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Arnold Spek
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Journal Articles

Insights Into the Mechanism of Zymogen Protein C Protection Against Cancer Progression

Julie M Crudele, BA, Geerte L. Van Sluis, MD, Paris Margaritis, DPhil, Joshua I Siner, Michael Sliozberg, Jenna Maurer, Armida Faella, Shangzhen Zhou, MD, Katherine A. High, MD, Charles T Esmon, PhD, C. Arnold Spek, PhD, Valder R Arruda, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3350.
https://doi.org/10.1182/blood.V120.21.3350.3350
Published: 2012
Journal Articles

The Role of Activated Protein C in Cancer

C. Arnold Spek, PhD, Valder Arruda, MD, PhD
Journal: Blood
Blood (2011) 118 (21): SCI-18.
https://doi.org/10.1182/blood.V118.21.SCI-18.SCI-18
Published: 2011
Journal Articles

Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain

Netanel A. Horowitz, Elizabeth A. Blevins, Whitney M. Miller, Ashley R. Perry, Kathryn E. Talmage, Eric S. Mullins, Matthew J. Flick, Karla C. S. Queiroz, Kun Shi, C. Arnold Spek, Edward M. Conway, Brett P. Monia, Hartmut Weiler, Jay L. Degen, Joseph S. Palumbo
Journal: Blood
Blood (2011) 118 (10): 2889–2895.
https://doi.org/10.1182/blood-2011-03-341222
Published: 2011
Includes: Supplemental data
Journal Articles

Zymogen Protein C as a Novel Modulator of Cancer Progression In Murine Models

Geerte L. Van Sluis, Paris Margaritis, DPhil, Michael Sliozberg, Jenna Mauer, Armida Faella, Shangzhen Zhou, Katherine A. High, MD, Arnold Spek, Valder R. Arruda, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 718.
https://doi.org/10.1182/blood.V116.21.718.718
Published: 2010
Journal Articles

Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1–mediated vascular endothelial barrier enhancement

Geerte L. Van Sluis, Tatjana M.H. Niers, Charles T. Esmon, Wikky Tigchelaar, Dick J. Richel, Harry R. Buller, Cornelis J.F. Van Noorden, C. Arnold Spek
Journal: Blood
Blood (2009) 114 (9): 1968–1973.
https://doi.org/10.1182/blood-2009-04-217679
Published: 2009
Journal Articles

Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation

Sjoukje H. Slofstra, Maarten F. Bijlsma, Angelique P. Groot, Pieter H. Reitsma, Theo Lindhout, Hugo ten Cate, C. Arnold Spek
Journal: Blood
Blood (2007) 110 (9): 3176–3182.
https://doi.org/10.1182/blood-2007-02-075440
Published: 2007
Journal Articles

High throughput mRNA profiling highlights associations between myocardial infarction and aberrant expression of inflammatory molecules in blood cells

Stephanie Bezzina Wettinger, Carine J. M. Doggen, C. Arnold Spek, Frits R. Rosendaal, Pieter H. Reitsma
Journal: Blood
Blood (2005) 105 (5): 2000–2006.
https://doi.org/10.1182/blood-2004-08-3283
Published: 2005
Journal Articles

The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation

Rendrik F. Franco, Evert de Jonge, Pascale E. P. Dekkers, Janneke J. Timmerman, C. Arnold Spek, Sander J. H. van Deventer, Peter van Deursen, Liesbeth van Kerkhoff, Bob van Gemen, Hugo ten Cate, Tom van der Poll, Pieter H. Reitsma
Journal: Blood
Blood (2000) 96 (2): 554–559.
https://doi.org/10.1182/blood.V96.2.554
Published: 2000