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Issue Archive

Volume 4, Issue 7
April 14 2020
Issue Cover

Table of Contents

BLOOD ADVANCES TALK

Access to specialized care and outcomes in adults with acute leukemias
Lori Muffly,Vijaya R. Bhatt
View Articletitled, Access to specialized care and outcomes in adults with acute leukemias
Supplemental data

EXCEPTIONAL CASE REPORTS

Targeting EZH2 for the treatment of hepatosplenic T-cell lymphoma
Clinical Trials & Observations
Yana Pikman,Amy Saur Conway,Amanda L. Robichaud,Samuel Kitara,Alanna J. Church,Alyssa L. Kennedy,Lewis B. Silverman,Amy L. Billett,David M. Weinstock,Marian H. Harris,Kimberly Stegmaier
View Articletitled, Targeting EZH2 for the treatment of hepatosplenic T-cell lymphoma
First case of COVID-19 in a patient with multiple myeloma successfully treated with tocilizumab
Clinical Trials & Observations Global Advances
Xuhan Zhang,Kaidi Song,Fei Tong,Mingming Fei,Hui Guo,Zhaohui Lu,Jinquan Wang,Changcheng Zheng
View Articletitled, First case of COVID-19 in a patient with multiple myeloma successfully treated with tocilizumab
Daratumumab in light chain deposition disease: rapid and profound hematologic response preserves kidney function
Clinical Trials & Observations
Paolo Milani,Marco Basset,Paola Curci,Andrea Foli,Rita Rizzi,Mario Nuvolone,Raffaella Guido,Loreto Gesualdo,Giorgina Specchia,Giampaolo Merlini,Giovanni Palladini
View Articletitled, Daratumumab in light chain deposition disease: rapid and profound hematologic response preserves kidney function
Supplemental data
Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes
Clinical Trials & Observations
Caitlin Ritz,Wenzhao Meng,Natasha L. Stanley,Miren L. Baroja,Chong Xu,Patrick Yan,Alexander C. Huang,Ryan Hausler,Peter Nicholas,Jian-Meng Fan,David Lieberman,Beatriz M. Carreno,Eline T. Luning Prak,Timothy S. Olson,Daria V. Babushok
View Articletitled, Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8<sup>+</sup> lymphocytes
Supplemental data
Efficacy of ruxolitinib in subcutaneous panniculitis-like T-cell lymphoma and hemophagocytic lymphohistiocytosis
Clinical Trials & Observations
Romain Lévy,Mathieu Fusaro,Frédéric Guerin,Ahmed Chetouani,Despina Moshous,Alain Fischer,Geneviève de Saint Basile,Fernando E. Sepulveda,Bénédicte Neven
View Articletitled, Efficacy of ruxolitinib in subcutaneous panniculitis-like T-cell lymphoma and hemophagocytic lymphohistiocytosis

STIMULUS REPORT

The K666N mutation in SF3B1 is associated with increased progression of MDS and distinct RNA splicing
W. Brian Dalton,Eric Helmenstine,Lisa Pieterse,Bing Li,Christopher D. Gocke,Joshua Donaldson,Zhijian Xiao,Lukasz P. Gondek,Gabriel Ghiaur,Ivana Gojo,B. Douglas Smith,Mark J. Levis,Amy E. DeZern
View Articletitled, The K666N mutation in SF3B1 is associated with increased progression of MDS and distinct RNA splicing
Supplemental data

