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Journal Articles

Final results of a phase I/II trial of palbociclib and CPX-351 in patients with Acute Myeloid Leukemia

Chana Peysin, Aziz Nazha, Wei Wei, Aaron Gerds, Xiaoying Chen, Hetty Carraway, Abhay Singh, Anjali Advani, Moaath Mustafa Ali, John Molina, Sophia Balderman, Akriti Jain, Eric Parsons, Jenna Thomas, Bhumika Patel, Jaroslaw Maciejewski, Mikkael Sekeres, Babal Jha, Sudipto Mukherjee

Blood (2025) 146 (Supplement 1): 3420.

https://doi.org/10.1182/blood-2025-3420

Published: 2025

Journal Articles

Multi‑omics analysis of Del20q reveals PHF20 haploinsufficiency and an HDAC2-centered epigenetic circuit in myeloid neoplasms

Mark Orland, Arda Durmaz, Zachary Brady, Carlos Bravo-Perez, Aashray Mandala, Kartik Lakhotiya, Atsushi Marumo, Serhan Unlu, Matteo D'Addona, Luca Guarnera, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 5616.

https://doi.org/10.1182/blood-2025-5616

Published: 2025

Journal Articles

Germline alterations of hematopoietic growth factor receptors and maladaptive somatic genetic rescue leads to myeloid neoplasia

Serhan Unlu, Tariq Kewan, Christopher Haddad, Olisaemeka Ogbue, Asfand Yar Cheema, Zachary Brady, Mark Orland, Praveena Thiagarajan, Aashray Mandala, Matteo D'Addona, Luca Guarnera, Carlos Bravo-Perez, Carmelo Gurnari, Valeria Visconte, Arda Durmaz, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 5614.

https://doi.org/10.1182/blood-2025-5614

Published: 2025

Journal Articles

Which molecular patterns of high-risk myeloid malignancies are concordantly identified using two machine learning algorithms?

Tariq Kewan, Arda Durmaz, Waled Bahaj, Carmelo Gurnari, Olisaemeka Ogbue, Matteo D'Addona, Ahmad Kiwan, Hussein Awada, Simona Pagliuca, Hetty Carraway, Amer Zeidan, Suresh Kumar Balasubramanian, Taha Bat, Yazan Madanat, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 3485.

https://doi.org/10.1182/blood-2025-3485

Published: 2025

Journal Articles

Idiopathic neutropenia after clonal and antigenic exclusion: A progesterone-dependent subtype

Mark Orland, Carlos Bravo-Perez, Olisaemeka Ogbue, Asfand Yar Cheema, Aashray Mandala, Serhan Unlu, Zachary Brady, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 2995.

https://doi.org/10.1182/blood-2025-2995

Published: 2025

Journal Articles

Prognostic impact of pre-transplant IPSS-m risk downstaging in Myelodysplastic Syndromes

Asmita Shukla, Jeff Justin Aguilar, Vikramjit Dhillon, Sikander Chohan, Nagasai Yalavarthi, Dakshin Padmanabhan, Sushmitha Nanja Reddy, Anisha Rajavel, Jay Yang, Jaroslaw Maciejewski, Suresh Kumar Balasubramanian

Blood (2025) 146 (Supplement 1): 3872.

https://doi.org/10.1182/blood-2025-3872

Published: 2025

Journal Articles

The prognostic significance (or lack) of achieving marrow complete remission (mCR) with hypomethylating agent-based therapy in patients with myelodysplastic syndrome

Benjamin Rolles, Jan Philipp Bewersdorf, Tariq Kewan, Ondrej Blaha, Jessica Stempel, Luca Lanino, Najla Al Ali, Amy DeZern, Mikkael Sekeres, Geoffrey Uy, Samuel Urrutia, Hetty Carraway, Pinkal Desai, Elizabeth Griffiths, Eytan Stein, Andrew Brunner, Christine McMahon, Rory Shallis, Joshua Zeidner, Michael Savona, Namrata Chandhok, Constantine Logothetis, Aram Bidikian, Theodore Getz, Gail Roboz, Eunice Wang, Maria Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Zhuoer Xie, Yazan Madanat, Yasmin Abaza, Talha Badar, Jaclynn Campos, Torsten Haferlach, Jaroslaw Maciejewski, David Sallman, Anoop Enjeti, Kamal Alrabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vassiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Matteo Della Porta, Rami Komrokji, Amer Zeidan, Maximilian Stahl

Blood (2025) 146 (Supplement 1): 3865.

