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Journal Articles

Genetic Insights into Myeloid Malignancies: A Comparative Analysis of NCCN Guidelines, the World Health Organization Classification, and the ICC System

Roisin Puentes, Jonathan Feld, Christopher G. Smith, Derek D Lyle
Journal: Blood
Blood (2024) 144 (Supplement 1): 7646.
https://doi.org/10.1182/blood-2024-212344
Published: 2024
Journal Articles

Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a Haematological Malignancy Research Network report

Stuart E. Lacy, Sharon L. Barrans, Philip A. Beer, Daniel Painter, Alexandra G. Smith, Eve Roman, Susanna L. Cooke, Camilo Ruiz, Paul Glover, Suzan J. L. Van Hoppe, Nichola Webster, Peter J. Campbell, Reuben M. Tooze, Russell Patmore, Cathy Burton, Simon Crouch, Daniel J. Hodson
Journal: Blood
Blood (2020) 135 (20): 1759–1771.
https://doi.org/10.1182/blood.2019003535
Published: 2020
Includes: Supplemental data
Journal Articles

Genome-wide minor histocompatibility matching as related to the risk of graft-versus-host disease

Paul J. Martin, David M. Levine, Barry E. Storer, Edus H. Warren, Xiuwen Zheng, Sarah C. Nelson, Anajane G. Smith, Bo K. Mortensen, John A. Hansen
Journal: Blood
Blood (2017) 129 (6): 791–798.
https://doi.org/10.1182/blood-2016-09-737700
Published: 2017
Includes: Supplemental data
Journal Articles

Novel Targeted Therapies and Their Impact on Survival from Multiple Myeloma (MM) and Chronic Lymphocytic Leukaemia (CLL) in the Real World

Alexandra G Smith, PhD, Timothy Bagguley, MSc, Eve Roman, PhD, Andy C Rawstron, James R Bailey, MA MBBS MRCP, Debra Howell, PhD, John Ashcroft, MD MBBChir, PhD MRCP, MA, FRCPath, Burton Cathy, Gordon Cook, MD PhD, Russell Patmore, MRCP FRCPath
Journal: Blood
Blood (2016) 128 (22): 3546.
https://doi.org/10.1182/blood.V128.22.3546.3546
Published: 2016
Journal Articles

A Chemical Modifier Screen in Zebrafish Mutants for the Spliceosomal Component Sf3b1reveals Genotype-Selective Vulnerabilities

Rosannah C. Cameron, PhD, Mia McKinstry, Adriana De La Garza, Sara Nik, Peter G Smith, PhD, Silvia Buonamici, PhD, Robert K. Bradley, PhD, Teresa V. Bowman, PhD
Journal: Blood
Blood (2016) 128 (22): 965.
https://doi.org/10.1182/blood.V128.22.965.965
Published: 2016
Journal Articles

H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies

Silvia Buonamici, PhD, Akihide Yoshimi, MD PhD, Michael Thomas, Michael Seiler, PhD, Betty Chan, PhD, Benjamin Caleb, Rachel Darman, PhD, Peter Fekkes, PhD, Craig Karr, PhD, Gregg F. Keaney, PhD, Virginia M. Klimek, MD, Kaiko Kunii, Linda Lee, Stanley Chun-Wei Lee, PhD, Xiang Liu, PhD, Carol Meeske, Yoshiharu Mizui, PhD, Eric Padron, MD, Eunice Park, PhD, Ermira Pazolli, PhD, Sudeep Prajapati, PhD, Justin Taylor, MD, John Wang, PhD, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, MD, Omar Abdel-Wahab, MD, Peter G Smith, PhD
Journal: Blood
Blood (2016) 128 (22): 966.
https://doi.org/10.1182/blood.V128.22.966.966
Published: 2016
Journal Articles

Suppression of plasma hepcidin by venesection during steady-state hypoxia

Nick P. Talbot, Thomas G. Smith, Samira Lakhal-Littleton, Cafer Gülsever, Maria Rivera-Ch, Keith L. Dorrington, David R. Mole, Peter A. Robbins
Journal: Blood
Blood (2016) 127 (9): 1206–1207.
https://doi.org/10.1182/blood-2015-05-647404
Published: 2016
Journal Articles

Heterozygous Hotspot SF3B1 Mutations Found in Myelodysplastic Syndromes Downregulate Genes Involved in Differentiation of Erythroid Cells

