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Journal Articles

Iron Deficiency Anemia Caused By Malabsorption from Proton Pump Inhibition

Michael Boxer, MD

Blood (2019) 134 (Supplement_1): 962.

https://doi.org/10.1182/blood-2019-122154

Published: 2019

Journal Articles

Smooth Muscle Cytochrome b5 Reductase 3 Deficiency Accelerates Pulmonary Hypertension Development in Sickle Cell Mice

Katherine Wood, PhD BA, Brittany Durgin, PhD, Heidi M Schmidt, BSE, Scott Hahn, Jeffrey Baust, Tim Bachman, Dario A. Vitturi, PhD, Samit Ghosh, Solomon Fiifi Ofori-Acquah, Ana Mora, MD, Mark T Gladwin, MD, Adam Straub, PhD

Blood (2019) 134 (Supplement_1): 3619.

https://doi.org/10.1182/blood-2019-124159

Published: 2019

Journal Articles

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

John D Belcher, PhD, Margaret Biddle, PhD, Domi Stickens, PhD, Lyndsay Olson, Eric Bell, Chunsheng Chen, Fuad Abdulla, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Jacob Lloyd, MD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 983.

https://doi.org/10.1182/blood-2019-127300

Published: 2019

Journal Articles

Peroxiredoxin II ( PRDX2 ) Is a Novel Candidate Gene for Congenital Dyserythropoietic Anemia

Myesa Emberesh, MBBS, Katie Giger Seu, PhD, Sana Emberesh, MBBS, Lisa Trump, Mary Risinger, PhD, Wenying Zhang, MD PhD, Ammar Husami, Carolyn Lutzko, PhD, Vinod Gidvani-Diaz, Robert B. Lorsbach, MD PhD, Theodosia A. Kalfa, MD PhD

Blood (2018) 132 (Supplement 1): 3605.

https://doi.org/10.1182/blood-2018-99-120056

Published: 2018

Journal Articles

Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a β-thalassemia mouse model

Daniel Garcia-Santos, Amel Hamdi, Zuzana Saxova, Carine Fillebeen, Kostas Pantopoulos, Monika Horvathova, Prem Ponka

Blood (2018) 131 (2): 236–246.

https://doi.org/10.1182/blood-2017-07-798728

Published: 2018

Includes: Supplemental data

Journal Articles

Heme Regulates the Expression in Erythroblasts of Placenta Growth Factor, a Contributor to Pulmonary Hypertension in Sickle Cell Disease, through the Oxidant Response Transcription Factor NRF2

Maria G Kapetanaki, PhD, Oluwabukola Gbotosho, BSc, MSc, PhD, Deva Sharma, MD MS, Schrott Valerie, MS, Frances Weidert, MSc, Solomon Fiifi Ofori-Acquah, PhD, Grant C. Bullock, MD PhD, Gregory J. Kato, MD

Blood (2017) 130 (Supplement 1): 3496.

https://doi.org/10.1182/blood.V130.Suppl_1.3496.3496

Published: 2017

Journal Articles

LRP1 Expression in Sickle Cell Disorders: Insights into the Heterogeneity of Monocytic Response to Heme

Leticia Marani, BS, Felipe Vendrame, BS, MSc, Marina Dorigatti Borges, BS, Sara Teresinha Olalla Saad, MD PhD, Fernando Ferreira Costa, MD PhD, Kleber Yotsumoto Fertrin, MD PhD

Blood (2017) 130 (Supplement 1): 3515.

https://doi.org/10.1182/blood.V130.Suppl_1.3515.3515

Published: 2017

Journal Articles

High Concentrations of Folic Acid Are Associated with Decreased Hemin Absorption in Caco-2 Cells

Juliano Felix Bertinato, MSc, Ralph Green, MD PhD, Bo Lonnerdal, PhD, Tina Du, Clovis Paniz, PhD, Maylla Rodrigues Lucena, MSc, Guilherme Wataru Gomes, MSc, Elvira Maria Guerra-Shinohara, PhD

Blood (2017) 130 (Supplement 1): 4752.