https://doi.org/10.1182/blood-2025-3865

Published: 2025

Journal Articles

Clinical implications of TP53 mutations (TP53MT) in patients (pts) with higher risk Myelodysplastic Syndromes (HR-MDS) treated with hypomethylating agents (HMA) and allogeneic hematopoietic transplantation (allo-HCT): An analysis from the international consortium of MDS (icMDS) validate database

Tariq Kewan, Jan Philipp Bewersdorf, Luca Lanino, Ondrej Blaha, Jessica Stempel, Najla Al Ali, Amy DeZern, Mikkael Sekeres, Geoffrey Uy, Samuel Urrutia, Hetty Carraway, Pinkal Desai, Elizabeth Griffiths, Eytan Stein, Andrew Brunner, Christine McMahon, Rory Shallis, Joshua Zeidner, Michael Savona, Namrata Chandhok, Constantine Logothetis, Aram Bidikian, Theodore Getz, Gail Roboz, Benjamin Rolles, Eunice Wang, Amyah Harris, Maria Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Zhuoer Xie, Yazan Madanat, Yasmin Abaza, Talha Badar, Jaclynn Campos, Torsten Haferlach, Jaroslaw Maciejewski, Anoop Enjeti, Kamal Al-Rabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vassiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Rami Komrokji, Maximilian Stahl, Matteo Della Porta, David Sallman, Amer Zeidan

Blood (2025) 146 (Supplement 1): 3863.

https://doi.org/10.1182/blood-2025-3863

Published: 2025

Journal Articles

Novel approaches to identify cellular vulnerabilities in TET2-dependent MDS

Blood (2025) 146 (Supplement 1): 3838.

https://doi.org/10.1182/blood-2025-3838

Published: 2025

Journal Articles

Serum erythropoietin level as a selective pressure in clonal hematopoiesis: Insights into the mutational landscape of myeloid neoplasias

Zachary Brady, Charlotte Zurowski, Felipe de Almeida Sartori, Tariq Kewan, Olivia Hunyadi, Mark Orland, Aashray Mandala, Christopher Haddad, Hetty Carraway, Abhay Singh, Serhan Unlu, Atsushi Marumo, Kartik Lakhotiya, Carmelo Gurnari, Arda Durmaz, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 3174.

https://doi.org/10.1182/blood-2025-3174

Published: 2025

Journal Articles

The presence of SH2B3 mutations identifies a distinct subtype of myelodysplastic neoplasms

Blood (2025) 146 (Supplement 1): 2070.

https://doi.org/10.1182/blood-2025-2070

Published: 2025

Journal Articles

Refining the prognostic hierarchy of TP53 multihit alterations and isolated deletion of chromosome 5q in myelodysplastic syndromes

Blood (2025) 146 (Supplement 1): 2068.

https://doi.org/10.1182/blood-2025-2068

Published: 2025

Journal Articles

C-CBL mutations affecting residue 371 confer dismal prognosis in MDS and CMML

Luca Guarnera, Carmelo Gurnari, Zachary Brady, Carlos Bravo-Perez, Matteo D'Addona, Atsushi Marumo, Mark Orland, Praveena Thiagarajan, Serhan Unlu, Christopher Haddad, Aashray Mandala, Eleonora Lumia, Nicole Lelli, Arda Durmaz, Emiliano Fabiani, Maria Teresa Voso, Jaroslaw Maciejewski, Valeria Visconte

Blood (2025) 146 (Supplement 1): 2064.

https://doi.org/10.1182/blood-2025-2064

Published: 2025

Journal Articles

Machine learning uncovers invariant evolutionary molecular trajectories in MDS.

Matteo D'Addona, Arda Durmaz, Tariq Kewan, Waled Bahaj, Carlos Bravo-Perez, Luca Guarnera, Simona Pagliuca, Zachary Brady, Kartik Lakhotiya, Praveena Thiagarajan, Moaath Mustafa Ali, Abhay Singh, Hetty Carraway, Mark Orland, Carmelo Gurnari, Jacob Scott, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 2060.

https://doi.org/10.1182/blood-2025-2060

Published: 2025

Journal Articles

Clone wars: Evidence of clonal stability in a longitudinal prospective cohort of cancer survivors with serial NGS analysis

Blood (2025) 146 (Supplement 1): 6712.

https://doi.org/10.1182/blood-2025-6712

Published: 2025

Journal Articles

Invariant patterns of global mutational signatures allow new fundamental insights in etiopathogenesis of bone marrow failure including aplastic anemia and myelodysplasia

Felipe de Almeida Sartori, Arda Durmaz, Carlos Bravo-Perez, Zachary Brady, Mark Orland, Aashray Mandala, Atsushi Marumo, Olivia Hunyadi, Eno-obong Udoh, Kartik Lakhotiya, Charlotte Zurowski, Paulo Campregher, Carmelo Gurnari, Thomas Laframboise, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 4985.

