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Journal Articles

Treosulfan Metabolite (S, S-EBDM) Pharmacokinetics Influences Regimen Related Toxicity in Patients with Beta Thalassaemia Major Undergoing HSCT

Aswin Anand PAI, MSc, John C Panetta, PhD, Ezhil Pavai Mohanan, PhD, Raveen Stephen Stallon Illangeswaran, MSc, Balaji Balakrishnan, PhD, Eunice Sindhuvi Edison, PhD, Kavitha M Lakshmi, MSc, Uday Prakash Kulkarni, MD DM, Anup Joseph Devasia, MD DM, Fouzia N., Anu Korula, MD DM, Aby Abraham, MD DM, Biju George, MDDM, Vikram Mathews, MD DM, Alok Srivastava, MD,FRACP,FRCPA, Poonkuzhali Balasubramanian, PhD

Blood (2019) 134 (Supplement_1): 1977.

https://doi.org/10.1182/blood-2019-125604

Published: 2019

Journal Articles

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

Dipti Gupta, Samuel Lessard, PhD, Nancy Moore, Jicheng Duan, PhD, Yukio Nakamura, MD PhD, Feng-Chun Yang, MD PhD, Alexandra Hicks, PhD, David R. Light, PhD, Sriram Krishnamoorthy, PhD

Blood (2019) 134 (Supplement_1): 210.

https://doi.org/10.1182/blood-2019-129479

Published: 2019

Journal Articles

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, G. David Roodman, MD PhD, Larry D. Cripe, MD, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Katie J Sargent, RN, Hamid Sayar, MD MSc, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD

Blood (2019) 134 (Supplement_1): 5051.

https://doi.org/10.1182/blood-2019-124384

Published: 2019

Journal Articles

Novel Small Molecule Stimulants of Hematopoietic Stem Cells and Their Mode of Action

Sergei Vatolin, PhD, Jaroslaw P. Maciejewski

Blood (2018) 132 (Supplement 1): 1302.

https://doi.org/10.1182/blood-2018-99-114838

Published: 2018

Journal Articles

Imatinib Induces Apoptosis of NK/T Cell Neoplasms by Inhibiting Hematopoietic Cell Kinase and NQO2

Takeshi Yoroidaka, MD, Luis Espinoza, MDPhD, Kenichi Harada, MD PhD, Ly Quoc Trung, MD PhD, Shinji Nakao, MD PhD

Blood (2017) 130 (Supplement 1): 1270.

https://doi.org/10.1182/blood.V130.Suppl_1.1270.1270

Published: 2017

Journal Articles

Role of NF-E2 Related Factor 2 (NRF2) on Chemotherapy Resistance in Acute Myeloid Leukemia (AML) and the Effect of Pharmacological Inhibition of NRF2

Sreeja Karathedath, MSc, Bharathi M Rajamani, M.Phil, Savitha Varatharajan, MSc, Ajay Abraham, MSc, Vikram Mathews, DM, Shaji R Velayudhan, PhD, Poonkuzhali Balasubramanian, PhD

Blood (2015) 126 (23): 1272.

https://doi.org/10.1182/blood.V126.23.1272.1272

Published: 2015

Journal Articles

Dimethyl Fumarate Induces Cytoprotection and Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Mice

John D. Belcher, PhD, Julia Nguyen, Chunsheng Chen, Fuad Abdulla, Phong Nguyen, Minh Nguyen, Ping Zhang, PhD, Pauline Xu, Nicholas J. Slipek, Gregory M. Vercellotti, MD

Blood (2014) 124 (21): 219.

https://doi.org/10.1182/blood.V124.21.219.219

Published: 2014

Journal Articles

Effects of Sulforaphane Obtained from Broccoli Sprout Homogenate in Patients with Sickle Cell Disease (SCD)

Jennifer Doss, BS, Jude Jonassaint, RN, Nirmish Shah, MD, Marilyn J. Telen, MD, Jen-Tsan A. Chi, MD, PhD

Blood (2014) 124 (21): 4931.

https://doi.org/10.1182/blood.V124.21.4931.4931

Published: 2014

Journal Articles

Dimeric Naphthoquinones: Novel Anti-Leukemic Agents Modulating Cellular Redox Status

