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Journal Articles

Broad Efficacy of the Translation Inhibitor Omacetaxine in Relapsed/Refractory Multiple Myeloma Samples

Zachary J Walker, BS, MS, Beau M Idler, BA, Michael J VanWyngarden, BS, Brett M. Stevens, PhD, Shelby C Bearrows, BS, Lorraine N Davis, BS, Andrew Hammes, MS, Clayton Smith, MD, Craig T Jordan, PhD, Tomer M Mark, MD MS, Peter A Forsberg, MD, Daniel W Sherbenou, MD PhD

Blood (2019) 134 (Supplement_1): 4404.

https://doi.org/10.1182/blood-2019-121937

Published: 2019

Journal Articles

Targeting Mitochondrial Translation Overcomes Venetoclax Resistance in Acute Myeloid Leukemia (AML) through Activation of the Integrated Stress Response

David Sharon, PhD, Severine Cathelin, PhD, Amit Subedi, PhD, Ryan Williams, Mariana Benicio, PhD, Troy Ketela, Steven M. Chan, MDPhD

Blood (2017) 130 (Supplement 1): 297.

https://doi.org/10.1182/blood.V130.Suppl_1.297.297

Published: 2017

Journal Articles

Stat5 Feedback Control Switches MYC- and BCL6-Dependent Cell Fates in Normal and Transformed B Cells

Zhengshan Chen, MDPhD, Lai N Chan, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Cheryl L. Willman, MD, Markus Muschen, MDPhD

Blood (2017) 130 (Supplement 1): 1440.

https://doi.org/10.1182/blood.V130.Suppl_1.1440.1440

Published: 2017

Journal Articles

Distinct Metabolic Properties of MDS Stem Cells Provide Novel Opportunities for Therapeutic Intervention

Brett M Stevens, PhD, Daniel A Pollyea, MD, Nabilah Khan, PhD, Craig T Jordan, PhD

Blood (2016) 128 (22): 4316.

https://doi.org/10.1182/blood.V128.22.4316.4316

Published: 2016

Journal Articles

Functional Link Between Heat Shock Protein HSP90alpha and Sirtuin 1 (SIRT1) in the Pathogenesis of Diffuse Large B Cell Lymphoma

Emilia Bialopiotrowicz, PhD, Tomasz Sewastianik, PhD, Monika Noyszewska-Kania, MSc, Maciej Szydlowski, PhD, Ewa Jablonska, PhD, Patryk Gorniak, PhD, Anna Polak, PhD, Przemyslaw Kiliszek, PhD, Krzysztof Warzocha, Przemyslaw Juszczynski, MD PhD

Blood (2016) 128 (22): 4120.

https://doi.org/10.1182/blood.V128.22.4120.4120

Published: 2016

Journal Articles

Detection and Monitoring of BCR-ABL1 Kinase Domain Mutations By Next Generation Sequencing

Pascal Vannuffel, PhD, Barbara Cauwelier, PhD MD, Céline De Rop, Friedel Nollet, PhD

Blood (2015) 126 (23): 4042.

https://doi.org/10.1182/blood.V126.23.4042.4042

Published: 2015

Journal Articles

Characterization and Targeting of Myelodysplastic Syndrome Stem Cells

Brett M Stevens, PhD, Daniel Pollyea, MD MS, Nabilah Khan, PhD, Craig T Jordan, PhD

Blood (2015) 126 (23): 4104.

https://doi.org/10.1182/blood.V126.23.4104.4104

Published: 2015

Journal Articles

The NEDD8 Activating Enzyme Inhibitor Pevonedistat Induces ER Stress/UPR-Mediated Cell Death and Rebalances Homeostasis of Pro- and Anti-Apoptotic Proteins in Favor of Cell Death in Acute Lymphoblastic Leukemia Cells

Gilles M. Leclerc, PhD, Shuhua Zheng, BS, Guy J. Leclerc, PhD, Joanna DeSalvo, BSc, Ronan T. Swords, MDPhDFRCPI FRCPath, Julio C. Barredo, MD

Blood (2015) 126 (23): 1327.

https://doi.org/10.1182/blood.V126.23.1327.1327

Published: 2015

Journal Articles

Lead-in Stage Results of a Pivotal Trial of SL-401, an Interleukin-3 Receptor (IL-3R) Targeting Biologic, in Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) or Acute Myeloid Leukemia (AML)

