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Journal Articles

Fedratinib Induces Cytokine Changes Correlating with Clinical Response in Ruxolitinib Exposed Myelofibrosis Patients: Biomarker Analysis from the Freedom Trial

Danny V Jeyaraju, Sheida Hayati, Ann Polonskaia, Maryam Alapa, Manuel Ugidos, Andrew Browne, Alberto Risueño, Patrick Hagner, Vikas Gupta, Moshe Talpaz, Christopher Hernandez, Vincent Chia, Patricia Martin-Regueira, Daniel Lopes de Menezes, Ross La Motte-Mohs, Rajasekhar NVS Suragani, Anita K. Gandhi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3865–3867.
https://doi.org/10.1182/blood-2022-166407
Published: 2022
Journal Articles

Genetic Investigation of the Role of GDF11 in the Treatment of β-Thalassemia and MDS

Paraskevi Rea Oikonomidou, MD, Ping La, PhD, Ritama Gupta, MSc, Vania Lo Presti, Carla Casu, PhD, Laura Breda, PhD, Deborah Watson, PhD, Rajasekhar NVS Suragani, PhD, Ravindra Kumar, PhD, Stefano Rivella, PhD
Journal: Blood
Blood (2016) 128 (22): 2439.
https://doi.org/10.1182/blood.V128.22.2439.2439
Published: 2016
Journal Articles

Rap-536 (Murine ACE-536/Luspatercept) Inhibits Smad2/3 Signaling and Promotes Erythroid Differentiation By Restoring GATA-1 Function in Murine b-Thalassemia

Pedro A. Martinez, PhD, Rajasekhar NVS Suragani, PhD, Manoj Bhasin, PhD, Robert Li, Robert Scott Pearsall, PhD, Ravindra Kumar, PhD
Journal: Blood
Blood (2015) 126 (23): 751.
https://doi.org/10.1182/blood.V126.23.751.751
Published: 2015
Journal Articles

TGFb1 Antagonist Inhibits Fibrosis in a Murine Model of Myelofibrosis

Rajasekhar NVS Suragani, PhD, Pedro A. Martinez, PhD, Sharon M Cawley, PhD, Robert Li, Robert Scott Pearsall, PhD, Ravindra Kumar, PhD
Journal: Blood
Blood (2015) 126 (23): 605.
https://doi.org/10.1182/blood.V126.23.605.605
Published: 2015
Journal Articles

Modified Actriib-Fc Fusion Protein (ACE-536) Mitigates Sickling and Red Cell Pathology in a Murine Model of Sickle Cell Disease

Rajasekhar NVS Suragani, PhD, Robert Li, Sharon M Cawley, R. Scott Pearsall, Ravindra Kumar
Journal: Blood
Blood (2014) 124 (21): 4055.
https://doi.org/10.1182/blood.V124.21.4055.4055
Published: 2014
Journal Articles

Modified Activin Receptor Type IIb-Fc Fusion Protein (RAP-536) Decreases Anemia In a Murine Model Of Myelodysplastic Syndrome and Improves Overall Survival

Rajasekhar NVS Suragani, PhD, Robert Li, Sharon Cawley, R. Scott Pearsall, Ph.D., Ravi Kumar, Ph.D.
Journal: Blood
Blood (2013) 122 (21): 749.
https://doi.org/10.1182/blood.V122.21.749.749
Published: 2013
Journal Articles

RAP-536 Promotes Terminal Erythroid Differentiation and Reduces Anemia in a Murine Model of Myelodysplastic Syndromes

Rajasekhar NVS Suragani, Robert Li, Dianne Sako, Asya Grinberg, R. Scott Pearsall, Ravindra Kumar
Journal: Blood
Blood (2012) 120 (21): 3796.
https://doi.org/10.1182/blood.V120.21.3796.3796
Published: 2012
Journal Articles

ACE-536 Improves Ineffective Erythropoiesis, Anemia and Co-Morbidities in β-Thalassemia

Rajasekhar NVS Suragani, Robert Li, Sharon Cawley, Stefano Rivella, PhD, R. Scott Pearsall, Ravindra Kumar
Journal: Blood
Blood (2012) 120 (21): 248.
https://doi.org/10.1182/blood.V120.21.248.248
Published: 2012
Journal Articles

RAP-536 Promotes Terminal Erythroid Differentiation and Reduces Anemia in Myelodysplastic Syndromes

Rajasekhar NVS Suragani, Aaron Mulivor, R. Scott Pearsall, Ravindra Kumar
Journal: Blood
Blood (2011) 118 (21): 610.
https://doi.org/10.1182/blood.V118.21.610.610
Published: 2011
Journal Articles

RAP-536, A Soluble Activin Receptor Type IIb Murine IgG-Fc Fusion Protein, Prevents Myelodysplastic Syndrome Related Anemia

Aaron Mulivor, Samuel M. Cadena, Rajasekhar NVS Suragani, Ravindra Kumar, Kathryn Underwood, Jas Seehra, R. Scott Pearsall
Journal: Blood
Blood (2010) 116 (21): 978.
https://doi.org/10.1182/blood.V116.21.978.978
Published: 2010
Journal Articles

RAP-536 Accelerates Recovery From Chemotherapy-Induced Anemia (CIA) without Promoting Tumor Growth In Murine Models of Cancer and CIA

Samuel M. Cadena, Rajasekhar NVS Suragani, Dianne Mitchell, Jeff Ucran, Katia Liharska, Dianne Sako, Travis Monnell, Kathryn Underwood, Ravindra Kumar, R. Scott Pearsall
Journal: Blood
Blood (2010) 116 (21): 4230.
https://doi.org/10.1182/blood.V116.21.4230.4230
Published: 2010
Journal Articles

ACE-536, a Modified Type II Activin Receptor Increases Red Blood Cells In Vivo by Promoting Maturation of Late Stage Erythroblasts

Rajasekhar NVS Suragani, Samuel M. Cadena, Dianne Mitchell, Dianne Sako, Monique Davies, Kathleen Tomkinson, Mathew Devine, Jeff Ucran, Asya Grinberg, Kathryn Underwood, R. Scott Pearsall, Jasbir Seehra, Ravindra Kumar
Journal: Blood
Blood (2010) 116 (21): 4236.
https://doi.org/10.1182/blood.V116.21.4236.4236
Published: 2010
Journal Articles

Oxidative Stress Signaling Pathway of Heme Regulated eIF2α Kinase in mitigating the Severity of β-Thalassemia

Rajasekhar NVS Suragani, Sijin Liu, Wanting Zhao, Jane-Jane Chen, PhD
Journal: Blood
Blood (2008) 112 (11): 127.
https://doi.org/10.1182/blood.V112.11.127.127
Published: 2008