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Journal Articles

Human Acute Leukemia Is Addicted to Branched-Chain Amino Acid Metabolism to Maintain Leukemia Stemness

Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Takahiro Maeda, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 2516.

https://doi.org/10.1182/blood-2019-129372

Published: 2019

Journal Articles

Functional Interrogation of Variants of Undetermined Significance of the Isocitrate Dehydrogenase 1 and 2 Genes in Myeloid Neoplasms

Terra Lasho, PhD, Alexander Tischer, PhD, Guadalupe Belen Antelo, MD, Animesh Pardanani, MBBS, PhD, Christy Finke, BS, Giacomo Coltro, MD, Wilson I Gonsalves, MD, Ayalew Tefferi, MD, Abhishek A Mangaonkar, MBBS, Naseema Gangat, MBBS, Mrinal M Patnaik, MDMBBS

Blood (2019) 134 (Supplement_1): 1697.

https://doi.org/10.1182/blood-2019-128067

Published: 2019

Journal Articles

Lessons from Nature: A Novel Class of TET Inhibitors for TET2 Mutant Associated Diseases

Yihong Guan, Anand D. Tiwari, PhD, Metis Hasipek, PhD, Dale Grabowski, BS, Yvonne Parker, Cassandra M. Hirsch, Amy C Graham, BS, MS, Yasunobu Nagata, Bartlomiej P. Przychodzen, Aziz Nazha, Daniel Lindner, MD PhD, Tomas Radivoyevitch, PhD, James G Phillips, PhD, Jaroslaw P. Maciejewski, Babal K. Jha

Blood (2018) 132 (Supplement 1): 4345.

https://doi.org/10.1182/blood-2018-99-117186

Published: 2018

Journal Articles

IDH1 Mutant AML Is Susceptible to Targeting De Novo Lipid Synthesis Independent of 2-Hydroxyglutarate and Has a Distinct Metabolic Profile from IDH2 Mutant AML

Daniel Thomas, MD PhD, Yusuke Nakauchi, MD PhD, Manhong Wu, PhD, Ming Zheng, PhD, Subarna Sinha, PhD, David Dill, PhD, Gary Peltz, MD PhD, Ravindra Majeti, MD PhD

Blood (2018) 132 (Supplement 1): 440.

https://doi.org/10.1182/blood-2018-99-115040

Published: 2018

Journal Articles

Characteristic Amino Acid and Energy Metabolism in AML Stem Cells As Revealed By Quantitative Multiplex Proteomics

Simon Raffel, MD, Jenny Hansson, Mattia Falcone, Christoph Lutz, Oliver Bischel, MD, Anthony D Ho, Jeroen Krijgsveld, Andreas Trumpp, Prof, PhD

Blood (2018) 132 (Supplement 1): 2780.

https://doi.org/10.1182/blood-2018-99-117046

Published: 2018

Journal Articles

Branched Chain Amino Acid Catabolism Restricts Alpha-Ketoglutarate Levels Resembling IDH mut -Driven DNA Hypermethylation in AML Stem Cells

Blood (2017) 130 (Supplement 1): 472.

https://doi.org/10.1182/blood.V130.Suppl_1.472.472

Published: 2017

Journal Articles

SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls

Meng Li, PhD, Ying-Ling Chiang, PhD, Costas Lyssiotis, PhD, Matthew Teater, PhD, Hao Shen, MD, Ling Wang, MS, Jun Young Hong, BS, Hui Jin, PhD, Cihangir Duy, PhD, Sucharita Mistry, PhD, Leandro Cerchietti, MD, Justin Cross, PhD, Lewis Cantley, MD, Hening Lin, PhD, Ari Melnick, MD

Blood (2017) 130 (Supplement 1): 643.

https://doi.org/10.1182/blood.V130.Suppl_1.643.643

Published: 2017

Journal Articles

AMPK Links Metabolic Regulation to Epigenome Modification in Leukemia-Initiating-Cell

Yajian Jiang, MBBS, Daisuke Nakada, PhD, Ayumi Kitano

Blood (2017) 130 (Supplement 1): 2488.

https://doi.org/10.1182/blood.V130.Suppl_1.2488.2488

Published: 2017

Journal Articles

Mitochondrial Metabolism and RNA Methylation in DLBCL

Sara Elkashef, PhD, An-Ping Lin, MD, Lilly Chiou, Jamie Myers, MSc, ZhiJun Qiu, PhD, Ricardo C.T. Aguiar, MD PhD

Blood (2017) 130 (Supplement 1): 2732.

