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Issue Archive

Volume 5, Issue 16
August 24 2021
Issue Cover

Table of Contents

EXCEPTIONAL CASE REPORT

B-cell acute lymphoblastic leukemia in patients with germline RUNX1 mutations
Clinical Trials & Observations
Kathryn A. Six,Ulrike Gerdemann,Anna L. Brown,Andrew E. Place,Alan B. Cantor,Matthew A. Kutny,Serine Avagyan
View Articletitled, B-cell acute lymphoblastic leukemia in patients with germline <em>RUNX1</em> mutations

STIMULUS REPORTS

Delayed-onset cytomegalovirus infection is frequent after discontinuing letermovir in cord blood transplant recipients
Clinical Trials & Observations
Joshua A. Hill,Danniel Zamora,Hu Xie,Laurel A. Thur,Colleen Delaney,Ann Dahlberg,Steven A. Pergam,Wendy M. Leisenring,Michael Boeckh,Filippo Milano
View Articletitled, Delayed-onset cytomegalovirus infection is frequent after discontinuing letermovir in cord blood transplant recipients
Supplemental data
Concordance of peripheral blood and bone marrow measurable residual disease in adult acute lymphoblastic leukemia
Clinical Trials & Observations
Lori Muffly,Vandana Sundaram,Connie Chen,Ilana Yurkiewicz,Eric Kuo,Sarah Burnash,Jay Y. Spiegel,Sally Arai,Matthew J. Frank,Laura J. Johnston,Robert Lowsky,Everett H. Meyer,Robert S. Negrin,Andrew R. Rezvani,Surbhi Sidana,Parveen Shiraz,Judith A. Shizuru,Wen-Kai Weng,Michaela Liedtke,Hyma T. Vempaty,David B. Miklos
View Articletitled, Concordance of peripheral blood and bone marrow measurable residual disease in adult acute lymphoblastic leukemia
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with B-cell non-Hodgkin lymphoma
Clinical Trials & Observations
C. Perry,E. Luttwak,R. Balaban,G. Shefer,M. M. Morales,A. Aharon,Y. Tabib,Y. C. Cohen,N. Benyamini,O. Beyar-Katz,M. Neaman,R. Vitkon,N. Keren-Khadmy,M. Levin,Y. Herishanu,I. Avivi
View Articletitled, Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with B-cell non-Hodgkin lymphoma
Final results of a phase 2 clinical trial of LCL161, an oral SMAC mimetic for patients with myelofibrosis
Clinical Trials & Observations
Naveen Pemmaraju,Bing Z. Carter,Prithviraj Bose,Nitin Jain,Tapan M. Kadia,Guillermo Garcia-Manero,Carlos E. Bueso-Ramos,Courtney D. DiNardo,Sharon Bledsoe,Naval G. Daver,Uday Popat,Marina Y. Konopleva,Lingsha Zhou,Sherry Pierce,Zeev E. Estrov,Gautam M. Borthakur,Maro Ohanian,Wei Qiao,Lucia Masarova,Xuemei Wang,Po Yee Mak,Jorge Cortes,Elias Jabbour,Srdan Verstovsek
View Articletitled, Final results of a phase 2 clinical trial of LCL161, an oral SMAC mimetic for patients with myelofibrosis

