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Journal Articles

Targeting Nucleolin for Reversal of Chemotherapy Resistance in Acute Lymphoblastic Leukemia

Jianda Hu, PhD, Yanxin Chen, MD PhD, Zhengjun Wu, Lingyan Wang, PhDMD, Jingjing Wen, Peifang Jiang, Yun Zhang, Minhui Lin, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5058.
https://doi.org/10.1182/blood-2019-127073
Published: 2019
Journal Articles

Downregulation of Sprr1a Contributes to the Pathobiology of Sickle Cell Disease

Donovan A Argueta, BSc, Anupam Aich, PhD, Jianxun Lei, PhD, Sergei Nekhai, PhD, Tatiana Ammosova, PhD, Xionghao Lin, PhD, Anindya Bagchi, PhD, Kalpna Gupta, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 75.
https://doi.org/10.1182/blood-2019-129004
Published: 2019
Journal Articles

Targeting NEK2 Induces Cellular Senescence in B-Cell Malignancies through p53-Independent Signaling Pathways

Yuqi Zhu, Ye Yang, PhD, Yogesh Jethava, MBBS,MDFRCPath,MRCP, Ivana Frech, DSc, PhD MBA, Guido J. Tricot, MD PhD, Fenghuang Zhan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3102.
https://doi.org/10.1182/blood-2019-123815
Published: 2019
Journal Articles

Inhibition of Anti-Apoptotic Mcl-1 Exerts Anti-Leukemia Activity through Modulation of Leukemia-Stromal Interactions and Metabolic Functions in AML

Bing Z Carter, PhD, Po Yee Mak, Marc Warmoes, Wenjing Tao, Philip Lorenzi, Vivian Ruvolo, MS, Lin Tan, Justin Cidado, PhD, Lisa Drew, PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3727.
https://doi.org/10.1182/blood-2019-124453
Published: 2019
Journal Articles

SIX1 Transcription Factor Enhances Human Erythropoiesis Via GATA1

Michael Creed, MSc, Christian Eberly, Jevon Cutler, PhD, MinJung Kim, PhD, Akhilesh Pandey, MD PhD, Curt I Civin, MD, Tami J Kingsbury, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3503.
https://doi.org/10.1182/blood-2019-131203
Published: 2019
Journal Articles

MYC Overexpressing Multiple Myeloma Are Dependent on GLS1

Katarina K Jovanovic, PhD, Léa Fléchon, MSc, Mairead Reidy, PhD, Jihye Park, BS, DVM, Xavier Leleu, MD PhD, Irene M. Ghobrial, MD, Thierry Facon, MD, Bruno Quesnel, Salomon Manier, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 853.
https://doi.org/10.1182/blood-2019-128484
Published: 2019
Journal Articles

PARP1-Mediated Alt-NHEJ Repair Is a Therapeutic Target in Multiple Myeloma

Daniele Caracciolo, MD, Giada Juli, PhD, Francesca Scionti, PhD, Gaetanina Golino, PhD, Mariamena Arbitrio, MD, Emanuela Altomare, PhD, Katia Todoerti, PhD, Katia Grillone, PhD, Maria Teresa Di Martino, PhD, Marco Rossi, MD, Antonino Neri, MD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3107.
https://doi.org/10.1182/blood-2019-128245
Published: 2019
Journal Articles

A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency

Kerstin B. Kaufmann, Laura Garcia-Prat, Qiang Liu, Stanley W. K. Ng, Shin-Ichiro Takayanagi, Amanda Mitchell, Erno Wienholds, Peter van Galen, Christian A. Cumbaa, Mike J. Tsay, Chiara Pastrello, Elvin Wagenblast, Gabriela Krivdova, Mark D. Minden, Eric R. Lechman, Sasan Zandi, Igor Jurisica, Jean C. Y. Wang, Stephanie Z. Xie, John E. Dick
Journal: Blood
Blood (2019) 133 (20): 2198–2211.
https://doi.org/10.1182/blood-2018-10-881441
Published: 2019
Includes: Supplemental data
Journal Articles

Suv39h1 Represses the Progression of MLL -Rearranged Myeloid Leukemia Via Hoxb13

Yajing Chu, PhD, Yangpeng Chen, Huidong Guo, PhD, Mengke Li, Jun Shi, MD, Tao Cheng, MD, Feng-Chun Yang, MD PhD, Mingjiang Xu, MD PhD, Weiping Yuan, PhDMD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3878.
https://doi.org/10.1182/blood-2018-99-113732
Published: 2018
Journal Articles

Identification of Gene Regulatory Networks Governing Stemness Properties of Human HSC and LSC

Stanley W.K. Ng, Stephanie Zhi-Juan Xie, PhD, Elvin Wagenblast, PhD, Naoya Takayama, MD PhD, Liqing Jin, MD, Nathan Mbong, Alex Murison, Schoof E Erwin, Amanda Mitchell, PhD, Peter Van Galen, PhD, Mathieu Lupien, PhD, Mark D. Minden, MD PhD, Jean C.Y. Wang, MD PhD, Peter W. Zandstra, PhD, John E. Dick
Journal: Blood
Blood (2018) 132 (Supplement 1): 3832.
https://doi.org/10.1182/blood-2018-99-114314
Published: 2018
Journal Articles

AraC-Daunorubicin-Etoposide (ADE) Response Prediction in Pediatric AML Patients Using a Computational Biology Modeling (CBM) Based Precision Medicine Workflow

