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Journal Articles

Terminal Erythroid Maturation Is Associated with Dynamic Changes in the Abundance of Histone Marks Associated with Active Transcription Elongation and RNA Polymerase II Pausing

Zachary C. Murphy, PhD, Tyler A Couch, BS, Jacquelyn Lillis, MS, Michael Getman, MS, Kimberly Lezon-Geyda, PhD, Vincent P Schulz, PhD, Mohandas Narla, DSc, Patrick G. Gallagher, MD, Laurie A. Steiner, MD

Blood (2019) 134 (Supplement_1): 154.

https://doi.org/10.1182/blood-2019-129561

Published: 2019

Journal Articles

Mitochondrial Activity Identifies a Transcriptionally and Functionally Distinct Subset of Aged HSCs with Lineage-Balanced Output

Els Mansell, PhD, Valgardur Sigurdsson, PhD, Elitza Deltcheva, PhD, John Brown, PhD, Chela James, PhD, Kenichi Miharada, PhD, Shamit Soneji, PhD, Jonas Larsson, MD PhD, Tariq Enver, PhD

Blood (2019) 134 (Supplement_1): 2480.

https://doi.org/10.1182/blood-2019-124001

Published: 2019

Journal Articles

NSD2 Interacts with SMARCA2 and Regulates Expression of Oncogenes CCND1 and PRL3 in T(4;14) Multiple Myeloma

Jing Yuan Chooi, BSc, Zhigang Xie, PhD, Jayantha Gunaratne, PhD, Dennis Keppei, PhD, Wee Joo Chng, MB ChB, PhD FRCP(UK), FRCPath, FAMS

Blood (2018) 132 (Supplement 1): 4479.

https://doi.org/10.1182/blood-2018-99-110671

Published: 2018

Journal Articles

Small Molecule Screens Identify CDK8-Inhibitors As Candidate Diamond-Blackfan Anemia Drugs

Blood (2018) 132 (Supplement 1): 753.

https://doi.org/10.1182/blood-2018-99-114570

Published: 2018

Journal Articles

Genome-Wide Analysis of BRD4-Targets Reveals the Therapeutic Relevance of Simultaneous Targeting of BCR Pathway and IKZF-MYC Axis in Mantle Cell Lymphoma

Junya Kuroda, MD PhD, Taku Tsukamoto, MD PhD, Shingo Nakahata, Kazuhiro Morishita, MD PhD, Ryuichi Sato, Akinori Kanai, PhD, Toshiya Inaba, Masakazu Nakano, Kei Tashiro, Masafumi Taniwaki, MD PhD

Blood (2018) 132 (Supplement 1): 4100.

https://doi.org/10.1182/blood-2018-99-109982

Published: 2018

Journal Articles

Mechanisms Underlying Superior Efficacy of Co-Targeting BET Proteins and Anti-Apoptotic BCL2 or MCL1 Protein Against AML Blast Progenitor Cells

Christopher Peter Mill, PhD BA, Tianyu Cai, PhD, Warren Fiskus, BSc,PhD, Gautam Borthakur, MD, Steven M. Kornblau, MD, Tapan M. Kadia, MD, Courtney D. DiNardo, MDMSc, Agnieszka J Nowak, Dyana T. Saenz, PhD, David N Saenz, Baohua Sun, MD PhD, Thurika Ganesh, Wendy Jin, Vaishnavi Rao, Joseph David Khoury, MD, Yu Shen, Marina Y. Konopleva, MD PhD, Kapil N. Bhalla, MD

Blood (2018) 132 (Supplement 1): 1351.

https://doi.org/10.1182/blood-2018-99-113976

Published: 2018

Journal Articles

Fetal γ-globin genes are regulated by the BGLT3 long noncoding RNA locus

Maria Soledad Ivaldi, Luis Francisco Diaz, Lyubomira Chakalova, Jongjoo Lee, Ivan Krivega, Ann Dean

Blood (2018) 132 (18): 1963–1973.

https://doi.org/10.1182/blood-2018-07-862003

Published: 2018

Includes: Supplemental data

Journal Articles

CDK9 Inhibition with LDC526 Is an Effective Treatment for T-Cell Prolymphocytic Leukemia (T-PLL) in Vitro

Patricia Johansson, MD, Peter Habenberger, PhD, Ludger Klein-Hitpass, PhD, Ulrich Duehrsen, MD, Ralf Küppers, PhD, Carsten Schultz-Fademrecht, PhD, Axel Choidas, PhD, Jan Dürig, MD

Blood (2017) 130 (Supplement 1): 1262.

https://doi.org/10.1182/blood.V130.Suppl_1.1262.1262

Published: 2017

Journal Articles

RNA Polymerase 1 Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Malignancies: Results of a Phase I First in Human Study

