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Journal Articles

High Dimensional Immunophenotyping of Neonatal and Adult Platelets: Differential Reactivity to Agonists, Maximal Marker Expression, and Abundance of Defined Platelet Subsets

Andrew L Frelinger, III, Benjamin E.J. Spurgeon, Erin L Soule-Albridge, Jacqueline R Perry, Martha Sola-Visner, Patricia E Davenport

Blood (2024) 144 (Supplement 1): 2546.

https://doi.org/10.1182/blood-2024-200231

Published: 2024

Journal Articles

Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome

Blood (2023) 142 (15): 1281–1296.

https://doi.org/10.1182/blood.2022019117

Published: 2023

Includes: Supplemental data

Journal Articles

Evaluation of Longitudinal Pain Study in Sickle Cell Disease (ELIPSIS) by patient-reported outcomes, actigraphy, and biomarkers

Debra D. Pittman, Patrick C. Hines, David Beidler, Denis Rybin, Andrew L. Frelinger, III, Alan D. Michelson, Ke Liu, Xiufeng Gao, Jennell White, Ahmar U. Zaidi, Robert J. Charnigo, Michael U. Callaghan

Blood (2021) 137 (15): 2010–2020.

https://doi.org/10.1182/blood.2020006020

Published: 2021

Includes: Supplemental data

Journal Articles

Synergistic Platelet Inhibitory Effects of Riociguat and Nitric Oxide Are Decreased By Protein Binding

Yifeng WU, MD, Alan D Michelson, MD, Andrew L Frelinger, III, PhD

Blood (2018) 132 (Supplement 1): 4971.

https://doi.org/10.1182/blood-2018-99-117070

Published: 2018

Journal Articles

Elipsis: A Longitudinal Study of Electronic Patient-Reported Outcomes, Actigraphy and Biomarkers to Identify and Assess at-Home Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease

Michael U. Callaghan, Patrick C. Hines, MD PhD, Debra D Pittman, MS, David Beidler, PhD, Denis Rybin, PhD, Ahmar Urooj Zaidi, MD BSc, Jennell White, PhD, Ke Liu, PhD, Bryan Hannan, MS, Xiufeng Gao, MD, Andreas M Pleil, PhD, Alexandra Barsdorf, PhD, Martin David, Pharm D, Melanie Simmons, PMP, PSM, Andrew L Frelinger, III, PhD, Alan D Michelson, MD, Nick Clarke, PhD, Robert J Charnigo, MS

Blood (2017) 130 (Supplement 1): 973.

https://doi.org/10.1182/blood.V130.Suppl_1.973.973

Published: 2017

Journal Articles

A Phase 1b, Randomized, Double-Blind, Placebo-Controlled Study of PF-04447943 in Patients with Stable Sickle Cell Disease: Changes in Exploratory Biomarkers

Robert J Charnigo, MS, Jo Howard, MBBCh, David Beidler, PhD, Denis Rybin, PhD, Beesan Tan, PhD, Alan D Michelson, MD, Andrew L Frelinger, III, PhD, Nicholas Clarke, PhD

Blood (2017) 130 (Supplement 1): 974.

https://doi.org/10.1182/blood.V130.Suppl_1.974.974

Published: 2017

Journal Articles

Mass Cytometry of Platelets: Simultaneous Functional and Phenotypic Analysis of Multiple Surface Markers in Healthy Subjects and Patients with Inherited Platelet Disorders Reveals Novel Platelet Sub-Populations

Thomas A. Blair, PhD, Alan D Michelson, MD, Andrew L Frelinger, III, PhD

Blood (2017) 130 (Supplement 1): 2311.

https://doi.org/10.1182/blood.V130.Suppl_1.2311.2311

Published: 2017

Journal Articles

Platelet Function in Thrombocytopenic Patients with Chronic Liver Disease

Elena Smolensky Koganov, PhD, Sabrina L Carmichael, BS, Emma E Forde, BS, Andrew L Frelinger, III, PhD, Alan D Michelson, MD

Blood (2017) 130 (Supplement 1): 2314.

https://doi.org/10.1182/blood.V130.Suppl_1.2314.2314

Published: 2017

Journal Articles

Avatrombopag, a Novel Thrombopoietin Receptor Agonist, Increases Platelet Counts without Increasing Platelet Activation in Patients with Thrombocytopenia Due to Chronic Liver Disease

