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Brent Ferrell, Jr.
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Journal Articles

Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics

Alyssa C. Parker, Joseph Van Amburg, J Brett Heimlich, Yash Pershad, Nicole Angelina Mickels, Taralynn Mack, Paul Brent Ferrell, Jr., Michael R. Savona, Angela Jones, Alexander G. Bick
Journal: Blood
Blood blood.2024026555.
https://doi.org/10.1182/blood.2024026555
Published: 2024
Includes: Supplemental data
Journal Articles

Distinct Transcriptomic Cell States Differentiate Low-Risk MDS from Healthy Marrow

Pawan Bhat, Joseph C. Van Amburg, Thomas J. Gracie, Justin A Cartailler, Chad R Potts, Alexander G. Bick, Robert Welner, P. Brent Ferrell, Jr.
Journal: Blood
Blood (2024) 144 (Supplement 1): 1814.
https://doi.org/10.1182/blood-2024-211672
Published: 2024
Journal Articles

Bone Marrow Spatial Multi-Omics Identifies Reduced Interactions between Hematopoietic Stem Cells and Myeloid Cells in Myelodysplastic Syndrome

Alyssa C. Parker, Joseph C. Van Amburg, Tianzi Zhang, Diane C. Saunders, Thomas J. Gracie, Pawan Bhat, J. Brett Heimlich, John W. Hickey, Emily F. Mason, Ashwin Kishtagari, P. Brent Ferrell, Jr., Alexander G. Bick
Journal: Blood
Blood (2024) 144 (Supplement 1): 4577.
https://doi.org/10.1182/blood-2024-210307
Published: 2024
Journal Articles

Combined Human and In Vivo Analyses Implicate the Critical Importance of Acute Myeloid Leukemia Associated CD8 T Cells and Identifies Their Molecular Dysfunction

Y. Emily Chu, Matthew A Cottam, Chad R Potts, Kirsten M Dickerson, Matthew T Jenkins, Justin A Cartailler, Rui Lu, Stanley C. Lee, Ross L Levine, Robert L. Bowman, Robert Welner, P. Brent Ferrell, Jr.
Journal: Blood
Blood (2024) 144 (Supplement 1): 2939.
https://doi.org/10.1182/blood-2024-205733
Published: 2024
Journal Articles

Factors Impacting Response to Olutasidenib in Patients with mIDH1 Acute Myeloid Leukemia

Eunice S. Wang, Brian A. Jonas, Justin M. Watts, Joseph Jurcic, P. Brent Ferrell, Jr., Shira N. Dinner, Jay Yang, Karen Seiter, Alice Mims, William B. Donnellan, William Blum, Jorge Cortes
Journal: Blood
Blood (2023) 142 (Supplement 1): 6047.
https://doi.org/10.1182/blood-2023-187584
Published: 2023
Journal Articles

Clonal Hematopoiesis and Inflammation in the Vasculature (CHIVE), a Prospective, Longitudinal Clonal Hematopoiesis Cohort and Biorepository

Jonathan Heimlich, Morgan Shannon, Sydney Olson, Alexander J Silver, Ariana Debevec, Zachary Copeland, Caitlyn Vlasschaert, Christina Snider, Ashwin Kishtagari, Donovan J Brown, Travis Spaulding, Manasa R Bhatta, Kelly Pugh, Shannon S Stockton, Jessica Ulloa, Yaomin Xu, Muhamed Baljevic, Sanjay Mohan, Javid J. Moslehi, Eiman Jahangir, Brent Ferrell, Jr., David Slosky, Alexander G. Bick, Michael R. Savona
Journal: Blood
Blood (2023) 142 (Supplement 1): 5594.
https://doi.org/10.1182/blood-2023-189808
Published: 2023
Journal Articles

Olutasidenib for the Treatment of mIDH1 Acute Myeloid Leukemia in Patients Relapsed or Refractory to Hematopoietic Stem Cell Transplant, Prior mIDH1 Inhibitor, or Venetoclax

Jorge Cortes, Joseph Jurcic, Maria R. Baer, William Blum, P. Brent Ferrell, Jr., Brian A. Jonas, Sangmin Lee, Alice Mims, Shyam Ajay Patel, Gary J. Schiller, Jay Yang, Justin M. Watts
Journal: Blood
Blood (2023) 142 (Supplement 1): 2888.
https://doi.org/10.1182/blood-2023-187861
Published: 2023
Journal Articles

