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Journal Articles

Disease Phenotype and Clonal Amplification in Calreticulin del52 and ins5 Knock-in Mice Are Dependent on the Type of Mutations and Gene Dosage

Camélia Benlabiod, Maira da Costa Cacemiro, PhD, Thomas Balligand, MD, Barbara Panneau-Schmaltz, PhD, Delphine Muller, Laure Touchard, Patrick Gonin, DVM, Jean-Luc Villeval, PhD, Stefan N Constantinescu, MD PhD, Hana Raslova, PhD, William Vainchenker, MD PhD, Isabelle Plo, Caroline Marty, PhD

Blood (2019) 134 (Supplement_1): 311.

https://doi.org/10.1182/blood-2019-127918

Published: 2019

Journal Articles

Engineering a Hematopoietic Stem Cell Niche By Revitalizing Mesenchymal Stem Cells with Five Transcription Factors

Fumio Nakahara, MD PhD, Sandra Pinho, PhD, Daniel K. Borger, MS, Qiaozhi Wei, PhD, Maria Maryanovich, PhD, Ali H. Zahalka, Masako Suzuki, Cristian Cruz, Zichen Wang, Chunliang Xu, PhD, Philip Boulais, PhD, Avi Ma'ayan, John M. Greally, MB, PhD, Paul S. Frenette, MD

Blood (2019) 134 (Supplement_1): 5004.

https://doi.org/10.1182/blood-2019-125045

Published: 2019

Journal Articles

The CDK6 Inhibitor Palbociclib in Combination with Ruxolitinib Remarkably Improves Myelofibrosis in Murine Models

Golam Mohi, PhD, Avik Dutta, PhD, Dipmoy Nath, PhD, Yue Yang, PhD

Blood (2019) 134 (Supplement_1): 4200.

https://doi.org/10.1182/blood-2019-132038

Published: 2019

Journal Articles

Aberrant RNA Splicing Contributes to the Pathogenesis of EVI-Rearranged Myeloid Leukemias

Daichi Inoue, MD PhD, Stanley C Lee, PhD, Akihide Yoshimi, MD PhD, Justin Taylor, MD, Lillian E Bitner, BSc, Atsushi Tanaka, MD, Yasutaka Hayashi, MD PhD, Hana Cho, MSc, Chie Fukui, Ruth Saganty, Alexander V Penson, PhD, Omar Abdel-Wahab, MD

Blood (2019) 134 (Supplement_1): 917.

https://doi.org/10.1182/blood-2019-124722

Published: 2019

Journal Articles

The Innate Immune Sensor Sting Regulates Intestinal Inflammation and GVHD after Allogeneic Hematopoietic Stem Cell Transplantation in Knock-out and Human Allele Knock-in Recipient Mice

Cameron S. Bader, BS, Henry Barreras, MPH, Casey O. Lightbourn, MS, Sabrina Copsel, PhD, Jeonghyun Ahn, PhD, Glen N. Barber, PhD, Lei Jin, PhD MSc, Robert B. Levy, PhD

Blood (2018) 132 (Supplement 1): 65.

https://doi.org/10.1182/blood-2018-99-109999

Published: 2018

Journal Articles

αIIb(R990W), a Gain-of Function Mutation of αIIbβ3, Knock-in Mice Show Moderately Impaired Thrombopoiesis

Keigo Akuta, Kazunobu Kiyomizu, MD, Hirokazu Kashiwagi, Shinji Kunishima, PhD, Fumiaki Banno, Koichi Kokame, Nobuko Nishiura, Hisashi Kato, MD PhD, Shigenori Honda, MD, Yuzuru Kanakura, MD PhD, Toshiyuki Miyata, Yoshiaki Tomiyama, MD

Blood (2018) 132 (Supplement 1): 3743.

https://doi.org/10.1182/blood-2018-99-115953

Published: 2018

Journal Articles

Role of Rhoa G17V in Cell Migration and Transformation in Angioimmunoblastic T-Cell Lymphoma

Teresa Palomero, PhD, Jose R. Cortes, PhD, Anisha R. Cooke, Laura Belver, PhD, Govind Bhagat, Adolfo A. Ferrando, MD PhD

Blood (2018) 132 (Supplement 1): 4122.

https://doi.org/10.1182/blood-2018-99-115005

Published: 2018

Journal Articles

The PIM Kinase Inhibitor TP-3654 in Combination with Ruxolitinib Exhibits Marked Improvement of Myelofibrosis in Murine Models

Dipmoy Nath, PhD, Avik Dutta, MSc, Yue Yang, BS, Clifford Whatcott, PhD, Steven L. Warner, PhD, Golam Mohi, PhD

Blood (2018) 132 (Supplement 1): 54.

https://doi.org/10.1182/blood-2018-99-119421

Published: 2018

Journal Articles

MLL-Menin Inhibition Reverses Pre-Leukemic Progenitor Self-Renewal Induced By NPM1 Mutations and Prevents AML Development