Silvia Buonamici, PhD, Rachel Darman, PhD, Samantha Perino, BS, Anant Agrawal, PhD, Shouyong Peng, PhD, Michael Seiler, PhD, Kian Huat Lim, PhD, Erica B. Bhavsar, Jacob Feala, PhD, Esther A. Obeng, MDPhD, Suzanna Bailey, PhD, Betty Chan, PhD, Peter Fekkes, PhD, Gregg F. Keaney, PhD, Pavan Kumar, PhD, Kaiko Kunii, Linda Lee, MS, Crystal Mackenzie, Mark Matijevic, Yoshiharu Mizui, PhD, Khin Myint, Eunice Park, Ermira Pazolli, Michael Thomas, John Wang, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, Richard R. Furman, MD, Benjamin L Ebert, MD PhD, Peter G Smith, PhD
Journal: Blood
Blood (2015) 126 (23): 1643.
https://doi.org/10.1182/blood.V126.23.1643.1643
Published: 2015
Journal Articles

SRSF2 Mutations Impair Hematopoietic Differentiation By Altering Exonic Splicing Enhancer Preference

Eunhee Kim, PhD, Janine O. Ilagan, PhD, Stanley Lee, PhD, Aravind Ramakrishnan, MD, Young Rock Chung, MS, Jean-Baptiste Micol, MD, Michele E. Murphy, Min-Kyung Kim, BS, Ahmad S. Zebari, Jacob Feala, Silvia Buonamici, PhD, Peter G Smith, PhD, H. Joachim Deeg, MD, Camille Lobry, PhD, Iannis Aifantis, PhD MSC, Robert K. Bradley, PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2014) 124 (21): 824.
https://doi.org/10.1182/blood.V124.21.824.824
Published: 2014
Journal Articles

Cancer-Associated Mutations in SF3B1 Exhibit Neomorphic Splicing Activity and Block Erythroid Differentiation

Silvia Buonamici, PhD, Samantha Perino, Kian Huat Lim, Jacob Feala, Esther A. Obeng, MDPhD, Michelle Aicher, Daniel Aird, Suzanna Bailey, Anna Berkenblit, Betty Chan, Corcoran Erik, Laura Corson, PhD, Rachel Darman, Peter Fekkes, Richard R. Furman, MD, Gregg F Keaney, PhD, Pavan Kumar, Kaiko Kunii, Linda Lee, Crystal Mackenzie, Eunice Park, Xiaoling Puyang, Anand Selvaraj, Michael Thomas, John Wang, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, Yoshiharu Mizui, PhD, Benjamin L. Ebert, MDPhD, Peter G Smith, PhD
Journal: Blood
Blood (2014) 124 (21): 4615.
https://doi.org/10.1182/blood.V124.21.4615.4615
Published: 2014
Journal Articles

Regulation of hepcidin expression at high altitude

Brief Report
Nick P. Talbot, Samira Lakhal, Thomas G. Smith, Catherine Privat, Annabel H. Nickol, Maria Rivera-Ch, Fabiola León-Velarde, Keith L. Dorrington, David R. Mole, Peter A. Robbins
Journal: Blood
Blood (2012) 119 (3): 857–860.
https://doi.org/10.1182/blood-2011-03-341776
Published: 2012
Journal Articles

Immunosuppressive Treatment for Patients with Myelodysplastic Syndromes: A Review of 358 Patients

Ankur R. Parikh, DO, Yang Yang, Colin O. Wu, PhD, Andrea Poon, Karen G. Smith, Neal S. Young, MD, A. John Barrett, MD, Matthew J. Olnes, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1717.
https://doi.org/10.1182/blood.V118.21.1717.1717
Published: 2011
Journal Articles

Azacitidine/Decitabine Synergism with the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML Models

Peter G Smith, PhD, Tary Traore, Steve Grossman, Usha Narayanan, Jennifer S Carew, PhD, Anya Lublinksky, Michael Kuranda, PhD, Michael Milhollen
Journal: Blood
Blood (2011) 118 (21): 578.
https://doi.org/10.1182/blood.V118.21.578.578
Published: 2011
Journal Articles

Treatment Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML and DLBCL Models