DNMT3A R882H Exhibits Greater Inflammatory Potential Than R882C in Primary Hematopoietic Stem and Progenitor Cell Knock-in Model and Population Data

Alexander J Silver, Donovan J Brown, Caitlyn Vlasschaert, Pawan Bhat, Fabio Puddu, Joseph C Van Amburg, Matthew T Villaume, Melissa A Fischer, Maria P Arrate, Yu Wang, Jamie Scotcher, Kristy Stengel, Brianna Nicole Smith, Brian Sharber, Chad R Potts, Mark Consugar, Jonathan Brett Heimlich, Yaomin Xu, P. Brent Ferrell, Jr., Alexander G. Bick, Michael R. Savona
Journal: Blood
Blood (2023) 142 (Supplement 1): 815.
https://doi.org/10.1182/blood-2023-187244
Published: 2023
Journal Articles

Multi-Omics Analysis Reveals That TET2 Loss Epigenetically Primes Monocytes for Inflammatory Responses Via AP-1 Signaling

Matthew Jenkins, Yunli Chu, Sajesan Aryal, Xinyue Zhou, Kirsten Dickerson, Rebecca Dubin, Chad R Potts, Valeriya Kuznetsova, Alana Franceski, Paran Goel, Stanley C Lee, Rui Lu, Robert Welner, P. Brent Ferrell, Jr.
Journal: Blood
Blood (2023) 142 (Supplement 1): 4061.
https://doi.org/10.1182/blood-2023-182278
Published: 2023
Journal Articles

Multi-Recombinase Mouse Models of Flt3-Driven Leukemia Identifies Distinct Trajectories of Mutational Cooperativity and Leukemic Transformation

Robert L. Bowman, Tanmay Mishra, Shira E. Eisman, Louise Cai, Wenbin Xiao, Michael R. Waarts, Pablo Sanchez Vela, Inés Fernández-Maestre, Isabelle S. Csete, Chad R. Potts, Matthew T. Jenkins, Linde A. Miles, Jennifer J. Trowbridge, Paul Brent Ferrell, Jr., Ross L. Levine
Journal: Blood
Blood (2021) 138 (Supplement 1): 2220.
https://doi.org/10.1182/blood-2021-149846
Published: 2021
Journal Articles

Olutasidenib (FT-2102), an IDH1m Inhibitor As a Single Agent or in Combination with Azacitidine, Induces Deep Clinical Responses with Mutation Clearance in Patients with Acute Myeloid Leukemia Treated in a Phase 1 Dose Escalation and Expansion Study

Justin M. Watts, MD, Maria R. Baer, MD, Jay Yang, MD, Thomas Prebet, MD PhD, Sangmin Lee, MD, Gary J. Schiller, MD, Shira Dinner, MD, Arnaud Pigneux, Pau Montesinos, MD PhD, Eunice S. Wang, MD, Karen Seiter, MD, Andrew H. Wei, PhD FRACP, FRCPA, MBBS, Stephane De Botton, Montserrat Arnan Sangerman, William B. Donnellan, MD, Brian A Jonas, MD PhD, Paul Brent Ferrell, Jr., MD, Kim-Hien Dao, DO, PhD, Patrick Kelly, MD, Jennifer Sweeney, Sanjeev Forsyth, Sylvie Guichard, Julie Brevard, Patrick Henrick, Hesham Mohamed, MD, Jorge E. Cortes, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 231.
https://doi.org/10.1182/blood-2019-123920
Published: 2019
Journal Articles

Single Cell Signaling Responses Stratify Immune and Leukemia Cell Populations in Acute Myeloid Leukemia

Kathryn I Sunthankar, MD, Benjamin J Reisman, BS, Candace H Cote, BS, Paul Brent Ferrell, Jr., MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2680.
https://doi.org/10.1182/blood-2019-129602
Published: 2019
Journal Articles

Venetoclax-Based Salvage Therapy for Post-Hematopoietic Cell Transplantation Relapse in Acute Myeloid Leukemia

