H Weston-Davies, MB FRCS, Miles A Nunn, DPhil, Fernando O Pinto, MDFRCPath, Ian J Mackie, PhDFRCPath, Stephen John Richards, PhD FRCPath, Samuel J Machin, MDFRCPath, Raymond Prudo, MB FRCP(C) MRCPsych, Peter Hillmen, MBChB, PhD

Blood (2014) 124 (21): 4280.

https://doi.org/10.1182/blood.V124.21.4280.4280

Published: 2014

Journal Articles

Domain Specificity and Mechanism of Action of Anti-ADAMTS13 Antibodies at Presentation and Relapse in Acquired Thrombotic Thrombocytopenic Purpura (TTP)

Mari R. Thomas, FRCPath, James T. Crawley, PhD, Samuel J Machin, MDFRCPath, Marie Scully, MDFRCPath

Blood (2014) 124 (21): 468.

https://doi.org/10.1182/blood.V124.21.468.468

Published: 2014

Journal Articles

The Prognostic Effects of Anti-ADAMTS13 IgG, IgA and IgM Antibody Subclasses In Acute Idiopathic TTP and the Effect of Rituximab,

Vickie McDonald, MA, MRCP, FRCPath, Samuel J Machin, MD FRCPath, Ian J Mackie, PhD FRCPath, Marie A Scully, MD FRCPath

Blood (2011) 118 (21): 3305.

https://doi.org/10.1182/blood.V118.21.3305.3305

Published: 2011

Journal Articles

A phase 2 study of the safety and efficacy of rituximab with plasma exchange in acute acquired thrombotic thrombocytopenic purpura

Marie Scully, Vickie McDonald, Jamie Cavenagh, Beverley J. Hunt, Ian Longair, Hannah Cohen, Samuel J. Machin

Blood (2011) 118 (7): 1746–1753.

https://doi.org/10.1182/blood-2011-03-341131

Published: 2011

Includes: Supplemental data

Journal Articles

A Randomized, Double-Blind, Placebo-Controlled, Clinical Outcome Study of ARC1779 In Patients with Thrombotic Thrombocytopenic Purpura (TTP)

Spero R Cataland, MD, Flora Peyvandi, MD, PhD, Pier M. Mannucci, MD, Bernhard Lämmle, Johanna A Kremer Hovinga, MD, Samuel J Machin, Marie Scully, Gail Rock, PhD, MD, FRCP, James Gilbert, MD, Paul Knoebl, Shangbin Yang, PhD, Haifeng Wu, M.D., Bernd Jilma, MD

Blood (2010) 116 (21): 726.

https://doi.org/10.1182/blood.V116.21.726.726

Published: 2010

Journal Articles

A Phase II Study to Assess the Safety, Efficacy and Tolerability of Rituximab (Mabthera) In Combination with Plasma Exchange In Patients with Acute Thrombotic Thrombocytopenic Purpura (TTP).

Marie Scully, MD, James D Cavenagh, MD, Beverley Hunt, MD, Vicki McDonald, MD, Samuel J Machin, MD

Blood (2010) 116 (21): 3699.

https://doi.org/10.1182/blood.V116.21.3699.3699

Published: 2010

Journal Articles

The Effect of Plasma Exchange on Rituximab Levels and Response to Rituximab in Patients with Acute Idiopathic Thrombotic Thrombocytopenic Pupura (TTP).

Vickie McDonald, MA, MRCP, FRCPath, Marie Scully, MRCP, FRCPath, MD, Ian J. Mackie, PhD, FRCPath, Kate Manns, BA, Samuel J. Machin, FRCP, FRCPath, MD

Blood (2008) 112 (11): 2297.

https://doi.org/10.1182/blood.V112.11.2297.2297

Published: 2008

Journal Articles

A Phase II Study To Assess the Safety, Efficacy and Tolerability of Rituximab in Combination with Plasma Exchange in Patients with Acute Idiopathic Thrombotic Thrombocytopenic Purpura.