Kendra L. Sweet, MD, Naveen Pemmaraju, MD, Andrew A Lane, MD PhD, Anthony S. Stein, MD, Sumithira Vasu, MBBS, William Blum, MD, David A. Rizzieri, MD, Eunice S. Wang, MD, Eric K. Rowinsky, MD, Michael Szarek, PhD, Christopher L. Brooks, PhD, Sarah Disalvatore, MPH, David Liu, Madeleine Duvic, MD, Jonathan D. Schwartz, MD, Marina Konopleva, MD PhD

Blood (2015) 126 (23): 3795.

https://doi.org/10.1182/blood.V126.23.3795.3795

Published: 2015

Journal Articles

SETD2 Heterozygous Loss in Leukemia Leads to Chemotherapy Resistance through Attenuation of the DNA Damage Response

Brenton G. Mar, MDPhD, Josephine Kahn, MD MSc, Rebecca L Zon, BA, Peter V Grauman, BS, Kevin Boettger, BS, Scott Haihua Chu, PhD, Scott A. Armstrong, MD PhD, Benjamin L. Ebert, MD

Blood (2015) 126 (23): 2626.

https://doi.org/10.1182/blood.V126.23.2626.2626

Published: 2015

Journal Articles

Blast Phase Chronic Myeloid Leukemia: A Pooled Analysis of Subcutaneous Omacetaxine Mepesuccinate in Treatment-Resistant Patients

H. Jean Khoury, MD, Jorge E. Cortes, MD, Meir Wetzler, MD, Jeffrey H. Lipton, MD, PhD, Michele Baccarani, MD, Dan Douer, MD, Adam Craig, MD, PhD, Hagop M. Kantarjian, MD, Luke Akard, MD

Blood (2012) 120 (21): 3753.

https://doi.org/10.1182/blood.V120.21.3753.3753

Published: 2012

Journal Articles

Investigation of the Novel Anti-Leukemia Effects of the Marine Compound Pateamine A.

Andrea Dean, MD, Thien Nguyen, Nathan Cox, Matthew Cooper, Kristy L. Richards, PhD, MD, Thomas C. Shea, MD, Nathaniel Moorman, Ph.D, Lee Graves, Ph.D

Blood (2012) 120 (21): 2437.

https://doi.org/10.1182/blood.V120.21.2437.2437

Published: 2012

Journal Articles

Long-Term Follow-up of Ongoing Patients in 2 Studies of Omacetaxine Mepesuccinate for Chronic Myeloid Leukemia.

Hagop M. Kantarjian, MD, Jeffrey H. Lipton, MD, PhD, Michele Baccarani, MD, Franck E. Nicolini, MD, PhD, Meir Wetzler, MD, Luke Akard, MD, Laurence Legros, MD, PhD, Krzysztof Warzocha, Adam Craig, MD, PhD, Jorge E. Cortes, MD

Blood (2012) 120 (21): 2787.

https://doi.org/10.1182/blood.V120.21.2787.2787

Published: 2012

Journal Articles

Gene-Selective Histone Hyperacetylation and Enhanced Sp1 Occupancy Underpin Transcriptional Modulation of Genes of the Glycolytic-Pentose Phosphate Pathway in Response to Histone Deacetylase Inhibitors - Therapeutic Implications

Kalliopi Makarona, Valentina Caputo, David Roper, Joana Costa, Gillian Cowan, Aristeidis Chaidos, David O'Connor, Elisabeth Georgiou, Maria Papaioannou, Mark Layton, Irene Roberts, Anastasios Karadimitris

Blood (2012) 120 (21): 977.

https://doi.org/10.1182/blood.V120.21.977.977

Published: 2012

Journal Articles

Associations Between Baseline Mutation Status and Response to Treatment with Omacetaxine Mepesuccinate in Heavily Pretreated Patients with Chronic Myeloid Leukemia

Jeffrey H. Lipton, MD, PhD, Franck E. Nicolini, MD, PhD, Meir Wetzler, MD, Luke Akard, MD, Michele Baccarani, MD, Hagop M. Kantarjian, MD, Adam Craig, MD, PhD, Jorge E Cortes, MD

Blood (2012) 120 (21): 4433.

https://doi.org/10.1182/blood.V120.21.4433.4433

Published: 2012

Journal Articles

AMPK Regulates Nanog Gene Expression Via p53 in Mouse Embryonic Stem Cells.

Hee-Don Chae, PhD, Hal E. Broxmeyer, PhD

Blood (2009) 114 (22): 2537.

https://doi.org/10.1182/blood.V114.22.2537.2537

Published: 2009

Journal Articles

Environmental Mediated-Immune Resistance (EM-IR) to APO2L/TRAIL Mediated Apoptosis.

