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Volume 131, Issue 9

March 1 2018

In this Issue

BLOOD COMMENTARIES
CLINICAL TRIALS AND OBSERVATIONS
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
LETTER TO BLOOD
BLOOD WORK
ERRATUM

Table of Contents

BLOOD COMMENTARIES

CLINICAL TRIALS AND OBSERVATIONS

MRD negativity as a surrogate for PFS in CLL?
Clinical Trials & Observations

Philip A. Thompson

View Articletitled, MRD negativity as a surrogate for PFS in CLL?

IMMUNOBIOLOGY AND IMMUNOTHERAPY

The elusive pathogenesis of Schnitzler syndrome

Giovanni Palladini,Giampaolo Merlini

View Articletitled, The elusive pathogenesis of Schnitzler syndrome

Lymphoid Neoplasia

R-spondin(g) to syndecan-1 in myeloma

Steven Grant

View Articletitled, R-spondin(g) to syndecan-1 in myeloma

Lymphoid Neoplasia

“Dar”-ing to target CD38 in T-ALL

Joseph Wynne,Wendy Stock

View Articletitled, “Dar”-ing to target CD38 in T-ALL

PLATELETS AND THROMBOPOIESIS

BEACHcombing for α-granules

Sidney W. Whiteheart

View Articletitled, BEACHcombing for α-granules

Red Cells, Iron, and Erythropoiesis

Unwinding the path from anemia to stroke

John C. Wood

View Articletitled, Unwinding the path from anemia to stroke

THROMBOSIS AND HEMOSTASIS

Hemophilia gene therapy is effective and safe

Michael Makris

View Articletitled, Hemophilia gene therapy is effective and safe

CLINICAL TRIALS AND OBSERVATIONS

A model for predicting effect of treatment on progression-free survival using MRD as a surrogate end point in CLL
Clinical Trials & Observations

Natalie Dimier,Paul Delmar,Carol Ward,Rodica Morariu-Zamfir,Günter Fingerle-Rowson,Jasmin Bahlo,Kirsten Fischer,Barbara Eichhorst,Valentin Goede,Jacques J. M. van Dongen,Matthias Ritgen,Sebastian Böttcher,Anton W. Langerak,Michael Kneba,Michael Hallek

View Articletitled, A model for predicting effect of treatment on progression-free survival using MRD as a surrogate end point in CLL

Supplemental data

HEMATOPOIESIS AND STEM CELLS

Hif-1α and Hif-2α regulate hemogenic endothelium and hematopoietic stem cell formation in zebrafish

Claudia Gerri,Michele Marass,Andrea Rossi,Didier Y. R. Stainier

View Articletitled, Hif-1α and Hif-2α regulate hemogenic endothelium and hematopoietic stem cell formation in zebrafish

Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Molecular genetic investigation, clinical features, and response to treatment in 21 patients with Schnitzler syndrome

Dorota M. Rowczenio,Shelly Pathak,Juan I. Arostegui,Anna Mensa-Vilaro,Ebun Omoyinmi,Paul Brogan,Dan Lipsker,Thomas Scambler,Roger Owen,Hadija Trojer,Anna Baginska,Julian D. Gillmore,Ashutosh D. Wechalekar,Thirusha Lane,Rene Williams,Taryn Youngstein,Philip N. Hawkins,Sinisa Savic,Helen J. Lachmann

View Articletitled, Molecular genetic investigation, clinical features, and response to treatment in 21 patients with Schnitzler syndrome

Supplemental data

LYMPHOID NEOPLASIA

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins

Zemin Ren,Harmen van Andel,Wim de Lau,Robin B. Hartholt,Madelon M. Maurice,Hans Clevers,Marie José Kersten,Marcel Spaargaren,Steven T. Pals