SYSTEMATIC REVIEWS

Diagnosis of deep vein thrombosis of the lower extremity: a systematic review and meta-analysis of test accuracy
Meha Bhatt,Cody Braun,Payal Patel,Parth Patel,Housne Begum,Wojtek Wiercioch,Jamie Varghese,David Wooldridge,Hani J. Alturkmani,Merrill Thomas,Mariam Baig,Waled Bahaj,Rasha Khatib,Rohan Kehar,Rakesh Ponnapureddy,Anchal Sethi,Ahmad Mustafa,Robby Nieuwlaat,Wendy Lim,Shannon M. Bates,Eddy Lang,Grégoire Le Gal,Marc Righini,Nedaa M. Husainat,Mohamad A. Kalot,Yazan Nayif Al Jabiri,Holger J. Schünemann,Reem A. Mustafa
View Articletitled, Diagnosis of deep vein thrombosis of the lower extremity: a systematic review and meta-analysis of test accuracy
Supplemental data
DOACs vs LMWHs in hospitalized medical patients: a systematic review and meta-analysis that informed 2018 ASH guidelines
Ignacio Neumann,Ariel Izcovich,Yuqing Zhang,Gabriel Rada,Susan R. Kahn,Frederick Spencer,Suely Rezende,Franchesco Dentali,Kenneth Bauer,Gian Paolo Morgano,Juan J. Yepes-Nuñez,Robby Nieuwlaat,Wojtek Wiercioch,Liming Lu,Jiaming Wu,Mary Cushman,Holger Schunemann
View Articletitled, DOACs vs LMWHs in hospitalized medical patients: a systematic review and meta-analysis that informed 2018 ASH guidelines
Supplemental data
Thrombolytics for venous thromboembolic events: a systematic review with meta-analysis
Ariel Izcovich,Juan M. Criniti,Federico Popoff,Liming Lu,Jiaming Wu,Walter Ageno,Daniel M. Witt,Michael R. Jaff,Sam Schulman,Veena Manja,Peter Verhamme,Gabriel Rada,Yuqing Zhang,Robby Nieuwlaat,Wojtek Wiercioch,Holger J. Schünemann,Ignacio Neumann
View Articletitled, Thrombolytics for venous thromboembolic events: a systematic review with meta-analysis
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice
Stéphane Chappaz,Charity W. Law,Mark R. Dowling,Kirstyn T. Carey,Rachael M. Lane,Linh H. Ngo,Vihandha O. Wickramasinghe,Gordon K. Smyth,Matthew E. Ritchie,Benjamin T. Kile
View Articletitled, Germline heterozygous mutations in <em>Nxf1</em> perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Dimorphism in the TCRγ-chain repertoire defines 2 types of human immunity to Epstein-Barr virus
Zakia Djaoud,Peter Parham
View Articletitled, Dimorphism in the TCRγ-chain repertoire defines 2 types of human immunity to Epstein-Barr virus
Coexpression of FOXP3 and a Helios isoform enhances the effectiveness of human engineered regulatory T cells
Amara Seng,Kelsey L. Krausz,Dong Pei,Devin C. Koestler,Ryan T. Fischer,Thomas M. Yankee,Mary A. Markiewicz
View Articletitled, Coexpression of FOXP3 and a Helios isoform enhances the effectiveness of human engineered regulatory T cells
Supplemental data
Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing
Samantha L. Smith,Philippa R. Kennedy,Kevin B. Stacey,Jonathan D. Worboys,Annie Yarwood,Seungmae Seo,Everardo Hegewisch Solloa,Brandon Mistretta,Sujash S. Chatterjee,Preethi Gunaratne,Kimaada Allette,Ying-Chih Wang,Melissa Laird Smith,Robert Sebra,Emily M. Mace,Amir Horowitz,Wendy Thomson,Paul Martin,Steve Eyre,Daniel M. Davis
View Articletitled, Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing
Supplemental data
Chimeric antigen receptor–T cells with cytokine neutralizing capacity
Adrian H. J. Tan,Natasha Vinanica,Dario Campana
View Articletitled, Chimeric antigen receptor–T cells with cytokine neutralizing capacity
Supplemental data
Grading and management of cytokine release syndrome in patients treated with tisagenlecleucel in the JULIET trial
Clinical Trials & Observations
Stephen J. Schuster,Richard T. Maziarz,Elisha S. Rusch,Junlong Li,James E. Signorovitch,Vadim V. Romanov,Frederick L. Locke,David G. Maloney
View Articletitled, Grading and management of cytokine release syndrome in patients treated with tisagenlecleucel in the JULIET trial
Supplemental data
Grading of neurological toxicity in patients treated with tisagenlecleucel in the JULIET trial
Clinical Trials & Observations
Richard T. Maziarz,Stephen J. Schuster,Vadim V. Romanov,Elisha S. Rusch,Junlong Li,James E. Signorovitch,David G. Maloney,Frederick L. Locke
View Articletitled, Grading of neurological toxicity in patients treated with tisagenlecleucel in the JULIET trial
Supplemental data
Blinatumomab consolidation and maintenance therapy in adults with relapsed/refractory B-precursor acute lymphoblastic leukemia
Clinical Trials & Observations
Alessandro Rambaldi,Francoise Huguet,Pavel Zak,Paul Cannell,Qui Tran,Janet Franklin,Max S. Topp
View Articletitled, Blinatumomab consolidation and maintenance therapy in adults with relapsed/refractory B-precursor acute lymphoblastic leukemia
Supplemental data
Passively transferred IgG enhances humoral immunity to a red blood cell alloantigen in mice
David R. Gruber,Amanda L. Richards,Heather L. Howie,Ariel M. Hay,Jenna N. Lebedev,Xiaohong Wang,James C. Zimring,Krystalyn E. Hudson
View Articletitled, Passively transferred IgG enhances humoral immunity to a red blood cell alloantigen in mice
Supplemental data