https://doi.org/10.1182/blood.V130.Suppl_1.2732.2732

Published: 2017

Journal Articles

Arginine Deprivation and Autophagy Sustain Bioenergetics in Multiple Myeloma

Alessandra Romano, MDPhD, Laura Oliva, PhD, Jose Manuel Manteiga, Todoerti Katia, Lorenzo Canziani, Matteo Trudu, Francesca Fontana, Michela Ghizzinardi, Ugo Orfanelli, Magda Marcatti, MD, Fabio Ciceri, MD, Giovanni Tonon, MD PhD, Antonino Neri, MD, Claudio Cerichione, MD PhD, Francesco Di Raimondo, MD, Simone Cenci, MD

Blood (2017) 130 (Supplement 1): 3051.

https://doi.org/10.1182/blood.V130.Suppl_1.3051.3051

Published: 2017

Journal Articles

Modulation of TET2 Activity with Ascorbic Acid in Myeloid Neoplasia: Diagnostic and Therapeutic Implications

Edward F Greenberg, MD, Cassandra M. Hirsch, BS, Shi Chen, Xiaochen Liiu, Babal K Jha, PhD, Valeria Visconte, PhD, Dewen You, PhD, Bartlomiej P. Przychodzen, MSc, Thomas Laframboise, PhD, Hideki Makishima, MD PhD, Aziz Nazha, MD, Mingjiang Xu, MDPhD, Daniel Gackowski, PhD, Mridul Mukherji, D.Phil., Mikkael A. Sekeres, MD MS, Ryszard Ólinski, Professor, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 1205.

https://doi.org/10.1182/blood.V130.Suppl_1.1205.1205

Published: 2017

Journal Articles

Gls Inhibitor CB-839 Modulates Cellular Metabolism in AML and Potently Suppresses AML Cell Growth When Combined with 5-Azacitidine

Tianyu Cai, PhD, Philip L Lorenzi, PhD, Dinesh Rakheja, MD, Michael A Pontikos, Alessia Lodi, Lina Han, MD PhD, Qi Zhang, MD PhD, Helen Ma, MS, Mohamed Rahmani, PhD, Tushar Damodar Bhagat, PhD, Thomas D Horvath, PhD, Courtney D. DiNardo, MD MSCE, Steven Grant, MD, Stefano Tiziani, PhD, Amit Verma, MD, Marina Konopleva, MD PhD

Blood (2016) 128 (22): 4064.

https://doi.org/10.1182/blood.V128.22.4064.4064

Published: 2016

Journal Articles

Phenotype/Genotype Associations in TET2-Driven Myeloid Neoplasms

Cassandra M. Hirsch, BSc, Aziz Nazha, MD, Kassy E Kneen, Bartlomiej P Przychodzen, MSc, Niroshan Nadarajah, M.Sc., Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Torsten Haferlach, MD, Tomas Radivoyevitch, PhD, Jaroslaw P. Maciejewski, MD, PhD, FACP, Manja Meggendorfer, PhD

Blood (2016) 128 (22): 4313.

https://doi.org/10.1182/blood.V128.22.4313.4313

Published: 2016

Journal Articles

Isocitrate Dehydrogenase 1 Mutant Cancers Are Metabolically Vulnerable to Inhibition of Acetyl CoA Carboxylase Via a 2-Hydroxyglutarate Independent Mechanism

Daniel Thomas, MD PhD, Subarna Sinha, PhD, Steven M. Chan, MD PhD, Manhong Wu, Damoun Torabi, Gary Peltz, MD PhD, Yang Gao, David L Dill, PhD, Ravi Majeti, MD PhD

Blood (2016) 128 (22): 1054.

https://doi.org/10.1182/blood.V128.22.1054.1054

Published: 2016

Journal Articles

Whole-Exome Sequencing Identifies Germline IDH2 and IDH3 mutations That Predispose to Myeloid Neoplasms

Remco Molenaar, M.Sc., Srinivasa Reddy Sanikommu, MD, Bhumika J. Patel, Bartlomiej Przychodzen, MSc, Cornelis J van Noorden, PhD, Tomas Radivoyevitch, PhD, Hideki Makishima, MD PhD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 1405.

https://doi.org/10.1182/blood.V126.23.1405.1405

Published: 2015

Journal Articles

The Metabolite R-2-Hydroxyglutarate (R2HG) Collaborates with HoxA9 to Induce Monocytic Leukemia

Anuhar Chaturvedi, PhD, Michelle Maria Araujo Cruz, Nidhi Jyotsana, Amit Sharma, PhD, Ramya Goparaju, Vishwas Sharma, PhD, Adrian Schwarzer, MDPhD, Kerstin Goerlich, Renate Schottmann, Eduard A. Struys, PhD, Erwin E. Jansen, Robert Geffers, PhD, Gudrun Goehring, MD, Felicitas Thol, MD, Arnold Ganser, Michael Heuser, MD

Blood (2014) 124 (21): 366.

