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Journal Articles

Major Route Additional Chromosomal Aberrations (ACA) Precede Increase of Blasts in CML: An Analysis of the German CML-Studies III and IIIA

Christian T. Dietz, PhD, Alice Charlotte Fabarius, PhD, Michael Lauseker, PhD, Susanne Saussele, Lida Kalmanti, Sébastien Rinaldetti, Claudia Haferlach, MD, Brigitte Schlegelberger, MD PhD, Martine Jotterand, Alois Gratwohl, Axel R. Zander, Professor, Nicolaus Kröger, Dietrich W. Beelen, MD, Jürgen Novotny, Christoph Nerl, Christof Scheid, MD PhD, Karsten Spiekermann, Jiri Mayer, MD, Herbert G. Sayer, Christiane Falge, Donald Bunjes, MD, Hartmut Döhner, Prof. Dr., Arnold Ganser, Peter Brossart, MD, Rainer Schwerdtfeger, Herrad Baumann, Rolf Kuse, Hans Walter Lindemann, MD, Matthias Bormann, Bernd Hertenstein, MD, Gabriela M. Baerlocher, Carlo Aul, MD, Peter Staib, Matthias Edinger, MD, Michael Schatz, Axel A Fauser, Renate Arnold, MD, Dieter K. Hossfeld, MD, Hans-Jochem Kolb, Susanne Schnittger, PhD, Martin C. Müller, MD, Andreas Reiter, MD, Andreas Hochhaus, MD, Markus Pfirrmann, Joerg Hasford, Michele Baccarani, Ruediger Hehlmann, MD
Journal: Blood
Blood (2015) 126 (23): 1581.
https://doi.org/10.1182/blood.V126.23.1581.1581
Published: 2015
Journal Articles

A Two-Fold Rise of BCR-ABL Transcript Levels Advises BCR-ABL Mutation Analysis in Imatinib-Treated Chronic Myeloid Leukemia (CML) - an Analysis of the Randomized CML-Study IV

Benjamin Hanfstein, MD, Niklas Westhoff, MD, Rüdiger Hehlmann, MD, Susanne Saussele, MD, Michael Lauseker, PhD, Thomas Ernst, MD, Philipp Erben, MD, Christian Dietz, PhD, Alice Fabarius, PhD, Ulrike Proetel, MD, Susanne Schnittger, PhD, Stefan W. Krause, MD, Joerg Schubert, MD, Hermann Einsele, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Gabriela M. Baerlocher, MD, Markus Pfirrmann, PhD, Joerg Hasford, MD, Wolf-Karsten Hofmann, Andreas Hochhaus, MD, Martin C. Müller, MD
Journal: Blood
Blood (2014) 124 (21): 3138.
https://doi.org/10.1182/blood.V124.21.3138.3138
Published: 2014
Journal Articles

Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in the Imatinib-Era: Update on the Survival Outcome Following Allogeneic HSCT after Imatinib Failure; Results of the German CML Study IV

Susanne Saussele, MD, Michael Lauseker, PhD, Martin C. Müller, MD, Alois Gratwohl, Dietrich Beelen, MD, Donald W. Bunjes, MD, Rainer Schwerdtfeger, MD, Hans-Jochem Kolb, MD, Anthony D Ho, MD, Christiane Falge, MD, Ernst Holler, PhD, Günther Schlimok, MD, Axel R. Zander, MD, Renate Arnold, MD, Lothar Kanz, MD, Robert Dengler, MD, Claudia Haferlach, MD, Brigitte Schlegelberger, MD, Susanne Schnittger, PhD, Lida Kalmanti, MD, Ulrike Proetel, MD, Benjamin Hanfstein, MD, Wolf-Karsten Hofmann, Joerg Hasford, MD, Andreas Hochhaus, MD, Markus Pfirrmann, PhD, Rüdiger Hehlmann, MD
Journal: Blood
Blood (2014) 124 (21): 2567.
https://doi.org/10.1182/blood.V124.21.2567.2567
Published: 2014
Journal Articles