https://doi.org/10.1182/blood.V130.Suppl_1.4752.4752

Published: 2017

Journal Articles

Effects of Phenyl-1-Pyridin-2yl-Ethanone (PPY)-Based Iron Chelators on the Formation of Methemoglobin

Nowah K. A. Afangbedji, Namita Kumari, PhD, Dymtro Kowalskyy, Sergei Nekhai

Blood (2016) 128 (22): 4823.

https://doi.org/10.1182/blood.V128.22.4823.4823

Published: 2016

Journal Articles

The Oxidant Response Transcription Factor NRF2 Mediates Heme Activation of Placenta Growth Factor Expression in Erythroid Cells, a Contributor to Pulmonary Hypertension in Sickle Cell Disease

Maria G Kapetanaki, PhD, Deva Sharma, MD MS, Oluwabukola T Gbotosho, PhD, Valerie Schrott, MS, Frances Weidart, BS, Solomon Fiifi Ofori-Acquah, PhD, Grant C Bullock, MD PhD, Gregory J. Kato, MD

Blood (2015) 126 (23): 403.

https://doi.org/10.1182/blood.V126.23.403.403

Published: 2015

Journal Articles

A Mechanistic Investigation of the TTP-like State Associated with Intravenous Abuse of Opana ® ER

Ryan Hunt, MD, Ayla Yalamanoglu, MD, Jin Hyen Baek, PhD, Stephen Butler, MD, Tal Schiller, MD, Edward Wong, MD MA, Paul W Buehler, PhD, Chava Kimchi-Sarfaty, PhD

Blood (2015) 126 (23): 3521.

https://doi.org/10.1182/blood.V126.23.3521.3521

Published: 2015

Journal Articles

The Heme Scavenger Hemopexin Reverts Heme-Driven Pro-Inflammatory Phenotypic Switching of Macrophages in Sickle Cell Disease

Francesca Vinchi, PhD, Milene Costa da Silva, PhDstudent, Giada Ingoglia, PhDstudent, Sara Petrillo, PhDstudent, Nathan Brinkman, Adrian Zuercher, Adelheid Cerwenka, PhD, Emanuela Tolosano, PhD, Martina U. Muckenthaler, PhD

Blood (2015) 126 (23): 2205.

https://doi.org/10.1182/blood.V126.23.2205.2205

Published: 2015

Journal Articles

Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor

Xunde Wang, Laurel Mendelsohn, Heather Rogers, Susan Leitman, Nalini Raghavachari, Yanqin Yang, Yu Ying Yau, Michael Tallack, Andrew Perkins, James G. Taylor, VI, Constance Tom Noguchi, Gregory J. Kato

Blood (2014) 124 (6): 946–954.

https://doi.org/10.1182/blood-2013-11-539718

Published: 2014

Journal Articles

Methemoglobinemia In Rhesus Monkeys Due To M-Hemoglobinopathy

Osheiza Abdulmalik, DVM, MS, Larry Handt, DVM, MS, Martin Safo, PhD, Mary M Patterson, MS, DVM, Ping Wang, Caitlin A Fitzgerald, BS, Urs Giger, PD Dr. med. vet. MS FVH

Blood (2013) 122 (21): 4696.

https://doi.org/10.1182/blood.V122.21.4696.4696

Published: 2013

Journal Articles

Placenta Growth Factor Is Regulated By Heme-Bound Iron Via Erythroid Krüppel-Like Factor In Erythroid Cells and Is Linked To Iron Status In Vivo In Sickle Cell Disease and Hereditary Hemochromatosis

Xunde Wang, PH.D., Laurel G. Mendelsohn, B.S., Heather Marie Rogers, MS, Susan F. Leitman, MD, Andrew Perkins, PhD, Michael Tallack, PhD, James G Taylor, MD, Constance Tom Noguchi, PhD, Gregory J. Kato, M.D.