Ashkan Emadi, M.D., Ph.D., Mariola Sadowska, PhD, Brandon Carter-Cooper, BS, Omasiri Wonodi, BS, Nidal Muvarak, BS, Feyruz Rassool, PhD, Anil Jaiswal, PhD, Maria R. Baer, MD, Rena G. Lapidus, PhD, Edward A. Sausville, MD, PhD

Blood (2013) 122 (21): 1290.

https://doi.org/10.1182/blood.V122.21.1290.1290

Published: 2013

Journal Articles

Selective Damage to Antioxidant Gene Promoters in FA Cells

Wei Du, MD, PhD, Reena Rani, Jared Sipple, Jonathan Schick, Qishen Pang, PhD

Blood (2011) 118 (21): 2413.

https://doi.org/10.1182/blood.V118.21.2413.2413

Published: 2011

Journal Articles

Unique Familial MLL -rearranged Precursor B Cell Infant Acute Lymphoblastic Leukemia (ALL) in Non-Twin Siblings

Karen A. Urtishak, PhD, Blaine W. Robinson, PhD, Jaclyn A. Biegel, PhD, Kim E. Nichols, MD, Julie W. Stern, MD, Carolyn A. Felix, MD

Blood (2011) 118 (21): 2417.

https://doi.org/10.1182/blood.V118.21.2417.2417

Published: 2011

Journal Articles

Exploiting the NRF2/Antioxidant Response Element Signaling Pathway to Induce γ-Globin Gene Expression and HbF Production

Elizabeth R. Macari, BS, Rachel J. West, PhD, Christopher H. Lowrey, MD

Blood (2010) 116 (21): 2074.

https://doi.org/10.1182/blood.V116.21.2074.2074

Published: 2010

Journal Articles

ATM Mutant Lymphoid Tumour Cells Exhibit Impaired Activation of the Redox-Sensitive Nrf2-ARE Detoxification Pathway and Are Differentially Sensitive to Nrf2-Activating Compounds

Victoria J Weston, PhD, Angelo Agathanggelou, PhD, Paul AH Moss, MD, PhD, Pamela R. Kearns, BSc, MBBCh, MRCP, PhD, A. Malcolm R Taylor, PhD, Tatjana Stankovic, MD, PhD

Blood (2010) 116 (21): 49.

https://doi.org/10.1182/blood.V116.21.49.49

Published: 2010

Journal Articles

Cytoprotective Mechanisms of the Lung in Sickle Cell Disease.

Samit Ghosh, Fang Tan, Mario Monsunjac, Solomon F Ofori-Acquah

Blood (2009) 114 (22): 1538.

https://doi.org/10.1182/blood.V114.22.1538.1538

Published: 2009

Journal Articles

High Dose Cytarabine (HiDAC) and Mitoxantrone (MITO) Is An Effective Induction Therapy for High-Risk Acute Myeloid Leukemia (AML).

Sarah Larson, MD, Nicholas Campbell, MD, Dezheng Huo, PhD, Andrew Artz, MD, MS, Yanming Zhang, Devika Gajria, Margaret Green, Gamar Rahimova, Howard Weiner, Monica Torres, Olatoyosi Odenike, MD, Lucy A Godley, MD, PhD, Elizabeth Shima Rich, MD, PhD, Michael Thirman, MD, Richard A. Larson, MD, Wendy Stock, MD

Blood (2009) 114 (22): 1048.

https://doi.org/10.1182/blood.V114.22.1048.1048

Published: 2009

Journal Articles

Anti-Leukemic Activity of Mitochondrially-Directed Asymmetrical 2-2'-Binaphthoquinones.

Rebecca Ricklis, MSc, Milena Vuica-Ross, MD, Robert Brodsky, MD, Ed Sausville, MD, PhD, Chi Van Dang, MD, PhD, Judith E Karp, MD, Ashkan Emadi, MD, PhD

Blood (2009) 114 (22): 4799.

https://doi.org/10.1182/blood.V114.22.4799.4799

Published: 2009

Journal Articles

Induction of γ-Globin Gene Expression Via the Nrf2/Antioxidant Response Element Signaling Pathway.