Michael Milhollen, Michael Thomas, Tary Traore, Usha Narayanan, Jessica Riceberg, Todd Sells, PhD, Ben Amidon, PhD, Mark Manfredi, PhD, Neil Bence, PhD, James Brownell, PhD, Larry Dick, PhD, Erik Koenig, James Gavin, Peter G Smith, PhD
Journal: Blood
Blood (2011) 118 (21): 1413.
https://doi.org/10.1182/blood.V118.21.1413.1413
Published: 2011
Journal Articles

Investigational NEDD8-Activating Enzyme (NAE) Inhibitor, MLN4924, Demonstrates Activity Against Primary AML Blast, Progenitor and Stem Cell Populations

Siddhartha Sen, PhD, Jeanne P. De Leon, Peter G Smith, PhD, Gail J. Roboz, MD, Monica L. Guzman, PhD
Journal: Blood
Blood (2011) 118 (21): 1414.
https://doi.org/10.1182/blood.V118.21.1414.1414
Published: 2011
Journal Articles

The Novel, Investigational NEDD8-Activating Enzyme Inhibitor MLN4924 In Adult Patients with Acute Myeloid Leukemia (AML) or High-Grade Myelodysplastic Syndromes (MDS): A Phase 1 Study

Ronan T Swords, MD, MRCPI, FRCPath, Harry P Erba, MD, PhD, Daniel J DeAngelo, MD, PhD, Peter G Smith, PhD, Michael D Pickard, MA, Bruce J. Dezube, MD, Francis J. Giles, MB, MD, FRCPI, FRCPath, Bruno C. Medeiros, MD
Journal: Blood
Blood (2010) 116 (21): 658.
https://doi.org/10.1182/blood.V116.21.658.658
Published: 2010
Journal Articles

Disrupting NEDD8-Mediated Protein Turnover with MLN4924 Significantly Augments the Efficacy of Cytarabine

Steffan T Nawrocki, PhD, Kevin R Kelly, MD, Kelli Oberheu, B.S., Devalingam Mahalingam, MD, PhD, Peter G Smith, PhD, Jennifer S Carew, PhD
Journal: Blood
Blood (2010) 116 (21): 3255.
https://doi.org/10.1182/blood.V116.21.3255.3255
Published: 2010
Journal Articles

Phase 1 Dose-Escalation Study of Multiple Dosing Schedules of the Investigational Drug MLN4924, a Nedd8-Activating Enzyme Inhibitor, In Patients with Relapsed and/or Refractory Multiple Myeloma or Lymphoma.

Jatin J Shah, MD, R. Donald Harvey, PharmD, Owen A O'Connor, MD, PhD, Andrzej J Jakubowiak, MD, PhD, Mitchell R Smith, MD, PhD, Robert Z. Orlowski, MD, PhD, George J Mulligan, PhD, Peter G Smith, PhD, Michael D Pickard, MA, Bruce J. Dezube, MD, Sagar Lonial, MD
Journal: Blood
Blood (2010) 116 (21): 2801.
https://doi.org/10.1182/blood.V116.21.2801.2801
Published: 2010
Journal Articles

MLN4924, a Novel Investigational NEDD8 Activating Enzyme Inhibitor, Exhibits Preclinical Activity In Multiple Myeloma and Waldenström's Macroglobulinemia through Mechanism Distinct From Existing Proteasome Inhibitors

Douglas W. McMillin, Zachary Hunter, Jake Delmore, Val Monrose, Peter G Smith, Ann Birner, Paul G Richardson, Kenneth C. Anderson, Steven P. Treon, Andrew L. Kung, Constantine S. Mitsiades
Journal: Blood
Blood (2010) 116 (21): 2988.
https://doi.org/10.1182/blood.V116.21.2988.2988
Published: 2010
Journal Articles

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB–dependent lymphoma

Michael A. Milhollen, Tary Traore, Jennifer Adams-Duffy, Michael P. Thomas, Allison J. Berger, Lenny Dang, Lawrence R. Dick, James J. Garnsey, Erik Koenig, Steven P. Langston, Mark Manfredi, Usha Narayanan, Mark Rolfe, Louis M. Staudt, Teresa A. Soucy, Jie Yu, Julie Zhang, Joseph B. Bolen, Peter G. Smith
Journal: Blood
Blood (2010) 116 (9): 1515–1523.
https://doi.org/10.1182/blood-2010-03-272567
Published: 2010
Includes: Supplemental data