https://doi.org/10.1182/blood-2025-4985

Published: 2025

Journal Articles

A phase II study of eltrombopag in patients with low-risk MDS and CMML harboring TET2 mutations

Abhay Singh, Akriti Jain, Sophia Balderman, Sujata Patil, Anjali Advani, Moaath Mustafa Ali, John Molina, Taylor Lucas, Tracy Cinalli, Ramandeep Mann, Lucy McCahon, Sudipto Mukherjee, Aaron Gerds, Yogen Saunthararajah, Jaroslaw Maciejewski, Hetty Carraway, Babal Jha, Alex Adjei

Blood (2025) 146 (Supplement 1): 2096.

https://doi.org/10.1182/blood-2025-2096

Published: 2025

Journal Articles

Machine learning-derived, comprehensive “Geno-Immunome” of bone marrow failure syndromes reveals complex immunogenetic interactions with clinical implications

Aashray Mandala, Carlos Bravo-Perez, Mark Orland, Zachary Brady, Serhan Unlu, Atsushi Marumo, Kartik Lakhotiya, Christopher Haddad, Felipe de Almeida Sartori, Asfand Yar Cheema, Simona Pagliuca, Carmelo Gurnari, Valeria Visconte, Arda Durmaz, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 2583.

https://doi.org/10.1182/blood-2025-2583

Published: 2025

Journal Articles

Sequential tracking of FLT3-ITD architecture reveals length-dependant impact on clonal clearance and clinical outcome

Asmita Shukla, Jeff Justin Aguilar, Guru Subramanian Guru Murthy, Yazan Madanat, Clayton Jackson, Julia Anderson, Eno-obong Udoh, Vikramjit Dhillon, Sikander Chohan, Nagasai Yalavarthi, Anisha Rajavel, Holly Webb, David Carr, Jaroslaw Maciejewski, Suresh Kumar Balasubramanian

Blood (2025) 146 (Supplement 1): 5285.

https://doi.org/10.1182/blood-2025-5285

Published: 2025

Journal Articles

An integrative prognostic model for transplant outcomes in myelofibrosis

Blood (2025) 146 (Supplement 1): 912.

https://doi.org/10.1182/blood-2025-912

Published: 2025

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Final results of a phase I/II trial of palbociclib and CPX-351 in patients with Acute Myeloid Leukemia

Multi‑omics analysis of Del20q reveals PHF20 haploinsufficiency and an HDAC2-centered epigenetic circuit in myeloid neoplasms

Germline alterations of hematopoietic growth factor receptors and maladaptive somatic genetic rescue leads to myeloid neoplasia

Which molecular patterns of high-risk myeloid malignancies are concordantly identified using two machine learning algorithms?

Idiopathic neutropenia after clonal and antigenic exclusion: A progesterone-dependent subtype

Prognostic impact of pre-transplant IPSS-m risk downstaging in Myelodysplastic Syndromes

The prognostic significance (or lack) of achieving marrow complete remission (mCR) with hypomethylating agent-based therapy in patients with myelodysplastic syndrome

Clinical implications of TP53 mutations (TP53MT) in patients (pts) with higher risk Myelodysplastic Syndromes (HR-MDS) treated with hypomethylating agents (HMA) and allogeneic hematopoietic transplantation (allo-HCT): An analysis from the international consortium of MDS (icMDS) validate database

Novel approaches to identify cellular vulnerabilities in TET2-dependent MDS

Serum erythropoietin level as a selective pressure in clonal hematopoiesis: Insights into the mutational landscape of myeloid neoplasias

The presence of SH2B3 mutations identifies a distinct subtype of myelodysplastic neoplasms

Refining the prognostic hierarchy of TP53 multihit alterations and isolated deletion of chromosome 5q in myelodysplastic syndromes

C-CBL mutations affecting residue 371 confer dismal prognosis in MDS and CMML

Machine learning uncovers invariant evolutionary molecular trajectories in MDS.

Clone wars: Evidence of clonal stability in a longitudinal prospective cohort of cancer survivors with serial NGS analysis

Invariant patterns of global mutational signatures allow new fundamental insights in etiopathogenesis of bone marrow failure including aplastic anemia and myelodysplasia

A phase II study of eltrombopag in patients with low-risk MDS and CMML harboring TET2 mutations

Machine learning-derived, comprehensive “Geno-Immunome” of bone marrow failure syndromes reveals complex immunogenetic interactions with clinical implications

Sequential tracking of FLT3-ITD architecture reveals length-dependant impact on clonal clearance and clinical outcome

An integrative prognostic model for transplant outcomes in myelofibrosis

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