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Spleen section of a mouse with constitutive active CD30 in B lymphocytes 14 days after T cell–dependent immunization. Germinal center (GC) cells, peanut agglutinin, and metallophilic macrophages are stained in blue, and B lymphocytes (immunoglobulin M) are stained in red. CD30 signaling blocks GC development, enhances plasma cell differentiation, and leads to lymphomagenesis in aged mice. See the article by Sperling et al on page 2597.