LYMPHOID NEOPLASIA

Checkpoint inhibition before haploidentical transplantation with posttransplant cyclophosphamide in Hodgkin lymphoma
Chiara De Philippis,Faezeh Legrand-Izadifar,Stefania Bramanti,Laura Giordano,Catalina Montes de Oca,Rémy Duléry,Reda Bouabdallah,Angela Granata,Raynier Devillier,Jacopo Mariotti,Barbara Sarina,Samia Harbi,Valerio Maisano,Sabine Furst,Thomas Pagliardini,Pierre-Jean Weiller,Claude Lemarie,Boris Calmels,Christian Chabannon,Armando Santoro,Mohamad Mohty,Didier Blaise,Luca Castagna
View Articletitled, Checkpoint inhibition before haploidentical transplantation with posttransplant cyclophosphamide in Hodgkin lymphoma
Primary vitreoretinal lymphomas display a remarkably restricted immunoglobulin gene repertoire
Nabila Belhouachi,Aliki Xochelli,Myriam Boudjoghra,Claude Lesty,Nathalie Cassoux,Christine Fardeau,Thi Ha Chau Tran,Sylvain Choquet,Bishnu Sarker,Caroline Houillier,Agusti Alentorn,Phuc LeHoang,Carole Soussain,Valerie Touitou,Helene Merle-Beral,Khe Hoang-Xuan,Bahram Bodaghi,Kostas Stamatopoulos,Frederic Davi
View Articletitled, Primary vitreoretinal lymphomas display a remarkably restricted immunoglobulin gene repertoire
Supplemental data
LAG3: a novel immune checkpoint expressed by multiple lymphocyte subsets in diffuse large B-cell lymphoma
Colm Keane,Soi C. Law,Clare Gould,Simone Birch,Muhammed B. Sabdia,Lilia Merida de Long,Gayathri Thillaiyampalam,Emad Abro,Joshua W. Tobin,Xiaohong Tan,Zijun Y. Xu-Monette,Ken H. Young,Grace Gifford,Sara Gabreilli,William S. Stevenson,Anthony Gill,Dipti Talaulikar,Sanjiv Jain,Annette Hernandez,Sarah-Jane Halliday,Robert Bird,Donna Cross,Mark Hertzberg,Maher K. Gandhi
View Articletitled, LAG3: a novel immune checkpoint expressed by multiple lymphocyte subsets in diffuse large B-cell lymphoma
Supplemental data
The Connect CLL Registry: final analysis of 1494 patients with chronic lymphocytic leukemia across 199 US sites
Clinical Trials & Observations
Anthony Mato,Chadi Nabhan,Nicole Lamanna,Neil E. Kay,David L. Grinblatt,Christopher R. Flowers,Charles M. Farber,Matthew S. Davids,Arlene S. Swern,Kristen Sullivan,E. Dawn Flick,Sarah M. Gressett Ussery,Mecide Gharibo,Pavel Kiselev,Jeff P. Sharman
View Articletitled, The Connect CLL Registry: final analysis of 1494 patients with chronic lymphocytic leukemia across 199 US sites
Supplemental data
Pneumocystis jirovecii pneumonia and institutional prophylaxis practices in CLL patients treated with BTK inhibitors
Clinical Trials & Observations
Christine E. Ryan,Matthew P. Cheng,Nicolas C. Issa,Jennifer R. Brown,Matthew S. Davids
View Articletitled, <em>Pneumocystis jirovecii</em> pneumonia and institutional prophylaxis practices in CLL patients treated with BTK inhibitors

