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Journal Articles

Hemopexin deficiency promotes acute kidney injury in sickle cell disease

Solomon F. Ofori-Acquah, Rimi Hazra, Oluwaseun O. Orikogbo, Danielle Crosby, Bethany Flage, Ezekiel B. Ackah, Diane Lenhart, Roderick J. Tan, Dario A. Vitturi, Vivian Paintsil, Ellis Owusu-Dabo, Samit Ghosh, in collaboration with the SickleGenAfrica Network

Blood (2020) 135 (13): 1044–1048.

https://doi.org/10.1182/blood.2019002653

Published: 2020

Includes: Supplemental data

Journal Articles

Increased Release of Soluble MD-2 in Sickle Cell Disease and Its Role in Pro-Inflammatory Signaling in Endothelial Cells

Ping Zhang, PhD, John D Belcher, PhD, Julia Nguyen, Fuad Abdulla, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 208.

https://doi.org/10.1182/blood-2019-122912

Published: 2019

Journal Articles

Hemopexin Replacement Therapy Protects Sickle Cell Disease Mice from Acute Kidney Injury

Samit Ghosh, Oluwaseun Orikogbo, Rimi Hazra, Bethany Flage, Danielle Crosby, Solomon Fiifi Ofori-Acquah

Blood (2019) 134 (Supplement_1): 78.

https://doi.org/10.1182/blood-2019-127161

Published: 2019

Journal Articles

Targeted Therapy of Acute Chest Syndrome with Recombinant Heme Oxygenase-1 Revealed By the Resistance of Young Transgenic Sickle Cell Mice to Heme-Induced Acute Lung Injury

Rimi Hazra, Samit Ghosh, Bethany Flage, Matthew Crouthamel, Clark Pan, Xiuxia Sun, Bohong Zhang, Joseph Sypek, Solomon Fiifi Ofori-Acquah

Blood (2019) 134 (Supplement_1): 74.

https://doi.org/10.1182/blood-2019-127198

Published: 2019

Journal Articles

Anti-Inflammatory Effects of Hydroxyurea in a Murine Model of Chronic Intravascular Hemolysis

Erica M.F. Gotardo, PhD, Pamela L. Brito, M.Sc., Hanan Chweih, M.Sc., Flavia C. Leonardo, PhD, Fernando Ferreira Costa, MD PhD, Nicola Conran, PhD

Blood (2019) 134 (Supplement_1): 2263.

https://doi.org/10.1182/blood-2019-131741

Published: 2019

Journal Articles

Heme Overload Triggers Xanthine Oxidase Release and Mediates the Inflammatory Response

Heidi M Schmidt, BSE, Eric Kelley, PhD, Adam Straub, PhD

Blood (2019) 134 (Supplement_1): 3529.

https://doi.org/10.1182/blood-2019-130274

Published: 2019

Journal Articles

L-Glutamine Increases IGF-1 Liver Expression to Prevent Bone Loss in Sickle Mice

Mykel D Green, Mitchell Schaffler, PhD, Gilda A Barabino, PhD

Blood (2019) 134 (Supplement_1): 3561.

https://doi.org/10.1182/blood-2019-128950

Published: 2019

Journal Articles

Hemolysis in the Spleen Drives Erythrocyte Turnover

Thomas Klei, Robin Van Bruggen, PhD, Jill Dalimot, Martijn Veldthuis, Erik Mul, Timo Rademakers, Mark Hoogenboezem, Sietse Quirijn Nagelkerke, Wilfred Van Ijcken, Soren K. Moestrup, MD PhD, Floris van Alphen, Sander Meijer, PhD, Taco Kuijpers, Rob van Zwieten, Pia Svendsen

Blood (2019) 134 (Supplement_1): 946.

https://doi.org/10.1182/blood-2019-124342

Published: 2019

Journal Articles

Sickle Cell Hemoglobin Impairs Lysosomal Processing in Macrophages Leading to Inflammasome Activation and Inflammation

Marina Jerebtsova, PhD, Xiaomei Niu, MD, Sharmin Diaz, NP, Namita Kumari, PhD, Sergei Nekhai, PhD

Blood (2019) 134 (Supplement_1): 979.

https://doi.org/10.1182/blood-2019-130741

Published: 2019

Journal Articles

Interest of a New Method for Free Plasma Heme Related Species Dosages in Sickle Cell Disease and Beta Thalassemia

