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Jean-Yves Métais
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Journal Articles

CD123-CAR T Cells Manufactured in the Presence of Dasatinib Induce High Grade CRS and/or IEC-HS without Improving Efficacy in Pediatric Patients with Recurrent/Refractory Leukemia

Swati Naik, Madden Renee, Aimee C. Talleur, Rebecca Epperly, Timothy Lockey, Jennyfer Bran, Liqing Tian, Ying Li, Dinesh Keerthi, Alexandra Boyd, Amanda Lipsitt, Jeffrey E. Rubnitz, Jeffery M Klco, Barry Shulkin, Sarah Schell, Polly Adams, Jeoungeun John Park, Janice Riberdy, Na Shang, Jaquelyn T. Zoine, Raghuvaran Shanmugam, Chris Nevitt, Unmesha Thanekar, Jennifer Wallace, Elaine Harstead, Scott Perry, Catherine Willis, Jean-Yves Metais, Deanna M. Langfitt, Sheng Zhou, Salem M. Akel, Caitlin Zebley, Jeremy Chase Crawford, Benjamin Youngblood, Paul G. Thomas, Frank Fazio, Brandon M Triplett, Stephen Gottschalk, Mireya Paulina Velasquez
Journal: Blood
Blood (2024) 144 (Supplement 1): 2076.
https://doi.org/10.1182/blood-2024-208795
Published: 2024
Journal Articles

Memory T-Cell Add Back and Prophylactic blinatumomab Post Tcrαβ Depleted Haploidentical Transplantation Results in Promising Outcomes in Pediatric Patients with High-Risk Acute Leukemia

Swati Naik, Ying Li, Emily Zeng, Subodh Selukar, Senthil Velan Bhoopalan, Rebecca Epperly, Madden Renee, Ewelina Mamcarz, Esther A. Obeng, Amr Qudeimat, Akshay Sharma, Ali Y Suliman, Aimee C. Talleur, Mireya Paulina Velasquez, Caitlin Zebley, Sarah Schell, Polly Adams, Jean-Yves Metais, Salem M. Akel, Stephen Gottschalk, Brandon M Triplett
Journal: Blood
Blood (2024) 144 (Supplement 1): 383.
https://doi.org/10.1182/blood-2024-208547
Published: 2024
Journal Articles

Safety and Anti-Leukemic Activity of CD123-CAR T Cells in Pediatric Patients with AML: Preliminary Results from a Phase 1 Trial

Swati Naik, Renee M. Madden, Amanda Lipsitt, Timothy Lockey, Jennyfer Bran, Jeffrey E. Rubnitz, Jeffery Klco, Barry Shulkin, Sagar L. Patil, Sarah Schell, Jeoungeun John Park, Janice Riberdy, Na Shang, Jaquelyn T. Zoine, Jennifer Wallace, Elaine Harstead, Catherine Willis, Jean-Yves Metais, Deanna M. Langfitt, Sheng Zhou, Salem M. Akel, Michael M. Meagher, Brandon M. Triplett, Stephen Gottschalk, Mireya Paulina Velasquez
Journal: Blood
Blood (2022) 140 (Supplement 1): 4584–4585.
https://doi.org/10.1182/blood-2022-170201
Published: 2022
Journal Articles

A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions

Tae-Hoon Shin, Yifan Zhou, Shirley Chen, Stefan Cordes, Max Z. Grice, Xing Fan, Byung-Chul Lee, Aisha A. Aljanahi, So Gun Hong, Kelli L. Vaughan, Julie A. Mattison, Steven G. Kohama, Margarete A. Fabre, Naoya Uchida, Selami Demirci, Marcus A. F. Corat, Jean-Yves Métais, Katherine R. Calvo, Manuel Buscarlet, Hannah Natanson, Kathy L. McGraw, Alan F. List, Lambert Busque, John F. Tisdale, George S. Vassiliou, Kyung-Rok Yu, Cynthia E. Dunbar
Journal: Blood
Blood (2022) 140 (16): 1774–1789.
https://doi.org/10.1182/blood.2021014875
Published: 2022
Includes: Supplemental data
Journal Articles

CD19-CAR T Cells Develop Exhaustion Epigenetic Programs during a Clinical Response

