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Journal Articles

Genetically Engineered Hematopoietic Progenitors Derived from Human Induced Pluripotent Stem Cells Achieve the Feeder-Free and Robust Production of Neutrophils with the Functional Capacity In Vivo

Masashi Miyauchi, Yusuke ITO, MD, Fumio Nakahara, MD PhD, Fumi Nakamura, MD PhD, Yuki Iwasaki, Taiki Kawagoshi, Yuki Kagoya, MD PhD, Shunya Arai, MD PhD, Mineo Kurokawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 720.
https://doi.org/10.1182/blood-2019-126348
Published: 2019
Journal Articles

Exploiting the Zinc Finger Degrome Targeted By Lenalidomide to Engineer Reversible Off-Switch Degradable Chimeric Antigen Receptors

Max Jan, MD PhD, Ana Castano, MD, Amanda Walker, BA, Andrew A Guirguis, MD PhD, Jessica A Gasser, PhD, Amanda A Bouffard, Mikolaj Slabicki, PhD, Alexander Tepper, Daniel E Grinshpun, Taeyoon Kyung, PhD, Quinlan Sievers, MD PhD, Michael E Birnbaum, PhD, Marcela V Maus, MD PhD, Benjamin L. Ebert, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 866.
https://doi.org/10.1182/blood-2019-124210
Published: 2019
Journal Articles

Extensive Metabolic Correction of Hurler Disease By Hematopoietic Stem Cell-Based Gene Therapy: Preliminary Results from a Phase I/II Trial

Bernhard Gentner, MD, Maria Ester Bernardo, MD PhD, Francesca Tucci, MD, Erika Zonari, PhD, Francesca Fumagalli, MD, Silvia Pontesilli, MD, Serena Acquati, PhD, Paolo Silvani, MD, Fabio Ciceri, MD, Attilio Rovelli, MD, Giancarlo La Marca, PhD, Rossella Parini, MD, Silvia Gregori, PhD, Eugenio Montini, PhD, Luigi Naldini, MD PhD, Alessandro Aiuti, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 607.
https://doi.org/10.1182/blood-2019-128805
Published: 2019
Journal Articles

OPB-111077 in Combination with Decitabine and Venetoclax for the Treatment of Acute Myeloid Leukemia

Lindsay Wilde, MD, Ubaldo Martinez-Outschoorn, MD, Neil Palmisiano, MD MS, Margaret Kasner, MDMSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 2597.
https://doi.org/10.1182/blood-2019-131979
Published: 2019
Journal Articles

Cold Plasma with Immunomodulatory Properties Has Significant Anti-Lymphoma Activities in Vitro and In Vivo

Fengdong Cheng, MD, Dayun Yan, PhD, Jie Chen, PhD, Michael Keidar, PhD, Eduardo Sotomayor, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5307.
https://doi.org/10.1182/blood-2019-131065
Published: 2019
Journal Articles

Development of Novel Anti-CD10 Target Modules for Redirection of Universal CAR T Cells Against CD10-Positive Malignancies

Anja Feldmann, PhD, Stefanie Koristka, PhD, Claudia Arndt, PhD, Liliana Raquel Loureiro, PhD, Ralf Bergmann, PhD, Nicole Berndt, PhD, Anja Hoffmann, Justyna Jureczek, Nicola Mitwasi, Martin Bornhaeuser, MD, Václav Hořejší, Michael Bachmann, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5612.
https://doi.org/10.1182/blood-2019-128193
Published: 2019
Journal Articles

Development of an Easily Accessible Patient-Derived Xenograft (PDX) Mouse Model in Multiple Myeloma

Can Li, MD, Yogesh Jethava, MBBS, MDFRCPath, MRCP, Ivana Frech, DSc, PhD MBA, Fenghuang Zhan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5538.
https://doi.org/10.1182/blood-2019-121933
Published: 2019
Journal Articles

Splenic CD24 low Red Pulp Macrophages Provide an Alternate Niche for Chronic Myeloid Leukemia Stem Cells