Blood (2013) 122 (21): 432.

https://doi.org/10.1182/blood.V122.21.432.432

Published: 2013

Journal Articles

Heme-Induced Neutrophil Extracellular Traps (NETs) Formation Contributes To Sickle Cell Disease Pathogenesis

Grace Chen, PhD, Tobias A. Fuchs, PhD, Denisa D. Wagner, PhD, Paul S. Frenette, MD

Blood (2013) 122 (21): 184.

https://doi.org/10.1182/blood.V122.21.184.184

Published: 2013

Journal Articles

Turnover of Heme-Bound Iron Is Associated with Activation of TLR4 and Chemokine Receptor Pathways in the Peripheral Blood Mononuclear Cell Transcriptome in Sickle Cell Anemia

Eduard J. van Beers, MD, PhD, Yanqin Yang, MS, Susan Yuditskaya, M.D., Nalini Raghavachari, PhD, Gregory J. Kato, M.D.

Blood (2012) 120 (21): 819.

https://doi.org/10.1182/blood.V120.21.819.819

Published: 2012

Journal Articles

Iron Containing Compound Stimulates Expression of Pulmonary Hypertension Promoting Factor PlGF

Xunde Wang, Gregory J. Kato, MD, Laurel Mendelsohn

Blood (2011) 118 (21): 900.

https://doi.org/10.1182/blood.V118.21.900.900

Published: 2011

Journal Articles

Regulation of Flvcr by Macrophages in Response to Lipopolysaccharide

Mary Philip, MD PhD, Edison Y. Chiu, Janis L. Abkowitz, MD

Blood (2011) 118 (21): 2111.

https://doi.org/10.1182/blood.V118.21.2111.2111

Published: 2011

Journal Articles

Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity

Florence Vallelian, Christian A. Schaer, Theresa Kaempfer, Peter Gehrig, Elena Duerst, Gabriele Schoedon, Dominik J. Schaer

Blood (2010) 116 (24): 5347–5356.

https://doi.org/10.1182/blood-2010-04-277319

Published: 2010

Includes: Supplemental data

NARROW

Iron Deficiency Anemia Caused By Malabsorption from Proton Pump Inhibition

Smooth Muscle Cytochrome b5 Reductase 3 Deficiency Accelerates Pulmonary Hypertension Development in Sickle Cell Mice

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

Peroxiredoxin II ( PRDX2 ) Is a Novel Candidate Gene for Congenital Dyserythropoietic Anemia

Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a β-thalassemia mouse model

Heme Regulates the Expression in Erythroblasts of Placenta Growth Factor, a Contributor to Pulmonary Hypertension in Sickle Cell Disease, through the Oxidant Response Transcription Factor NRF2

LRP1 Expression in Sickle Cell Disorders: Insights into the Heterogeneity of Monocytic Response to Heme

High Concentrations of Folic Acid Are Associated with Decreased Hemin Absorption in Caco-2 Cells

Effects of Phenyl-1-Pyridin-2yl-Ethanone (PPY)-Based Iron Chelators on the Formation of Methemoglobin

The Oxidant Response Transcription Factor NRF2 Mediates Heme Activation of Placenta Growth Factor Expression in Erythroid Cells, a Contributor to Pulmonary Hypertension in Sickle Cell Disease

A Mechanistic Investigation of the TTP-like State Associated with Intravenous Abuse of Opana ® ER

The Heme Scavenger Hemopexin Reverts Heme-Driven Pro-Inflammatory Phenotypic Switching of Macrophages in Sickle Cell Disease

Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor

Methemoglobinemia In Rhesus Monkeys Due To M-Hemoglobinopathy

Placenta Growth Factor Is Regulated By Heme-Bound Iron Via Erythroid Krüppel-Like Factor In Erythroid Cells and Is Linked To Iron Status In Vivo In Sickle Cell Disease and Hereditary Hemochromatosis

Heme-Induced Neutrophil Extracellular Traps (NETs) Formation Contributes To Sickle Cell Disease Pathogenesis

Turnover of Heme-Bound Iron Is Associated with Activation of TLR4 and Chemokine Receptor Pathways in the Peripheral Blood Mononuclear Cell Transcriptome in Sickle Cell Anemia

Iron Containing Compound Stimulates Expression of Pulmonary Hypertension Promoting Factor PlGF

Regulation of Flvcr by Macrophages in Response to Lipopolysaccharide

Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity

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American Society of Hematology

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American Society of Hematology

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