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Dieter K Hossfeld
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High-Risk Additional Chromosomal Abnormalities in CML Herald Death By Blast Crisis Already at Low Blast Levels

Rüdiger Hehlmann, MD, Astghik Voskanyan, Michael Lauseker, Markus Pfirrmann, PhD, Lida Kalmanti, Sébastien Rinaldetti, Katharina Kohlbrenner, PhD, Claudia Haferlach, MD, Brigitte Schlegelberger, MD, Alice Fabarius, PhD, Stefan W Krause, MD, Hans-Jochem Kolb, MD, Andreas Neubauer, MD, Dieter K. Hossfeld, MD PhD, Christoph Nerl, MD PhD, Alois Gratwohl, MD, Gabriela M Baerlocher, MD, Andreas Burchert, MD, Tim H Brümmendorf, MD, Andreas Hochhaus, MD, Susanne Saussele, MD, Michele Baccarani, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 666.
https://doi.org/10.1182/blood-2019-127127
Published: 2019
Journal Articles

Final Evaluation of Randomized CML-Study IV: 10-Year Survival and Evolution of Terminal Phase

Rüdiger Hehlmann, MD, Michael Lauseker, PhD, Susanne Saussele, MD, Markus Pfirrmann, Stefan W. Krause, MD, Hans-Jochem Kolb, MD, Andreas Neubauer, MD, Dieter K. Hossfeld, Christoph Nerl, MD, Alois Gratwohl, MD, Gabriela M. Baerlocher, Dominik Heim, MD, Tim Henrik Bruemmendorf, Alice Fabarius, PhD, Claudia Haferlach, MD, Brigitte Schlegelberger, MD PhD, Martin C. Müller, MD, Sabine Jeromin, PhD, Ulrike Proetel, PhD, Katharina Kohlbrenner, PhD, Astghik Voskanyan, PhD, Sébastien Rinaldetti, Wolfgang Seifarth, PhD, Birgit Spiess, Leopold Balleisen, MD, Maria E Goebeler, MD, Mathias Hänel, MD, Anthony D. Ho, MD, J Dengler, C Falge, Lothar Kanz, MD, Claus-Henning Köhne, MD, PhD, Andreas Burchert, MD, Michael Kneba, MD PhD, Frank Stegelmann, MD, C Köhne, Hans-Walter Lindemann, C Waller, Michael Pfreundschuh, MD, Karsten Spiekermann, Wolfgang E Berdel, MD, L Müller, Matthias Edinger, MD, Jiri Mayer, Prof, MD SCs, Dietrich W Beelen, MD PhD, Martin Bentz, MD, Hartmut Link, MDPhD, Bernd Hertenstein, MD, R Fuchs, Martin Wernli, MD, F Schlegel, Rudolph Schlag, M de Wit, Lorenz Trümper, MD, H Hebarth, M Hahn, Jörg Thomalla, MD, Christof Scheid, MD, Philippe Schafhausen, MD, Walter Verbeek, MD, Michael J. Eckart, MD, Winfried Gassmann, MD PhD, Antonio Pezzutto, MD, Michael Schenk, Peter Brossart, MD, Thomas Geer, MD, Stephan Bildat, E Schäfer, Andreas Hochhaus, MD, Joerg Hasford
Journal: Blood
Blood (2017) 130 (Supplement 1): 897.
https://doi.org/10.1182/blood.V130.Suppl_1.897.897
Published: 2017
Journal Articles

Major Route Additional Chromosomal Aberrations (ACA) Precede Increase of Blasts in CML: An Analysis of the German CML-Studies III and IIIA

Christian T. Dietz, PhD, Alice Charlotte Fabarius, PhD, Michael Lauseker, PhD, Susanne Saussele, Lida Kalmanti, Sébastien Rinaldetti, Claudia Haferlach, MD, Brigitte Schlegelberger, MD PhD, Martine Jotterand, Alois Gratwohl, Axel R. Zander, Professor, Nicolaus Kröger, Dietrich W. Beelen, MD, Jürgen Novotny, Christoph Nerl, Christof Scheid, MD PhD, Karsten Spiekermann, Jiri Mayer, MD, Herbert G. Sayer, Christiane Falge, Donald Bunjes, MD, Hartmut Döhner, Prof. Dr., Arnold Ganser, Peter Brossart, MD, Rainer Schwerdtfeger, Herrad Baumann, Rolf Kuse, Hans Walter Lindemann, MD, Matthias Bormann, Bernd Hertenstein, MD, Gabriela M. Baerlocher, Carlo Aul, MD, Peter Staib, Matthias Edinger, MD, Michael Schatz, Axel A Fauser, Renate Arnold, MD, Dieter K. Hossfeld, MD, Hans-Jochem Kolb, Susanne Schnittger, PhD, Martin C. Müller, MD, Andreas Reiter, MD, Andreas Hochhaus, MD, Markus Pfirrmann, Joerg Hasford, Michele Baccarani, Ruediger Hehlmann, MD
Journal: Blood
Blood (2015) 126 (23): 1581.
https://doi.org/10.1182/blood.V126.23.1581.1581
Published: 2015
Journal Articles