Laurent Kiger, Sandia Adypagavane, Laura Bencheikh, PhD, Nicolas Hebert, Stephane Moutereau, MD, Frédéric Galactéros, MD PhD, Michael Marden, PhD, Yves Beuzard, MD, France Pirenne, MD PhD, Pablo Bartolucci, MD PhD

Blood (2019) 134 (Supplement_1): 3381.

https://doi.org/10.1182/blood-2019-130600

Published: 2019

Journal Articles

A Shared Signaling Network That Maintains Erythroid Homeostasis By Activating Stress Erythropoiesis Regulates Inflammation: Implications for the Anemia of Chronic Inflammation

James Fraser, BSc, Adwitia Dey, BSc, MS, Shaneice Nettleford, BSc, Siyang Hao, BSc, Luming Zhao, BSc, Pamela Hankey-Giblin, PhD, K. Sandeep Prabhu, PhD, Na Xiong, PhD, Robert Paulson, PhD

Blood (2018) 132 (Supplement 1): 629.

https://doi.org/10.1182/blood-2018-99-113448

Published: 2018

Journal Articles

Thrombin-Mediated Activation of PAR-1 Contributes to Microvascular Stasis in Mouse Models of Sickle Cell Disease Via Increased Endothelial Expression of P-Selectin and VWF

Erica Sparkenbaugh, PhD BS, Chunsheng Chen, MD, Julia Nguyen, BS, Shaobin Wang, PhD, Gregory M. Vercellotti, MD, John D Belcher, PhD, Rafal Pawlinski, PhD

Blood (2018) 132 (Supplement 1): 266.

https://doi.org/10.1182/blood-2018-99-116238

Published: 2018

Journal Articles

Acute Hemolysis Induces Pro-Angiogenic Molecule Production and Neovascularization In Vivo

Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Pamela L. Brito, B.Sc, Flavia C. Leonardo, PhD, Raquel Costa, PhD, Raquel Soares, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 3608.

https://doi.org/10.1182/blood-2018-99-118416

Published: 2018

Journal Articles

Elevated Levels of Hepatokine Angiopoietin-like 3 Correlate Paradoxically with Hypocholesterolemia and Hemolysis in Sickle Cell Anemia

Felipe Vendrame, MSc, Leticia Marani, MSc, Sara T. Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Kleber Yotsumoto Fertrin, MD PhD

Blood (2018) 132 (Supplement 1): 1069.

https://doi.org/10.1182/blood-2018-99-113851

Published: 2018

Journal Articles

Red Blood Cells Microparticles Are Associated with Hemolysis Markers and Leg Ulceration in Patients with Sickle Cell Disease

Oladele Olatunya, MD, Carolina Lanaro, PhD, Ana Leda Figueiredo Longhini, PhD, Carla Fernanda Franco-Penteado, BSc, PhD, Sara Teresinha Olalla Saad, MD PhD, Kleber Yotsumoto Fertrin, MD PhD, Adekunle Adekile, MBBS, PhD FMCPaed, FWACP, FRCPCH, FRCP, Fernando Ferreira Costa, MD PhD

Blood (2017) 130 (Supplement 1): 3510.

https://doi.org/10.1182/blood.V130.Suppl_1.3510.3510

Published: 2017

Journal Articles

Free Heme Induces a Heme Importer, Heme Catabolism and an Angiogenic Factor in Multiple Organs in Mice: Implications for Organ-Specific Response to Intravascular Hemolysis

Oluwabukola Gbotosho, BSc, MSc, PhD, Maria G Kapetanaki, PhD, Yu Lin, Frances Weidert, MSc, Solomon Fiifi Ofori-Acquah, PhD, Gregory J. Kato, MD

Blood (2017) 130 (Supplement 1): 3468.

https://doi.org/10.1182/blood.V130.Suppl_1.3468.3468

Published: 2017

Journal Articles

LRP1 Expression in Sickle Cell Disorders: Insights into the Heterogeneity of Monocytic Response to Heme

Leticia Marani, BS, Felipe Vendrame, BS, MSc, Marina Dorigatti Borges, BS, Sara Teresinha Olalla Saad, MD PhD, Fernando Ferreira Costa, MD PhD, Kleber Yotsumoto Fertrin, MD PhD

Blood (2017) 130 (Supplement 1): 3515.

