MPL-dependent and -independent features of JAK2V617F-driven MPN phenotypes. MPL plays a critical role in JAK2V617F MPNs by driving long-term self-renewal of HSCs, promoting megakaryocyte (MK) hyperplasia, thrombocytosis, and progression to MF. In contrast, other hallmark features of JAK2V617F MPNs s... More about this image found in MPL-dependent and -independent features of JAK2V617F-driven MPN phenotypes....

The B-cell developmental stage of arrest impacts InO sensitivity in B-ALL samples. Escherich et al used bulk RNA sequencing and a gene expression reference for normal B lymphopoiesis to infer the relative contribution of transformed B-cell developmental stages to individual B-ALL samples. The relati... More about this image found in The B-cell developmental stage of arrest impacts InO sensitivity in B-ALL s...

Postimmunotherapy lineage switch. In the international Project EVOLVE cohort, postimmunotherapy lineage switch (LS) occurred primarily in KMT2A-rearranged B-ALL; however, multiple other B-ALL subtypes were represented. LS occurred after CD19 and/or CD22 targeting CAR-T therapy, blinatumomab and inot... More about this image found in Postimmunotherapy lineage switch. In the international Project EVOLVE cohor...