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Journal Articles

Baseline Assessment of Patients with Newly-Diagnosed Acquired Bone Marrow Failure Enrolled in a Prospective Observational Study, "Search for Unidentified Links between PNH Clone Size and the Related Clinical Manifestations By High Precision Flow Cytometry (SUPREMACY)"

Yuji Yonemura, MD PhD, Tatsuya Kawaguchi, MD PhD, Ken Ishiyama, MD PhD, Chiharu Sugimori, MD PhD, Kohei Hosokawa, Naoshi Obara, MD PhD, Hideyoshi Noji, MD PhD, Yukari Shirasugi, MD PhD, Yasutaka Ueda, MD PhD, Hiroyuki Takamori, MD PhD, Tsutomu Shichishima, MD PhD, Shigeru Chiba, MD PhD, Haruhiko Ninomiya, MD PhD, Kiyoshi Ando, MD PhD, Jun-Ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD, Masanori Takahashi, Shinji Nakao, MD PhD

Blood (2017) 130 (Supplement 1): 2466.

https://doi.org/10.1182/blood.V130.Suppl_1.2466.2466

Published: 2017

Journal Articles

The First Follow-up Data Analysis of Patients with Acquired Bone Marrow Failure Harboring a Small Population of PNH-Type Cells in the Japanese, Multicenter, Prospective Study Optima

Yasutaka Ueda, MD PhD, Jun-Ichi Nishimura, MD PhD, Chiharu Sugimori, MD PhD, Kohei Hosokawa, MDPhD, Yuji Yonemura, MD PhD, Naoshi Obara, MDPhD, Hideyoshi Noji, MD PhD, Yoshihiko Nakamura, PhD, Yukari Shirasugi, MD PhD, Kiyoshi Ando, Tsutomu Shichishima, MD PhD, Haruhiko Ninomiya, MD PhD, Shigeru Chiba, MD, PhD, Tatsuya Kawaguchi, MD PhD, Yuzuru Kanakura, MD PhD, Shinji Nakao, MD PhD

Blood (2016) 128 (22): 3896.

https://doi.org/10.1182/blood.V128.22.3896.3896

Published: 2016

Journal Articles

An Interim 4-Year Analysis of Prospective Multicenter Observational Study of PNH-Type Cells in Japanese Patients with Bone Marrow Failure Syndrome (OPTIMA study)

Yukari Shirasugi, MD PhD, Hideyoshi Noji, MD PhD, Tsutomu Shichishima, MD PhD, Chiharu Sugimori, MD PhD, Naoshi Obara, MDPhD, Shigeru Chiba, MD, PhD, Haruhiko Ninomiya, MD PhD, Yoshihiko Nakamura, PhD, Kiyoshi Ando, MD PhD, Yuji Yonemura, MD PhD, Tatsuya Kawaguchi, MD PhD, Kohei Hosokawa, MDPhD, Yasutaka Ueda, MDPhD, Jun-Ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD, Shinji Nakao, MD PhD

Blood (2015) 126 (23): 4781.

https://doi.org/10.1182/blood.V126.23.4781.4781

Published: 2015

Journal Articles

A Profound Decrease in FoxP3 + Helios + CD4 + T Cells in a Subset of Patients with Acquired Aplastic Anemia and Pure Red Cell Aplasia: A Common Mechanism Underlying a Dependency on Cyclosporine

An T. T. Dao, MD, Kohei Hosokawa, MDPhD, Chiharu Sugimori, MD PhD, Luis J. Espinoza, MD PhD, Kana Maruyama, MD, Yoshitaka Zaimoku, MD, Hiroyuki Maruyama, MD, Takamasa Katagiri, PhD, Hirohito Yamazaki, MD PhD, Hiroyuki Takamatsu, MD PhD, Chizuru Saito, MD, Noriko Iwaki, MD, Shinji Nakao, MD PhD

Blood (2014) 124 (21): 4384.

https://doi.org/10.1182/blood.V124.21.4384.4384

Published: 2014

Journal Articles

The Interim Analysis of the Optima (observation of GPI-anchored protein-deficient [PNH-type]) Cells in Japanese Patients with Bone Marrow Failure Syndrome and in Those Suspected of Having PNH) Study