Defining Therapy Goals for Major Molecular Remission in Chronic Myeloid Leukemia: Results of the Randomized CML-Study IV

Susanne Saussele, MD, Rüdiger Hehlmann, MD, Christian Dietz, PhD, Susanne Schnittger, PhD, Alice Charlotte Fabarius, PhD, Lida Kalmanti, MD, Benjamin Hanfstein, MD, Ulrike Proetel, MD, Sebastien Rinaldetti, MD, Hermann Einsele, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Michael Pfreundschuh, Frank Stegelmann, MD, Cornelius F. Waller, MD, Gabriela M. Baerlocher, MD, Dominik Heim, MD, Stefan W. Krause, MD, Wolf-Karsten Hofmann, Joerg Hasford, MD, Markus Pfirrmann, PhD, Andreas Hochhaus, MD, Martin C. Müller, MD, Michael Lauseker, PhD
Journal: Blood
Blood (2014) 124 (21): 155.
https://doi.org/10.1182/blood.V124.21.155.155
Published: 2014
Journal Articles

Comparing the Prognostic Significance of Early Predictors of Survival in Chronic Myeloid Leukemia (CML) Treated with Imatinib - an Analysis of the Randomized CML-Study IV

Benjamin Hanfstein, MD, Michael Lauseker, PhD, Rüdiger Hehlmann, MD, Susanne Saussele, MD, Philipp Erben, MD, Christian Dietz, PhD, Alice Fabarius, PhD, Ulrike Proetel, MD, Lida Kalmanti, MD, Susanne Schnittger, PhD, Stefan W. Krause, MD, Jörg Schubert, MD, Hermann Einsele, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Gabriela M. Baerlocher, MD, Markus Pfirrmann, PhD, Joerg Hasford, MD, Wolf-Karsten Hofmann, Andreas Hochhaus, MD, Martin C. Müller, MD
Journal: Blood
Blood (2014) 124 (21): 156.
https://doi.org/10.1182/blood.V124.21.156.156
Published: 2014
Journal Articles

Achievement Of a MR 5.0 Within the Randomized CML-Study IV: Feasibility, Differences Between Treatment Arms, and Prognostic Implications

Martin C. Müller, MD, Michael Lauseker, Rüdiger Hehlmann, MD, Benjamin Hanfstein, MD, Christian Dietz, PhD, Philipp Erben, MD, Alice Fabarius, PhD, Ulrike Proetel, MD, Susanne Schnittger, PhD, Stefan W. Krause, MD, Jörg Schubert, MD, Hermann Einsele, MD, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, PhD, Gabriela M. Baerlocher, MD, Markus Pfirrmann, PhD, Joerg Hasford, MD, Wolf-Karsten Hofmann, MD, Andreas Hochhaus, MD, Susanne Saussele, MD
Journal: Blood
Blood (2013) 122 (21): 4008.
https://doi.org/10.1182/blood.V122.21.4008.4008
Published: 2013
Journal Articles

The Cytogenetic Profile In Lymphoid and Myeloid CML Blast Crisis

Lida Kalmanti, MD, Christian Dietz, PhD, Markus Pfirrmann, PhD, Claudia Haferlach, MD, Gudrun Göhring, MD, Brigitte Schlegelberger, MD, PhD, Martine Jotterand, MD, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, Martin C. Müller, MD, Benjamin Hanfstein, MD, Ulrike Proetel, MD, Stefan W. Krause, MD, Hermann Einsele, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD Prof, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Michael Lauseker, Joerg Hasford, MD, Wolf-Karsten Hofmann, MD, Susanne Saussele, MD, Alice Fabarius, PhD
Journal: Blood
Blood (2013) 122 (21): 1487.
https://doi.org/10.1182/blood.V122.21.1487.1487
Published: 2013
Journal Articles

The Impact Of Balanced and Unbalanced Karyotypes On Prognosis Of CML: From Chronic Phase To Blast Crisis

