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Issue Archive

Volume 3, Issue 5
March 12 2019
Issue Cover

Table of Contents

EXCEPTIONAL CASE REPORT

Activity of brentuximab vedotin in AIDS-related primary effusion lymphoma
Clinical Trials & Observations
Victoria A. Chang,Huan-You Wang,Erin G. Reid
View Articletitled, Activity of brentuximab vedotin in AIDS-related primary effusion lymphoma

STIMULUS REPORTS

Interleukin-2–inducible T-cell kinase inhibitors modify functional polarization of human peripheral T-cell lymphoma cells
Sami Mamand,Matthew Carr,Rebecca L. Allchin,Matthew J. Ahearne,Simon D. Wagner
View Articletitled, Interleukin-2–inducible T-cell kinase inhibitors modify functional polarization of human peripheral T-cell lymphoma cells
Supplemental data
Pharmacologic control of CAR-T cell function using dasatinib
Evan W. Weber,Rachel C. Lynn,Elena Sotillo,John Lattin,Peng Xu,Crystal L. Mackall
View Articletitled, Pharmacologic control of CAR-T cell function using dasatinib
Supplemental data
Expansion of IL-17A–secreting CD8+ mucosa-associated invariant T cells in peripheral blood following stem cell mobilization
Antiopi Varelias,Kate H. Gartlan,Andrew N. Wilkinson,Stuart D. Olver,Luke D. Samson,Siok-Keen Tey,Kelli P. A. MacDonald,Geoffrey R. Hill

In their Stimulus Report, Varelias et al demonstrate that granulocyte colony-stimulating factor (G-CSF) promotes interleukin-17A secretion by CD8+ mucosa-associated invariant T cells, which have been associated with chronic graft-versus-host disease (GVHD) in other studies. This is an important finding. In the current landscape, mobilization reagents other than G-CSF are available. It is imperative to know which reagent mobilizes the optimal stem cell product for survival, graft-versus-leukemia, and protection from GVHD after transplant.

View Articletitled, Expansion of IL-17A–secreting CD8<sup>+</sup> mucosa-associated invariant T cells in peripheral blood following stem cell mobilization
Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans
Anne Jan van der Meer,Anna Kroeze,Arie J. Hoogendijk,Aicha Ait Soussan,C. Ellen van der Schoot,Walter A. Wuillemin,Carlijn Voermans,Tom van der Poll,Sacha Zeerleder
View Articletitled, Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans
Supplemental data
Tranexamic acid is an active site inhibitor of urokinase plasminogen activator
Guojie Wu,Blake A. Mazzitelli,Adam J. Quek,Matthew J. Veldman,Paul J. Conroy,Tom T. Caradoc-Davies,Lisa M. Ooms,Kellie L. Tuck,Jonathan G. Schoenecker,James C. Whisstock,Ruby H. P. Law
View Articletitled, Tranexamic acid is an active site inhibitor of urokinase plasminogen activator
Supplemental data
Identification of enhancer of mRNA decapping 4 as a novel fusion partner of MLL in acute myeloid leukemia
Heiko Becker,Gabriele Greve,Keisuke Kataoka,Jan-Philipp Mallm,Jesús Duque-Afonso,Tobias Ma,Christoph Niemöller,Milena Pantic,Justus Duyster,Michael L. Cleary,Julia Schüler,Karsten Rippe,Seishi Ogawa,Michael Lübbert
View Articletitled, Identification of enhancer of mRNA decapping 4 as a novel fusion partner of <em>MLL</em> in acute myeloid leukemia
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Enhancing the antitumor functions of invariant natural killer T cells using a soluble CD1d-CD19 fusion protein
Rupali Das,Peng Guan,Susan J. Wiener,Nishant P. Patel,Trevor G. Gohl,Elizabeth Evans,Maurice Zauderer,Kim E. Nichols
View Articletitled, Enhancing the antitumor functions of invariant natural killer T cells using a soluble CD1d-CD19 fusion protein
Supplemental data

