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Journal Articles

Loss of FBXO11 Function Establishes a Stem Cell Program in Acute Myeloid Leukemia through Dysregulation of the Mitochondrial Protease LONP1

Angela Mo, Hayle Kincross, Xuan Wang, Linda Ya-Ting Chang, Gerben Duns, Harwood Kwan, Tammy Lau, Rod Docking, Se-Wing Grace Cheng, Shujun Huang, Nadia Gharaee, Elijah Willie, Jihong Jiang, Jeremy Parker, Josh Bridgers, Gregg Morin, Aly Karsan
Journal: Blood
Blood (2022) 140 (Supplement 1): 8688–8689.
https://doi.org/10.1182/blood-2022-170689
Published: 2022
Journal Articles

Elucidating the Mechanisms of Leukemogenesis Driven By FBXO11 Depletion

Angela Mo, Linda Ya-Ting Chang, Gerben Duns, Xuan Wang, Gregg Morin, Tammy Lau, Rod Docking, Shane Colborne, Se-Wing Grace Cheng, Shujun Huang, Hayle Kincross, Nadia Gharaee, Elijah Willie, Jihong Jiang, Jeremy Parker, Aly Karsan
Journal: Blood
Blood (2021) 138 (Supplement 1): 3328.
https://doi.org/10.1182/blood-2021-145384
Published: 2021
Journal Articles

A Mutation Pentad Defined Outcome of De Novo and Cytogenetically Normal Acute Myeloid Leukaemia in Young Adults

Sze Pui Tsui, MSc, Ip HW Alvin, Chunxiao Zhang, Tommy W.F. Tang, CH Lin, Arthur Cheung, Grace Cheng, Jason Chi Chiu So, FRCPath,MBBS, S.Y. Leung, Tommy CH Au, Edmond S. K. Ma, MD, Chris T.L. Chan, PhD, Margaret Ng, Kelvin CK Cheng, Kit Fai Wong, MBBS, MD FRCP, FRCPath, Lisa L.P. Siu, Sze Fai Yip, MD, S.Y. Lin, Szeman June Lau, T.H. Luk, Harold K K Lee, MD, Chi Kuen Lau, FRCP, Bonnie Kho, MD, Yok Lam Kwong, MD FRCP, Asif Javed, Anskar Yu Hung Leung, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1400.
https://doi.org/10.1182/blood-2019-130810
Published: 2019
Journal Articles

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

Tobias Berg, Silvia Thoene, Damian Yap, Tracee Wee, Nathalie Schoeler, Patty Rosten, Emilia Lim, Misha Bilenky, Andrew J. Mungall, Thomas Oellerich, Sherry Lee, Courteney K. Lai, Patricia Umlandt, Anisa Salmi, Harry Chang, Lisa Yue, David Lai, S.-W. Grace Cheng, Ryan D. Morin, Martin Hirst, Hubert Serve, Marco A. Marra, Gregg B. Morin, Randy D. Gascoyne, Samuel A. Aparicio, R. Keith Humphries
Journal: Blood
Blood (2014) 123 (25): 3914–3924.
https://doi.org/10.1182/blood-2012-12-473439
Published: 2014
Includes: Supplemental data
Journal Articles

Characterization Of The Effects Of Mutated EZH2 On Expression and Epigenome In a Mouse Lymphoma Model

Tobias Berg, MD, Silvia Thoene, PhD, Damian Yap, PhD, Tracee Wee, Nathalie Schoeler, Patty Rosten, Emilia Lim, Misha Bilenky, Andrew J Mungall, Ph.D., Thomas Oellerich, Patricia Umlandt, Anisa Salmi, Harry Chang, Lisa Yue, David Lai, Grace Cheng, PhD, Hubert Serve, MD, Ryan D Morin, Martin Hirst, Marco A. Marra, PhD, Gregg B. Morin, PhD, Randy D. Gascoyne, MD, Samuel A. Aparicio, PhD, R. Keith Humphries, PhD
Journal: Blood
Blood (2013) 122 (21): 346.
https://doi.org/10.1182/blood.V122.21.346.346
Published: 2013
Journal Articles

Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL + Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors

Xiaohu Liu, Min Chen, PhD, Paolo Lobo, Jianghong An, Ph.D., SW. Grace Cheng, Annie Moradian, Gregg B. Morin, PhD, Filip Van Petegem, PhD, Xiaoyan Jiang, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 966.
https://doi.org/10.1182/blood.V118.21.966.966
Published: 2011
Journal Articles

Mutated EZH2 Collaborates with Myc in Inducing Lymphoma in a Mouse Model

Tobias Berg, MD, Damian Yap, PhD, Silvia Thoene, PhD, Tracee Wee, Nathalie Schoeler, Patricia Umlandt, Harry Chang, Lisa Yue, David Lai, Grace Cheng, PhD, Ryan D Morin, M.Sc., Martin Hirst, Marco A. Marra, PhD, Gregg B. Morin, PhD, Randy D. Gascoyne, MD, Samuel A. Aparicio, PhD, R. Keith Humphries, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 227.
https://doi.org/10.1182/blood.V118.21.227.227
Published: 2011
Journal Articles

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

Damian B. Yap, Justin Chu, Tobias Berg, Matthieu Schapira, S.-W. Grace Cheng, Annie Moradian, Ryan D. Morin, Andrew J. Mungall, Barbara Meissner, Merrill Boyle, Victor E. Marquez, Marco A. Marra, Randy D. Gascoyne, R. Keith Humphries, Cheryl H. Arrowsmith, Gregg B. Morin, Samuel A. J. R. Aparicio
Journal: Blood
Blood (2011) 117 (8): 2451–2459.
https://doi.org/10.1182/blood-2010-11-321208
Published: 2011
Includes: Supplemental data