Caitlin C. Zebley, Charmaine Brown, Tian Mi, Yiping Fan, Shanta Alli, Shannon Boi, Giovanni Galletti, Enrico Lugli, Deanna Langfitt, Jean-Yves Metais, Timothy Lockey, Michael M Meagher, Brandon M Triplett, Aimee C Talleur, Stephen Gottschalk, Benjamin Youngblood
Journal: Blood
Blood (2021) 138 (Supplement 1): 2782.
https://doi.org/10.1182/blood-2021-151177
Published: 2021
Journal Articles

CRISPR-Cas9 Genome Editing of γ-Globin Promoters in Human Hematopoietic Stem Cells to Induce Erythrocyte Fetal Hemoglobin for Treatment of β-Hemoglobinopathies

Jean-Yves Metais, PhD, Phillip A Doerfler, PhD, Thiyagaraj Mayuranathan, Daniel E. Bauer, MD PhD, Stephanie Fowler, Matthew Hsieh, MD, Varun Katta, Sagar Keriwala, Cicera Lazzarotto, Kevin Luk, Michael Neel, Scott Perry, Shaina Porter, Byoung Y. Ryu, PhD, Akshay Sharma, MBBS, Devlin Shea, Samuel Peters, John F. Tisdale, MD, Scot A. Wolfe, PhD, Kaitly Jensen Woodard, BS, Naoya Uchida, MD, Yuxuan Wu, PhD, Yu Yao, MD, Jing Zeng, MD, Shondra M. Pruett-Miller, PhD, Shengdar Q. Tsai, PhD, Mitchell J. Weiss, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2066.
https://doi.org/10.1182/blood-2019-131318
Published: 2019
Journal Articles

Lentiviral Gene Therapy with Low Dose Busulfan for Infants with X-SCID Results in the Development of a Functional Normal Immune System: Interim Results of an Ongoing Phase I/II Clinical Study

Ewelina Mamcarz, MD, Sheng Zhou, PhD, Timothy Lockey, PhD, Shannon Boi, PhD, Yan Koon-Kiu, PhD, Shane Cross, Pharm.D., Guolian Kang, PhD, Zhijun Ma, MD, Jose Marcos Condori, PhD, Jolanta Dowdy, M.S., Jean-Yves Metais, PhD, Deanna Langfitt, PhD, Brandon Triplett, MD, Chen Li, M.S., Xiwen Zhao, MSPH, Gabriela Maron, MD, Sneha Suresh, MD, Juan Carlos Aldave Becerra, MD, Joseph Church, MD, Elif Dokmeci, MD, James T Love, MD, PhD, Hedi van der Watt, MD, Ana C da Matta Ain, MD, Christa Krupski, DO, MPH, Jiyang Yu, PhD, Lance E. Palmer, PhD, William Janssen, PhD, Suk See De Ravin, MD, PhD, Mitchell J. Weiss, MD, PhD, Benjamin Youngblood, PhD, Janel R Long-Boyle, PharmD, PhD, Michael M Meagher, PhD, Harry L. Malech, MD, Jennifer Puck, MD, Morton J Cowan, MD, Stephen Gottschalk, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2058.
https://doi.org/10.1182/blood-2019-126746
Published: 2019
Journal Articles

CRISPR/Cas9 PIG -A gene editing in nonhuman primate model demonstrates no intrinsic clonal expansion of PNH HSPCs

Tae-Hoon Shin, Eun Jung Baek, Marcus A. F. Corat, Shirley Chen, Jean-Yves Metais, Aisha A. AlJanahi, Yifan Zhou, Robert E. Donahue, Kyung-Rok Yu, Cynthia E. Dunbar
Journal: Blood
Blood (2019) 133 (23): 2542–2545.
https://doi.org/10.1182/blood.2019000800
Published: 2019
Includes: Supplemental data
Journal Articles

A Non-Human Primate CRISPR/Cas9 Model of Clonal Hematopoiesis of Indeterminate Potential Demonstrates Expansion of TET2-Disrupted Clones

