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Journal Articles

The Prolonged Inhibition of Chk1/Chk2 Kinases Enhances Genetic Instability and Compromises the Efficacy of Chemotherapy Against Acute Lymphoblastic Leukemia Cells

Andrea Ghelli Luserna Di Rorà, PhD, Antonella Padella, PhD, Maria Chiara Fontana, PhD, Eugenio Fonzi, PhD, Anna Ferrari, PhD, Enrica Imbrogno, PhD, Martina Ghetti, PhD, Roberta Napolitano, PhD, Maria Teresa Bochicchio, Giovanni Martinelli, MD, Giorgia Simonetti, PhD

Blood (2019) 134 (Supplement_1): 5047.

https://doi.org/10.1182/blood-2019-129964

Published: 2019

Journal Articles

Framework to Identify and Prioritize Candidate Inherited Myeloid Malignancy Germline Variants Leveraging the BEAT AML Cohort

Daniel Bottomly, Nicola Long, Fei Yang, MD, Tiffany Lee, MD, Uma Borate, MD, Beth Wilmot, PhD, Adam S DuVall, MD, Andrea Monteblanco, BS, Karina Thiel-Klare, Gabby Dewson, BA, Richard D. Press, MD PhD, Cristina E. Tognon, Brian J. Druker, Jeffrey W. Tyner, Shannon K. McWeeney, PhD, Anupriya Agarwal, PhD

Blood (2019) 134 (Supplement_1): 1407.

https://doi.org/10.1182/blood-2019-132224

Published: 2019

Journal Articles

Enhance the Efficacy of Doxorubicin Destabilizing the G2/M Checkpoint with a CHK1/CHK2 Inhibitor Pre-Treatment on Acute Lymphoblastic Leukemia

Andrea Ghelli Luserna di Rora', Anna Ferrari, PhD, Enrica Imbrogno, Valentina Robustelli, Cristina Papayannidis, MD, maria Chiara Abbenante, Giovanni Marconi, MD, Michele Cavo, MD, Giovanni Martinelli, MD

Blood (2017) 130 (Supplement 1): 5049.

https://doi.org/10.1182/blood.V130.Suppl_1.5049.5049

Published: 2017

Journal Articles

Distinct Roles of CHK2 and Cell Death in Suppressing Oncogenic Potential of Tandem DNA Breaks in Human Hematopoietic Stem Cells

Shahar Biechonski, M.Sc, Muhammad Yassin, Nasma Aqaqe, Leonid Olender, Melanie Rall, Lisa Wiesmüller, PhD, Yael Raz, MD PhD, Katia Beider, PhD, Arnon Nagler, Michael Milyavsky, PhD

Blood (2016) 128 (22): 2659.

https://doi.org/10.1182/blood.V128.22.2659.2659

Published: 2016

Journal Articles

Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms

David A. Hinds, Kimberly E. Barnholt, Ruben A. Mesa, Amy K. Kiefer, Chuong B. Do, Nicholas Eriksson, Joanna L. Mountain, Uta Francke, Joyce Y. Tung, Huong (Marie) Nguyen, Haiyu Zhang, Linda Gojenola, James L. Zehnder, Jason Gotlib

Blood (2016) 128 (8): 1121–1128.

https://doi.org/10.1182/blood-2015-06-652941

Published: 2016

Includes: Supplemental data

Journal Articles

The Wee1 Inhibitor, MK-1775, Sensitizes Leukemic Cells to Different Antineoplastic Drugs Interfering with DNA Damage Response Pathway

Andrea Ghelli Luserna Di Rora, Ilaria Iacobucci, PhD, Neil Beeharry, Simona Soverini, Cristina Papayannidis, MD PhD, Giovanni Martinelli, MD PhD, Timothy J Yen

Blood (2015) 126 (23): 1276.

https://doi.org/10.1182/blood.V126.23.1276.1276

Published: 2015

Journal Articles

Hereditary Mutations Are Present As Pathogenic or Predisposition Factors in Otherwise Typical Adult MDS

Bartlomiej P Przychodzen, Hideki Makishima, MD PhD, Brittney Dienes, Tomas Radivoyevitch, PhD, Hetty E. Carraway, MD MBA, Swapna Thota, MD, Bhumika J Patel, MD, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD

Blood (2014) 124 (21): 3233.

https://doi.org/10.1182/blood.V124.21.3233.3233

Published: 2014

Journal Articles

MMSET/WHSC1 Enhances DNA Damage Repair Leading To An Increase In Resistance To Chemotherapeutic Agents

Mrinal Y. Shah, PhD, Eva Martinez, PhD, Relja Popovic, PhD, Teresa Ezponda, PhD, Eliza C. Small, PhD, Christine Will, MS, Paola Neri, MD, PhD, Nizar J. Bahlis, MD, Jonathan D. Licht, MD

Blood (2013) 122 (21): 808.