Hideyoshi Noji, MD PhD, Tsutomu Shichishima, MD PhD, Chiharu Sugimori, MD PhD, Naoshi Obara, MD PhD, Kohei Hosokawa, MDPhD, Shigeru Chiba, MD PhD, Yoshihiko Nakamura, MD PhD, Kiyoshi Ando, MD PhD, Satoru Hayashi, MD PhD, Yuji Yonemura, MD PhD, Tatsuya Kawaguchi, MD PhD, Haruhiko Ninomiya, MD PhD, Jun-ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD, Shinji Nakao, MD PhD

Blood (2014) 124 (21): 1595.

https://doi.org/10.1182/blood.V124.21.1595.1595

Published: 2014

Journal Articles

Baseline Assessment Of GPI-Anchored Protein Deficient Blood Cells In Patients With Bone Marrow Failure (The OPTIMA study)

Naoshi Obara, MD, PhD, Shigeru Chiba, MD, PhD, Kohei Hosokawa, MD, PhD, Chiharu Sugimori, MD, PhD, Masaki Yamamoto, MD, Hideyoshi Noji, MD, PhD, Yuji Yonemura, MD, PhD, Yoshihiko Nakamura, MD, PhD, Kiyoshi Ando, MD, PhD, Tatsuya Kawaguchi, MD, PhD, Tsutomu Shichishima, MD, PhD, Haruhiko Ninomiya, MD, PhD, Jun-ichi Nishimura, MD, PhD, Yuzuru Kanakura, Shinji Nakao, MD, PhD

Blood (2013) 122 (21): 1241.

https://doi.org/10.1182/blood.V122.21.1241.1241

Published: 2013

Journal Articles

A Switch in Regulatory T-Cell Memory Phenotype Is Associated with Poor Survival in Lower Risk Myleodysplastic Syndrome Patients

Adam W Mailloux, PhD, Chiharu Sugimori, Rami S. Komrokji, MD, Jaroslaw P. Maciejewski, MD, PhD, Ronald Paquette, MD, PhD, Thomas P. Loughran, Jr., MD, Alan F. List, MD, P.K. Epling-Burnette, PharmD, PhD

Blood (2011) 118 (21): 1703.

https://doi.org/10.1182/blood.V118.21.1703.1703

Published: 2011

Journal Articles

Deletions of Xp22.2 Including PIG-A Locus Lead to Paroxysmal Nocturnal Hemoglobinuria.

Christine L. O'Keefe, Chiharu Sugimori, Manuel Afable, Michael Clemente, Kenneth Shain, David Araten, Alan F. List, P.K. Epling-Burnette, Jaroslaw Maciejewski

Blood (2010) 116 (21): 1158.

https://doi.org/10.1182/blood.V116.21.1158.1158

Published: 2010

Journal Articles

Clinical Significance of Chromosomal Abnormalities in Patients with Aplastic Anemia and Refractory Anemia Deduced From the Prevalence of PNH-Type Cells.

Naomi Sugimori, MD, PhD, Hirohito Yamazaki, Chiharu Sugimori, MD, Ken Ishiyama, Takamasa Katagiri, Shinji Nakao, MD, PhD

Blood (2009) 114 (22): 1085.

https://doi.org/10.1182/blood.V114.22.1085.1085

Published: 2009

Journal Articles

Pathogenetic Role of Impaired Telomere Repair in Myelodysplastic Syndrome.

P.K. Epling-Burnette, PhD, Alan F List, MD, Justine Clark, MS, Ji-Hyun Lee, Kristen A. Jonathan, William Fulp, Xiaohong Li, Weipeng Zheng, Jeffrey S. Painter, B.S., JianXiang Zou, MD, Rami S. Komrokji, MD, Sheng Wei, MD, Jong Park, Amber Schmidt, Undergraduate, student, Chiharu Sugimori, MD, Ashley Cole, Dana E Rollison, PhD

Blood (2009) 114 (22): 2777.

https://doi.org/10.1182/blood.V114.22.2777.2777

Published: 2009

Journal Articles

Co-Existance of JAK V617F and PIG-A mutations in Primary Budd-Chiari Syndrome.