Christopher R. Cogle, MD, Taher Abbasi, MS, MBA, Neeraj Kumar Singh, B.Tech, Mohammed Sauban, B.E, Rahul K Raman, M.Sc., Robinson Vidva, B.Tech, Anuj Tyagi, M.Sc., Anay Ashok Talawdekar, M.Tech, Arko Das, M.Sc., Steven M. Kornblau, MD, Fieke W Hoff, BSc, Terzah M. Horton, MD PhD, Shireen Vali, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4034.
https://doi.org/10.1182/blood-2018-99-115775
Published: 2018
Journal Articles

Functional Analysis of CD99 Upregulation in Acute Myeloid Leukemia

Vijaya Pooja Vaikari, MS, Jiawen Yang, BS, Mojtaba Akhtari, MD, Houda Alachkar, PharmD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5129.
https://doi.org/10.1182/blood-2018-99-120348
Published: 2018
Journal Articles

MRTFA Augments Megakaryocyte Maturation By Enhancing the SRF Regulatory Axis

Nur-Taz Rahman, BS, MPhil, Vincent P Schulz, PhD, Lin Wang, MS, Patrick G. Gallagher, MD, Oleg Denisenko, PhD, Francesco Gualdrini, PhD, Esnault Cyril, PhD, Diane S. Krause, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 640.
https://doi.org/10.1182/blood-2018-99-118954
Published: 2018
Journal Articles

Mcl-1/CDK9 Targeting By AZD5991/AZD4573 Overcomes Intrinsic and Acquired Venetoclax Resistance in Vitro and In Vivo in PDX Model of AML through Modulation of Cell Death and Metabolic Functions

Bing Z Carter, PhD, Po Yee Mak, Wenjing Tao, Mark Warmoes, Philip L Lorenzi, PhD, Duncan Mak, BSc, MPhil, Vivian Ruvolo, MS, Xiangmeng Wang, Huaxian Ma, MS, Hong Mu, MD PhD, Justin Cidado, PhD, Lisa Drew, PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 768.
https://doi.org/10.1182/blood-2018-99-113491
Published: 2018
Journal Articles

Microrna-130a Regulates Hematopoietic Stem Cell Self-Renewal By Repressing Chromatin Modifiers and Shaping the Accessible Chromatin Landscape

Gabriela Krivdova, BSc, MSc, Schoof E Erwin, Veronique Voisin, PhD, Alex Murison, Karin G. Hermans, Laura Garcia Prat, Olga I. Gan, Elvin Wagenblast, PhD, Aaron Trotman-Grant, Eric R. Lechman,, PhD MSC, Mark D. Minden, MD PhD, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3824.
https://doi.org/10.1182/blood-2018-99-116866
Published: 2018
Journal Articles

Nucleosome Binding Protein HMGN1 Promotes HSPC Competitive Advantage with Decreased Quiescence and Cooperates with AML Oncogenes to Block Differentiation and Increase Clonogenicity

Lucia Cabal-Hierro, PhD, Katsuhiro Togami, MD PhD, Kelly Higby, Andrew A. Lane, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2606.
https://doi.org/10.1182/blood-2018-99-119348
Published: 2018
Journal Articles

A Stemness Screen Reveals C3ORF54/INKA1 As a Gate-Keeper of Human Stem Cell Latency

Kerstin B. Kaufmann, PhD, Laura Garcia Prat, Shin-Ichiro Takayanagi, PhD, Jessica McLeod, BSc, Olga I. Gan, Kristele Pan, Stephanie Zhi-Juan Xie, PhD, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 325.
https://doi.org/10.1182/blood-2018-99-115065
Published: 2018
Journal Articles

Predicting Carfilzomib Resistance Mechanisms and Therapeutics Using Computational Modelling of Genomics and Proteomics

Andrej Besse, M.Sc, Christopher R. Cogle, MD, Leylah M. Drusbosky, PhD, Shireen Vali, PhD, Taher Abbasi, MS, MBA, Neeraj Kumar Singh, B.Tech, Neha G Gupta, M.Sc., Abha Kushwaha, M.Sc., Pallavi Kumari, M.Sc., Karthik Sundara Raju, M.Sc., Ganesh Naga, B.Tech, Sayani Basu, M.Tech, Christoph Driessen, MD, Lenka Besse, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3193.
https://doi.org/10.1182/blood-2018-99-116939
Published: 2018
Journal Articles

Microrna-126 Levels Modulate B-ALL Aggressiveness but Require Tight Regulation to Guarantee Disease Maintenance

Carolina Caserta, Silvia Nucera, MD, Matteo Maria Naldini, Nadia Foligno, Giacomo Desantis, PhD, Fabio Ciceri, MD, Davide Cittaro, PhD, Bernhard Gentner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2834.
https://doi.org/10.1182/blood-2018-99-115101
Published: 2018
Journal Articles

Sphingosine-1-Phosphate Receptor 3 (S1PR3) Promotes Myeloid Commitment of Human Hematopoietic and Leukemic Stem Cells

Stephanie Zhi-Juan Xie, PhD, Kerstin Kaufmann, PhD, Olga I. Gan, PhD, Elisa Laurenti, PhD, Stanley W.K. Ng, Qiang Liu, Melissa Kleinau, Joseph Jargostf, Gareth Holmes, Chiara Luberto, PhD, Lina M Obeid, MD, Yusuf A. Hannun, MD, Jean C.Y. Wang, MD PhD, Mark D. Minden, MD PhD, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1329.
https://doi.org/10.1182/blood-2018-99-119128
Published: 2018