The Pattern Of Cytogenetic Aberrations In CML BC Stratified For Treatment

Christian Dietz, PhD, Lida Kalmanti, MD, Michael Lauseker, Claudia Haferlach, MD, Gudrun Göhring, MD, Brigitte Schlegelberger, MD, PhD, Martine Jotterand, MD, Barbara Heinze, MD, Dieter K. Hossfeld, MD, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, Martin C. Müller, MD, Benjamin Hanfstein, MD, Ulrike Proetel, MD, Annette Schreiber, MD, Stefan W. Krause, MD, Andreas Neubauer, MD, Cornelius F. Waller, MD, Markus Pfirrmann, PhD, Joerg Hasford, MD, Wolf-Karsten Hofmann, MD, Hans-Jochem Kolb, MD, Hermann Heimpel, MD, Susanne Saussele, MD, Alice Fabarius, PhD
Journal: Blood
Blood (2013) 122 (21): 2737.
https://doi.org/10.1182/blood.V122.21.2737.2737
Published: 2013
Journal Articles

Complete Molecular Remission (CMR 4.5) of CML Is Induced Faster by Dose – Optimized Imatinib and Predicts Better Survival - Results From the Randomized CML-Study IV

Rüdiger Hehlmann, MD, Michael Lauseker, Benjamin Hanfstein, MD, Martin C. Müller, MD, Annette Schreiber, MD, Ulrike Proetel, MD, Markus Pfirrmann, Claudia Haferlach, MD, Susanne Schnittger, PhD, Hermann Einsele, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Gabriela M. Baerlocher, MD, Gerhard Ehninger, Dominik Heim, MD, Hermann Heimpel, Christoph Nerl, MD, Stefan W. Krause, Dieter K. Hossfeld, MD, Hans-Jochem Kolb, MD, Andreas Hochhaus, MD, Joerg Hasford, Susanne Saussele, MD
Journal: Blood
Blood (2012) 120 (21): 67.
https://doi.org/10.1182/blood.V120.21.67.67
Published: 2012
Journal Articles

Secondary Malignancies in CML Patients – Data From the German CML Study IV

Manuel Barreto Miranda, MD, Michael Lauseker, Ulrike Proetel, MD, Annette Schreiber, MD, Benjamin Hanfstein, MD, Gabriela M. Baerlocher, MD, Dominik Heim, MD, Gerhard Ehninger, Dieter K. Hossfeld, MD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Hermann Einsele, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Wolf-Karsten Hofmann, Martin C. Müller, MD, Markus Pfirrmann, Andreas Hochhaus, MD, Joerg Hasford, Rüdiger Hehlmann, MD, Susanne Saussele, MD
Journal: Blood
Blood (2012) 120 (21): 3746.
https://doi.org/10.1182/blood.V120.21.3746.3746
Published: 2012
Journal Articles

Prognostic Factors Identified Via a Cox Proportional Hazard Cure Model Explain Survival Differences After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Chronic Myeloid Leukemia (CML) Between Two Consecutive Patient Cohorts

Markus Pfirrmann, Susanne Saussele, Andreas Hochhaus, MD, Andreas Reiter, MD, Ute Berger, Dieter K. Hossfeld, Christoph Nerl, Christof Scheid, Karsten Spiekermann, Jiri Mayer, M.D., PhD., Prof., Christiane Falge, Herbert G. Sayer, Donald Bunjes, Arnold Ganser, Dietrich W. Beelen, Helen Baldomero, Urs Schanz, Hermann Heimpel, Joerg Hasford, Hans-Jochem Kolb, Alois Gratwohl, Rüdiger Hehlmann, The German CML Study Group
Journal: Blood
Blood (2012) 120 (21): 3748.
https://doi.org/10.1182/blood.V120.21.3748.3748
Published: 2012
Journal Articles

Prediction of Molecular Response of Chronic Phase CML Patients by the EUTOS Score: Results of the Randomized CML-Study IV,