View Articletitled, Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins

Supplemental data

Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia
Brief Report

Karen L. Bride,Tiffaney L. Vincent,Soo-Yeon Im,Richard Aplenc,David M. Barrett,William L. Carroll,Robin Carson,Yunfeng Dai,Meenakshi Devidas,Kimberly P. Dunsmore,Tori Fuller,Tina Glisovic-Aplenc,Terzah M. Horton,Stephen P. Hunger,Mignon L. Loh,Shannon L. Maude,Elizabeth A. Raetz,Stuart S. Winter,Stephan A. Grupp,Michelle L. Hermiston,Brent L. Wood,David T. Teachey

View Articletitled, Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia

Supplemental data

PLATELETS AND THROMBOPOIESIS

Nbeal2 interacts with Dock7, Sec16a, and Vac14

Louisa Mayer,Maria Jasztal,Mercedes Pardo,Salvadora Aguera de Haro,Janine Collins,Tadbir K. Bariana,Peter A. Smethurst,Luigi Grassi,Romina Petersen,Paquita Nurden,Rémi Favier,Lu Yu,Stuart Meacham,William J. Astle,Jyoti Choudhary,Wyatt W. Yue,Willem H. Ouwehand,Jose A. Guerrero

View Articletitled, Nbeal2 interacts with Dock7, Sec16a, and Vac14

Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia

Kristin P. Guilliams,Melanie E. Fields,Dustin K. Ragan,Cihat Eldeniz,Michael M. Binkley,Yasheng Chen,Liam S. Comiskey,Allan Doctor,Monica L. Hulbert,Joshua S. Shimony,Katie D. Vo,Robert C. McKinstry,Hongyu An,Jin-Moo Lee,Andria L. Ford

View Articletitled, Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia

Supplemental data

THROMBOSIS AND HEMOSTASIS

Gene therapy with adeno-associated virus vector 5–human factor IX in adults with hemophilia B
Clinical Trials & Observations

Wolfgang Miesbach,Karina Meijer,Michiel Coppens,Peter Kampmann,Robert Klamroth,Roger Schutgens,Marco Tangelder,Giancarlo Castaman,Joachim Schwäble,Halvard Bonig,Erhard Seifried,Federica Cattaneo,Christian Meyer,Frank W. G. Leebeek

View Articletitled, Gene therapy with adeno-associated virus vector 5–human factor IX in adults with hemophilia B

Supplemental data

LETTER TO BLOOD

Loss of Toll-like receptor 2 results in accelerated leukemogenesis in the NUP98-HOXD13 mouse model of MDS

Darlene A. Monlish,Sima T. Bhatt,Eric J. Duncavage,Zev J. Greenberg,John L. Keller,Molly P. Romine,Wei Yang,Peter D. Aplan,Matthew J. Walter,Laura G. Schuettpelz

View Articletitled, Loss of Toll-like receptor 2 results in accelerated leukemogenesis in the <em>NUP98-HOXD13</em> mouse model of MDS

Supplemental data

BLOOD WORK

Myelophthisic marrow involved by breast cancer and acute myeloid leukemia

William Shomali,Jason Gotlib

View Articletitled, Myelophthisic marrow involved by breast cancer and acute myeloid leukemia

ERRATUM

Lin RJ, Behera M, Diefenbach CS, Flowers CR. Role of anthracycline and comprehensive geriatric assessment for elderly patients with diffuse large B-cell lymphoma. Blood. 2017;130(20):2180-2185.

View Articletitled, Lin RJ, Behera M, Diefenbach CS, Flowers CR. Role of anthracycline and comprehensive geriatric assessment for elderly patients with diffuse large B-cell lymphoma. <em>Blood</em>. 2017;130(20):2180-2185.

Cover Image

Cover Image

The interaction between Nbeal2 and Vac14 is illustrated by a proximity ligation assay where red dots indicate such interaction. Megakaryocytes are counterstained with phalloidin (green) and DAPI (4',6-diamidino-2-phenylindole; blue) to allow their visualization. See the article by Mayer et al on page 1000.
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