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Journal Articles

A Novel Cereblon E3 Ligase Modulator Eradicates Acute Myeloid Leukemia Stem Cells through Degradation of Translation Termination Factor GSPT1

Liqing Jin, MD, Nathan Mbong, Stanley W.K. Ng, PhD, Jean C.Y. Wang, MD, Mark D. Minden, MD PhD, Jinhong Fan, Daniel W. Pierce, Michael Pourdehnad, MD, John E. Dick, PhD

Blood (2019) 134 (Supplement_1): 3940.

https://doi.org/10.1182/blood-2019-128450

Published: 2019

Journal Articles

Β-Catenin-Tcf/Lef Signaling Promotes Steady State and Emergency Granulopoiesis through G-CSF Receptor Upregulation

Petr Danek, MSc, Miroslava Kardosova, PhD, Lucie Janeckova, PhD, Vladimir Korinek, PhD, Touati Benoukraf, PhD, Daniel G. Tenen, MD, Meritxell Alberich-Jorda

Blood (2019) 134 (Supplement_1): 1193.

https://doi.org/10.1182/blood-2019-122254

Published: 2019

Journal Articles

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

Peng Huang, PhD, Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Malini Sharma, BS, Kunhua Qin, PhD, Cheryl A Keller, PhD, Belinda Giardine, Junwei Shi, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 814.

https://doi.org/10.1182/blood-2019-123837

Published: 2019

Journal Articles

Optimizing Mechanisms for Induction of Immunogenic Cell Death to Improve Patient Outcome in Multiple Myeloma

Annamaria Gulla, MD, Eugenio Morelli, MD, Teru Hideshima, MD PhD, Mehmet Kemal Samur, PhD, Giada Bianchi, MD, Mariateresa Fulciniti, PhD, Nikhil Munshi, MD, Kenneth C. Anderson, MD

Blood (2018) 132 (Supplement 1): 1932.

https://doi.org/10.1182/blood-2018-99-116951

Published: 2018

Journal Articles

Concomitant Targeting of FLT3 and BTK with CG'806 Overcomes FLT3-Inhibitor Resistance through Inhibition of Autophagy

Weiguo Zhang, MD PhD, Guopan Yu, MD, PhD, Hongying Zhang, MD, PhD, Charlie Ly, BS, Bin Yuan, Vivian Ruvolo, MS, Sujan Piya, PhD, Seemana Bhattacharya, PhD, Qi Zhang, PhD, Gautam Borthakur, MD, Venkata Lokesh Battula, PhD, Marina Y. Konopleva, MD PhD, William G Rice, PhD, Michael Andreeff, MD PhD

Blood (2018) 132 (Supplement 1): 2635.

https://doi.org/10.1182/blood-2018-99-116643

Published: 2018

Journal Articles

Salubrinal Mediated Fetal Hemoglobin Induction through the eIF2α-ATF4 Signaling Pathway

Nicole Hope Lopez, BS, Biaoru Li, MD PhD, Levi Makala, DVM, MBA, PhD, Betty S. Pace, MD

Blood (2017) 130 (Supplement 1): 2235.

https://doi.org/10.1182/blood.V130.Suppl_1.2235.2235

Published: 2017

Journal Articles

DNA Copy Number Gains of TCF4 (E2-2) Are Associated with Poor Outcome in Diffuse Large B-Cell Lymphoma

Blood (2016) 128 (22): 2686.

https://doi.org/10.1182/blood.V128.22.2686.2686

Published: 2016

Journal Articles

Heme-Regulated eIF2α Kinase Coordinates Translational Repression of eIF2αP and mTORC1 Signaling during Iron Deficiency to Mitigate Ineffective Erythropoiesis

Shuping Zhang, PhD, Alejandra Macias-Garcia, PhD, Jason Velazquez, BS, Jane-Jane Chen, PhD

Blood (2016) 128 (22): 1037.

https://doi.org/10.1182/blood.V128.22.1037.1037

Published: 2016

Journal Articles

MUC1-C drives MYC in multiple myeloma

Ashujit Tagde, Hasan Rajabi, Audrey Bouillez, Maroof Alam, Reddy Gali, Shannon Bailey, Yu-Tzu Tai, Teru Hideshima, Kenneth Anderson, David Avigan, Donald Kufe