Hannah J. Uckelmann, PhD, Stephanie M. Kim, BA, Noa J. C. Antonissen, Andrei V. Krivtsov, PhD, Charles Hatton, Gerard M. McGeehan, PhD, Ross L. Levine, MD, George S. Vassiliou, Scott A. Armstrong, MD PhD

Blood (2018) 132 (Supplement 1): 546.

https://doi.org/10.1182/blood-2018-99-110851

Published: 2018

Journal Articles

Distinct Roles of GATA2 in Development and Evolution of CBFB-MYH11 AML

Satoshi Saida, MDPhD, Tao Zhen, PhD, Erika Mijin Kwon, PhD, Guadalupe Lopez, Paul P Liu, MD PhD

Blood (2018) 132 (Supplement 1): 770.

https://doi.org/10.1182/blood-2018-99-110636

Published: 2018

Journal Articles

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

Blood (2018) 132 (Supplement 1): 4.

https://doi.org/10.1182/blood-2018-99-118348

Published: 2018

Journal Articles

Cells with DNMT3A Mutations Are More Sensitive to Cytarabine-Induced DNA Damage

Kartika Venugopal, MS, Jianping Li, MD, Daniil E Shabashvili, PhD, Luisa M Posada, Yang Feng, MS, Daphne Dupere-Richer, PhD, Aditya Bele, PhD, Jonathan D. Licht, MD, Olga A Guryanova, MD PhD

Blood (2018) 132 (Supplement 1): 2643.

https://doi.org/10.1182/blood-2018-99-118708

Published: 2018

Journal Articles

Characterization of Novel Subtypes in B Progenitor Acute Lymphoblastic Leukemia

Zhaohui Gu, PhD, Michelle L. Churchman, PhD, Kathryn G. Roberts, PhD, Ian Moore, MS, Xin Zhou, PhD, Joy Nakitandwe, PhD, Kohei Hagiwara, MD, Stephane Pelletier, PhD, Sebastian Gingras, PhD, Hartmut Berns, PhD, Debbie Payne-Turner, Ashley Hill, BS, Ilaria Iacobucci, PhD, Lei Shi, PhD, Stanley Pounds, PhD, Cheng Cheng, PhD, Deqing Pei, MS, Chunxu Qu, PhD, Meenakshi Devidas, PhD, Yunfeng Dai, PhD, Shalini C. Reshmi, PhD, Julie Gastier Foster, PhD, Elizabeth A. Raetz, MD, Michael J. Borowitz, MD PhD, Brent Wood, MD PhD, William L. Carroll, MD, Patrick Zweider McKay, MD PhD, Karen R. Rabin, MD PhD, Leonard A. Mattano, MD, Kelly W. Maloney, MD, Alessandro Rambaldi, MD PhD, Orietta Spinelli, PhD, Jerald Radich, MD, Mark D. Minden, MD PhD, Jacob M. Rowe, MD, Selina Luger, MD, Mark R. Litzow, MD, Martin S. Tallman, MD, Janis Recevskis, PhD, Yanming Zhang, Ravi Bhatia, MD, Jessica Kohlschmidt, PhD, Krzysztof Mrózek, MDPhD, Clara D. Bloomfield, MD, Wendy Stock, MD, Steven M. Kornblau, MD, Hagop M. Kantarjian, MD, Marina Y. Konopleva, MD PhD, William E. Evans, PharmD, Sima Jeha, MD, Ching-Hon Pui, MD, Jun J. Yang, PhD, Elisabeth M. Paietta, PhD, James R. Downing, MD, Mary V Relling, PharmD, Jinghui Zhang, Mignon L. Loh, MD, Stephen P. Hunger, MD, Charles G. Mullighan, MBBS, MD

Blood (2018) 132 (Supplement 1): 565.

https://doi.org/10.1182/blood-2018-99-111219

Published: 2018

Journal Articles

Biological Characterization of the U2af1 S34F Mutation in the Pathogenesis of Myelodysplasia

Ayana Kon, MD PhD, Yasuhito Nannya, MD PhD, Masahiro Nakagawa, MD PhD, Keisuke Kataoka, MD PhD, Masashi Sanada, MD PhD, Manabu Nakayama, PhD, Haruhiko Koseki, PhD, Seishi Ogawa, MD PhD

Blood (2018) 132 (Supplement 1): 3080.

https://doi.org/10.1182/blood-2018-99-117453

Published: 2018

Journal Articles

Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage

Juan Li, Daniel Prins, Hyun Jung Park, Jacob Grinfeld, Carlos Gonzalez-Arias, Stephen Loughran, Oliver M. Dovey, Thorsten Klampfl, Cavan Bennett, Tina L. Hamilton, Dean C. Pask, Rachel Sneade, Matthew Williams, Juliet Aungier, Cedric Ghevaert, George S. Vassiliou, David G. Kent, Anthony R. Green

Blood (2018) 131 (6): 649–661.

