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Volume 8, Issue 5

March 12 2024

In this Issue

INSIDE BLOOD ADVANCES
CLINICAL TRIALS AND OBSERVATIONS
HEALTH SERVICES AND OUTCOMES
IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
VASCULAR BIOLOGY
RESEARCH LETTERS
ERRATUM

INSIDE BLOOD ADVANCES

Add-on erythropoietin in autoimmune hemolytic anemia
Clinical Trials & Observations

Miriam M. Moser,Bernd Jilma

View Articletitled, Add-on erythropoietin in autoimmune hemolytic anemia

A sweet deal: blocking NMDAR for safer t-PA in diabetes

Frederik Denorme

View Articletitled, A sweet deal: blocking NMDAR for safer t-PA in diabetes

CLINICAL TRIALS AND OBSERVATIONS

Single-center randomized trial of T-reg graft alone vs T-reg graft plus tacrolimus for the prevention of acute GVHD
Clinical Trials & Observations

Cameron S. Bader,Anna Pavlova,Robert Lowsky,Lori S. Muffly,Parveen Shiraz,Sally Arai,Laura J. Johnston,Andrew R. Rezvani,Wen-Kai Weng,David B. Miklos,Matthew J. Frank,John S. Tamaresis,Vaibhav Agrawal,Sushma Bharadwaj,Surbhi Sidana,Judith A. Shizuru,Nathaniel B. Fernhoff,Amy Putnam,Scott Killian,Bryan J. Xie,Robert S. Negrin,Everett H. Meyer

View Articletitled, Single-center randomized trial of T-reg graft alone vs T-reg graft plus tacrolimus for the prevention of acute GVHD

Supplemental data

Durable immunity to EBV after rituximab and third-party LMP-specific T cells: a Children’s Oncology Group study
Clinical Trials & Observations

Birte Wistinghausen,Keri Toner,Donald A. Barkauskas,Lauren P Jerkins,Hannah Kinoshita,Pamela Chansky,Gloria Pezzella,Lauren Saguilig,Robert J. Hayashi,Harshal Abhyankar,Brooks Scull,Vivekanudeep Karri,Jay Tanna,Patrick Hanley,Michelle L. Hermiston,Carl E. Allen,Catherine M. Bollard

View Articletitled, Durable immunity to EBV after rituximab and third-party LMP-specific T cells: a Children’s Oncology Group study

Supplemental data

A robust and validated integrated prognostic index for defining risk groups in adult acute lymphoblastic leukemia: an EWALL collaborative study
Clinical Trials & Observations

Amir Enshaei,Melvin Joy,Ellie Butler,Amy A. Kirkwood,Monica Messina,Chiara Pavoni,Mireia Morgades,Christine J. Harrison,Robin Foà,Josep-Maria Ribera,Sabina Chiaretti,Renato Bassan,Adele K. Fielding,Anthony V. Moorman

View Articletitled, A robust and validated integrated prognostic index for defining risk groups in adult acute lymphoblastic leukemia: an EWALL collaborative study

Supplemental data

Pediatric transplant–associated thrombotic microangiopathy health care utilization and implications of eculizumab therapy
Clinical Trials & Observations

Michelle L. Schoettler,Leslie Lehmann,Pei-Chi Kao,Nan Chen,Sonata Jodele,Satheesh Chonat,Kirsten M. Williams,Wendy B. London,Christine Duncan,Christopher Dandoy

View Articletitled, Pediatric transplant–associated thrombotic microangiopathy health care utilization and implications of eculizumab therapy

Supplemental data

The intrinsic coagulation pathway plays a dominant role in driving hypercoagulability in ANCA-associated vasculitis
Clinical Trials & Observations

Matthias H. Busch,Renée Ysermans,Joop P. Aendekerk,Sjoerd A. M. E. G. Timmermans,Judith Potjewijd,Jan G. M. C. Damoiseaux,Henri M. H. Spronk,Hugo ten Cate,Chris P. Reutelingsperger,Magdolna Nagy,Pieter van Paassen

View Articletitled, The intrinsic coagulation pathway plays a dominant role in driving hypercoagulability in ANCA-associated vasculitis

Supplemental data

HEALTH SERVICES AND OUTCOMES

Burden of employment loss and absenteeism in adults and caregivers of children with sickle cell disease

Rachel D’Amico Gordon,Rina Li Welkie,Nives Quaye,Jane S. Hankins,Adetola A. Kassim,Alexis A. Thompson,Marsha Treadwell,Chyongchiou J. Lin,Robert M. Cronin