Andrew L Frelinger, III, PhD, Elena Smolensky Koganov, PhD, Emma E Forde, BS, Sabrina L Carmichael, BS, Alan D Michelson, MD

Blood (2017) 130 (Supplement 1): 290.

https://doi.org/10.1182/blood.V130.Suppl_1.290.290

Published: 2017

Journal Articles

GLS-409, a Synergistic Inhibitor of Both P2Y 1 and P2Y 12 : Efficacy in a Canine Model of Recurrent Coronary Thrombosis and Reversibility of Human Platelet Inhibition

Elena Smolensky Koganov, PhD, Alan D Michelson, MD, Ivan B Yanachkov, PhD, Milka I Yanachkova, PhD, George E Wright, PhD, Karin Przyklenk, PhD, Andrew L Frelinger, III, PhD

Blood (2017) 130 (Supplement 1): 630.

https://doi.org/10.1182/blood.V130.Suppl_1.630.630

Published: 2017

Journal Articles

The Platelet Phenotype of Children with ITP Is Consistent over Time and Is Associated with Both Concurrent and Subsequent Bleeding Severity

Andrew L. Frelinger, III, PhD, Rachael F Grace, MD, Anja J. Gerrits, PhD, Sabrina L Carmichael, BS, Emma E Forde, BS, Alan D. Michelson, MD

Blood (2016) 128 (22): 2550.

https://doi.org/10.1182/blood.V128.22.2550.2550

Published: 2016

Journal Articles

Hypoxia Reoxygenation Treatment Induces Platelet Hyperactivity and Relieves Calpain-1-Mediated Inhibition of Platelet Aggregation in a Mouse Model of Severe Sickle Cell Disease

Jennifer O. Nwankwo, BS, Rod R. Warburton, BA, Thomas Gremmel, MD, Anja J. Gerrits, PhD, Lauren J. Richey, DVM, PhD, Nicholas S. Hill, MD, Alicia Rivera, Joseph A. Jakubowski, PhD, Andrew L. Frelinger, III, PhD, Athar H. Chishti, PhD

Blood (2015) 126 (23): 413.

https://doi.org/10.1182/blood.V126.23.413.413

Published: 2015

Journal Articles

Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia

Anja J. Gerrits, Emily A. Leven, Andrew L. Frelinger, III, Sophie L. Brigstocke, Michelle A. Berny-Lang, W. Beau Mitchell, Shoshana Revel-Vilk, Hannah Tamary, Sabrina L. Carmichael, Marc R. Barnard, Alan D. Michelson, James B. Bussel

Blood (2015) 126 (11): 1367–1378.

https://doi.org/10.1182/blood-2014-09-602573

Published: 2015

Journal Articles

Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP

Andrew L. Frelinger, III, Rachael F. Grace, Anja J. Gerrits, Michelle A. Berny-Lang, Travis Brown, Sabrina L. Carmichael, Ellis J. Neufeld, Alan D. Michelson

Blood (2015) 126 (7): 873–879.

https://doi.org/10.1182/blood-2015-02-628461

Published: 2015

Includes: Supplemental data

Journal Articles

Association Of Platelet Function Markers, Independent Of Platelet Count, With Bleeding Score In Patients With Immune Thrombocytopenia

Andrew L. Frelinger, III, PhD, Anja J Gerrits, PhD, Michelle A. Berny-Lang, PhD, Travis Brown, Sabrina L. Carmichael, BS, Ellis J. Neufeld, MD, PhD, Alan D. Michelson, MD, Rachael F. Grace, MD

Blood (2013) 122 (21): 3534.

https://doi.org/10.1182/blood.V122.21.3534.3534

Published: 2013

Journal Articles

Effects Of Eltrombopag On Thrombocytopenia, Platelet Function and Bleeding In Patients With Wiskott-Aldrich Syndrome/X-Linked Thrombocytopenia

Anja J Gerrits, PhD, Emily Leven, Andrew L. Frelinger, III, PhD, Michelle A. Berny-Lang, PhD, Hannah Tamary, MD, Shoshana Revel-Vilk, MD, MSc, Sabrina L. Carmichael, BS, W. Beau Mitchell, MD, Alan D. Michelson, MD, James B Bussel, MD

Blood (2013) 122 (21): 3536.

https://doi.org/10.1182/blood.V122.21.3536.3536

Published: 2013

Journal Articles

The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation

Blood (2013) 122 (3): 376–385.