Amit Khot, MBBS, MD MRCP, FRCPath, FRACP, Natalie Brajanovski, BSc, Donald P Cameron, BSc, Gretchen Poortinga, PhD, Elaine Sanij, PhD, John Lim, PharmD, John Soong, MD FCAP, Nadine Hein, PhD, Emma Link, DPhil, Richard B Pearson, PhD, Ross Hannan, Grant A. McArthur, MBBS, PhD BSc, FRACP, Simon J. Harrison, MBBS,MRCP,FRCPath,FRACP,PhD

Blood (2017) 130 (Supplement 1): 3835.

https://doi.org/10.1182/blood.V130.Suppl_1.3835.3835

Published: 2017

Journal Articles

Effects of Rigosertib (RIGO) Alone or in Combination with Azacitidine or Vorinostat on Epigenetic Reprogramming of CD34+ Cells in the Myelodysplastic Syndrome

Lewis R Silverman, MD, Pratima Chaurasia, PhD, Stella Melana, PhD, Rosalie Odchimar-Reissig, RN, Erin P. Demakos, BA, BSN, MSN, RN, Shyamala C. Navada, MD, E. Premkumar Reddy, PhD BSc, MSc

Blood (2017) 130 (Supplement 1): 4235.

https://doi.org/10.1182/blood.V130.Suppl_1.4235.4235

Published: 2017

Journal Articles

Targeting the Transcriptional Addiction of Leukemia Stem Cells By a New Class of Protein Kinase Inhibitors

Yinon Ben-Neriah, MD PhD, Avanthika Venkatachalam, MSc, Avner Fink, PhD, Eric Hung, MSc, Joseph Vacca, PhD, Frank Mercurio, PhD, Moshe Oren, PhD, Eli Pikarsky, MDPhD, Irit Snir-Alkalay, PhD, Waleed Minzel, MSc

Blood (2017) 130 (Supplement 1): 812.

https://doi.org/10.1182/blood.V130.Suppl_1.812.812

Published: 2017

Journal Articles

Therapeutic Targeting of GLI1 in Acute Myeloid Leukemia

Metis Hasipek, PhD, Sayer Al-Harbi, PhD, James G Phillips, PhD, Bartlomiej P. Przychodzen, MSc, Alek Nielsen, BS, Yihong Guan, PhD, Dale Grabowski, BS, Phillip J Maciejewski, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Babal K Jha, PhD

Blood (2017) 130 (Supplement 1): 2654.

https://doi.org/10.1182/blood.V130.Suppl_1.2654.2654

Published: 2017

Journal Articles

Targeted Therapy for AML Expressing RUNX1 Mutation

Christopher Peter Mill, PhD BA, Warren Fiskus, BSc,PhD, Courtney D. DiNardo, MDMSc, Yimin Qian, PhD, Kanak Raina, PhD, Koichi Takahashi, MD, Tapan Kadia, MD, Dyana T. Saenz, PhD, Agnieszka J Nowak, Baohua Sun, MD PhD, Craig M Crews, PhD, Kapil N. Bhalla, MD

Blood (2017) 130 (Supplement 1): 2472.

https://doi.org/10.1182/blood.V130.Suppl_1.2472.2472

Published: 2017

Journal Articles

mTOR Restricts Chromatin Access and Genomic Activity to Maintain Hematopoietic Stem Cell Quiescence and Engraftment

Cuiqing Fan, PhD, Chuntao Zhao, PhD, Feng Zhang, Xiongwei Cai, PhD, Lingli Xu, Shan Lin, PhD, Xiaoyi Chen, PhD, Fukun Guo, PhD, Richard Q Lu, PhD, Weidong Tian, PhD, Yi Zheng, PhD

Blood (2017) 130 (Supplement 1): 2416.

https://doi.org/10.1182/blood.V130.Suppl_1.2416.2416

Published: 2017

Journal Articles

Identification of Super-Enhancer-Associated Cancer Genes Provides Novel Therapeutic Targets in Adult T-Cell Leukemia/Lymphoma

Regina Wan Ju Wong, BSc, Phuong Thi Ngoc Cao, PhD, Wei Zhong Leong, BSc, Alice Wei Yee Yam, Bsc, Tinghu Zhang, PhD, Shinsuke Iida, MD PhD, Takashi Okamoto, MD PhD, Ryuzo Ueda, MD PhD, Nathanael S. Grey, PhD, Takashi Ishida, MD PhD, Takaomi Sanda, MD PhD

Blood (2016) 128 (22): 2720.

https://doi.org/10.1182/blood.V128.22.2720.2720

Published: 2016

Journal Articles

DYRK1A Is a Therapeutic Target in B-ALL in Children with Down Syndrome

Paul Lee, MD PhD, Rahul Bhansali, BA, Malini Rammohan, BS, MS, Nobuko Hijiya, MD, Shai Izraeli, MD Prof, Jean-Pierre Bourquin, MD PhD, Sebastien Malinge, PhD, John Crispino, PhD MBA