MYELOID NEOPLASIA

Targeting CD300f to enhance hematopoietic stem cell transplantation in acute myeloid leukemia
Edward Abadir,Pablo A. Silveira,Robin E. Gasiorowski,Murari Ramesh,Adelina Romano,Ahmed H. Mekkawy,Tsun-Ho Lo,Karieshma Kabani,Sarah Sutherland,Geoffrey A. Pietersz,P. Joy Ho,Christian E. Bryant,Stephen R. Larsen,Georgina J. Clark
View Articletitled, Targeting CD300f to enhance hematopoietic stem cell transplantation in acute myeloid leukemia
Supplemental data
Outcomes of older patients with NPM1-mutated AML: current treatments and the promise of venetoclax-based regimens
Clinical Trials & Observations
Curtis A. Lachowiez,Sanam Loghavi,Tapan M. Kadia,Naval Daver,Gautam Borthakur,Naveen Pemmaraju,Kiran Naqvi,Yesid Alvarado,Musa Yilmaz,Nicholas Short,Maro Ohanian,Sherry R. Pierce,Keyur P. Patel,Wei Qiao,Jing Ning,Koji Sasaki,Koichi Takahashi,Elias Jabbour,Michael Andreeff,Farhad Ravandi,Hagop M. Kantarjian,Marina Konopleva,Courtney D. DiNardo
View Articletitled, Outcomes of older patients with NPM1-mutated AML: current treatments and the promise of venetoclax-based regimens
Supplemental data
Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736
Andrew S. Moore,Amir Faisal,Grace W. Y. Mak,Farideh Miraki-Moud,Vassilios Bavetsias,Melanie Valenti,Gary Box,Albert Hallsworth,Alexis de Haven Brandon,Cristina P. R. Xavier,Randal Stronge,Andrew D. J. Pearson,Julian Blagg,Florence I. Raynaud,Rajesh Chopra,Suzanne A. Eccles,David C. Taussig,Spiros Linardopoulos
View Articletitled, Quizartinib-resistant <em>FLT3</em>-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736
Supplemental data