https://doi.org/10.1182/blood.V122.21.808.808

Published: 2013

Journal Articles

In Vitro and in Vivo Single-Agent Efficacy of Checkpoint Kinase 1 (Chk1) and 2 (Chk2) Inhibitor PF-0477736 (Pfizer) in B- and T-Acute Lymphoblastic Leukemia (ALL)

Ilaria Iacobucci, Andrea Ghelli Luserna Di Rorà, Maria Vittoria Verga Falzacappa, Enrico Derenzini, MD, Anna Ferrari, Cristina Papayannidis, Claudia Venturi, Annalisa Lonetti, Viviana Guadagnuolo, Federica Cattina, Emanuela Ottaviani, Maria Chiara Abbenante, Domenico Russo, Michele Baccarani, MD, Pier Giuseppe Pelicci, Giovanni Martinelli, MD

Blood (2012) 120 (21): 1496.

https://doi.org/10.1182/blood.V120.21.1496.1496

Published: 2012

Journal Articles

CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis

Weijun Pan, Van N. Pham, Amber N. Stratman, Daniel Castranova, Makoto Kamei, Kameha R. Kidd, Brigid D. Lo, Kenna M. Shaw, Jesus Torres-Vazquez, Constantinos M. Mikelis, J. Silvio Gutkind, George E. Davis, Brant M. Weinstein

Blood (2012) 120 (2): 489–498.

https://doi.org/10.1182/blood-2012-02-408328

Published: 2012

Includes: Supplemental data

Journal Articles

The Small Molecule CHK1/CHK2 Inhibitor PF-0477736 (Pfizer) Demonstrates Single Agent Activity and Synergizes with Chemotherapy in Diffuse Large B-Cell Lymphoma

Enrico Derenzini, MD, Ilaria Iacobucci, PhD, Elisa Brighenti, PhD, Federica Cattina, MD, Richard Eric Davis, MD, Stefano Pileri, MD, Giovanni Martinelli, MD, Michele Baccarani, MD, Pier Luigi Zinzani, MD

Blood (2011) 118 (21): 2732.

https://doi.org/10.1182/blood.V118.21.2732.2732

Published: 2011

Journal Articles

The Novel Small Molecule Chk1/Chk2 Inhibitor PF-0477736 (Pfizer) Is Highly Active As Single Agent in Philadelphia-Positive Acute Lymphoblastic Leukemia (Ph+ ALL)

Blood (2011) 118 (21): 76.

https://doi.org/10.1182/blood.V118.21.76.76

Published: 2011

Journal Articles

Genome-Wide shRNA Screen for DNA Damage Response Regulators in Human Hematopoietic Stem and Progenitor Cells

Olga I Gan, Michael Milyavsky, Mark F van Delft, Alla Buzina, Irina Kalatskaya, Troy Ketela, Lincoln Stein, Jason Moffat, John E. Dick, PhD

Blood (2011) 118 (21): 1289.

https://doi.org/10.1182/blood.V118.21.1289.1289

Published: 2011

Journal Articles

ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes

Krystyna Mazan-Mamczarz, Patrick R. Hagner, Yongqing Zhang, Bojie Dai, Elin Lehrmann, Kevin G. Becker, Jack D. Keene, Myriam Gorospe, Zhenqui Liu, Ronald B. Gartenhaus

Blood (2011) 117 (8): 2441–2450.

https://doi.org/10.1182/blood-2010-09-310987

Published: 2011

Includes: Supplemental data

Journal Articles

Homologous Recombination Repair of DNA Strand Breaks Induced by the Nucleoside Analogue CNDAG.

Xiaojun Liu, Ph.D., Yingjun Jiang, Ph.D., Akira Matsuda, Ph.D., William Plunkett, PhD

Blood (2010) 116 (21): 1189.

https://doi.org/10.1182/blood.V116.21.1189.1189

Published: 2010

Journal Articles

Specimen Source (BM or PB) Does Not Affect Proteomic Signaling In Patients with AML and Circulating Blasts

Alessandra Cesano, MD, David B. Rosen, PhD, Santosh Putta, Urte Gayko, Ph.D., Larry Cripe, MD, Zhuoxin Sun, PhD, Hajime Uno, PhD, Mark R. Litzow, MD, Martin S. Tallman, MD, Elisabeth Paietta, PhD

Blood (2010) 116 (21): 2693.

https://doi.org/10.1182/blood.V116.21.2693.2693

Published: 2010

Journal Articles

Zalypsis Possess Potent Antileukemic Effect through the Induction of a DNA Damage Response, Independently of the p53 Status.