https://doi.org/10.1182/blood.V124.21.366.366

Published: 2014

Journal Articles

Histone Demethylase Inhibition As a Novel Therapeutic Strategy in Myeloma

Charlotte Pawlyn, MBBChir, Edward Hookway, MBBChir, Peter Cain, PhD, Laurynas Pliuskys, BSc, Martin F Kaiser, MD, Michael Bright, PhD, Lauren I Aronson, BSc(Hons), Alexander Murison, PhD, Morten Lindow, PhD, Susanna Obad, PhD, Henrik Oerum, PhD, Udo Opperman, PhD, Gareth J. Morgan, MD PhD, Faith E Davies, MD

Blood (2014) 124 (21): 2087.

https://doi.org/10.1182/blood.V124.21.2087.2087

Published: 2014

Journal Articles

IDH Mutations, 2-Oxoglutarate-dependent Dioxygenases, and Leukemia

William G. Kaelin, MD

Blood (2014) 124 (21): SCI-6.

https://doi.org/10.1182/blood.V124.21.SCI-6.SCI-6

Published: 2014

Journal Articles

Leukemia-Associated Oncometabolite 2-Hydroxyglutarate Regulates Epigenetic Modifications in Response to Oxygen Availability in Cells without IDH1/2 Mutations

Andrew M. Intlekofer, MD PhD, Raymond G. Dematteo, BS, Lydia W. Finley, PhD, Justin R. Cross, PhD, Craig B. Thompson, MD

Blood (2014) 124 (21): 872.

https://doi.org/10.1182/blood.V124.21.872.872

Published: 2014

Journal Articles

Evaluation of Pharmacokinetic-Pharmacodynamic (PKPD) Relationship of an Oral, Selective, First-in-Class, Potent IDH2 Inhibitor, AG-221, from a Phase 1 Trial in Patients with Advanced IDH2 Mutant Positive Hematologic Malignancies

Bin Fan, Yue Chen, Fang Wang, Katharine Yen, Luke Utley, Caroline Almon, Scott Biller, Sam Agresta, Hua Yang

Blood (2014) 124 (21): 3737.

https://doi.org/10.1182/blood.V124.21.3737.3737

Published: 2014

NARROW

Human Acute Leukemia Is Addicted to Branched-Chain Amino Acid Metabolism to Maintain Leukemia Stemness

Functional Interrogation of Variants of Undetermined Significance of the Isocitrate Dehydrogenase 1 and 2 Genes in Myeloid Neoplasms

Lessons from Nature: A Novel Class of TET Inhibitors for TET2 Mutant Associated Diseases

IDH1 Mutant AML Is Susceptible to Targeting De Novo Lipid Synthesis Independent of 2-Hydroxyglutarate and Has a Distinct Metabolic Profile from IDH2 Mutant AML

Characteristic Amino Acid and Energy Metabolism in AML Stem Cells As Revealed By Quantitative Multiplex Proteomics

Branched Chain Amino Acid Catabolism Restricts Alpha-Ketoglutarate Levels Resembling IDH mut -Driven DNA Hypermethylation in AML Stem Cells

SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls

AMPK Links Metabolic Regulation to Epigenome Modification in Leukemia-Initiating-Cell

Mitochondrial Metabolism and RNA Methylation in DLBCL

Arginine Deprivation and Autophagy Sustain Bioenergetics in Multiple Myeloma

Modulation of TET2 Activity with Ascorbic Acid in Myeloid Neoplasia: Diagnostic and Therapeutic Implications

Gls Inhibitor CB-839 Modulates Cellular Metabolism in AML and Potently Suppresses AML Cell Growth When Combined with 5-Azacitidine

Phenotype/Genotype Associations in TET2-Driven Myeloid Neoplasms

Isocitrate Dehydrogenase 1 Mutant Cancers Are Metabolically Vulnerable to Inhibition of Acetyl CoA Carboxylase Via a 2-Hydroxyglutarate Independent Mechanism

Whole-Exome Sequencing Identifies Germline IDH2 and IDH3 mutations That Predispose to Myeloid Neoplasms

The Metabolite R-2-Hydroxyglutarate (R2HG) Collaborates with HoxA9 to Induce Monocytic Leukemia

Histone Demethylase Inhibition As a Novel Therapeutic Strategy in Myeloma

IDH Mutations, 2-Oxoglutarate-dependent Dioxygenases, and Leukemia

Leukemia-Associated Oncometabolite 2-Hydroxyglutarate Regulates Epigenetic Modifications in Response to Oxygen Availability in Cells without IDH1/2 Mutations

Evaluation of Pharmacokinetic-Pharmacodynamic (PKPD) Relationship of an Oral, Selective, First-in-Class, Potent IDH2 Inhibitor, AG-221, from a Phase 1 Trial in Patients with Advanced IDH2 Mutant Positive Hematologic Malignancies

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American Society of Hematology

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ASH Publications

American Society of Hematology

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