GENE THERAPY

Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency
Matteo Zoccolillo,Immacolata Brigida,Federica Barzaghi,Serena Scala,Raisa Jofra Hernández,Luca Basso-Ricci,Mariasilvia Colantuoni,Emanuela Pettinato,Lucia Sergi Sergi,Giulia Milardi,Paola Capasso,Angelo Lombardo,Silvia Gregori,Francesca Sanvito,Francesca Schena,Simone Cesaro,Francesca Conti,Andrea Pession,Fabio Benedetti,Marco Gattorno,Pui Y. Lee,Luigi Naldini,Maria Pia Cicalese,Alessandro Aiuti,Alessandra Mortellaro
View Articletitled, Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis
Derek C. H. Chan,Joshua Xu,Ana Vujovic,Nicholas Wong,Victor Gordon,Laura P. M. H. de Rooij,Steven Moreira,Cailin E. Joyce,Jose La Rose,María-José Sandí,Bradley W. Doble,Carl D. Novina,Robert K. Rottapel,Kristin J. Hope
View Articletitled, Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis
Supplemental data
The predictive value of PNH clones, 6p CN-LOH, and clonal TCR gene rearrangement for aplastic anemia diagnosis
Yash B. Shah,Salvatore F. Priore,Yimei Li,Chi N. Tang,Peter Nicholas,Peter Kurre,Timothy S. Olson,Daria V. Babushok
View Articletitled, The predictive value of PNH clones, 6p CN-LOH, and clonal TCR gene rearrangement for aplastic anemia diagnosis
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection
Chiara Pantarelli,Dingxin Pan,Stephen Chetwynd,Anne-Katrien Stark,Kirsti Hornigold,Polly Machin,Laraine Crossland,Simon J. Cleary,Martin J. Baker,Elizabeth Hampson,Anna Mandel,Anne Segonds-Pichon,Rachael Walker,Cornelis van ’t Veer,Yanira Riffo-Vasquez,Klaus Okkenhaug,Simon Pitchford,Heidi C.E. Welch
View Articletitled, The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection
Supplemental data
The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1+ leukemia
Eileen Y. Hu,Priscilla Do,Swagata Goswami,Jessica Nunes,Chi-ling Chiang,Sara Elgamal,Ann M. Ventura,Carolyn Cheney,Kevan Zapolnik,Erich Williams,Rajeswaran Mani,Frank Frissora,Xiaokui Mo,Lorenz Waldmeier,Roger R. Beerli,Haiyong Peng,Christoph Rader,Meixiao Long,Ulf Grawunder,John C. Byrd,Natarajan Muthusamy
View Articletitled, The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1<sup>+</sup> leukemia
Supplemental data

LYMPHOID NEOPLASIA

Development and characterization of prototypes for in vitro and in vivo mouse models of ibrutinib-resistant CLL
Burcu Aslan,Gorkem Kismali,Lisa S. Chen,LaKesla R. Iles,Mikhila Mahendra,Michael Peoples,Mihai Gagea,Natalie W. Fowlkes,Xiaofeng Zheng,Jing Wang,Christopher P. Vellano,Joseph R. Marszalek,Maria Teresa Sabrina Bertilaccio,Varsha Gandhi
View Articletitled, Development and characterization of prototypes for in vitro and in vivo mouse models of ibrutinib-resistant CLL
Supplemental data
Validation of the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders
James Peter Stewart,Jana Gazdova,Nikos Darzentas,Dörte Wren,Paula Proszek,Grazia Fazio,Simona Songia,Miguel Alcoceba,Maria Eugenia Sarasquete,Patrick Villarese,Michèle Y. van der Klift,Kim C. Heezen,Neil McCafferty,Karol Pal,Mark Catherwood,Chang Sik Kim,Shambhavi Srivastava,Leonie I. Kroeze,Elizabeth Hodges,Kostas Stamatopoulos,Wolfram Klapper,Elisa Genuardi,Simone Ferrero,Michiel van den Brand,Giovanni Cazzaniga,Frederic Davi,Lesley-Ann Sutton,Ramon Garcia-Sanz,Patricia J. T. A. Groenen,Elizabeth A. Macintyre,Monika Brüggemann,Christiane Pott,Anton W. Langerak,David Gonzalez,on behalf of the EuroClonality-NGS Working Group
View Articletitled, Validation of the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders
Supplemental data
Clinicopathological features and survival in EBV-positive diffuse large B-cell lymphoma not otherwise specified
Clinical Trials & Observations
Estelle Bourbon,Delphine Maucort-Boulch,Juliette Fontaine,Claire Mauduit,Pierre Sesques,Violaine Safar,Emmanuelle Ferrant,Camille Golfier,Dana Ghergus,Lionel Karlin,Anne Lazareth,Fadhela Bouafia,Gian Matteo Pica,Frédérique Orsini-Piocelle,Clément Rocher,François-Xavier Gros,Marie Parrens,Arthur Dony,Cédric Rossi,Hervé Ghesquières,Emmanuel Bachy,Alexandra Traverse-Glehen,Clémentine Sarkozy
View Articletitled, Clinicopathological features and survival in EBV-positive diffuse large B-cell lymphoma not otherwise specified
Supplemental data