Chiharu Sugimori, MD, Kenneth H Shain, MD, PhD, Gisela Caceres, PhD, Lubomir Sokol, MD, PhD, David Araten, MD, Jaroslaw P. Maciejewski, MD, PhD, JianXiang Zou, MD, P.K. Epling-Burnette, PhD, Alan F List, MD

Blood (2009) 114 (22): 3193.

https://doi.org/10.1182/blood.V114.22.3193.3193

Published: 2009

Journal Articles

Dysregulated Distribution of Naïve and Memory FoxP3 Positive Regulatory T-Cells Associated with Anemia in Myelodysplastic Syndrome (MDS)

Chiharu Sugimori, MD, JianXiang Zou, MD, Christine O’Keefe, PhD, Michael Clemente, MS, Tie-Ying Wei, BS, Jaroslaw Maciejewski, Thomas P. Loughran, Jr., MD, Ron Paquette, MD, Alan F. List, MD, P.K. Epling-Burnette, PhD

Blood (2008) 112 (11): 3654.

https://doi.org/10.1182/blood.V112.11.3654.3654

Published: 2008

Journal Articles

Expansion of donor-derived hematopoietic stem cells with PIGA mutation associated with late graft failure after allogeneic stem cell transplantation

Kanako Mochizuki, Chiharu Sugimori, Zhirong Qi, Xuzhang Lu, Akiyoshi Takami, Ken Ishiyama, Yukio Kondo, Hirohito Yamazaki, Hirokazu Okumura, Shinji Nakao

Blood (2008) 112 (5): 2160–2162.

https://doi.org/10.1182/blood-2008-02-141325

Published: 2008

Includes: Supplemental data

Journal Articles

CD55 − CD59 − Granulocytes in Patients with Aplastic Anemia Are Clonal Populations Derived from Single PIG-A Mutant Stem Cells without Any Proliferative Advantage.

Kanako Mochizuki, MD, Chiharu Sugimori, MD, PhD, Zhirong Qi, Xuzhang Lu, Shinji Nakao, MD, PhD

Blood (2007) 110 (11): 1702.

https://doi.org/10.1182/blood.V110.11.1702.1702

Published: 2007

Journal Articles

Donor-Cell Derived Aplastic Anemia (AA) with a Small Population of CD55 − CD59 − Blood Cells after Allogeneic Stem Cell Transplantation: Evidence for the Immune System Attack Against Normal Hematopoietic Stem Cells in AA.

Chiharu Sugimori, Kanako Mochizuki, Hirohito Yamazaki, Shinji Nakao

Blood (2007) 110 (11): 3682.

https://doi.org/10.1182/blood.V110.11.3682.3682

Published: 2007

Journal Articles

Specific antibodies to moesin, a membrane-cytoskeleton linker protein, are frequently detected in patients with acquired aplastic anemia

Hiroyuki Takamatsu, Xingmin Feng, Tatsuya Chuhjo, Xuzhang Lu, Chiharu Sugimori, Katsuya Okawa, Miyuki Yamamoto, Shoichi Iseki, Shinji Nakao

Blood (2006) 109 (6): 2514–2520.

https://doi.org/10.1182/blood-2006-07-036715

Published: 2006

Journal Articles

Roles of HLA-DR15 Alleles in the Pathogenesis of Acquired Aplastic Anemia (AA): DRB1*1502 Is in Linkages Disequilibrium with Unique Genes Which Determine Susceptibility to AA.

Chiharu Sugimori, Kanako Mochizuki, Xingmin Feng, Shinji Nakao

Blood (2006) 108 (11): 981.

https://doi.org/10.1182/blood.V108.11.981.981

Published: 2006

Journal Articles

Small Populations of PNH-Type Cells in Aplastic Anemia Patients Are Derived from PIG-A Mutant Stem Cell Clones without Proliferative Advantage.

Kanako Mochizuki, Chiharu Sugimori, Xingmin Feng, Xuzhang Lu, Gudrun H. Reed, Carl T. Wittwer, Shinji Nakao

Blood (2006) 108 (11): 974.

https://doi.org/10.1182/blood.V108.11.974.974

Published: 2006

Journal Articles

Minor population of CD55 - CD59 - blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia

Chiharu Sugimori, Tatsuya Chuhjo, Xingmin Feng, Hirohito Yamazaki, Akiyoshi Takami, Masanao Teramura, Hideaki Mizoguchi, Mitsuhiro Omine, Shinji Nakao

Blood (2006) 107 (4): 1308–1314.

https://doi.org/10.1182/blood-2005-06-2485

Published: 2006

Journal Articles

Specific Antibodies to Moesin, a Membrane-Cytoskeleton Linker Protein, Are Frequently Detected in Patients with Immune-Mediated Aplastic Anemia.