View Articletitled, Burden of employment loss and absenteeism in adults and caregivers of children with sickle cell disease

Supplemental data

Advanced practice providers in hematology: actionable findings from national paired APP and physician surveys

Ariela L. Marshall,Leah E. Masselink,Peter A. Kouides,Faith E. Davies,Azam Farooqui,Srikanth Nagalla,Alex Herrera,Nicole Mortier,Robert Brodsky,Clese E. Erikson

View Articletitled, Advanced practice providers in hematology: actionable findings from national paired APP and physician surveys

Supplemental data

Defining the impact of immune tolerance induction on clinically relevant outcomes in a US cohort of severe hemophilia A

Christine L. Kempton,Stacey A. Fedewa

View Articletitled, Defining the impact of immune tolerance induction on clinically relevant outcomes in a US cohort of severe hemophilia A

Supplemental data

Health care costs among patients with hematologic malignancies receiving allogeneic transplants: a US payer perspective

Richard T. Maziarz,Usama Gergis,Marie Louise Edwards,Yan Song,Qing Liu,Annika Anderson,James Signorovitch,Rocio Manghani,Ronit Simantov,Heayoung Shin,Smitha Sivaraman

View Articletitled, Health care costs among patients with hematologic malignancies receiving allogeneic transplants: a US payer perspective

Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Distinct peripheral T-cell and NK-cell profiles in HGBL-MYC/BCL2 vs patients with DLBCL NOS

A. Vera de Jonge,Carolien Duetz,Wassilis S. C. Bruins,Charlotte L. B. M. Korst,Rosa Rentenaar,Meliha Cosovic,Merve Eken,Inoka Twickler,Marcel Nijland,Marjolein W. M. van der Poel,Koen de Heer,Clara P. W. Klerk,Leonie Strobbe,Margriet Oosterveld,Rinske Boersma,Harry R. Koene,Margaretha G. M. Roemer,Erik van Werkhoven,Martine E. D. Chamuleau,Tuna Mutis

View Articletitled, Distinct peripheral T-cell and NK-cell profiles in HGBL-MYC/BCL2 vs patients with DLBCL NOS

Supplemental data

LYMPHOID NEOPLASIA

An inducible Cd79b mutation confers ibrutinib sensitivity in mouse models of Myd88-driven diffuse large B-cell lymphoma

Ruth Flümann,Julia Hansen,Jörn Meinel,Pauline Pfeiffer,Hannah Goldfarb Wittkopf,Anna Lütz,Jessica Wirtz,Michael Möllmann,Tanja Zhou,Areya Tabatabai,Tim Lohmann,Maximilian Jauch,Filippo Beleggia,Benedikt Pelzer,Fabian Ullrich,Svenja Höfmann,Aastha Arora,Thorsten Persigehl,Reinhard Büttner,Bastian von Tresckow,Sebastian Klein,Ron D. Jachimowicz,Hans Christian Reinhardt,Gero Knittel

View Articletitled, An inducible Cd79b mutation confers ibrutinib sensitivity in mouse models of Myd88-driven diffuse large B-cell lymphoma

Supplemental data

ZAP-70 augments tonic B-cell receptor and CCR7 signaling in IGHV–unmutated chronic lymphocytic leukemia

Jingyu Chen,Vijitha Sathiaseelan,Chandra Sekkar Reddy Chilamakuri,Valar Nila Roamio Franklin,Constanze A. Jakwerth,Clive D’Santos,Ingo Ringshausen

View Articletitled, ZAP-70 augments tonic B-cell receptor and CCR7 signaling in IGHV–unmutated chronic lymphocytic leukemia

Supplemental data

Ibrutinib as first-line therapy for mantle cell lymphoma: a multicenter, real-world UK study
Clinical Trials & Observations