PLATELETS AND THROMBOPOIESIS

A murine photothrombotic stroke model with an increased fibrin content and improved responses to tPA-lytic treatment
Yu-Yo Sun,Yi-Min Kuo,Hong-Ru Chen,Jonah C. Short-Miller,Marchelle R. Smucker,Chia-Yi Kuan
View Articletitled, A murine photothrombotic stroke model with an increased fibrin content and improved responses to tPA-lytic treatment
Supplemental data
IVMP+IVIG raises platelet counts faster than IVIG alone: results of a randomized, blinded trial in childhood ITP
Clinical Trials & Observations
Manuel Carcao,Mariana Silva,Michele David,Robert J. Klaassen,MacGregor Steele,Victoria Price,Cindy Wakefield,Lussia Kim,Derek Stephens,Victor S. Blanchette
View Articletitled, IVMP+IVIG raises platelet counts faster than IVIG alone: results of a randomized, blinded trial in childhood ITP
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Life expectancy and risk factors for early death in patients with severe thalassemia syndromes in South India
Global Advances
Rakesh Dhanya,Amit Sedai,Kumari Ankita,Lalith Parmar,Rajat Kumar Agarwal,Santhosh Hegde,Gayathri Ramaswami,Ashwini Gowda,S. Girija,Pooja Gujjal,H. Pushpa,J. Dasaratha Ramaiah,Chandrakala Karri,Sujata Jali,Neelavva Rayappa Tallur,U. V. Shenoy,Diana Pinto,Stalin Ramprakash,C. P. Raghuram,Deepa Trivedi,Xueyuan Cao,Lawrence Faulkner
View Articletitled, Life expectancy and risk factors for early death in patients with severe thalassemia syndromes in South India
Comprehensive proteomic analysis of murine terminal erythroid differentiation
Emilie-Fleur Gautier,Marjorie Leduc,Meriem Ladli,Vincent P. Schulz,Carine Lefèvre,Ismael Boussaid,Michaela Fontenay,Catherine Lacombe,Frédérique Verdier,François Guillonneau,Christopher D. Hillyer,Narla Mohandas,Patrick G. Gallagher,Patrick Mayeux
View Articletitled, Comprehensive proteomic analysis of murine terminal erythroid differentiation
Supplemental data
Progression of albuminuria in patients with sickle cell anemia: a multicenter, longitudinal study
Clinical Trials & Observations
Omar Niss,Adam Lane,Monika R. Asnani,Marianne E. Yee,Ashok Raj,Susan Creary,Courtney Fitzhugh,Prasad Bodas,Santosh L. Saraf,Sharada Sarnaik,Prasad Devarajan,Punam Malik
View Articletitled, Progression of albuminuria in patients with sickle cell anemia: a multicenter, longitudinal study
Supplemental data

THROMBOSIS AND HEMOSTASIS

Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation
Christian Valladolid,Marina Martinez-Vargas,Nitin Sekhar,Fong Lam,Cameron Brown,Timothy Palzkill,Alexander Tischer,Mathew Auton,K. Vinod Vijayan,Rolando E. Rumbaut,Trung C. Nguyen,Miguel A. Cruz
View Articletitled, Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation
Supplemental data