Kyung-Rok Yu, PhD, Cynthia E Dunbar, MD, Marcus Corat, Shirley Chen, Aisha Aljanahi, Eun Jung Baek, Jean-Yves Metais, Hannah Natanson, Thomas Winkler, MD, Robert E Donahue, VMD
Journal: Blood
Blood (2017) 130 (Supplement 1): 117.
https://doi.org/10.1182/blood.V130.Suppl_1.117.117
Published: 2017
Journal Articles

Progress Towards Creation of a Rhesus Macaque Animal Model for PNH Disease Via Crispr/Cas9 Technology to Knock out the PIG-a Gene

Marcus A.F. Corat, PhD, Jean-Yves Metais, PhD, Cynthia E. Dunbar, MD
Journal: Blood
Blood (2014) 124 (21): 4389.
https://doi.org/10.1182/blood.V124.21.4389.4389
Published: 2014
Journal Articles

Culture Of Mobilized Rhesus Macaque CD34+ Cells In Hypoxic Conditions Does Not Improve Lentiviral Transduction Efficiency In Long-Term Repopulating Hematopoietic Stem Cells

Andre Larochelle, M.D., Ph.D., Ayla Cash, B.Sc., Zanetta Chang, B.Sc., Brian Ichwan, B.Sc., Jean-Yves Metais, Ph.D., Cynthia E. Dunbar, MD
Journal: Blood
Blood (2013) 122 (21): 5557.
https://doi.org/10.1182/blood.V122.21.5557.5557
Published: 2013
Journal Articles

Dynamic clonal analysis of murine hematopoietic stem and progenitor cells marked by 5 fluorescent proteins using confocal and multiphoton microscopy

e-blood
Daniela Malide, Jean-Yves Métais, Cynthia E. Dunbar
Journal: Blood
Blood (2012) 120 (26): e105–e116.
https://doi.org/10.1182/blood-2012-06-440636
Published: 2012
Includes: Multimedia, Supplemental data
Journal Articles

Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia

Georg Aue, Yang Du, Susan M. Cleveland, Stephen B. Smith, Utpal P. Davé, Delong Liu, Marc A. Weniger, Jean Yves Metais, Nancy A. Jenkins, Neal G. Copeland, Cynthia E. Dunbar
Journal: Blood
Blood (2011) 118 (17): 4674–4681.
https://doi.org/10.1182/blood-2011-04-351528
Published: 2011
Includes: Supplemental data
Journal Articles

Analysis of Viral Integration Sites in Human Induced Pluripotent Stem Cells.

Thomas Winkler, MD, Amy R Cantelina, Jean-Yves Metais, Ph.D., Xiuli Xu, Ph.D., Anh-Dao Nguyen, Ph.D., Tyra Wolfsberg, Ph.D., Jessica Antosiewicz-Bourget, MBA, James Alexander Thomson, Ph.D., Cynthia E. Dunbar, MD
Journal: Blood
Blood (2009) 114 (22): 1485.
https://doi.org/10.1182/blood.V114.22.1485.1485
Published: 2009
Journal Articles

BCL2A1 Is a Survival and Immortalization Factor for Primitive Hematopoietic Cells.

Jean-Yves Metais, PhD, Thomas Winkler, MD, Rodrigo T. Calado, MD-PhD, Cynthia E. Dunbar, MD
Journal: Blood
Blood (2009) 114 (22): 2957.
https://doi.org/10.1182/blood.V114.22.2957.2957
Published: 2009
Journal Articles

BCL2A1 Is A Survival and Immortalization Factor for Primitive Myeloid Hematopoietic Cells.

Jean-Yves Metais, PhD, Ashley E. Dunfee, Rodrigo T. Calado, MD, PhD, Cynthia E. Dunbar, MD
Journal: Blood
Blood (2007) 110 (11): 3365.
https://doi.org/10.1182/blood.V110.11.3365.3365
Published: 2007
Journal Articles

MDS1-EVI1 and EVI1 Overexpression Results in Changes in the Behavior of Murine Hematopoietic Cells.

Jean-Yves Metais, PhD, Rotraud Wieser, Cynthia E. Dunbar, MD
Journal: Blood
Blood (2006) 108 (11): 1452.
https://doi.org/10.1182/blood.V108.11.1452.1452
Published: 2006