Ann Tivey,Rohan Shotton,Toby A. Eyre,David Lewis,Louise Stanton,Rebecca Allchin,Harriet Walter,Fiona Miall,Rui Zhao,Anna Santarsieri,Rory McCulloch,Mark Bishton,Amy Beech,Victoria Willimott,Nicole Fowler,Claudia Bedford,Jack Goddard,Sam Protheroe,Angharad Everden,David Tucker,Josh Wright,Vasavi Dukka,Miriam Reeve,Shankara Paneesha,Mahesh Prahladan,Andrew Hodson,Iman Qureshi,Manasvi Koppana,Mary Owen,Kushani Ediriwickrema,Helen Marr,Jamie Wilson,Jonathan Lambert,David Wrench,Claire Burney,Chloe Knott,Georgina Talbot,Adam Gibb,Angela Lord,Barry Jackson,Simon Stern,Taylor Sutton,Amy Webb,Marketa Wilson,Nicky Thomas,Jane Norman,Elizabeth Davies,Lisa Lowry,Jamie Maddox,Neil Phillips,Nicola Crosbie,Marcin Flont,Emma Nga,Andres Virchis,Raisa Guerrero Camacho,Wunna Swe,Arvind Pillai,Clare Rees,James Bailey,Steve Jones,Susan Smith,Faye Sharpley,Catherine Hildyard,Sajir Mohamedbhai,Toby Nicholson,Simon Moule,Anshuman Chaturvedi,Kim Linton

View Articletitled, Ibrutinib as first-line therapy for mantle cell lymphoma: a multicenter, real-world UK study

Supplemental data

Patterns of progression after immune checkpoint inhibitors for Hodgkin lymphoma: implications for radiation therapy

Jessica F. Burlile,Kelsey M. Frechette,William G. Breen,Steven R. Hwang,Alexandra S. Higgins,Adrienne N. Nedved,William S. Harmsen,Sydney D. Pulsipher,Thomas E. Witzig,Ivana N. Micallef,Bradford S. Hoppe,Thomas M. Habermann,Gita Thanarajasingam,Patrick B. Johnston,David J. Inwards,N. Nora Bennani,Jennifer L. Peterson,Bradley J. Stish,William G. Rule,Stephen M. Ansell,Scott C. Lester

View Articletitled, Patterns of progression after immune checkpoint inhibitors for Hodgkin lymphoma: implications for radiation therapy

Supplemental data

RNA-seq–based miRNA signature as an independent predictor of relapse in pediatric B-cell acute lymphoblastic leukemia

Hirohito Kubota,Hiroo Ueno,Keiji Tasaka,Tomoya Isobe,Satoshi Saida,Itaru Kato,Katsutsugu Umeda,Mitsuteru Hiwatari,Daiichiro Hasegawa,Toshihiko Imamura,Nobuyuki Kakiuchi,Yasuhito Nannya,Seishi Ogawa,Hidefumi Hiramatsu,Junko Takita

View Articletitled, RNA-seq–based miRNA signature as an independent predictor of relapse in pediatric B-cell acute lymphoblastic leukemia

Supplemental data

Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion

Caterina Tretti Parenzan,Anna Dal Molin,Giorgia Longo,Enrico Gaffo,Alessia Buratin,Alice Cani,Elena Boldrin,Valentina Serafin,Paola Guglielmelli,Alessandro M. Vannucchi,Giovanni Cazzaniga,Andrea Biondi,Franco Locatelli,Lueder H. Meyer,Barbara Buldini,Geertruij te Kronnie,Silvia Bresolin,Stefania Bortoluzzi

View Articletitled, Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion

Supplemental data

MYELOID NEOPLASIA

Mutations highly specific for secondary AML are associated with poor outcomes in ELN favorable risk NPM1-mutated AML

Onyee Chan,Najla Al Ali,Hammad Tashkandi,Austin Ellis,Somedeb Ball,Justin Grenet,Caroline Hana,Yehuda Deutsch,Ling Zhang,Mohammad Hussaini,Jinming Song,Seongseok Yun,Chetasi Talati,Andrew Kuykendall,Eric Padron,Alison Walker,Gail Roboz,Pinkal Desai,David Sallman,Kendra Sweet,Rami Komrokji,Jeffrey Lancet

View Articletitled, Mutations highly specific for secondary AML are associated with poor outcomes in ELN favorable risk NPM1-mutated AML

IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells

Shivam Rai,Yang Zhang,Elodie Grockowiak,Quentin Kimmerlin,Nils Hansen,Cedric B. Stoll,Marc Usart,Damien Luque Paz,Hui Hao-Shen,Yexuan Zhu,Julien Roux,Michael S. Bader,Stefan Dirnhofer,Christopher J. Farady,Timm Schroeder,Simón Méndez-Ferrer,Radek C. Skoda

View Articletitled, IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells

Supplemental data

Outcomes of intensive and nonintensive blast-reduction strategies in accelerated and blast-phase MPN

