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Journal Articles

TP-0184 Inhibits ALK2/ACVR1, Decreases Hepcidin Levels, and Demonstrates Activity in Preclinical Mouse Models of Functional Iron Deficiency

Free
Peter Peterson, PhD, W K, Clifford Whatcott, PhD, Adam Siddiqui-Jain, PhD, Steven Weitman, MD PhD, Mark Kieran, MD PhD, David J. Bearss, PhD, Steven L. Warner, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 937.
https://doi.org/10.1182/blood.V130.Suppl_1.937.937
Published: 2017
Journal Articles

The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes

Free
Silvia Colucci, Alessia Pagani, Mariateresa Pettinato, Irene Artuso, Antonella Nai, Clara Camaschella, Laura Silvestri
Journal: Blood
Blood (2017) 130 (19): 2111–2120.
https://doi.org/10.1182/blood-2017-04-780692
Published: 2017
Includes: Supplemental data
Journal Articles

A new form of IRIDA due to combined heterozygous mutations of TMPRSS6 and ACVR1A encoding the BMP receptor ALK2

Free
Alessia Pagani, Silvia Colucci, Renata Bocciardi, Marta Bertamino, Carlo Dufour, Roberto Ravazzolo, Laura Silvestri, Clara Camaschella
Journal: Blood
Blood (2017) 129 (25): 3392–3395.
https://doi.org/10.1182/blood-2017-03-773481
Published: 2017
Includes: Supplemental data
Journal Articles

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents

Free
Malte Asshoff, Verena Petzer, Matthew R. Warr, David Haschka, Piotr Tymoszuk, Egon Demetz, Markus Seifert, Wilfried Posch, Manfred Nairz, Pat Maciejewski, Peter Fowles, Christopher J. Burns, Gregg Smith, Kay-Uwe Wagner, Guenter Weiss, J. Andrew Whitney, Igor Theurl
Journal: Blood
Blood (2017) 129 (13): 1823–1830.
https://doi.org/10.1182/blood-2016-09-740092
Published: 2017
Includes: Supplemental data
Journal Articles

Preclinical Modeling of ACVR1-Dependent Hepcidin Production and Anemia By Momelotinib

Free
Matthew Warr, Malte Asshoff, Jim Zheng, Shringi Sharma, Pat Maciejewski, Guenter Weiss, Igor Theurl, J. Andrew Whitney
Journal: Blood
Blood (2016) 128 (22): 1967.
https://doi.org/10.1182/blood.V128.22.1967.1967
Published: 2016
Journal Articles

ALK2 Inhibition Via TP-0184 Abrogates Inflammation-Induced Hepcidin Expression and Is a Potential Therapeutic for Anemia of Chronic Disease

Free
Peter Peterson, PhD, Katherine K. Soh, Ye Sol Lee, Wontak Kim, Clifford J. Whatcott, PhD, Adam Siddiqui-Jain, PhD, David J. Bearss, PhD, Steven L. Warner, PhD
Journal: Blood
Blood (2015) 126 (23): 273.
https://doi.org/10.1182/blood.V126.23.273.273
Published: 2015
Journal Articles

The Jak1/Jak2 Inhibitor Momelotinib Inhibits Alk2, Decreases Hepcidin Production and Ameliorates Anemia of Chronic Disease (ACD) in Rodents

Free
Malte Asshoff, MD, Matthew Warr, PhD, David Haschka, MD, Piotr Tymoszuk, PhD, Verena Petzer, Egon Demetz, PhD, Pat Maciejewski, PhD, Markus Seifert, Manfred Nairz, MDPhD, Wilfried Posch, PhD, Peter Fowles, Guenter Weiss, MD, Andy Whitney, Igor Theurl, MDPhD
Journal: Blood
Blood (2015) 126 (23): 538.
https://doi.org/10.1182/blood.V126.23.538.538
Published: 2015
Journal Articles

Novel Series of ALK2 Inhibitors That Alter Hepcidin Expression As Potential Therapeutics for Anemia of Chronic Disease

Free
Wontak Kim, Kyle S. Maughan, Katherine K. Soh, Jeremiah J. Bearss, Brigham L. Bahr, David J. Bearss, PhD, Steven L. Warner, PhD
Journal: Blood
Blood (2014) 124 (21): 212.
https://doi.org/10.1182/blood.V124.21.212.212
Published: 2014
Journal Articles

The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6

Free
Claire Mayeur, Lisa K. Lohmeyer, Patricio Leyton, Sonya M. Kao, Alexandra E. Pappas, Starsha A. Kolodziej, Ester Spagnolli, Binglan Yu, Rita L. Galdos, Paul B. Yu, Randall T. Peterson, Donald B. Bloch, Kenneth D. Bloch, Andrea U. Steinbicker
Journal: Blood
Blood (2014) 123 (14): 2261–2268.
https://doi.org/10.1182/blood-2013-02-480095
Published: 2014
Includes: Supplemental data
Journal Articles

Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium

Free
Yucheng Yao, Medet Jumabay, Albert Ly, Melina Radparvar, Anthony H. Wang, Raushan Abdmaulen, Kristina I. Boström
Journal: Blood
Blood (2012) 119 (21): 5037–5047.
https://doi.org/10.1182/blood-2011-10-385906
Published: 2012
Journal Articles

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

Free
Andrea U. Steinbicker, Thomas B. Bartnikas, Lisa K. Lohmeyer, Patricio Leyton, Claire Mayeur, Sonya M. Kao, Alexandra E. Pappas, Randall T. Peterson, Donald B. Bloch, Paul B. Yu, Mark D. Fleming, Kenneth D. Bloch
Journal: Blood
Blood (2011) 118 (15): 4224–4230.
https://doi.org/10.1182/blood-2011-03-339952
Published: 2011
Includes: Supplemental data