Susanne Saussele, MD, Michael Lauseker, Verena Hoffmann, MA., Ulrike Proetel, MD, Benjamin Hanfstein, MD, Gabriela M. Baerlocher, MD, Dominik Heim, MD, Gerhard Ehninger, MD, Dieter K. Hossfeld, MD, PhD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Joerg E. A. Schubert, MD, Hermann Einsele, MD, Matthias Hänel, MD, Anthony D. Ho, MD, PhD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Susanne Schnittger, PhD, Markus Pfirrmann, PhD, Andreas Hochhaus, MD, Jörg Hasford, MD, Rüdiger Hehlmann, MD, Martin C Müller, MD, for The SAKK, The German CML Study Group
Journal: Blood
Blood (2011) 118 (21): 3762.
https://doi.org/10.1182/blood.V118.21.3762.3762
Published: 2011
Journal Articles

Second Line Therapy with Second Generation TKI After Intolerance to Imatinib Based Treatments Showed High Overall Survival in Contrast to Second Line Therapy After Resistance; Results of the Randomized CML Study IV

Susanne Saussele, MD, Michael Lauseker, Ulrike Proetel, MD, Martin C. Müller, MD, Benjamin Hanfstein, MD, Annette Schreiber, MD, Florian Nolte, MD, Gabriela M. Baerlocher, MD, Gerhard Ehninger, MD, Dominik Heim, MD, Dieter K. Hossfeld, MD, PhD, Stefan W. Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Joerg E. A. Schubert, MD, Hermann Einsele, MD, Matthias Hänel, MD, Anthony D. Ho, MD, PhD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Wolf Karsten Hofmann, MD, PhD, Jörg Hasford, MD, Markus Pfirrmann, PhD, Andreas Hochhaus, MD, Rüdiger Hehlmann, MD, for The SAKK, for The German CML Study Group
Journal: Blood
Blood (2011) 118 (21): 781.
https://doi.org/10.1182/blood.V118.21.781.781
Published: 2011
Journal Articles

Pretreatment Expression Levels of MDR1 and OCT-1 Predict Response to First Line Imatinib Treatment In Chronic Phase CML Patients

Philipp Erben, MD, Benjamin Hanfstein, MD, Umang Munjal, PhD, Hannah Daikeler, MD, Mridul Agrawal, Jr., Juliana Popa, MD, Daniel Nowak, MD, Armin Leitner, MD, Dieter K Hossfeld, MD, Hans J Kolb, MD, Stefan W Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Dominik Heim, MD, Gabriela M Baerlocher, MD, Jörg Hasford, MD, Hermann Heimpel, MD, Susanne Saussele, MD, Wolf-Karsten Hofmann, MD, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, Martin C Mueller, MD
Journal: Blood
Blood (2010) 116 (21): 671.
https://doi.org/10.1182/blood.V116.21.671.671
Published: 2010
Journal Articles

Molecular Response After 3 Months of 1st Line Imatinib Therapy Is Predictive for Treatment Failure and Disease Progression In Patients with Chronic Phase Chronic Myeloid Leukemia - a Follow-up Analysis of the German CML Study IV

Benjamin Hanfstein, MD, Martin C. Müller, MD, Philipp Erben, MD, Susanne Schnittger, PhD, Susanne Saussele, MD, Armin Leitner, MD, Ulrike Proetel, MD, Gerhard Ehninger, MD, Dieter K. Hossfeld, MD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Hermann Heimpel, MD, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, The German CML-Study Group
Journal: Blood
Blood (2010) 116 (21): 360.
https://doi.org/10.1182/blood.V116.21.360.360
Published: 2010
Journal Articles

Therapy with Imatinib In Elderly CML Patients (>65years): Results of the German CML-Study IV.

Susanne Saussele, MD, Nadine Pletsch, MD, Michael Lauseker, Armin Leitner, MD, Susanne Jung-Munkwitz, MD, Ulrike Proetel, MD, Martin C. Müller, MD, Claudia Haferlach, MD, Brigitte Schlegelberger, MD, PhD, Gerhard Ehninger, MD, Dieter K. Hossfeld, MD, Stefan W. Krause, MD, Christoph Nerl, MD, PhD, Hans Pralle, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Leopold Balleisen, MD, Hermann Einsele, MD, Anthony D. Ho, MD, FRCPC, Christiane Falge, MD, Matthias Hänel, MD, M. Pfreundschuh, Lothar Kanz, MD, Frank Stegelmann, MD, Claus-Henning Köhne, MD, Stephan Kremers, MD, Karsten Spiekermann, MD, Steffen Koschmieder, MD, Cornelius F. Waller, MD, Martin Bentz, MD, Markus Pfirrmann, PhD, Andreas Hochhaus, Jörg Hasford, MD, Rüdiger Hehlmann, MD, for The German CML-Study Group
Journal: Blood
Blood (2010) 116 (21): 3411.
https://doi.org/10.1182/blood.V116.21.3411.3411
Published: 2010
Journal Articles