Elizabeth Macari, BS, Rachel West, PhD, William J. Lowrey, Rodwell Mabaera, PhD, Christopher H. Lowrey, MD

Blood (2009) 114 (22): 975.

https://doi.org/10.1182/blood.V114.22.975.975

Published: 2009

Journal Articles

Efficacy of the Novel Non-Quinone Based HSP-90 Inhibitor PU-H71 in JAK2V617F and MPLW515L-Induced Murine Models of Myeloproliferative Neoplasms.

Priya Koppikar, PhD, Sachie Marubayashi, Tony Taldone, Omar Abdel-Wahab, Nathan West, Alexander Gozman, James Ahn, Anna Rodina, Neha Bhagwat, Cyrus V. Hedvat, MD, PhD, James E. Bradner, MD, Gabriela Chiosis, Ross L. Levine, MD

Blood (2009) 114 (22): 3898.

https://doi.org/10.1182/blood.V114.22.3898.3898

Published: 2009

Journal Articles

Molecular Phenotype of Sickle Chronic Lung Disease Revealed by Global Gene Expression Profiling

Fang Tan, Tianwei Yu, Yuhua Li, Samit Ghosh, Mario Mosunjac, Solomon F Ofori-Acquah

Blood (2008) 112 (11): 2480.

https://doi.org/10.1182/blood.V112.11.2480.2480

Published: 2008

Journal Articles

Antitumor Efficacy of the Purine-Scaffold Hsp90 Inhibitor PU-H71 in Diffuse Large-B Cell Lymphoma

Eloisi Caldas Lopes, Leandro Cerchietti, Shao Ning Yang, Ari Melnick, Gabriela Chiosis

Blood (2008) 112 (11): 602.

https://doi.org/10.1182/blood.V112.11.602.602

Published: 2008

NARROW

Treosulfan Metabolite (S, S-EBDM) Pharmacokinetics Influences Regimen Related Toxicity in Patients with Beta Thalassaemia Major Undergoing HSCT

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Novel Small Molecule Stimulants of Hematopoietic Stem Cells and Their Mode of Action

Imatinib Induces Apoptosis of NK/T Cell Neoplasms by Inhibiting Hematopoietic Cell Kinase and NQO2

Role of NF-E2 Related Factor 2 (NRF2) on Chemotherapy Resistance in Acute Myeloid Leukemia (AML) and the Effect of Pharmacological Inhibition of NRF2

Dimethyl Fumarate Induces Cytoprotection and Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Mice

Effects of Sulforaphane Obtained from Broccoli Sprout Homogenate in Patients with Sickle Cell Disease (SCD)

Dimeric Naphthoquinones: Novel Anti-Leukemic Agents Modulating Cellular Redox Status

Selective Damage to Antioxidant Gene Promoters in FA Cells

Unique Familial MLL -rearranged Precursor B Cell Infant Acute Lymphoblastic Leukemia (ALL) in Non-Twin Siblings

Exploiting the NRF2/Antioxidant Response Element Signaling Pathway to Induce γ-Globin Gene Expression and HbF Production

ATM Mutant Lymphoid Tumour Cells Exhibit Impaired Activation of the Redox-Sensitive Nrf2-ARE Detoxification Pathway and Are Differentially Sensitive to Nrf2-Activating Compounds

Cytoprotective Mechanisms of the Lung in Sickle Cell Disease.

High Dose Cytarabine (HiDAC) and Mitoxantrone (MITO) Is An Effective Induction Therapy for High-Risk Acute Myeloid Leukemia (AML).

Anti-Leukemic Activity of Mitochondrially-Directed Asymmetrical 2-2'-Binaphthoquinones.

Induction of γ-Globin Gene Expression Via the Nrf2/Antioxidant Response Element Signaling Pathway.

Efficacy of the Novel Non-Quinone Based HSP-90 Inhibitor PU-H71 in JAK2V617F and MPLW515L-Induced Murine Models of Myeloproliferative Neoplasms.

Molecular Phenotype of Sickle Chronic Lung Disease Revealed by Global Gene Expression Profiling

Antitumor Efficacy of the Purine-Scaffold Hsp90 Inhibitor PU-H71 in Diffuse Large-B Cell Lymphoma

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American Society of Hematology

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American Society of Hematology

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