Lida Kalmanti, MD, Christian Dietz, PhD, Claudia Haferlach, MD, Gudrun Göring, MD, Brigitte Schlegelberger, MD, Martine Jotterand, MD, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, Martin C. Müller, MD, Benjamin Hanfstein, MD, Ulrike Proetel, MD, Stefan W. Krause, MD, Hermann Einsele, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Michael Lauseker, Markus Pfirrmann, PhD, Joerg Hasford, MD, Wolf-Karsten Hofmann, MD, Susanne Saussele, MD, Alice Fabarius, PhD
Journal: Blood
Blood (2013) 122 (21): 3996.
https://doi.org/10.1182/blood.V122.21.3996.3996
Published: 2013
Journal Articles

Adverse Events (AE) Under Imatinib Treatment Over 10 Years: Results From 1501 Patients Of The Randomized CML-Study IV

Rüdiger Hehlmann, MD, Michael Lauseker, Annette Schreiber, MD, Ulrike Proetel, MD, Lida Kalmanti, MD, Andreas Hochhaus, MD, Martin C. Müller, MD, Alice Fabarius, PhD, Stefan W. Krause, MD, Hermann Einsele, MD, Jolanta Dengler, MD, Christiane Falge, MD, Gabriela M. Baerlocher, MD, Lothar Kanz, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, Prof MD, Cornelius F. Waller, MD, Karsten Spiekermann, PhD, Markus Pfirrmann, PhD, Susanne Saussele, MD, Joerg Hasford, MD
Journal: Blood
Blood (2013) 122 (21): 4012.
https://doi.org/10.1182/blood.V122.21.4012.4012
Published: 2013
Journal Articles

Comorbidity, Measured By The Charlson Index, Has No Negative Impact On Remission In Patients With Chronic Myeloid Leukemia: Results Of The Randomized CML-Study IV

Susanne Saussele, MD, Marie Paloma Krauss, Michael Lauseker, Rüdiger Hehlmann, MD, Ulrike Proetel, MD, Annette Schreiber, MD, Lida Kalmanti, MD, Benjamin Hanfstein, MD, Hermann Einsele, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Gabriela M. Baerlocher, MD, Dominik Heim, MD, Stefan W. Krause, MD, Wolf Karsten Hofmann, MD, Joerg Hasford, MD, Andreas Hochhaus, MD, Markus Pfirrmann, PhD, Martin C. Müller, MD
Journal: Blood
Blood (2013) 122 (21): 91.
https://doi.org/10.1182/blood.V122.21.91.91
Published: 2013
Journal Articles

Optimizing Early Prediction Of Outcome In CML Using The Exact Decline Of BCR-ABL Transcript Levels Within 3 Months Of Imatinib Treatment As a Prognostic Marker

Benjamin Hanfstein, MD, Valeria Shlyakhto, Michael Lauseker, Rüdiger Hehlmann, MD, Susanne Saussele, MD, Philipp Erben, MD, Christian Dietz, PhD, Alice Fabarius, PhD, Ulrike Proetel, MD, Susanne Schnittger, PhD, Stefan W. Krause, MD, Jörg Schubert, MD, Hermann Einsele, MD, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Gabriela M. Baerlocher, MD, Markus Pfirrmann, PhD, Joerg Hasford, MD, Wolf-Karsten Hofmann, MD, Andreas Hochhaus, MD, Martin C. Müller, MD
Journal: Blood
Blood (2013) 122 (21): 253.
https://doi.org/10.1182/blood.V122.21.253.253
Published: 2013
Journal Articles

Complete Molecular Remission (CMR 4.5) of CML Is Induced Faster by Dose – Optimized Imatinib and Predicts Better Survival - Results From the Randomized CML-Study IV