Superior CMR-Rates with Tolerability-Adapted Imatinib 800 Mg Vs. 400 Mg Vs. 400 Mg + IFN In CML: The Randomized German CML-Study IV

Rüdiger Hehlmann, MD, Susanne Jung-Munkwitz, MD, Michael Lauseker, Martin C. Müller, MD, Armin Leitner, MD, Nadine Pletsch, MD, Ulrike Proetel, MD, Alois Gratwohl, MD, Gerhard Ehninger, MD, Dieter K. Hossfeld, MD, Christoph Nerl, MD, PhD, Hans Pralle, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Leopold Balleisen, MD, Hermann Einsele, MD, Christiane Falge, MD, Anthony D. Ho, MD, FRCPC, Matthias Hänel, MD, Michael Pfreundschuh, MD, Lothar Kanz, MD, Frank Stegelmann, MD, Claus-Henning Köhne, MD, Stephan Kremers, CA, MD, Karsten Spiekermann, MD, Steffen Koschmieder, Cornelius F. Waller, MD, Martin Bentz, MD, Stefan W. Krause, MD, Benjamin Hanfstein, MD, Susanne Schnittger, PhD, Markus Pfirrmann, PhD, Jörg Hasford, MD, Andreas Hochhaus, Susanne Saussele, MD, for The German CML-Study Group
Journal: Blood
Blood (2010) 116 (21): 357.
https://doi.org/10.1182/blood.V116.21.357.357
Published: 2010
Journal Articles

Optimaization of Imatinib Therapy by Combination. 5 Year Survival and Response Results of the Pilot Phase of the Randomized German CML STUDY IV.

Nadine Pletsch, Susanne Saussele, Michael Lauseker, Armin Leitner, Susanne Jung-Munkwitz, Samina Shazi, Claudia Haferlach, Brigitte Schlegelberger, Martin C Müller, Thomas Schenk, Susanne Schnittger, Markus Pfirrmann, Gerhard Ehninger, Thomas Fischer, Dieter K. Hossfeld, Hans-Jochem Kolb, Stefan W Krause, Christoph Nerl, Hans Pralle, Alois Gratwohl, Andreas Tobler, Hermann Heimpel, Leopold Balleisen, Hermann Einsele, Anthony D. Ho, Christine Falge, Mathias Hänel, Michael Pfreundschuh, Lothar Kanz, Frank Stegelmann, Claus-Henning Köhne, Stephan Kremers, Karsten Spiekermann, Wolfgang E Berdel, Cornelius F. Waller, Martin Bentz, Joerg Hasford, Andreas Hochhaus, Rüdiger Hehlmann, The German CML Study Group
Journal: Blood
Blood (2009) 114 (22): 862.
https://doi.org/10.1182/blood.V114.22.862.862
Published: 2009
Journal Articles

Randomized Comparison of Imatinib 800 Mg Vs. Imatinib 400 Mg +/- IFN in Newly Diagnosed BCR/ABL Positive Chronic Phase CML: Analysis of Molecular Remission at 12 Months; The German CML-Study IV.

Rudiger Hehlmann, Susanne Jung-Munkwitz, Michael Lauseker, Armin Leitner, Nadine Pletsch, Samina Shazi, Martin C. Müller, Claudia Haferlach, Brigitte Schlegelberger, Susanne Schnittger, PhD, Cornelius F. Waller, Andreas Neubauer, Lothar Kanz, MD, Mathias Hänel, Jiri Mayer, Frank Stegelmann, Roland Fuchs, Wolfgang E. Berdel, Leopold Balleisen, Markus Pfirrmann, Gerhard Ehninger, Thomas Fischer, Dieter K. Hossfeld, Hans- Jochem Kolb, Stefan W. Krause, Christoph Nerl, Hans Pralle, Alois Gratwohl, Andreas Tobler, Hermann Heimpel, Joerg Hasford, Andreas Hochhaus, Susanne Saussele, The German CML Study Group
Journal: Blood
Blood (2009) 114 (22): 339.
https://doi.org/10.1182/blood.V114.22.339.339
Published: 2009
Journal Articles

Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) with a Related Donor in Chronic Myeloid Leukemia (CML): An Explanation for Fast Improvement of Survival in Two Consecutive German CML Studies.