Marie Scully, MD, Jamie Cavenagh, MD, Beverley Hunt, MD, Hannah Cohen, MD, Samuel J. Machin, MD

Blood (2007) 110 (11): 1303.

https://doi.org/10.1182/blood.V110.11.1303.1303

Published: 2007

Journal Articles

Pronounced Reduction in ADAMTS13 Activity Occurs in Heparin Induced Thrombocytopenia but Is Not Due to IgG ANTI-ADAMTS13.

Steven K. Austin, MBBS, Simon J. Davidson, Andrew S. Lawrie, Ian J. Mackie, Samuel J. Machin

Blood (2007) 110 (11): 2085.

https://doi.org/10.1182/blood.V110.11.2085.2085

Published: 2007

Journal Articles

Acute Idiopathic Thrombotic Thrombocytopenic Purpura: Predicting Relapse and Response to Treatment.

Marie Scully, MD, Richard Starke, PhD, Ian Mackie, PhD, Samuel J. Machin, MD

Blood (2006) 108 (11): 1059.

https://doi.org/10.1182/blood.V108.11.1059.1059

Published: 2006

Journal Articles

The South East England Thrombotic Thrombocytopenic Purpura Registry.

Marie Scully, MD, Helen Yarranton, MD, Ri Liesner, MD, Jamie Cavenagh, MD, Beverley Hunt, MD, Sylvia Benjamin, MD, Michael Laffan, MD, David Bevan, MD, Ian Mackie, PhD, Samuel J. Machin, MD

Blood (2006) 108 (11): 1064.

https://doi.org/10.1182/blood.V108.11.1064.1064

Published: 2006

Journal Articles

Cryosupernatant and Solvent Detergent Fresh Frozen Plasma (Octaplas, Octapharma) Usage in Acute Thrombotic Thrombocytopenic Purpura-Review of 50 Episodes.

Marie Scully, MD, Michael Flynn, Jenny Berryman, Samuel J. Machin, MD

Blood (2006) 108 (11): 4139.

https://doi.org/10.1182/blood.V108.11.4139.4139

Published: 2006

Journal Articles

Acceptibility of Patient Self-Testing of Oral Anticoagulation in New Patients.

Marie A. Pescott, Ian Longair, Bsc, Chris Gardiner, BSc, Steven K. Austin, MD, Samuel J. Machin, MD

Blood (2006) 108 (11): 4122.

https://doi.org/10.1182/blood.V108.11.4122.4122

Published: 2006

Journal Articles

High Affinity Autoantibodies to ADAMTS13 in the Antiphospholipid Syndrome.

Steven K. Austin, MD, Richard D. Starke, PhD, Gordon Purdy, Andrew S. Lawrie, FIBMS, Samuel J. Machin, MD, Ian J. Mackie, PhD

Blood (2006) 108 (11): 1467.

https://doi.org/10.1182/blood.V108.11.1467.1467

Published: 2006

Journal Articles

Management of HIV Associated Thrombotic Thrombocytopenic Purpura.

Marie Scully, Robert Miller, Hannah Cohen, Sherie Roedling, Simon Edwards, Samuel J. Machin

Blood (2005) 106 (11): 3017.

https://doi.org/10.1182/blood.V106.11.3017.3017

Published: 2005

Journal Articles

Successful Pregnancy Outcome in 5 Patients with Thrombotic Thrombocytopenic Purpura.

Marie Scully, Richard Starke, Richard Lee, Ian Mackie, Samuel J. Machin, Hannah Cohen

Blood (2005) 106 (11): 3016.

https://doi.org/10.1182/blood.V106.11.3016.3016

Published: 2005

Journal Articles

HLA-DQ7 Is Associated with Susceptibility to Idiopathic Thrombotic Thrombocytopenic Purpura.

Marie Scully, Julliette Brown, Rajeshree Patel, Samuel J. Machin, Colin Brown

Blood (2005) 106 (11): 1231.

https://doi.org/10.1182/blood.V106.11.1231.1231

Published: 2005

Journal Articles

A Genetic Basis for Adult Onset TTP?.

