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Journal Articles

Heme: driver of erythrocyte elimination

Jordan D. Dimitrov, Lubka T. Roumenina

Blood (2021) 138 (13): 1092–1094.

https://doi.org/10.1182/blood.2021012875

Published: 2021

Journal Articles

Type I interferon is induced by hemolysis and drives antibody-mediated erythrophagocytosis in sickle cell disease

Yunfeng Liu, Mouli Pal, Weili Bao, Patricia A. Shi, Cheryl A. Lobo, Xiuli An, Deepa Manwani, Hui Zhong, Karina Yazdanbakhsh

Blood (2021) 138 (13): 1162–1171.

https://doi.org/10.1182/blood.2021011629

Published: 2021

Includes: Supplemental data

Journal Articles

Macrophage metabolic adaptation to heme detoxification involves CO-dependent activation of the pentose phosphate pathway

Gael F. P. Bories, Scott Yeudall, Vlad Serbulea, Todd E. Fox, Brant E. Isakson, Norbert Leitinger

Blood (2020) 136 (13): 1535–1548.

https://doi.org/10.1182/blood.2020004964

Published: 2020

Includes: Supplemental data

Journal Articles

Diamond-Blackfan anemia

Lydie Da Costa, Thierry Leblanc, Narla Mohandas

Blood (2020) 136 (11): 1262–1273.

https://doi.org/10.1182/blood.2019000947

Published: 2020

Journal Articles

Heme induces rapid endothelial barrier dysfunction via the MKK3/p38MAPK axis

Joel James, Anup Srivastava, Mathews Valuparampil Varghese, Cody A. Eccles, Marina Zemskova, Olga Rafikova, Ruslan Rafikov

Blood (2020) 136 (6): 749–754.

https://doi.org/10.1182/blood.2019003986

Published: 2020

Includes: Supplemental data

Journal Articles

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Erica M. Sparkenbaugh, Chunsheng Chen, Tomasz Brzoska, Julia Nguyen, Shaobin Wang, Gregory M. Vercellotti, Nigel S. Key, Prithu Sundd, John D. Belcher, Rafal Pawlinski

Blood (2020) 135 (20): 1783–1787.

https://doi.org/10.1182/blood.2019003543

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Hemopexin deficiency promotes acute kidney injury in sickle cell disease

Solomon F. Ofori-Acquah, Rimi Hazra, Oluwaseun O. Orikogbo, Danielle Crosby, Bethany Flage, Ezekiel B. Ackah, Diane Lenhart, Roderick J. Tan, Dario A. Vitturi, Vivian Paintsil, Ellis Owusu-Dabo, Samit Ghosh, in collaboration with the SickleGenAfrica Network

Blood (2020) 135 (13): 1044–1048.

https://doi.org/10.1182/blood.2019002653

Published: 2020

Includes: Supplemental data

Journal Articles

Heme A1M’ed at the kidney in sickle cell disease

Santosh L. Saraf

Blood (2020) 135 (13): 979–981.

https://doi.org/10.1182/blood.2020005134

Published: 2020

Journal Articles

Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies

Jane-Jane Chen, Shuping Zhang

Blood (2019) 134 (20): 1697–1707.

https://doi.org/10.1182/blood.2019001915

Published: 2019

Journal Articles

Fast Onset of Action of Subcutaneously Administered Marzeptacog Alfa (Activated) Supports on-Demand Treatment in Hemophilia a Mice

Frank Del Greco, MBA, Linda Neuman, MD, Howard Levy, PhD MBBChir, Jill Reckless, Tom Knudsen, PhD DVM, Grant E. Blouse, PhD

Blood (2019) 134 (Supplement_1): 2420.

https://doi.org/10.1182/blood-2019-128971

Published: 2019

Journal Articles

2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies

Blood (2019) 134 (Supplement_1): 2244.

https://doi.org/10.1182/blood-2019-127017

Published: 2019

Journal Articles

Lactate Dehydrogenase to Carboxyhemoglobin Ratio As a Biomarker of Heme Release to Heme Processing Is Associated with Higher Tricuspid Regurgitant Jet Velocity and Early Death in Sickle Cell Disease

Annelies J. Van Vuren, MD, Laurel Mendelsohn, BS, Richard van Wijk, PhD, Caterina P. Minniti, MD, John Baird, MD, Gregory J Kato, MD, Eduard J. van Beers, MD PhD

Blood (2019) 134 (Supplement_1): 2274.

https://doi.org/10.1182/blood-2019-124048

Published: 2019

Journal Articles

Treatment of Delayed Hemolytic Transfusion Reactions in Sickle Cell Disease Patients By an Anti-C5 Antibody

Blood (2019) 134 (Supplement_1): 2458.

https://doi.org/10.1182/blood-2019-127176

Published: 2019

Journal Articles

Evaluation of Markers of Intravascular Hemolysis and Endothelial Dysfunction in Sickle Cell Anemia Patients with and without Hydroxyurea Therapy

Francine Chenou, Bidossessi Wilfried Hounkpe, Igor de Farias Domingos, MSc, Thais Helena Chaves Batista, Rodrigo Marcionilo Santana, Aderson da Silva Araujo, MD PhD, Marcos Andre Cavalcanti Bezerra, PhD, Fernando Ferreira Costa, MD PhD, Maria de Fátima Sonati, MSc, PhD, Erich V De Paula, MD PhD, Magnun Nueldo Nunes Santos, MSc, PhD