Michael A Amrein, MD PhD, Elias D Bührer, MD PhD, Stefan Forster, MD, Stephan Isringhausen, Christian M Schürch, MD PhD, Salil S. Bhate, MMath, Mohamad Al Sayed, PhD, Cesar Nombela Arrieta, PhD, Ramin Radpour, PhD, Carsten Riether, PhD, Adrian F Ochsenbein, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1634.
https://doi.org/10.1182/blood-2019-126593
Published: 2019
Journal Articles

First-in-Human Assessment of Feasibility and Safety of Multiplexed Genetic Engineering of Autologous T Cells Expressing NY-ESO -1 TCR and CRISPR/Cas9 Gene Edited to Eliminate Endogenous TCR and PD-1 (NYCE T cells) in Advanced Multiple Myeloma (MM) and Sarcoma

Edward A. Stadtmauer, MD FACP, Adam D. Cohen, MD, Kristy Weber, MD, Simon F Lacey, PhD, Vanessa E. Gonzalez, J. Joseph Melenhorst, PhD, Joseph A Fraietta, PhD, Gabriela Plesa, MD, Joanne Shea, Tina Matlawski, RN, Amanda Cervini, RN, Patricia Mangan, CRNP, Avery Gaymon, Stephanie Desjardins, Eric Lancaster, MD, January Salas-Mckee, Megan M. Suhoski, PhD, Andrew Fesnak, MD, Matthew O'Rourke, Anne Lamontagne, Don L. Siegel, MD PhD, Regina M Young, PhD, Anne Chew, PhD, Christopher L Nobles, PhD, Frederic D. Bushman, PhD, Howard Y. Chang, MD PhD, Ansuman T. Satpathy, MD PhD, Yangbing Zhao, PhD MD, Wei-Ting Hwang, PhD, Elizabeth O. Hexner, MDMS, Carl H June, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 49.
https://doi.org/10.1182/blood-2019-122374
Published: 2019
Journal Articles

Development of an Allogeneic Anti-Bcma T Cell Therapy Utilizing a Novel Dimeric Antigen Receptor (DAR) Structure

Bei Bei Ding, PhD, John Dixon Gray, PhD, Nan Zhang, Yanliang Zhang, PhD, Xia Cao, MSc, Irina Krapf, MSc, Qingdong Mark Deng, Angel Wei, MD, Jerome B. Zeldis, MD PhD, Robert D. Knight, MD, Gunnar F. Kaufmann, PhD, Henry Ji, PhD, Wenzhong Guo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1942.
https://doi.org/10.1182/blood-2019-131892
Published: 2019
Journal Articles

Excellent Survival and Immune Reconstitution Following Matched/Mismatched Unrelated and Mismatched Related Transplantation in Adult Patients with Sickle Cell Disease: Updated Results from a Single Center Experience

Amer Assal, MD, Diane George, MD, Monica Bhatia, MD, Divaya Bhutani, MD, Christian Gordillo, BS, Suzanne Lentzsch, MD PhD, Ran Reshef, MDMSc, Markus Y Mapara, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2043.
https://doi.org/10.1182/blood-2019-132113
Published: 2019
Journal Articles

Interrogating the Role of ASXL1 and JAK2 mutations in Myeloproliferative Neoplasms Utilizing Human Pluripotent Stem Cells

Taylor B. Collins, Stephanie A. Luff, PhD, Luis F.Z. Batista, PhD, Christopher M. Sturgeon, PhD, Stephen T. Oh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2971.
https://doi.org/10.1182/blood-2019-130541
Published: 2019
Journal Articles

Cell-Intrinsic Inflammation Drives Progression from Myelodysplastic Syndromes to Leukemia

Laura Barreyro, PhD, Avery Sampson, BSc, Kathleen Hueneman, Kwangmin Choi, PhD, Susanne Christie, BSc, Dehua Wang, MD, Gang Huang, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2983.
https://doi.org/10.1182/blood-2019-127307
Published: 2019
Journal Articles

Open-Label Pilot Study of Genetically Engineered NY-ESO-1 Specific T Cells (GSK3377794) Alone or in Combination with Pembrolizumab in Relapsed and Refractory Multiple Myeloma