Rüdiger Hehlmann, MD, Michael Lauseker, Benjamin Hanfstein, MD, Martin C. Müller, MD, Annette Schreiber, MD, Ulrike Proetel, MD, Markus Pfirrmann, Claudia Haferlach, MD, Susanne Schnittger, PhD, Hermann Einsele, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Gabriela M. Baerlocher, MD, Gerhard Ehninger, Dominik Heim, MD, Hermann Heimpel, Christoph Nerl, MD, Stefan W. Krause, Dieter K. Hossfeld, MD, Hans-Jochem Kolb, MD, Andreas Hochhaus, MD, Joerg Hasford, Susanne Saussele, MD
Journal: Blood
Blood (2012) 120 (21): 67.
https://doi.org/10.1182/blood.V120.21.67.67
Published: 2012
Journal Articles

Absolute BCR-ABL Transcript Levels At 3 Months but Not At Diagnosis Predict Survival of Chronic Myeloid Leukemia (CML) Patients On Imatinib Therapy

Benjamin Hanfstein, MD, Valeria Shlyakhto, Michael Lauseker, Philipp Erben, MD, Susanne Saussele, MD, Alice Fabarius, PhD, Ulrike Proetel, MD, Susanne Schnittger, PhD, Hans-Jochem Kolb, MD, Stefan W. Krause, Joerg Schubert, MD, Hermann Einsele, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, PhD, Gabriela M. Baerlocher, MD, Markus Pfirrmann, Joerg Hasford, Wolf-Karsten Hofmann, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, Martin C. Müller, MD
Journal: Blood
Blood (2012) 120 (21): 3761.
https://doi.org/10.1182/blood.V120.21.3761.3761
Published: 2012
Journal Articles

Secondary Malignancies in CML Patients – Data From the German CML Study IV

Manuel Barreto Miranda, MD, Michael Lauseker, Ulrike Proetel, MD, Annette Schreiber, MD, Benjamin Hanfstein, MD, Gabriela M. Baerlocher, MD, Dominik Heim, MD, Gerhard Ehninger, Dieter K. Hossfeld, MD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Hermann Einsele, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Wolf-Karsten Hofmann, Martin C. Müller, MD, Markus Pfirrmann, Andreas Hochhaus, MD, Joerg Hasford, Rüdiger Hehlmann, MD, Susanne Saussele, MD
Journal: Blood
Blood (2012) 120 (21): 3746.
https://doi.org/10.1182/blood.V120.21.3746.3746
Published: 2012
Journal Articles

Prognostic Factors Identified Via a Cox Proportional Hazard Cure Model Explain Survival Differences After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Chronic Myeloid Leukemia (CML) Between Two Consecutive Patient Cohorts

Markus Pfirrmann, Susanne Saussele, Andreas Hochhaus, MD, Andreas Reiter, MD, Ute Berger, Dieter K. Hossfeld, Christoph Nerl, Christof Scheid, Karsten Spiekermann, Jiri Mayer, M.D., PhD., Prof., Christiane Falge, Herbert G. Sayer, Donald Bunjes, Arnold Ganser, Dietrich W. Beelen, Helen Baldomero, Urs Schanz, Hermann Heimpel, Joerg Hasford, Hans-Jochem Kolb, Alois Gratwohl, Rüdiger Hehlmann, The German CML Study Group
Journal: Blood
Blood (2012) 120 (21): 3748.
https://doi.org/10.1182/blood.V120.21.3748.3748
Published: 2012
Journal Articles

Impact of Balanced or Unbalanced Karyotype At Diagnosis On Prognosis of CML: Long-Term Observation From 1346 Patients of the Randomized CML Study IV

Alice Fabarius, PhD, Claudia Haferlach, MD, Andreas Hochhaus, MD, Martin C. Müller, MD, Benjamin Hanfstein, MD, Gudrun Göhring, MD, Brigitte Schlegelberger, Martine Jotterrand, MD, Ulrike Proetel, MD, Wolf-Karsten Hofmann, Stefan W. Krause, Hermann Einsele, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, PhD, Michael Lauseker, Markus Pfirrmann, Joerg Hasford, Rüdiger Hehlmann, MD, Susanne Saussele, MD
Journal: Blood
Blood (2012) 120 (21): 913.
https://doi.org/10.1182/blood.V120.21.913.913
Published: 2012
Journal Articles

Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV

Clinical Trials & Observations
Alice Fabarius, Armin Leitner, Andreas Hochhaus, Martin C. Müller, Benjamin Hanfstein, Claudia Haferlach, Gudrun Göhring, Brigitte Schlegelberger, Martine Jotterand, Andreas Reiter, Susanne Jung-Munkwitz, Ulrike Proetel, Juliana Schwaab, Wolf-Karsten Hofmann, Jörg Schubert, Hermann Einsele, Anthony D. Ho, Christiane Falge, Lothar Kanz, Andreas Neubauer, Michael Kneba, Frank Stegelmann, Michael Pfreundschuh, Cornelius F. Waller, Karsten Spiekermann, Gabriela M. Baerlocher, Michael Lauseker, Markus Pfirrmann, Joerg Hasford, Susanne Saussele, Rüdiger Hehlmann, for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group
Journal: Blood
Blood (2011) 118 (26): 6760–6768.
https://doi.org/10.1182/blood-2011-08-373902
Published: 2011
Journal Articles

Prediction of Molecular Response of Chronic Phase CML Patients by the EUTOS Score: Results of the Randomized CML-Study IV,

Susanne Saussele, MD, Michael Lauseker, Verena Hoffmann, MA., Ulrike Proetel, MD, Benjamin Hanfstein, MD, Gabriela M. Baerlocher, MD, Dominik Heim, MD, Gerhard Ehninger, MD, Dieter K. Hossfeld, MD, PhD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Joerg E. A. Schubert, MD, Hermann Einsele, MD, Matthias Hänel, MD, Anthony D. Ho, MD, PhD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Susanne Schnittger, PhD, Markus Pfirrmann, PhD, Andreas Hochhaus, MD, Jörg Hasford, MD, Rüdiger Hehlmann, MD, Martin C Müller, MD, for The SAKK, The German CML Study Group
Journal: Blood
Blood (2011) 118 (21): 3762.
https://doi.org/10.1182/blood.V118.21.3762.3762
Published: 2011
Journal Articles

Distinct Characteristics of e13a2 versus e14a2 BCR-ABL Chronic Myeloid Leukemia under Upfront Treatment with Imatinib – an Analysis of the German CML Study IV,

Benjamin Hanfstein, MD, Philipp Erben, MD, Susanne Saussele, MD, Michael Lauseker, Ulrike Proetel, MD, Sven Haag, Susanne Schnittger, PhD, Claudia Haferlach, MD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Jörg E. A. Schubert, MD, Hermann Einsele, MD, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Markus Pfirrmann, PhD, Jörg Hasford, MD, Wolf-Karsten Hofmann, MD, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, Martin C. Müller, MD, for The German CML Study Group, for The SAKK
Journal: Blood
Blood (2011) 118 (21): 3773.
https://doi.org/10.1182/blood.V118.21.3773.3773
Published: 2011
Journal Articles

Second Line Therapy with Second Generation TKI After Intolerance to Imatinib Based Treatments Showed High Overall Survival in Contrast to Second Line Therapy After Resistance; Results of the Randomized CML Study IV

Susanne Saussele, MD, Michael Lauseker, Ulrike Proetel, MD, Martin C. Müller, MD, Benjamin Hanfstein, MD, Annette Schreiber, MD, Florian Nolte, MD, Gabriela M. Baerlocher, MD, Gerhard Ehninger, MD, Dominik Heim, MD, Dieter K. Hossfeld, MD, PhD, Stefan W. Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Joerg E. A. Schubert, MD, Hermann Einsele, MD, Matthias Hänel, MD, Anthony D. Ho, MD, PhD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Wolf Karsten Hofmann, MD, PhD, Jörg Hasford, MD, Markus Pfirrmann, PhD, Andreas Hochhaus, MD, Rüdiger Hehlmann, MD, for The SAKK, for The German CML Study Group
Journal: Blood
Blood (2011) 118 (21): 781.
https://doi.org/10.1182/blood.V118.21.781.781
Published: 2011