Michael T Byrne, DO, Nathalie Danielson, MSN, Adrianne Rasche, MSN, Rachel Hammers, MSN, Kathryn A Culos, PharmD, Katie S Gatwood, PharmD, Houston Wyatt, PharmD, Kristin Fogo, BSN, Bhagirathbhai Dholaria, MBBS, Brian G Engelhardt, MD, Paul Brent Ferrell, Jr., MD, Madan Jagasia, MBBS, MS, MMHC, Adetola A. Kassim, MDMS, Sanjay R Mohan, MD MSCI, Bipin N. Savani, MD, Stephen A. Strickland, MD, Salyka M. Sengsayadeth, MD, Michael R. Savona, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2643.
https://doi.org/10.1182/blood-2019-129146
Published: 2019
Journal Articles

FT-2102, an IDH1m Inhibitor, in Combination with Azacitidine in Patients with Acute Myeloid Leukemia (AML) or Myelodysplastic Ayndrome (MDS): Results from a Phase 1 Study

Jorge E. Cortes, MD, Justin Watts, MD, Thomas Prebet, MD PhD, Gary J. Schiller, MD, Sangmin Lee, MD, Jay Yang, MD, Eunice S. Wang, MD, Shira Dinner, MD, Paul Brent Ferrell, Jr., MD, Will Donnellan, MD, Brian A. Jonas, MD PhD, Andrew H Wei, MBBS, PhD, Pau Montesinos, MD PhD, Montserrat Arnan Sangerman, MD, Patrick Kelly, MD, Ping Li, PhD, Jennifer Sweeney, Courtney Watson, Hesham Mohamed, MD, Maria R. Baer, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1452.
https://doi.org/10.1182/blood-2018-99-114126
Published: 2018
Journal Articles

Phase 1 Study of the IDH1m Inhibitor FT-2102 As a Single Agent in Patients with IDH1 m Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

Justin Watts, MD, Maria R. Baer, MD, Jay Yang, MD, Shira Dinner, MD, Sangmin Lee, MD, Karen Seiter, MD, Thomas Prebet, MD PhD, Gary J. Schiller, MD, Paul Brent Ferrell, Jr., MD, Kim-Hien Dao, DO, PhD, Hagop M. Kantarjian, MD, Patrick Kelly, MD, Ping Li, PhD, Jennifer Sweeney, Courtney Watson, Hesham Mohamed, MD, Jorge E. Cortes, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1453.
https://doi.org/10.1182/blood-2018-99-114263
Published: 2018
Journal Articles

IDH2 Mutations Induce Altered STAT Signaling and Cytokine Responses Which Are Restored By Enasidenib

Kathryn S Ivy, BA, Candace H Cote, BS, Paul Brent Ferrell, Jr., MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1468.
https://doi.org/10.1182/blood-2018-99-117783
Published: 2018
Journal Articles

Expression of S100A9 in Bone Marrow Cells Differentiates Refractory Cytopenia with Multilineage Dysplasia (RCMD) from Refractory Anemia with Excess Blasts (RAEB) and Acute Myeloid Leukemia (AML)

Paul Brent Ferrell, Jr., MD, Caroline R. Maier, BS, Mikael Roussel, MD PhD, Michael R. Savona, MD, Jonathan Michael Irish, PhD
Journal: Blood
Blood (2016) 128 (22): 4303.
https://doi.org/10.1182/blood.V128.22.4303.4303
Published: 2016
Journal Articles

Mutational Burden in Acute Myeloid Leukemia Is Largely Age Dependent

Aaron C. Shaver, MD PhD, Adam C. Seegmiller, MD PhD, Stephen A. Strickland, MD, Robert D. Daber, PhD, Sanjay R. Mohan, MD, Paul Brent Ferrell, Jr., MD, Cindy Vnencak-Jones, PhD, David R. Head, MD, Annette S. Kim, MD PhD, Mary M. Zutter, MD, Michael R. Savona, MD
Journal: Blood
Blood (2015) 126 (23): 2605.
https://doi.org/10.1182/blood.V126.23.2605.2605
Published: 2015
Journal Articles

Dissecting Signaling Network Responses to PAK4 Allosteric Modulators (PAMs) in Cell Subsets within Primary Human Acute Myeloid Leukemia Samples

Paul Brent Ferrell, Jr., MD, William Senapedis, PhD, Alexander Cook, Erkan Baloglu, PhD, Yosef Landesman, PhD, Jonathan Michael Irish, PhD, Michael R. Savona, MD
Journal: Blood
Blood (2015) 126 (23): 3686.
https://doi.org/10.1182/blood.V126.23.3686.3686
Published: 2015