Taiga Nishihori, MD, Jonathan L. Kaufman, MD, James E. Hoffman, Kristin Blouch, Sunil Pandit, Emily Butler, Amit Jain, Yuehui Wu, M. Phillip DeYoung, Aisha N. Hasan, Aaron P. Rapoport
Journal: Blood
Blood (2019) 134 (Supplement_1): 3134.
https://doi.org/10.1182/blood-2019-128059
Published: 2019
Journal Articles

Oncolytic Virus Therapy with HSV-1 for Hematologic Malignancies

Ryo Ishino, Yumi Kawase, MD, Toshio Kitawaki, MD PhD, Naoshi Sugimoto, MD PhD, Maki Oku, MD, Shumpei Uchida, MD, Osamu Imataki, MD PhD, Akihito Matsuoka, MD PhD, Teruhisa Taoka, MD PhD, Kimihiro Kawakami, MD PhD, Tomoki Todo, MD PhD, Akifumi Takaori-Kondo, MD PhD, Norimitsu Kadowaki, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3242.
https://doi.org/10.1182/blood-2019-127754
Published: 2019
Journal Articles

FT576: A Novel Multiplexed Engineered Off-the-Shelf Natural Killer Cell Immunotherapy for the Dual-Targeting of CD38 and Bcma for the Treatment of Multiple Myeloma

Ryan Bjordahl, PhD, Svetlana Gaidarova, MS, Jode P Goodridge, PhD, Sajid Mahmood, PhD, Greg Bonello, PhD, Megan Robinson, Chelsea Ruller, Mochtar Pribadi, PhD, Tom Lee, PhD, Ramzey Abujarour, PhD, Jason Dinella, PhD, Janel Huffman, MS, Hui-yi Chu, PhD, Uta Hopken, Armin Rehm, Bahram Valamehr, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3214.
https://doi.org/10.1182/blood-2019-131373
Published: 2019
Journal Articles

A CRISPR/Cas9 Library Screen in Patients' Leukemia Cells In Vivo

Ehsan Bahrami, PhD, Martin Becker, PhD, Anna-Katharina Wirth, MSc, Jan Phillip Schmid, MSc, Tobias Herold, MD, Rupert Öllinger, PhD, Roland Rad, Irmela Jeremias, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3945.
https://doi.org/10.1182/blood-2019-124288
Published: 2019
Journal Articles

Characterization of a Genetically Engineered HUDEP2 Cell Line Harboring a Sickle Cell Disease Mutation As a Potential Research Tool for Preclinical Sickle Cell Disease Drug Discovery

Dipti Gupta, Sarah Sturtevant, BSc, Benjamin Vieira, BS, Yukio Nakamura, MD PhD, Sriram Krishnamoorthy, PhD, Melanie Demers, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3559.
https://doi.org/10.1182/blood-2019-127330
Published: 2019
Journal Articles

Identification of Dual Positive CD19+/CD3+ T Cells in an Apheresis Product Undergoing Chimeric Antigen Receptor (CAR) Transduction

Liora M Schultz, MD, Shabnum Patel, PhD, Sneha Ramakrishna, MD, Alice Bertaina, MD PhD, Neehar Bhatia, Jean Oak, MD PhD, Robbie G. Majzner, MD, Christina Baggott, RN, PhD, Kara L. Davis, DO, Crystal L. Mackall, MD, Steven A Feldman, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4471.
https://doi.org/10.1182/blood-2019-129436
Published: 2019
Journal Articles

Development of a Genetically-Engineered Allogeneic Anti-CD38 T Cell Therapy Utilizing a Novel Antigen Receptor Structure

Bei Bei Ding, PhD, John Dixon Gray, PhD, Irina Krapf, MSc, Yanliang Zhang, PhD, Nan Zhang, Qingdong Mark Deng, Angel Wei, MD, Robert D. Knight, MD, Jerome B. Zeldis, MD PhD, Gunnar F. Kaufmann, PhD, Henry Ji, PhD, Wenzhong Guo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4444.
https://doi.org/10.1182/blood-2019-131586
Published: 2019