Blood (2016) 127 (21): 2587–2597.

https://doi.org/10.1182/blood-2015-07-659151

Published: 2016

Includes: Supplemental data

Journal Articles

Cap Analysis of Gene Expression (CAGE) Sequencing Reveals Alterations of the Transcript Signatures in Acute Monocytic Leukemia Cells By Fatty Acid Oxidation Inhibition

Yoko Tabe, MD PhD, Marina Konopleva, MD PhD, Norikazu Monma, PhD, Kazuho Ikeo, PhD, Kaoru Mogushi, PhD, Yasunari Yamanaka, MD PhD, Hiromichi Matsushita, MD PhD, Takashi Miida, MD PhD, Yoshihide Hayashizaki, MD PhD, Michael Andreeff, MD PhD

Blood (2015) 126 (23): 3631.

https://doi.org/10.1182/blood.V126.23.3631.3631

Published: 2015

Journal Articles

ONC201 Induces Apoptosis in Cutaneous T-Cell Lymphoma Cells through a Mechanism That Involves the Integrated Stress Response and Inactivation of Jak/Stat Signaling

Madeleine Duvic, MD, Xiang Zhang, Xiao Ni, MD PhD, Timothy Langridge, Rohinton Tarapore, PhD, Josh Allen, PhD

Blood (2015) 126 (23): 4011.

https://doi.org/10.1182/blood.V126.23.4011.4011

Published: 2015

Journal Articles

ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver

Blood (2015) 126 (21): 2383–2391.

https://doi.org/10.1182/blood-2015-03-633354

Published: 2015

Includes: Supplemental data

Journal Articles

The Leukemia-Associated Protein BTG1 Is Required for ATF4-Mediated Cellular Stress Responses

Laurensia Yuniati, MSc, Laurens T van der Meer, PhD, Geert JV Poelmans, MD PhD, Sander AL Palit, BSc, Caroline Rodenbach, Dorette S van IngenSchenau, MSc, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N van Leeuwen, PhD

Blood (2014) 124 (21): 3587.

https://doi.org/10.1182/blood.V124.21.3587.3587

Published: 2014

Journal Articles

Loss Of Tumor Suppressor BTG1 Enhances ATF4 Function and Promotes Cell Survival

Laurens T. van der Meer, PhD, Laurensia Yuniati, MSc, Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Manon Alkema, Caroline Rodenbach, Blanca Scheijen, PhD, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD

Blood (2013) 122 (21): 3796.

https://doi.org/10.1182/blood.V122.21.3796.3796

Published: 2013

Journal Articles

Treatment with β-Catenin Antagonist BC2059 Exerts Single Agent Efficacy and Exerts Improved Activity with Tyrosine Kinase Inhibitor (TKI) or Pan-Histone Deacetylase (HDAC) Inhibitor Against Human CML and Myeloproliferative Neoplasm (MPN) Progenitor Cells

Warren Fiskus, PhD, Jacqueline Smith, MS, Uma Mudunuru, MS, Stacey Hembruff, MS, Ruben Reyes, MD, Sunil Abhyankar, MD, Joseph McGuirk, DO, Omar S. Aljitawi, MD, Siddhartha Ganguly, MD, Stephen K. Horrigan, PhD, Sunil Sharma, MD, Kapil N. Bhalla, MD

Blood (2011) 118 (21): 65.

https://doi.org/10.1182/blood.V118.21.65.65

Published: 2011

Journal Articles

Exportin 7 (RanBP16) Plays An Essential Role In Terminal Erythroid Differentiation

Shilpa Hattangadi, MD, Karly Burke, Harvey Lodish

Blood (2010) 116 (21): 3877.

https://doi.org/10.1182/blood.V116.21.3877.3877

Published: 2010

Journal Articles

Oxidative Stress Signaling Pathway of Heme Regulated eIF2α Kinase in mitigating the Severity of β-Thalassemia

Rajasekhar NVS Suragani, Sijin Liu, Wanting Zhao, Jane-Jane Chen, PhD

Blood (2008) 112 (11): 127.