Blood (2019) 134 (Supplement_1): 4826.

https://doi.org/10.1182/blood-2019-131169

Published: 2019

Journal Articles

Acid-Based Decalcification Methods Compromise Genomic Profiling from DNA and RNA

Ian Duncan, Natalie Danziger, Daniel Duncan, MD, Amanda Hemmerich, MD, Claire Edgerly, MD, Richard Huang, MD, Jo-Anne Vergilio, MD, Julia A Elvin, MD PhD, Jie He, PhD, Nicholas Britt, Prasanth Reddy, MD, Pratheesh Sathyan, MD, Brian Alexander, MD, Jeffrey S. Ross, MD, Charlotte Brown, PhD, Shakti H. Ramkissoon, MD PhD, Eric A. Severson, MD, PhD, MMSc

Blood (2019) 134 (Supplement_1): 4659.

https://doi.org/10.1182/blood-2019-131362

Published: 2019

Journal Articles

Iron Deficiency Anemia Caused By Malabsorption from Proton Pump Inhibition

Michael Boxer, MD

Blood (2019) 134 (Supplement_1): 962.

https://doi.org/10.1182/blood-2019-122154

Published: 2019

Journal Articles

Validation of Instrument to Assess Hemophilia-Related Distress

Christine L. Kempton, MD MSc, Vaughn Barry, PhD MPH, Tyler W. Buckner, MD MSc, Janet Figueroa, MPH, Shanna Mattis, MPH, Mary Ellen Lynch, PhD, Mary E Stout, MD, Stephanie Whitten, Scott Gillespie, Courtney McCracken, PhD

Blood (2019) 134 (Supplement_1): 936.

https://doi.org/10.1182/blood-2019-122544

Published: 2019

Journal Articles

Hemolysis in the Spleen Drives Erythrocyte Turnover

Thomas Klei, Robin Van Bruggen, PhD, Jill Dalimot, Martijn Veldthuis, Erik Mul, Timo Rademakers, Mark Hoogenboezem, Sietse Quirijn Nagelkerke, Wilfred Van Ijcken, Soren K. Moestrup, MD PhD, Floris van Alphen, Sander Meijer, PhD, Taco Kuijpers, Rob van Zwieten, Pia Svendsen

Blood (2019) 134 (Supplement_1): 946.

https://doi.org/10.1182/blood-2019-124342

Published: 2019

Journal Articles

Mechanism of Pulmonary Thrombosis in Hemolytic Disorders

Tomasz Brzoska, PhD, Margaret F. Bennewitz, PhD, Egemen Tutuncuoglu, MSc, Margaret V. Ragni, MD MPH, Matthew D Neal, MD, Mark T Gladwin, MD, Prithu Sundd, PhD

Blood (2019) 134 (Supplement_1): 976.

https://doi.org/10.1182/blood-2019-130592

Published: 2019

Journal Articles

A Unique Monocyte Transcriptome Discriminates Sickle Cell Disease from Other Hereditary Hemolytic Anemias and Shows the Particular Importance of Lipid and Interferon Signaling

Annelies J. Van Vuren, MD, Stephanie van Straaten, MD PhD, Michal Mokry, PhD, Richard van Wijk, PhD, Eduard J. van Beers, MD PhD

Blood (2019) 134 (Supplement_1): 980.

https://doi.org/10.1182/blood-2019-124070

Published: 2019

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Heme: driver of erythrocyte elimination

Type I interferon is induced by hemolysis and drives antibody-mediated erythrophagocytosis in sickle cell disease

Macrophage metabolic adaptation to heme detoxification involves CO-dependent activation of the pentose phosphate pathway

Diamond-Blackfan anemia

Heme induces rapid endothelial barrier dysfunction via the MKK3/p38MAPK axis

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Hemopexin deficiency promotes acute kidney injury in sickle cell disease

Heme A1M’ed at the kidney in sickle cell disease

Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies

Fast Onset of Action of Subcutaneously Administered Marzeptacog Alfa (Activated) Supports on-Demand Treatment in Hemophilia a Mice

2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies

Lactate Dehydrogenase to Carboxyhemoglobin Ratio As a Biomarker of Heme Release to Heme Processing Is Associated with Higher Tricuspid Regurgitant Jet Velocity and Early Death in Sickle Cell Disease

Treatment of Delayed Hemolytic Transfusion Reactions in Sickle Cell Disease Patients By an Anti-C5 Antibody

Evaluation of Markers of Intravascular Hemolysis and Endothelial Dysfunction in Sickle Cell Anemia Patients with and without Hydroxyurea Therapy

Acid-Based Decalcification Methods Compromise Genomic Profiling from DNA and RNA

Iron Deficiency Anemia Caused By Malabsorption from Proton Pump Inhibition

Validation of Instrument to Assess Hemophilia-Related Distress

Hemolysis in the Spleen Drives Erythrocyte Turnover

Mechanism of Pulmonary Thrombosis in Hemolytic Disorders

A Unique Monocyte Transcriptome Discriminates Sickle Cell Disease from Other Hereditary Hemolytic Anemias and Shows the Particular Importance of Lipid and Interferon Signaling

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American Society of Hematology

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