TRANSPLANTATION

Late infectious complications in hematopoietic cell transplantation survivors: a population-based study
Aimee M. Foord,Kara L. Cushing-Haugen,Michael J. Boeckh,Paul A. Carpenter,Mary E. D. Flowers,Stephanie J. Lee,Wendy M. Leisenring,Beth A. Mueller,Joshua A. Hill,Eric J. Chow
View Articletitled, Late infectious complications in hematopoietic cell transplantation survivors: a population-based study
Supplemental data
Facilitating resolution of life-threatening acute GVHD with human chorionic gonadotropin and epidermal growth factor
Clinical Trials & Observations
Shernan G. Holtan,Andrea L. Hoeschen,Qing Cao,Mukta Arora,Veronika Bachanova,Claudio G. Brunstein,Jeffrey S. Miller,Armin Rashidi,Arne Slungaard,Celalettin Ustun,Gregory M. Vercellotti,Erica D. Warlick,Brian C. Betts,Najla El Jurdi,Fiona He,Chi Chen,Isha Gandhi,John E. Wagner,Bruce R. Blazar,Pamala Ann Jacobson,Ashraf Shabaneh,Jinhua Wang,Angela Panoskaltsis-Mortari,Margaret L. MacMillan,Daniel J. Weisdorf
View Articletitled, Facilitating resolution of life-threatening acute GVHD with human chorionic gonadotropin and epidermal growth factor
Supplemental data
Idiopathic refractory ascites after allogeneic stem cell transplantation: a previously unrecognized entity
Clinical Trials & Observations
Ankur Varma,Susan C. Abraham,Rohtesh S. Mehta,Neeraj Y. Saini,Medhavi Honhar,Munazza Rashid,Julianne Chen,Samer A. Srour,Qaiser Bashir,Gabriela Rondon,Betul Oran,Chitra M. Hosing,Yago Nieto,Partow Kebriaei,Amin M. Alousi,Sairah Ahmed,David Marin,Issa F. Khouri,Stefan O. Ciurea,Muzaffar H. Qazilbash,Katy Rezvani,Paolo Anderlini,Borje S. Andersson,Elizabeth J. Shpall,Richard E. Champlin,Uday R. Popat
View Articletitled, Idiopathic refractory ascites after allogeneic stem cell transplantation: a previously unrecognized entity
Investigation of donor KIR content and matching in children undergoing hematopoietic cell transplantation for acute leukemia
Clinical Trials & Observations
Michael R. Verneris,Jeffrey S. Miller,Katherine C. Hsu,Tao Wang,Jennifer A. Sees,Sophie Paczesny,Hemalatha Rangarajan,Dean A. Lee,Stephen R. Spellman,Stephanie J. Lee
View Articletitled, Investigation of donor KIR content and matching in children undergoing hematopoietic cell transplantation for acute leukemia

ERRATA

Zhan J, Irudayam MJ, Nakamura Y, Kurita R, Nienhuis AW. High level of fetal-globin reactivation by designed transcriptional activator-like effector. Blood Adv. 2020;4(4):687-695.
View Articletitled, Zhan J, Irudayam MJ, Nakamura Y, Kurita R, Nienhuis AW. High level of fetal-globin reactivation by designed transcriptional activator-like effector. <em>Blood Adv.</em> 2020;4(4):687-695.
Brown LM, Lonsdale A, Zhu A, et al. The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemia. Blood Adv. 2020;4(5):930-942.
View Articletitled, Brown LM, Lonsdale A, Zhu A, et al. The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemia. <em>Blood Adv.</em> 2020;4(5):930-942.
Ediriwickrema A, Aleshin A, Reiter JG, et al. Single-cell mutational profiling enhances the clinical evaluation of AML MRD. Blood Adv. 2020;4(5):943-952.
View Articletitled, Ediriwickrema A, Aleshin A, Reiter JG, et al. Single-cell mutational profiling enhances the clinical evaluation of AML MRD. <em>Blood Adv.</em> 2020;4(5):943-952.
Etxeandia-Ikobaltzeta I, Zhang Y, Brundisini F, et al. Patient values and preferences regarding VTE disease: a systematic review to inform American Society of Hematology guidelines. Blood Adv. 2020;4(5):953-968.
View Articletitled, Etxeandia-Ikobaltzeta I, Zhang Y, Brundisini F, et al. Patient values and preferences regarding VTE disease: a systematic review to inform American Society of Hematology guidelines. <em>Blood Adv.</em> 2020;4(5):953-968.
Pan D, Rampal R, Mascarenhaset J. Clinical developments in epigenetic-directed therapies in acute myeloid leukemia. Blood Adv. 2020;4(5):970-982.
View Articletitled, Pan D, Rampal R, Mascarenhaset J. Clinical developments in epigenetic-directed therapies in acute myeloid leukemia. <em>Blood Adv.</em> 2020;4(5):970-982.
Lee AYY. The changing landscape of anticoagulation in cancer-associated thrombosis. Blood Adv. 2020;4(5):969.
View Articletitled, Lee AYY. The changing landscape of anticoagulation in cancer-associated thrombosis. <em>Blood Adv.</em> 2020;4(5):969.
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Complete absence of GLUT1 does not impair human terminal erythroid differentiation

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