Hiroyuki Takamatsu, MD, ME, Xingmin Feng, MS, Xuzhang Lu, MD, Chiharu Sugimori, MD, Tatsuya Chuhjo, MD, PhD, Akiyoshi Takami, MD, PhD, Katsuya Okawa, ME, Shinji Nakao, MD, PhD

Blood (2005) 106 (11): 1038.

https://doi.org/10.1182/blood.V106.11.1038.1038

Published: 2005

NARROW

Baseline Assessment of Patients with Newly-Diagnosed Acquired Bone Marrow Failure Enrolled in a Prospective Observational Study, "Search for Unidentified Links between PNH Clone Size and the Related Clinical Manifestations By High Precision Flow Cytometry (SUPREMACY)"

The First Follow-up Data Analysis of Patients with Acquired Bone Marrow Failure Harboring a Small Population of PNH-Type Cells in the Japanese, Multicenter, Prospective Study Optima

An Interim 4-Year Analysis of Prospective Multicenter Observational Study of PNH-Type Cells in Japanese Patients with Bone Marrow Failure Syndrome (OPTIMA study)

A Profound Decrease in FoxP3 + Helios + CD4 + T Cells in a Subset of Patients with Acquired Aplastic Anemia and Pure Red Cell Aplasia: A Common Mechanism Underlying a Dependency on Cyclosporine

The Interim Analysis of the Optima (observation of GPI-anchored protein-deficient [PNH-type]) Cells in Japanese Patients with Bone Marrow Failure Syndrome and in Those Suspected of Having PNH) Study

Baseline Assessment Of GPI-Anchored Protein Deficient Blood Cells In Patients With Bone Marrow Failure (The OPTIMA study)

A Switch in Regulatory T-Cell Memory Phenotype Is Associated with Poor Survival in Lower Risk Myleodysplastic Syndrome Patients

Deletions of Xp22.2 Including PIG-A Locus Lead to Paroxysmal Nocturnal Hemoglobinuria.

Clinical Significance of Chromosomal Abnormalities in Patients with Aplastic Anemia and Refractory Anemia Deduced From the Prevalence of PNH-Type Cells.

Pathogenetic Role of Impaired Telomere Repair in Myelodysplastic Syndrome.

Co-Existance of JAK V617F and PIG-A mutations in Primary Budd-Chiari Syndrome.

Dysregulated Distribution of Naïve and Memory FoxP3 Positive Regulatory T-Cells Associated with Anemia in Myelodysplastic Syndrome (MDS)

Expansion of donor-derived hematopoietic stem cells with PIGA mutation associated with late graft failure after allogeneic stem cell transplantation

CD55 − CD59 − Granulocytes in Patients with Aplastic Anemia Are Clonal Populations Derived from Single PIG-A Mutant Stem Cells without Any Proliferative Advantage.

Donor-Cell Derived Aplastic Anemia (AA) with a Small Population of CD55 − CD59 − Blood Cells after Allogeneic Stem Cell Transplantation: Evidence for the Immune System Attack Against Normal Hematopoietic Stem Cells in AA.

Specific antibodies to moesin, a membrane-cytoskeleton linker protein, are frequently detected in patients with acquired aplastic anemia

Roles of HLA-DR15 Alleles in the Pathogenesis of Acquired Aplastic Anemia (AA): DRB1*1502 Is in Linkages Disequilibrium with Unique Genes Which Determine Susceptibility to AA.

Small Populations of PNH-Type Cells in Aplastic Anemia Patients Are Derived from PIG-A Mutant Stem Cell Clones without Proliferative Advantage.

Minor population of CD55 - CD59 - blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia

Specific Antibodies to Moesin, a Membrane-Cytoskeleton Linker Protein, Are Frequently Detected in Patients with Immune-Mediated Aplastic Anemia.

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American Society of Hematology

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American Society of Hematology

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