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Clinical Trials & Observations
Journal: Blood
Blood (2025) 145 (23): 2674–2676.
Published: 2025
Journal Articles
Clinical Trials & Observations
Journal: Blood
Blood (2025) 145 (23): 2682–2684.
Published: 2025
Journal Articles
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Autocrine and paracrine activities of DLBCL tumor cell–derived IL-10. (Left) In an autostimulatory loop, lymphoma cell–derived IL-10 activates STAT3 downstream of the IL-10 receptor, leading to upregulation of PD-L1 expression and downregulation of the calcium channel CACNA1C. (Right) Lymphoma cell–derived IL-10 exerts functions on several immune cell types localized in the LME, thus contributing to the composition and functionality of the LME. Red arrows depict inhibitory activities of IL-10; green arrows depict IL-10 activities that maintain the physiological cell phenotype in the LME. The biological consequences of autocrine and paracrine IL-10 activity are indicated in the yellow (tumor cell–intrinsic functions) and green (functions in the lymphoma microenvironment) boxes.
Published: 2025
Autocrine and paracrine activities of DLBCL tumor cell–derived IL-10. (Left) In an autostimulatory loop, lymphoma cell–derived IL-10 activates STAT3 downstream of the IL-10 receptor, leading to upregulation of PD-L1 expression and downregulation of the calcium channel CACNA1C. (Right) Lymphoma cell–... More about this image found in Autocrine and paracrine activities of DLBCL tumor cell–derived IL-10. (Left...
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Answered and open questions from 7 years of the MURANO trial. CIT, chemoimmunotherapy; BCL2i, BCL2 inhibitor; BTKi, BTK inhibitor; r/r, relapsed/refractory.
Published: 2025
Answered and open questions from 7 years of the MURANO trial. CIT, chemoimmunotherapy; BCL2i, BCL2 inhibitor; BTKi, BTK inhibitor; r/r, relapsed/refractory. More about this image found in Answered and open questions from 7 years of the MURANO trial. CIT, chemoimm...
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Improving Burkitt lymphoma outcomes at every juncture. BL, Burkitt lymphoma; EBV, Epstein-Barr virus; FDG-PET, [18F]fluorodeoxyglucose positron emission tomography; LDH, lactate dehydrogenase; MRD, measurable residual disease.
Published: 2025
Improving Burkitt lymphoma outcomes at every juncture. BL, Burkitt lymphoma; EBV, Epstein-Barr virus; FDG-PET, [ 18 F]fluorodeoxyglucose positron emission tomography; LDH, lactate dehydrogenase; MRD, measurable residual disease. More about this image found in Improving Burkitt lymphoma outcomes at every juncture. BL, Burkitt lymphoma...
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Leukemic blasts are organized into a hierarchical structure of differential capability for stem cell–like proliferation and renewal, with HSPC-like cells at the root of a tree shown for descriptive purposes, and more differentiated lineage-like blasts reside as leaves on the tree. Chen et al found that these HSPC-like blasts are enriched for stem cell transcriptional phenotypes. These stem-cell cells are disproportionately resistant to chemotherapy. Figure created with BioRender.com.
Published: 2025
Leukemic blasts are organized into a hierarchical structure of differential capability for stem cell–like proliferation and renewal, with HSPC-like cells at the root of a tree shown for descriptive purposes, and more differentiated lineage-like blasts reside as leaves on the tree. Chen et al found t... More about this image found in Leukemic blasts are organized into a hierarchical structure of differential...
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