Marta B. Davidson,James A. Kennedy,Jose-Mario Capo-Chichi,Yuliang Shi,Wei Xu,Verna Cheung,Andrea Arruda,Aniket Bankar,Guillaume Richard-Carpentier,Steven Chan,Dawn Maze,Mark D. Minden,Aaron D. Schimmer,Andre C. Schuh,Hassan Sibai,Karen Yee,Anne Tierens,Auro Viswabandya,Vikas Gupta

View Articletitled, Outcomes of intensive and nonintensive blast-reduction strategies in accelerated and blast-phase MPN

Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Recombinant erythropoietin in autoimmune hemolytic anemia with inadequate bone marrow response: a prospective analysis
Clinical Trials & Observations

Bruno Fattizzo,Giacinto Luca Pedone,Caterina Brambilla,Loredana Pettine,Anna Zaninoni,Francesco Passamonti,Wilma Barcellini

View Articletitled, Recombinant erythropoietin in autoimmune hemolytic anemia with inadequate bone marrow response: a prospective analysis

Supplemental data

Add-on erythropoietin in autoimmune hemolytic anemia
Clinical Trials & Observations

Miriam M. Moser,Bernd Jilma

View Articletitled, Add-on erythropoietin in autoimmune hemolytic anemia

THROMBOSIS AND HEMOSTASIS

Effectiveness and safety of prophylactic anticoagulation among hospitalized patients with inflammatory bowel disease

Ghadeer K. Dawwas,Adam Cuker,Douglas E. Schaubel,James D. Lewis

View Articletitled, Effectiveness and safety of prophylactic anticoagulation among hospitalized patients with inflammatory bowel disease

Supplemental data

TRANSPLANTATION

Differential clinical impact of letermovir prophylaxis according to graft sources: a KSGCT multicenter retrospective analysis

Takashi Toya,Kota Mizuno,Masatoshi Sakurai,Jun Kato,Takehiko Mori,Noriko Doki,Shinichi Masuda,Nobuyuki Aotsuka,Shokichi Tsukamoto,Emiko Sakaida,Yuki Nakajima,Shin Fujisawa,Shinichiro Machida,Yasuyuki Aoyama,Hiroki Yokoyama,Katsuhiro Shono,Yoshihiro Hatta,Kensuke Usuki,Keisuke Kataoka,Yoshinobu Kanda

View Articletitled, Differential clinical impact of letermovir prophylaxis according to graft sources: a KSGCT multicenter retrospective analysis

Supplemental data

Incidence and risk factors of early onset VOD/SOS differ in younger vs older adults after stem cell transplantation

Curtis Marcoux,Rima M. Saliba,Whitney Wallis,Sajad Khazal,Dristhi Ragoonanan,Gabriela Rondon,Priti Tewari,Uday Popat,Betul Oran,Amanda Olson,Qaiser Bashir,Muzaffar Qazilbash,Amin Alousi,Chitra Hosing,Yago Nieto,Gheath Alatrash,David Marin,Katayoun Rezvani,Issa Khouri,Samer Srour,Richard Champlin,Elizabeth Shpall,Partow Kebriaei

View Articletitled, Incidence and risk factors of early onset VOD/SOS differ in younger vs older adults after stem cell transplantation

Supplemental data

VASCULAR BIOLOGY

Improving stroke outcomes in hyperglycemic mice by modulating tPA/NMDAR signaling to reduce inflammation and hemorrhages

Florent Lebrun,Damien Levard,Eloïse Lemarchand,Mervé Yetim,Jonathane Furon,Fanny Potzeha,Pauline Marie,Flavie Lesept,Manuel Blanc,Benoit Haelewyn,Marina Rubio,Annelise Letourneur,Nicolas Violle,Cyrille Orset,Denis Vivien

View Articletitled, Improving stroke outcomes in hyperglycemic mice by modulating tPA/NMDAR signaling to reduce inflammation and hemorrhages

Supplemental data

A sweet deal: blocking NMDAR for safer t-PA in diabetes

Frederik Denorme

View Articletitled, A sweet deal: blocking NMDAR for safer t-PA in diabetes

RESEARCH LETTERS

Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes

B. Bishal Paudel,Su-Fern Tan,Todd E. Fox,Johnson Ung,Upendarrao Golla,Jeremy J. P. Shaw,Wendy Dunton,Irene Lee,Wisam A. Fares,Satyam Patel,Arati Sharma,Aaron D. Viny,Brian M. Barth,Martin S. Tallman,Myles Cabot,Francine E. Garrett-Bakelman,Ross L. Levine,Mark Kester,David J. Feith,David Claxton,Kevin A. Janes,Thomas P. Loughran, Jr.