Lia E. Perez, MD, Nancy Parquet, BS, Marina Molisano, BS, Ken Shain, Ph.D, Melisa Alsina, MD, Claudio Anasetti, MD, William Dalton, Ph.D. MD

Blood (2007) 110 (11): 3521.

https://doi.org/10.1182/blood.V110.11.3521.3521

Published: 2007

Journal Articles

Gfi1 Protein Turnover Is Regulated by the Ubiquitin Ligase Triad1.

Laurens T. van der Meer, Jurgen A.F. Marteijn, Theo M. de Witte, Joop H. Jansen, Bert A. van der Reijden

Blood (2006) 108 (11): 1173.

https://doi.org/10.1182/blood.V108.11.1173.1173

Published: 2006

Journal Articles

p38-MAP Kinase Activation Followed by BIM Induction Is Critical for Glucocorticoid-Induced Apoptosis in Lymphoblastic Leukemia Cells.

Hisashi Harada, PhD, Jianghua Lu, Ph.D., Bonnie Quearry

Blood (2006) 108 (11): 1382.

https://doi.org/10.1182/blood.V108.11.1382.1382

Published: 2006

Journal Articles

New Role for ATP P2X 1 Receptors in the Control of Neutrophil Apoptosis and Respiratory Burst Activity.

Celine Faccinetto, Christelle Lecut, PhD, Roland Greimers, PhD, Vincent Bours, MD PhD, Cecile Oury, PhD

Blood (2006) 108 (11): 1647.

https://doi.org/10.1182/blood.V108.11.1647.1647

Published: 2006

NARROW

Broad Efficacy of the Translation Inhibitor Omacetaxine in Relapsed/Refractory Multiple Myeloma Samples

Targeting Mitochondrial Translation Overcomes Venetoclax Resistance in Acute Myeloid Leukemia (AML) through Activation of the Integrated Stress Response

Stat5 Feedback Control Switches MYC- and BCL6-Dependent Cell Fates in Normal and Transformed B Cells

Distinct Metabolic Properties of MDS Stem Cells Provide Novel Opportunities for Therapeutic Intervention

Functional Link Between Heat Shock Protein HSP90alpha and Sirtuin 1 (SIRT1) in the Pathogenesis of Diffuse Large B Cell Lymphoma

Detection and Monitoring of BCR-ABL1 Kinase Domain Mutations By Next Generation Sequencing

Characterization and Targeting of Myelodysplastic Syndrome Stem Cells

The NEDD8 Activating Enzyme Inhibitor Pevonedistat Induces ER Stress/UPR-Mediated Cell Death and Rebalances Homeostasis of Pro- and Anti-Apoptotic Proteins in Favor of Cell Death in Acute Lymphoblastic Leukemia Cells

Lead-in Stage Results of a Pivotal Trial of SL-401, an Interleukin-3 Receptor (IL-3R) Targeting Biologic, in Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) or Acute Myeloid Leukemia (AML)

SETD2 Heterozygous Loss in Leukemia Leads to Chemotherapy Resistance through Attenuation of the DNA Damage Response

Blast Phase Chronic Myeloid Leukemia: A Pooled Analysis of Subcutaneous Omacetaxine Mepesuccinate in Treatment-Resistant Patients

Investigation of the Novel Anti-Leukemia Effects of the Marine Compound Pateamine A.

Long-Term Follow-up of Ongoing Patients in 2 Studies of Omacetaxine Mepesuccinate for Chronic Myeloid Leukemia.

Gene-Selective Histone Hyperacetylation and Enhanced Sp1 Occupancy Underpin Transcriptional Modulation of Genes of the Glycolytic-Pentose Phosphate Pathway in Response to Histone Deacetylase Inhibitors - Therapeutic Implications

Associations Between Baseline Mutation Status and Response to Treatment with Omacetaxine Mepesuccinate in Heavily Pretreated Patients with Chronic Myeloid Leukemia

AMPK Regulates Nanog Gene Expression Via p53 in Mouse Embryonic Stem Cells.

Environmental Mediated-Immune Resistance (EM-IR) to APO2L/TRAIL Mediated Apoptosis.

Gfi1 Protein Turnover Is Regulated by the Ubiquitin Ligase Triad1.

p38-MAP Kinase Activation Followed by BIM Induction Is Critical for Glucocorticoid-Induced Apoptosis in Lymphoblastic Leukemia Cells.

New Role for ATP P2X 1 Receptors in the Control of Neutrophil Apoptosis and Respiratory Burst Activity.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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