MYELOID NEOPLASIA

A predictive algorithm using clinical and laboratory parameters may assist in ruling out and in diagnosing MDS
Howard S. Oster,Simon Crouch,Alexandra Smith,Ge Yu,Bander Abu Shrkihe,Shoham Baruch,Albert Kolomansky,Jonathan Ben-Ezra,Shachar Naor,Pierre Fenaux,Argiris Symeonidis,Reinhard Stauder,Jaroslav Cermak,Guillermo Sanz,Eva Hellström-Lindberg,Luca Malcovati,Saskia Langemeijer,Ulrich Germing,Mette Skov Holm,Krzysztof Madry,Agnes Guerci-Bresler,Dominic Culligan,Laurence Sanhes,Juliet Mills,Ioannis Kotsianidis,Corine van Marrewijk,David Bowen,Theo de Witte,Moshe Mittelman
View Articletitled, A predictive algorithm using clinical and laboratory parameters may assist in ruling out and in diagnosing MDS
Benign and malignant hematologic manifestations in patients with VEXAS syndrome due to somatic mutations in UBA1
Clinical Trials & Observations
Ifeyinwa Emmanuela Obiorah,Bhavisha A. Patel,Emma M. Groarke,Weixin Wang,Megan Trick,Amanda K. Ombrello,Marcela A. Ferrada,Zhijie Wu,Fernanda Gutierrez-Rodrigues,Jennifer Lotter,Lorena Wilson,Patrycja Hoffmann,Daniela Ospina Cardona,Nisha Patel,Alina Dulau-Florea,Daniel L. Kastner,Peter C. Grayson,David B. Beck,Neal S. Young,Katherine R. Calvo
View Articletitled, Benign and malignant hematologic manifestations in patients with VEXAS syndrome due to somatic mutations in <em>UBA1</em>
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications
Clinical Trials & Observations
Marta Lopes,Tiago L. Duarte,Maria J. Teles,Laura Mosteo,Sérgio Chacim,Eliana Aguiar,Joana Pereira-Reis,Mónica Oliveira,André M. N. Silva,Nuno Gonçalves,Gabriela Martins,Isabella Y. Kong,Magnus Zethoven,Stephin Vervoort,Sandra Martins,Miguel Quintela,Edwin D Hawkins,Fernanda Trigo,João T. Guimarães,José M. Mariz,Graça Porto,Delfim Duarte
View Articletitled, Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications
Supplemental data

TRANSPLANTATION

Long-term effect of hematopoietic cell transplantation on systemic inflammation in patients with mucopolysaccharidoses
Brigitte T.A. van den Broek,Caroline A. Lindemans,Jaap Jan Boelens,Eveline M. Delemarre,Julia Drylewicz,Nanda Verhoeven-Duif,Peter M. van Hasselt,Stefan Nierkens
View Articletitled, Long-term effect of hematopoietic cell transplantation on systemic inflammation in patients with mucopolysaccharidoses
Supplemental data

COMMENTARY

Activity of mRNA COVID-19 vaccines in patients with lymphoid malignancies
Clinical Trials & Observations
Jennifer L. Crombie,Amy C. Sherman,Chi-An Cheng,Christine E. Ryan,Rebecca Zon,Michaël Desjardins,Peter Baker,Mikaela McDonough,Natalie Izaguirre,Bruce Bausk,Jonathan Krauss,Tal Gilboa,Yasmeen Senussi,David R. Walt,Matthew S. Davids,Jennifer R. Brown,Philippe Armand,Lindsey R. Baden,Nicolas Issa
View Articletitled, Activity of mRNA COVID-19 vaccines in patients with lymphoid malignancies
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