View Articletitled, Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes

Supplemental data

Association between hemoglobin values and VWF assays: a multicenter investigation

Jillian Simoneau,Cindy Tay,Allison Wheeler,Lauren Amos,Meghan McCormick,Yonairy Collado,Megan Brown,Angela C. Weyand

View Articletitled, Association between hemoglobin values and VWF assays: a multicenter investigation

ERRATUM

Wu J, Moriwaki K, Asuka T, et al. EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts. Blood Adv. 2023;7(14):3382–3394.

View Articletitled, Wu J, Moriwaki K, Asuka T, et al. EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts. Blood Adv. 2023;7(14):3382–3394.

Cover Image

Cover Image

Proximity ligation assays (PLAs) were deployed to detect the colocalization of the toll-like receptor adaptor protein myeloid differentiation primary response 88 (MYD88) and Bruton’s tyrosine kinase. The PLAs were performed on formalin-fixed paraffin-embedded tissue sections derived from murine lymphomas isolated from Cd19^Cre/wt;Myd88^{c.-p.L252P/wt}; Rosa26^{LSL.BCL2.IRES.GFP/wt};Prdm1^fl/fl;Cd79b^{c.-p.Y195H/wt} mice that were treated with ibrutinib (30 mg/kg orally daily for 3 days) prior to lymphoma isolation. PLA foci are visualized in yellow, and the B-cell–specific antigen B220 (violet) was used to determine cell numbers. See the article by Flümann et al.

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Issue Archive

Table of Contents

INSIDE BLOOD ADVANCES

Add-on erythropoietin in autoimmune hemolytic anemia Clinical Trials & Observations

CLINICAL TRIALS AND OBSERVATIONS

Single-center randomized trial of T-reg graft alone vs T-reg graft plus tacrolimus for the prevention of acute GVHD Clinical Trials & Observations

Durable immunity to EBV after rituximab and third-party LMP-specific T cells: a Children’s Oncology Group study Clinical Trials & Observations

A robust and validated integrated prognostic index for defining risk groups in adult acute lymphoblastic leukemia: an EWALL collaborative study Clinical Trials & Observations

Pediatric transplant–associated thrombotic microangiopathy health care utilization and implications of eculizumab therapy Clinical Trials & Observations

The intrinsic coagulation pathway plays a dominant role in driving hypercoagulability in ANCA-associated vasculitis Clinical Trials & Observations

HEALTH SERVICES AND OUTCOMES

IMMUNOBIOLOGY AND IMMUNOTHERAPY

LYMPHOID NEOPLASIA

Ibrutinib as first-line therapy for mantle cell lymphoma: a multicenter, real-world UK study Clinical Trials & Observations

MYELOID NEOPLASIA

RED CELLS, IRON, AND ERYTHROPOIESIS

Recombinant erythropoietin in autoimmune hemolytic anemia with inadequate bone marrow response: a prospective analysis Clinical Trials & Observations

Add-on erythropoietin in autoimmune hemolytic anemia Clinical Trials & Observations

THROMBOSIS AND HEMOSTASIS

TRANSPLANTATION

VASCULAR BIOLOGY

RESEARCH LETTERS

ERRATUM

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ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Add-on erythropoietin in autoimmune hemolytic anemia
Clinical Trials & Observations

Single-center randomized trial of T-reg graft alone vs T-reg graft plus tacrolimus for the prevention of acute GVHD
Clinical Trials & Observations

Durable immunity to EBV after rituximab and third-party LMP-specific T cells: a Children’s Oncology Group study
Clinical Trials & Observations

A robust and validated integrated prognostic index for defining risk groups in adult acute lymphoblastic leukemia: an EWALL collaborative study
Clinical Trials & Observations

Pediatric transplant–associated thrombotic microangiopathy health care utilization and implications of eculizumab therapy
Clinical Trials & Observations

The intrinsic coagulation pathway plays a dominant role in driving hypercoagulability in ANCA-associated vasculitis
Clinical Trials & Observations

Ibrutinib as first-line therapy for mantle cell lymphoma: a multicenter, real-world UK study
Clinical Trials & Observations

Recombinant erythropoietin in autoimmune hemolytic anemia with inadequate bone marrow response: a prospective analysis
Clinical Trials & Observations

Add-on erythropoietin in autoimmune hemolytic anemia
Clinical Trials & Observations