https://doi.org/10.1182/blood-2012-11-466722

Published: 2013

Includes: Supplemental data

Journal Articles

Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms ( CYP2C19 , ABCB1 , PON1 ), Non-Compliance, Diet, Smoking, Co-Medications (including Proton Pump Inhibitors), and Pre-Existent Variability in Platelet Function

Andrew L. Frelinger, III, PhD, Deepak L. Bhatt, MD, MPH, Ronald D. Lee, PhD, Darcy J. Mulford, PhD, Jingtao Wu, PhD, Sai Nudurupati, PhD, Anu Nigam, MS, Michael Lampa, BS, Julie K. Brooks, MS, Marc R. Barnard, MS, Alan D. Michelson, MD

Blood (2012) 120 (21): 4356.

https://doi.org/10.1182/blood.V120.21.4356.4356

Published: 2012

Journal Articles

Platelet Activation and Inhibition in Sickle Cell Disease (PAINS) Study

Andrew L. Frelinger, III, PhD, Joseph A. Jakubowski, PhD, Julie K. Brooks, MS, Sabrina L. Zayas, BS, Michelle A. Berny-Lang, PhD, Marc R. Barnard, MS, Matthew M. Heeney, MD, Alan D. Michelson, MD

Blood (2012) 120 (21): 5147.

https://doi.org/10.1182/blood.V120.21.5147.5147

Published: 2012

Journal Articles

In vivo effects of eltrombopag on platelet function in immune thrombocytopenia: no evidence of platelet activation

Bethan Psaila, James B. Bussel, Matthew D. Linden, Bracken Babula, Youfu Li, Marc R. Barnard, Chinara Tate, Kanika Mathur, Andrew L. Frelinger, Alan D. Michelson

Blood (2012) 119 (17): 4066–4072.

https://doi.org/10.1182/blood-2011-11-393900

Published: 2012

Includes: Supplemental data

NARROW

High Dimensional Immunophenotyping of Neonatal and Adult Platelets: Differential Reactivity to Agonists, Maximal Marker Expression, and Abundance of Defined Platelet Subsets

Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome

Evaluation of Longitudinal Pain Study in Sickle Cell Disease (ELIPSIS) by patient-reported outcomes, actigraphy, and biomarkers

Synergistic Platelet Inhibitory Effects of Riociguat and Nitric Oxide Are Decreased By Protein Binding

Elipsis: A Longitudinal Study of Electronic Patient-Reported Outcomes, Actigraphy and Biomarkers to Identify and Assess at-Home Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease

A Phase 1b, Randomized, Double-Blind, Placebo-Controlled Study of PF-04447943 in Patients with Stable Sickle Cell Disease: Changes in Exploratory Biomarkers

Mass Cytometry of Platelets: Simultaneous Functional and Phenotypic Analysis of Multiple Surface Markers in Healthy Subjects and Patients with Inherited Platelet Disorders Reveals Novel Platelet Sub-Populations

Platelet Function in Thrombocytopenic Patients with Chronic Liver Disease

Avatrombopag, a Novel Thrombopoietin Receptor Agonist, Increases Platelet Counts without Increasing Platelet Activation in Patients with Thrombocytopenia Due to Chronic Liver Disease

GLS-409, a Synergistic Inhibitor of Both P2Y 1 and P2Y 12 : Efficacy in a Canine Model of Recurrent Coronary Thrombosis and Reversibility of Human Platelet Inhibition

The Platelet Phenotype of Children with ITP Is Consistent over Time and Is Associated with Both Concurrent and Subsequent Bleeding Severity

Hypoxia Reoxygenation Treatment Induces Platelet Hyperactivity and Relieves Calpain-1-Mediated Inhibition of Platelet Aggregation in a Mouse Model of Severe Sickle Cell Disease

Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia

Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP

Association Of Platelet Function Markers, Independent Of Platelet Count, With Bleeding Score In Patients With Immune Thrombocytopenia

Effects Of Eltrombopag On Thrombocytopenia, Platelet Function and Bleeding In Patients With Wiskott-Aldrich Syndrome/X-Linked Thrombocytopenia

The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation

Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms ( CYP2C19 , ABCB1 , PON1 ), Non-Compliance, Diet, Smoking, Co-Medications (including Proton Pump Inhibitors), and Pre-Existent Variability in Platelet Function

Platelet Activation and Inhibition in Sickle Cell Disease (PAINS) Study

In vivo effects of eltrombopag on platelet function in immune thrombocytopenia: no evidence of platelet activation

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American Society of Hematology

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American Society of Hematology

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