Markus Pfirrmann, Susanne Saussele, Armin Leitner, MD, Nadine Pletsch, Michael Lauseker, Martin C Mueller, MD, Claudia Haferlach, MD, Brigitte Schlegelberger, Susanne Schnittger, Gerhard Ehninger, Thomas Fischer, Dieter K Hossfeld, Hans-Jochem Kolb, Stefan W Krause, Christoph Nerl, Hans Pralle, Andreas Tobler, Hermann Heimpel, Dietrich W Beelen, Axel R Zander, Donald Bunjes, Hubert Schrezenmeier, Ulrike Feldmann, Carlheinz Mueller, Helen Baldomero, Urs Schanz, Andreas Hochhaus, Joerg Hasford, Alois Gratwohl, Ruediger Hehlmann, The German CML Study Group
Journal: Blood
Blood (2009) 114 (22): 3281.
https://doi.org/10.1182/blood.V114.22.3281.3281
Published: 2009
Journal Articles

Molecular Response to First Line Imatinib Therapy Is Predictive for Long Term Event Free Survival in Patients with Chronic Phase Chronic Myelogenous Leukemia – An Interim Analysis of the Randomized German CML Study IV

Martin C. Müller, MD, Benjamin Hanfstein, MD, Philipp Erben, MD, Susanne Schnittger, PhD, Susanne Saussele, MD, Armin Leitner, MD, Ulrike Proetel, MD, Michael Lauseker, Markus Pfirrmann, PhD, Gerhard Ehninger, MD, Thomas Fischer, MD, Joerg Hasford, MD, Dieter K. Hossfeld, MD, PhD, Hans Jochem Kolb, MD, Stefan W Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Alois Gratwohl, MD, Andreas Tobler, MD, Ruediger Hehlmann, MD, Andreas Hochhaus, MD, The German CML Study Group
Journal: Blood
Blood (2008) 112 (11): 333.
https://doi.org/10.1182/blood.V112.11.333.333
Published: 2008
Journal Articles

Randomized Comparison of Imatinib 400 Mg Vs. Imatinib + IFN Vs. Imatinib + AraC Vs. Imatinib after IFN Vs. Imatinib 800 Mg: Optimized Treatment and Survival. Designed First Interim Analysis of the German CML Study IV

Ruediger Hehlmann, MD, Susanne Saussele, MD, Michael Lauseker, Ulrike Proetel, MD, Elena Kovalevskaya, MD, Armin Leitner, MD, Claudia Haferlach, MD, Brigitte Schlegelberger, MD, Martin C Müller, MD, Benjamin Hanfstein, MD, Markus Pfirrmann, PhD, Gerhard Ehninger, Thomas Fischer, MD, Joerg Hasford, MD, Andreas Hochhaus, MD, Dieter K. Hossfeld, MD, PhD, Hans- Jochem Kolb, MD, Stefan W Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Alois Gratwohl, Andreas Tobler, MD, Hermann Heimpel, MD, The German CML Study Group
Journal: Blood
Blood (2008) 112 (11): 184.
https://doi.org/10.1182/blood.V112.11.184.184
Published: 2008
Journal Articles

Response: Drug treatment and allografting as first-line therapy in young patients with CML

Rüdiger Hehlmann, Alois Gratwohl, Markus Pfirrmann, Jörg Hasford, Andreas Hochhaus, Dieter K. Hossfeld, Hermann Heimpel
Journal: Blood
Blood (2007) 110 (13): 4618–4619.
https://doi.org/10.1182/blood-2007-07-103861
Published: 2007
Journal Articles

Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia

Clinical Trials & Observations
Rüdiger Hehlmann, Ute Berger, Markus Pfirrmann, Hermann Heimpel, Andreas Hochhaus, Joerg Hasford, Hans-Jochem Kolb, Tanja Lahaye, Ole Maywald, Andreas Reiter, Dieter K. Hossfeld, Christoph Huber, Helmut Löffler, Hans Pralle, Wolfgang Queisser, Andreas Tobler, Christoph Nerl, Max Solenthaler, Mariele E. Goebeler, Martin Griesshammer, Thomas Fischer, Stephan Kremers, Hartmut Eimermacher, Michael Pfreundschuh, Wolf-Dietrich Hirschmann, Klaus Lechner, Barbara Wassmann, Christiane Falge, Hartmut H. Kirchner, Alois Gratwohl
Journal: Blood
Blood (2007) 109 (11): 4686–4692.
https://doi.org/10.1182/blood-2006-11-055186
Published: 2007
Includes: Supplemental data