LYMPHOID NEOPLASIA

Outcomes with early response to first-line treatment in patients with newly diagnosed multiple myeloma
Clinical Trials & Observations
Nidhi Tandon,Surbhi Sidana,S. Vincent Rajkumar,Morie A. Gertz,Francis K. Buadi,Martha Q. Lacy,Prashant Kapoor,Wilson I. Gonsalves,Angela Dispenzieri,Taxiarchis V. Kourelis,Rahma Warsame,David Dingli,Amie L. Fonder,Suzanne R. Hayman,Miriam A. Hobbs,Yi Lisa Hwa,Robert A. Kyle,Nelson Leung,Ronald S. Go,John A. Lust,Stephen J. Russell,Shaji K. Kumar
View Articletitled, Outcomes with early response to first-line treatment in patients with newly diagnosed multiple myeloma
Secretory status of monoclonal immunoglobulin is related to the outcome of patients with myeloma: a retrospective study
Clinical Trials & Observations
Xiao-Qi Qin,Gang An,Zeng-Jun Li,Lan-Ting Liu,Yan Xu,Lin-Hua Yang,Yan-Ping Ma,Shu-Hui Deng,Wei-Wei Sui,Yu Qin,Xiao-Yan Feng,Mei-Rong Zang,Wen-Juan Yang,Yan-Ru Zhang,Shu-Hua Yi,Ting-Yu Wang,Rui Lv,De-Hui Zou,Yao-Zhong Zhao,Lu-Gui Qiu
View Articletitled, Secretory status of monoclonal immunoglobulin is related to the outcome of patients with myeloma: a retrospective study
Oncolytic immunotherapy and bortezomib synergy improves survival of refractory multiple myeloma in a preclinical model
Chandini M. Thirukkumaran,Zhong Qiao Shi,Gerard J. Nuovo,Joanne Luider,Karen A. Kopciuk,Yuan Dong,Ahmed A. Mostafa,Satbir Thakur,Kathy Gratton,Ailian Yang,Alex C. Chin,Matt C. Coffey,Victor H. Jimenez-Zepeda,Douglas Stewart,Marta Chesi,P. Leif Bergsagel,Don Morris
View Articletitled, Oncolytic immunotherapy and bortezomib synergy improves survival of refractory multiple myeloma in a preclinical model
Supplemental data

PLATELETS AND THROMBOPOIESIS

Inactivation of platelet-derived TGF-β1 attenuates aortic stenosis progression in a robust murine model
Rohan Varshney,Brennah Murphy,Sean Woolington,Shahrouz Ghafoory,Sixia Chen,Tyler Robison,Jasimuddin Ahamed
View Articletitled, Inactivation of platelet-derived TGF-β1 attenuates aortic stenosis progression in a robust murine model
Supplemental data

THROMBOSIS AND HEMOSTASIS

High risk of adverse pregnancy outcomes in women with a persistent lupus anticoagulant
Clinical Trials & Observations
Johanna Gebhart,Florian Posch,Silvia Koder,Peter Quehenberger,Thomas Perkmann,Lorenz Kuessel,Cihan Ay,Ingrid Pabinger
View Articletitled, High risk of adverse pregnancy outcomes in women with a persistent lupus anticoagulant
Supplemental data
FVIII expression by its native promoter sustains long-term correction avoiding immune response in hemophilic mice
Simone Merlin,Rosella Famà,Ester Borroni,Diego Zanolini,Valentina Bruscaggin,Silvia Zucchelli,Antonia Follenzi
View Articletitled, FVIII expression by its native promoter sustains long-term correction avoiding immune response in hemophilic mice
Supplemental data

TRANSPLANTATION

Mixed chimerism established by hematopoietic stem cell transplantation is maintained by host and donor T regulatory cells
Clinical Trials & Observations
Francesca A. M. Kinsella,Jianmin Zuo,Charlotte F. Inman,Hayden Pearce,Luke Maggs,Suzy E. Eldershaw,Y. L. Tracey Chan,Jane Nunnick,Sandeep Nagra,Mike Griffiths,Charles Craddock,Ram Malladi,Paul Moss
View Articletitled, Mixed chimerism established by hematopoietic stem cell transplantation is maintained by host and donor T regulatory cells
Supplemental data

SYSTEMATIC REVIEW

Vitamin K for reversal of excessive vitamin K antagonist anticoagulation: a systematic review and meta-analysis
Clinical Trials & Observations
Rasha Khatib,Maja Ludwikowska,Daniel M. Witt,Jack Ansell,Nathan P. Clark,Anne Holbrook,Wojtek Wiercioch,Holger Schünemann,Robby Nieuwlaat
View Articletitled, Vitamin K for reversal of excessive vitamin K antagonist anticoagulation: a systematic review and meta-analysis
Supplemental data
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Immunofluorescence microscopy of lymph node section stained with anti-CD4, anti-FoxP3, and anti-RORγt demonstrating the functional polarization of tonsillar CD4+ T cells. See the article by Mamand et al.

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