Raymond S. Camilleri, Ian J. Mackie, Marie Scully, Samuel J. Machin, Hannah Cohen

Blood (2005) 106 (11): 1228.

https://doi.org/10.1182/blood.V106.11.1228.1228

Published: 2005

Journal Articles

An Increase in the Immature Platelet Fraction Predicts Reconstitution of the Platelet Count and May Reduce Prophylactic Platelet Transfusions after Stem Cell Transplantation.

Samuel J. Machin, FRCP FRCPath, Dan Hart, Bsc MBChB MRCP, Stefan Kunka, FIBMS, Carol Briggs, BSc FIBMS, Laurence Corash, MD

Blood (2004) 104 (11): 3632.

https://doi.org/10.1182/blood.V104.11.3632.3632

Published: 2004

Journal Articles

A Large Proportion of Patients With a Diagnosis of Essential Thrombocythemia Do Not Have a Clonal Disorder and May Be at Lower Risk of Thrombotic Complications

Claire N. Harrison, Rosemary E. Gale, Samuel J. Machin, David C. Linch

Blood (1999) 93 (2): 417–424.

https://doi.org/10.1182/blood.V93.2.417

Published: 1999

NARROW

Clinical and Immunological Characterisation of Coversin, a Novel Small Protein Inhibitor of Complement C5 with Potential As a Therapeutic Agent in PNH and Other Complement Mediated Disorders

Domain Specificity and Mechanism of Action of Anti-ADAMTS13 Antibodies at Presentation and Relapse in Acquired Thrombotic Thrombocytopenic Purpura (TTP)

The Prognostic Effects of Anti-ADAMTS13 IgG, IgA and IgM Antibody Subclasses In Acute Idiopathic TTP and the Effect of Rituximab,

A phase 2 study of the safety and efficacy of rituximab with plasma exchange in acute acquired thrombotic thrombocytopenic purpura

A Randomized, Double-Blind, Placebo-Controlled, Clinical Outcome Study of ARC1779 In Patients with Thrombotic Thrombocytopenic Purpura (TTP)

A Phase II Study to Assess the Safety, Efficacy and Tolerability of Rituximab (Mabthera) In Combination with Plasma Exchange In Patients with Acute Thrombotic Thrombocytopenic Purpura (TTP).

The Effect of Plasma Exchange on Rituximab Levels and Response to Rituximab in Patients with Acute Idiopathic Thrombotic Thrombocytopenic Pupura (TTP).

A Phase II Study To Assess the Safety, Efficacy and Tolerability of Rituximab in Combination with Plasma Exchange in Patients with Acute Idiopathic Thrombotic Thrombocytopenic Purpura.

Pronounced Reduction in ADAMTS13 Activity Occurs in Heparin Induced Thrombocytopenia but Is Not Due to IgG ANTI-ADAMTS13.

Acute Idiopathic Thrombotic Thrombocytopenic Purpura: Predicting Relapse and Response to Treatment.

The South East England Thrombotic Thrombocytopenic Purpura Registry.

Cryosupernatant and Solvent Detergent Fresh Frozen Plasma (Octaplas, Octapharma) Usage in Acute Thrombotic Thrombocytopenic Purpura-Review of 50 Episodes.

Acceptibility of Patient Self-Testing of Oral Anticoagulation in New Patients.

High Affinity Autoantibodies to ADAMTS13 in the Antiphospholipid Syndrome.

Management of HIV Associated Thrombotic Thrombocytopenic Purpura.

Successful Pregnancy Outcome in 5 Patients with Thrombotic Thrombocytopenic Purpura.

HLA-DQ7 Is Associated with Susceptibility to Idiopathic Thrombotic Thrombocytopenic Purpura.

A Genetic Basis for Adult Onset TTP?.

An Increase in the Immature Platelet Fraction Predicts Reconstitution of the Platelet Count and May Reduce Prophylactic Platelet Transfusions after Stem Cell Transplantation.

A Large Proportion of Patients With a Diagnosis of Essential Thrombocythemia Do Not Have a Clonal Disorder and May Be at Lower Risk of Thrombotic Complications

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American Society of Hematology

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American Society of Hematology

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