Blood (2016) 128 (22): 2721.

https://doi.org/10.1182/blood.V128.22.2721.2721

Published: 2016

Journal Articles

Mapping the Functional Cofactors of Oncogenic EZH2 in Natural Killer/ T Cell Lymphoma (NKTL)

Boheng Li, Junli Yan, PhD, Tae-Hoon Chung, PhD, Pei Tsung Lee, Wee Joo Chng, MD PhD

Blood (2016) 128 (22): 1773.

https://doi.org/10.1182/blood.V128.22.1773.1773

Published: 2016

Journal Articles

SETD2, a H3K36 Lysine Methyltransferase, Is Essential for Adult Normal Hematopoiesis and Leukemia Stem Cells

Yile Zhou, Yunzhu Dong, Jiachen Bu, Xiaomei Yan, MD PhD, Yoshihiro Hayashi, MD PhD, Qianfei Wang, PhD, Jie Jin, MD PhD, Gang Huang, PhD

Blood (2016) 128 (22): 1055.

https://doi.org/10.1182/blood.V128.22.1055.1055

Published: 2016

Journal Articles

Mutation of a GATA1 Binding Site in ALAS2 Intron 1 Arrests Murine Erythroid Development In Vivo

Yingchi Zhang, Jingliao Zhang, Wenbin An, Yang Wan, MD, Jie Gao, Lihong Shi, Tao Cheng, MD, Xiaofan Zhu, MD

Blood (2016) 128 (22): 2425.

https://doi.org/10.1182/blood.V128.22.2425.2425

Published: 2016

Journal Articles

The PAF Complex Regulation of Prmt5 Facilitates Leukemic Progression

Justin Serio, B.S., Wei Chen, Maria Mysliwski, Lili Chen, PhD, James Ropa, B.S., Jingya Wang, PhD, Andrew G. Muntean, PhD

Blood (2016) 128 (22): 3914.

https://doi.org/10.1182/blood.V128.22.3914.3914

Published: 2016

NARROW

Terminal Erythroid Maturation Is Associated with Dynamic Changes in the Abundance of Histone Marks Associated with Active Transcription Elongation and RNA Polymerase II Pausing

Mitochondrial Activity Identifies a Transcriptionally and Functionally Distinct Subset of Aged HSCs with Lineage-Balanced Output

NSD2 Interacts with SMARCA2 and Regulates Expression of Oncogenes CCND1 and PRL3 in T(4;14) Multiple Myeloma

Small Molecule Screens Identify CDK8-Inhibitors As Candidate Diamond-Blackfan Anemia Drugs

Genome-Wide Analysis of BRD4-Targets Reveals the Therapeutic Relevance of Simultaneous Targeting of BCR Pathway and IKZF-MYC Axis in Mantle Cell Lymphoma

Mechanisms Underlying Superior Efficacy of Co-Targeting BET Proteins and Anti-Apoptotic BCL2 or MCL1 Protein Against AML Blast Progenitor Cells

Fetal γ-globin genes are regulated by the BGLT3 long noncoding RNA locus

CDK9 Inhibition with LDC526 Is an Effective Treatment for T-Cell Prolymphocytic Leukemia (T-PLL) in Vitro

RNA Polymerase 1 Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Malignancies: Results of a Phase I First in Human Study

Effects of Rigosertib (RIGO) Alone or in Combination with Azacitidine or Vorinostat on Epigenetic Reprogramming of CD34+ Cells in the Myelodysplastic Syndrome

Targeting the Transcriptional Addiction of Leukemia Stem Cells By a New Class of Protein Kinase Inhibitors

Therapeutic Targeting of GLI1 in Acute Myeloid Leukemia

Targeted Therapy for AML Expressing RUNX1 Mutation

mTOR Restricts Chromatin Access and Genomic Activity to Maintain Hematopoietic Stem Cell Quiescence and Engraftment

Identification of Super-Enhancer-Associated Cancer Genes Provides Novel Therapeutic Targets in Adult T-Cell Leukemia/Lymphoma

DYRK1A Is a Therapeutic Target in B-ALL in Children with Down Syndrome

Mapping the Functional Cofactors of Oncogenic EZH2 in Natural Killer/ T Cell Lymphoma (NKTL)

SETD2, a H3K36 Lysine Methyltransferase, Is Essential for Adult Normal Hematopoiesis and Leukemia Stem Cells

Mutation of a GATA1 Binding Site in ALAS2 Intron 1 Arrests Murine Erythroid Development In Vivo

The PAF Complex Regulation of Prmt5 Facilitates Leukemic Progression

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American Society of Hematology

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ASH Publications

American Society of Hematology

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