https://doi.org/10.1182/blood-2017-09-806356

Published: 2018

Includes: Supplemental data

Journal Articles

Wt1 Haploinsufficiency Induces an Age-Dependent Enhancement in Stem Cell Self-Renewal and Cooperates with FLT3-ITD to Drives Leukemogenesis

Elodie Pronier, PhD, Justin T Whitfield, Tiffany Merlinsky, Jihae Ahn, Raajit K. Rampal, MD PhD, Benjamin H Durham, MD BS, Ari Melnick, MD, Ross L. Levine, MD

Blood (2017) 130 (Supplement 1): 1214.

https://doi.org/10.1182/blood.V130.Suppl_1.1214.1214

Published: 2017

Journal Articles

Modeling ASXL1 Mutation Revealed Myelodysplasia Caused By Derepression of p16Ink4a through Aberrant PRC1-Mediated Histone Modification

Masahiro Uni, MD PhD, Yosuke Masamoto, MD PhD, Tomohiko Sato, MD PhD, Shunya Arai, MD PhD, Eiji Hara, PhD, Mineo Kurokawa, MD PhD

Blood (2017) 130 (Supplement 1): 118.

https://doi.org/10.1182/blood.V130.Suppl_1.118.118

Published: 2017

Journal Articles

Severe Congenital Neutropenia-Associated Mutations Reveal Stage-Specific Gfi1-Dependent Checkpoints in Myeloid Development

David Muench, BS, Dietmar J Kappes, PhD, Nathan Salomonis, PhD, Kasiani C. Myers, MD, Lee Grimes

Blood (2017) 130 (Supplement 1): 544.

https://doi.org/10.1182/blood.V130.Suppl_1.544.544

Published: 2017

Journal Articles

Phosphorylation of Y311 on Pkcδ Regulates Protease Activated Receptor 4-Mediated Signaling in Platelets

John Kostyak, PhD, Akruti Patel, MSc, Haritha G Reddy, BS, Carol A Dangelmaier, BS, Satya P. Kunapuli, PhD

Blood (2017) 130 (Supplement 1): 3604.

https://doi.org/10.1182/blood.V130.Suppl_1.3604.3604

Published: 2017

Journal Articles

Spliceosomal Dysfunction Is a Critical Mediator of IDH2 Mutant Leukemogenesis

Blood (2017) 130 (Supplement 1): 473.

https://doi.org/10.1182/blood.V130.Suppl_1.473.473

Published: 2017

NARROW

Disease Phenotype and Clonal Amplification in Calreticulin del52 and ins5 Knock-in Mice Are Dependent on the Type of Mutations and Gene Dosage

Engineering a Hematopoietic Stem Cell Niche By Revitalizing Mesenchymal Stem Cells with Five Transcription Factors

The CDK6 Inhibitor Palbociclib in Combination with Ruxolitinib Remarkably Improves Myelofibrosis in Murine Models

Aberrant RNA Splicing Contributes to the Pathogenesis of EVI-Rearranged Myeloid Leukemias

The Innate Immune Sensor Sting Regulates Intestinal Inflammation and GVHD after Allogeneic Hematopoietic Stem Cell Transplantation in Knock-out and Human Allele Knock-in Recipient Mice

αIIb(R990W), a Gain-of Function Mutation of αIIbβ3, Knock-in Mice Show Moderately Impaired Thrombopoiesis

Role of Rhoa G17V in Cell Migration and Transformation in Angioimmunoblastic T-Cell Lymphoma

The PIM Kinase Inhibitor TP-3654 in Combination with Ruxolitinib Exhibits Marked Improvement of Myelofibrosis in Murine Models

MLL-Menin Inhibition Reverses Pre-Leukemic Progenitor Self-Renewal Induced By NPM1 Mutations and Prevents AML Development

Distinct Roles of GATA2 in Development and Evolution of CBFB-MYH11 AML

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

Cells with DNMT3A Mutations Are More Sensitive to Cytarabine-Induced DNA Damage

Characterization of Novel Subtypes in B Progenitor Acute Lymphoblastic Leukemia

Biological Characterization of the U2af1 S34F Mutation in the Pathogenesis of Myelodysplasia

Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage

Wt1 Haploinsufficiency Induces an Age-Dependent Enhancement in Stem Cell Self-Renewal and Cooperates with FLT3-ITD to Drives Leukemogenesis

Modeling ASXL1 Mutation Revealed Myelodysplasia Caused By Derepression of p16Ink4a through Aberrant PRC1-Mediated Histone Modification

Severe Congenital Neutropenia-Associated Mutations Reveal Stage-Specific Gfi1-Dependent Checkpoints in Myeloid Development

Phosphorylation of Y311 on Pkcδ Regulates Protease Activated Receptor 4-Mediated Signaling in Platelets

Spliceosomal Dysfunction Is a Critical Mediator of IDH2 Mutant Leukemogenesis

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American Society of Hematology

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American Society of Hematology

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