https://doi.org/10.1182/blood.V112.11.127.127

Published: 2008

Journal Articles

Overexpression of the LEF-1 and TCF4 Transcription Factors in B-CLL: Further Evidence for a Role of the Wnt Signaling Pathway in B-CLL Biology and Leukemogenesis

Albert Gutierrez, BS, Renee Tschumper, Jeanette Eckel-Passow, PhD, Neil E. Kay, MD, Diane F. Jelinek, PhD

Blood (2008) 112 (11): 544.

https://doi.org/10.1182/blood.V112.11.544.544

Published: 2008

Journal Articles

Oct4 and Its Pseudogenes Confuse Stem Cell Research.

Stefanie Liedtke, PhD, Jürgen Enczmann, Ph.D., Simon Waclawczyk, Dipl.biol., Peter Wernet, Gesine Kögler

Blood (2007) 110 (11): 3700.

https://doi.org/10.1182/blood.V110.11.3700.3700

Published: 2007

Journal Articles

Gene Expression in CLL Cells Associated with Lymphadenopathy and Chromosome 11q23 Deletion.

John D. Dickinson, BA, Avadhut Joshi, BS, Jamie Gilmore, BS, Philip J. Bierman, MD, Sanger Warren, PhD, Shantaram S. Joshi, PhD

Blood (2004) 104 (11): 971.

https://doi.org/10.1182/blood.V104.11.971.971

Published: 2004

NARROW

A Novel Cereblon E3 Ligase Modulator Eradicates Acute Myeloid Leukemia Stem Cells through Degradation of Translation Termination Factor GSPT1

Β-Catenin-Tcf/Lef Signaling Promotes Steady State and Emergency Granulopoiesis through G-CSF Receptor Upregulation

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

Optimizing Mechanisms for Induction of Immunogenic Cell Death to Improve Patient Outcome in Multiple Myeloma

Concomitant Targeting of FLT3 and BTK with CG'806 Overcomes FLT3-Inhibitor Resistance through Inhibition of Autophagy

Salubrinal Mediated Fetal Hemoglobin Induction through the eIF2α-ATF4 Signaling Pathway

DNA Copy Number Gains of TCF4 (E2-2) Are Associated with Poor Outcome in Diffuse Large B-Cell Lymphoma

Heme-Regulated eIF2α Kinase Coordinates Translational Repression of eIF2αP and mTORC1 Signaling during Iron Deficiency to Mitigate Ineffective Erythropoiesis

MUC1-C drives MYC in multiple myeloma

Cap Analysis of Gene Expression (CAGE) Sequencing Reveals Alterations of the Transcript Signatures in Acute Monocytic Leukemia Cells By Fatty Acid Oxidation Inhibition

ONC201 Induces Apoptosis in Cutaneous T-Cell Lymphoma Cells through a Mechanism That Involves the Integrated Stress Response and Inactivation of Jak/Stat Signaling

ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver

The Leukemia-Associated Protein BTG1 Is Required for ATF4-Mediated Cellular Stress Responses

Loss Of Tumor Suppressor BTG1 Enhances ATF4 Function and Promotes Cell Survival

Treatment with β-Catenin Antagonist BC2059 Exerts Single Agent Efficacy and Exerts Improved Activity with Tyrosine Kinase Inhibitor (TKI) or Pan-Histone Deacetylase (HDAC) Inhibitor Against Human CML and Myeloproliferative Neoplasm (MPN) Progenitor Cells

Exportin 7 (RanBP16) Plays An Essential Role In Terminal Erythroid Differentiation

Oxidative Stress Signaling Pathway of Heme Regulated eIF2α Kinase in mitigating the Severity of β-Thalassemia

Overexpression of the LEF-1 and TCF4 Transcription Factors in B-CLL: Further Evidence for a Role of the Wnt Signaling Pathway in B-CLL Biology and Leukemogenesis

Oct4 and Its Pseudogenes Confuse Stem Cell Research.

Gene Expression in CLL Cells Associated with Lymphadenopathy and Chromosome 11q23 Deletion.

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American Society of Hematology

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American Society of Hematology

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