Enrique Colado, Teresa Paíno, Enrique M Ocio, Patricia Maiso, Xi Chen, Stela Álvarez-Fernández, Jesús Martín-Sánchez, Lorena González, Laura San-Segundo, Mercedes Garayoa, Diego Fernández-Lázaro, Maria-Belén Vidriales, Carlos Galmarini, Pablo Avilés, Carmen Cuevas, Atanasio Pandiella, Jesús F. San-Miguel, MD, PhD

Blood (2009) 114 (22): 3792.

https://doi.org/10.1182/blood.V114.22.3792.3792

Published: 2009

Journal Articles

Reducing MCM Loading Causes Chromosomal Aneuploidy.

Stephen J. Orr, MSc, Terry Gaymes, Ph.D., Rong Wang, Ph.D., Barbara Czepulkowski, Ph.D., Darius Ladon, Ph.D., Constantinos Chronis, M.Sc., Ghulam J. Mufti, MBBS, DM, FRCP, FRCPath, Edward M. Marcotte, Ph.D., N. Shaun B. Thomas, Ph.D.

Blood (2007) 110 (11): 3349.

https://doi.org/10.1182/blood.V110.11.3349.3349

Published: 2007

Journal Articles

Modifier Genetics in Zebrafish Identify Chk1 and an Associated Survival Pathway as Targets for Pharmacotherapy of MDS/AML with P53 Mutations.

Samuel Sidi, PhD, Andreas T. Hagen, Richard Kennedy, PhD, Shintaro Imamura, PhD, Shuji Kishi, MD,PhD, John Kanki, PhD, Alan D’Andrea, MD, A. Thomas Look, MD

Blood (2006) 108 (11): 1432.

https://doi.org/10.1182/blood.V108.11.1432.1432

Published: 2006

Journal Articles

Identification of MDS-Specific and Methylation Associated Downregulation of Survivine and WT1 in Highly Purified Hematopoietic Progenitor Cells during In Vitro Lineage Specific Differentiation.

Olaf J. Hopfer, MD, Martina Komor, MD, Dieter Hoelzer, MD, PhD, Eckhard Thiel, MD, PhD, Wolf-Karsten Hofmann, MD, PhD

Blood (2005) 106 (11): 3442.

https://doi.org/10.1182/blood.V106.11.3442.3442

Published: 2005

NARROW

The Prolonged Inhibition of Chk1/Chk2 Kinases Enhances Genetic Instability and Compromises the Efficacy of Chemotherapy Against Acute Lymphoblastic Leukemia Cells

Framework to Identify and Prioritize Candidate Inherited Myeloid Malignancy Germline Variants Leveraging the BEAT AML Cohort

Enhance the Efficacy of Doxorubicin Destabilizing the G2/M Checkpoint with a CHK1/CHK2 Inhibitor Pre-Treatment on Acute Lymphoblastic Leukemia

Distinct Roles of CHK2 and Cell Death in Suppressing Oncogenic Potential of Tandem DNA Breaks in Human Hematopoietic Stem Cells

Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms

The Wee1 Inhibitor, MK-1775, Sensitizes Leukemic Cells to Different Antineoplastic Drugs Interfering with DNA Damage Response Pathway

Hereditary Mutations Are Present As Pathogenic or Predisposition Factors in Otherwise Typical Adult MDS

MMSET/WHSC1 Enhances DNA Damage Repair Leading To An Increase In Resistance To Chemotherapeutic Agents

In Vitro and in Vivo Single-Agent Efficacy of Checkpoint Kinase 1 (Chk1) and 2 (Chk2) Inhibitor PF-0477736 (Pfizer) in B- and T-Acute Lymphoblastic Leukemia (ALL)

CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis

The Small Molecule CHK1/CHK2 Inhibitor PF-0477736 (Pfizer) Demonstrates Single Agent Activity and Synergizes with Chemotherapy in Diffuse Large B-Cell Lymphoma

The Novel Small Molecule Chk1/Chk2 Inhibitor PF-0477736 (Pfizer) Is Highly Active As Single Agent in Philadelphia-Positive Acute Lymphoblastic Leukemia (Ph+ ALL)

Genome-Wide shRNA Screen for DNA Damage Response Regulators in Human Hematopoietic Stem and Progenitor Cells

ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes

Homologous Recombination Repair of DNA Strand Breaks Induced by the Nucleoside Analogue CNDAG.

Specimen Source (BM or PB) Does Not Affect Proteomic Signaling In Patients with AML and Circulating Blasts

Zalypsis Possess Potent Antileukemic Effect through the Induction of a DNA Damage Response, Independently of the p53 Status.

Reducing MCM Loading Causes Chromosomal Aneuploidy.

Modifier Genetics in Zebrafish Identify Chk1 and an Associated Survival Pathway as Targets for Pharmacotherapy of MDS/AML with P53 Mutations.

Identification of MDS-Specific and Methylation Associated Downregulation of Survivine and WT1 in Highly Purified Hematopoietic Progenitor Cells during In Vitro Lineage Specific Differentiation.

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American Society of Hematology

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American Society of Hematology

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