https://doi.org/10.1182/blood.V130.Suppl_1.3515.3515

Published: 2017

Journal Articles

Red Blood Cell Transfusions Shape Macrophages Towards an Anti-Inflammatory Functional Phenotype and Impair the Immune Response to Infectious Cues

Francesca Vinchi, Milene Costa da Silva, Richard Sparla, Heike Weidner, Martina Rauner, Emanuela Tolosano, Uwe Platzbecker, MD, Martina U. Muckenthaler

Blood (2017) 130 (Supplement 1): 227.

https://doi.org/10.1182/blood.V130.Suppl_1.227.227

Published: 2017

Journal Articles

The NLRP3 Inflammasome in Platelets Is Upregulated in Sickle Cell Disease and Promotes Platelet Aggregation and In Vitro Thrombosis

Sebastian Vogel, MD PhD, Taruna Arora, MD, Xunde Wang, PhD, Luis E. Almeida, MD PhD, Zenaide Quezado, MD, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP

Blood (2017) 130 (Supplement 1): 2234.

https://doi.org/10.1182/blood.V130.Suppl_1.2234.2234

Published: 2017

Journal Articles

Enhanced Renal Clearance of Heme Triggers Acute Kidney Injury in Sickle Cell Disease

Samit Ghosh, PhD, Vivian Paintsil, MD, Rimi Hazra, PhD, Oluowaseun O. Orikogbo, Bethany Flage, Ezekiel Bonwin Ackah, Ellis Owusu-Dabo, PhD, Solomon Fiifi Ofori-Acquah, PhD

Blood (2017) 130 (Supplement 1): 441.

https://doi.org/10.1182/blood.V130.Suppl_1.441.441

Published: 2017

NARROW

Hemopexin deficiency promotes acute kidney injury in sickle cell disease

Increased Release of Soluble MD-2 in Sickle Cell Disease and Its Role in Pro-Inflammatory Signaling in Endothelial Cells

Hemopexin Replacement Therapy Protects Sickle Cell Disease Mice from Acute Kidney Injury

Targeted Therapy of Acute Chest Syndrome with Recombinant Heme Oxygenase-1 Revealed By the Resistance of Young Transgenic Sickle Cell Mice to Heme-Induced Acute Lung Injury

Anti-Inflammatory Effects of Hydroxyurea in a Murine Model of Chronic Intravascular Hemolysis

Heme Overload Triggers Xanthine Oxidase Release and Mediates the Inflammatory Response

L-Glutamine Increases IGF-1 Liver Expression to Prevent Bone Loss in Sickle Mice

Hemolysis in the Spleen Drives Erythrocyte Turnover

Sickle Cell Hemoglobin Impairs Lysosomal Processing in Macrophages Leading to Inflammasome Activation and Inflammation

Interest of a New Method for Free Plasma Heme Related Species Dosages in Sickle Cell Disease and Beta Thalassemia

A Shared Signaling Network That Maintains Erythroid Homeostasis By Activating Stress Erythropoiesis Regulates Inflammation: Implications for the Anemia of Chronic Inflammation

Thrombin-Mediated Activation of PAR-1 Contributes to Microvascular Stasis in Mouse Models of Sickle Cell Disease Via Increased Endothelial Expression of P-Selectin and VWF

Acute Hemolysis Induces Pro-Angiogenic Molecule Production and Neovascularization In Vivo

Elevated Levels of Hepatokine Angiopoietin-like 3 Correlate Paradoxically with Hypocholesterolemia and Hemolysis in Sickle Cell Anemia

Red Blood Cells Microparticles Are Associated with Hemolysis Markers and Leg Ulceration in Patients with Sickle Cell Disease

Free Heme Induces a Heme Importer, Heme Catabolism and an Angiogenic Factor in Multiple Organs in Mice: Implications for Organ-Specific Response to Intravascular Hemolysis

LRP1 Expression in Sickle Cell Disorders: Insights into the Heterogeneity of Monocytic Response to Heme

Red Blood Cell Transfusions Shape Macrophages Towards an Anti-Inflammatory Functional Phenotype and Impair the Immune Response to Infectious Cues

The NLRP3 Inflammasome in Platelets Is Upregulated in Sickle Cell Disease and Promotes Platelet Aggregation and In Vitro Thrombosis

Enhanced Renal Clearance of Heme Triggers Acute Kidney Injury in Sickle Cell Disease

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American Society of Hematology

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American Society of Hematology

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