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Journal Articles

Selective Targeting BET Family Bdii Bromodomain with Abbv-744 and BCL-2 with Venetoclax (ABT-199) Is Synergistic in Primary Acute Myeloid Leukemia Models

Tianyu Cai, PhD, Vinitha Mary Kuruvilla, MSc, Xiaoyu Lin, Tamar Uziel, PhD, Xin Lu, Lu Zhang, Xiaoli Huang, Qi Zhang, PhD, Antonio Cavazos, Lina Han, PhD, Yu Shen, Marina Y Konopleva, MD PhD

Blood (2019) 134 (Supplement_1): 1369.

https://doi.org/10.1182/blood-2019-128618

Published: 2019

Journal Articles

Desialylation and Apoptosis Crosstalk to Modulate Platelet Clearance

Renata Grozovsky, PhD, Cameron Fraser, BS, Karin M. Hoffmeister, MD, Kristopher Sarosiek, PhD, Silvia Giannini, PhD

Blood (2019) 134 (Supplement_1): 1055.

https://doi.org/10.1182/blood-2019-122184

Published: 2019

Journal Articles

An Oral Combination Study of Novel Nucleoside Analogue Sapacitabine and BCL2 Inhibitor Venetoclax to Treat Patients with Relapsed or Refractory AML or MDS

Tapan M. Kadia, MD, Gautam M. Borthakur, MD, Elias Jabbour, MD, Marina Y Konopleva, MD PhD, Farhad Ravandi, MD, Courtney D. DiNardo, MDMSc, Daniella Zheleva, PhD, David Blake, PhD, Judy H Chiao, MD

Blood (2019) 134 (Supplement_1): 3926.

https://doi.org/10.1182/blood-2019-131930

Published: 2019

Journal Articles

Novel Genetic Mechanism of Venetoclax Resistance in AML: BAX Deletion

Farid Ahmed, MSc, PhD, Omar Abdullah Allehyani, BSc, MSc, Mansour Alfayez, MDMS, Hans-Jurgen Schulten, MSc, PhD, Heba Alkhattabi, MSc, PhD, Adeel G A Chaudhary, MSc, PhD, Mohammed H Alqahtani, MSc, PhD

Blood (2019) 134 (Supplement_1): 5057.

https://doi.org/10.1182/blood-2019-131637

Published: 2019

Journal Articles

Ex Vivo Co-Culture of AML Blasts and Bone Marrow Mesenchymal Stromal Cells to Accurately Predict the Clinical Efficacy of Cytarabine-Daunorubicin Treatment

Sukhraj Pal Singh Dhami, MSc, BSc, Andrea Tirincsi, MSc, BSc, Denis V Baev, PhD, Janusz Krawczyk, MD, John Quinn, MD PhD, Eva Szegezdi, PhD

Blood (2018) 132 (Supplement 1): 2636.

https://doi.org/10.1182/blood-2018-99-118619

Published: 2018

Journal Articles

Necrotic but Not Apoptotic Platelets Are Functionally Procoagulant

Andaleb Kholmukhamedov, MD, Shawn M. Jobe, MD PhD

Blood (2018) 132 (Supplement 1): 2420.

https://doi.org/10.1182/blood-2018-99-116972

Published: 2018

Journal Articles

Identifying Combination Therapies Targeting Apoptosis Pathways in Pediatric Acute Myeloid Leukemia (CAuSAL Study)

Katrina Lappin, PhD BSc, Kyle B Matchett, PhD, Jaine Blayney, PhD, Ken I Mills, PhD FRCPath, BSc

Blood (2018) 132 (Supplement 1): 2731.

https://doi.org/10.1182/blood-2018-99-111234

Published: 2018

Journal Articles

Drug Combinations Co-Targeting Myeloid Cell Leukemia-1 (Mcl-1) Protein Can Overcome Microenvironmentally-Induced Multi-Drug Tolerance in Non-Hodgkin Lymphomas

Kallesh D. Jayappa, DVM, PhD, Craig A. Portell, MD, Vicki L. Gordon, BSc, Goutham Narla, MD PhD, Timothy P. Bender, PhD, Michael E. Williams, MD, Michael J. Weber, PhD

Blood (2018) 132 (Supplement 1): 2649.

https://doi.org/10.1182/blood-2018-99-116759

Published: 2018

Journal Articles

Preclinical Activity of Novel MCL1 Inhibitor AZD5991 in Multiple Myeloma

Shannon M Matulis, PhD, Vikas A. Gupta, MD PhD, Izabelle Brown, Jonathan J Keats, PhD, Paul Secrist, PhD, Justin Cidado, PhD, Adriana E. Tron, PhD, Paola Neri, MD, Nizar Bahlis, MD, Jonathan L Kaufman, MD, Leonard Heffner, MD, Sagar Lonial, MD, Ajay K Nooka, MDMPH, Lawrence H. Boise, PhD

Blood (2018) 132 (Supplement 1): 952.

https://doi.org/10.1182/blood-2018-99-113504

Published: 2018

Journal Articles

In-Vitro Drug Sensitivity Screening in Chronic Lymphocytic Leukemia (CLL) Primary Patient Samples Identifies Drug Candidates for Precision Cancer Therapy

Deepak Balaji balaji Thimiri Govinda Raj, PhD MSc, Andrea Cremaschi, PhD MSc, Sigrid Strand Skånland, PhD, Alexandra Gade, Fredrik H. Schjesvold, MD PhD, Geir Erland Tjønnfjord, MD DMsc, Ludvig A Munthe, Kjetil Tasken

Blood (2018) 132 (Supplement 1): 4676.

https://doi.org/10.1182/blood-2018-99-110357

Published: 2018

Journal Articles

Cofilin-1 Activation in Stored Platelets

Swapan Kumar Dasgupta, PhD, Perumal Thiagarajan, MD

Blood (2018) 132 (Supplement 1): 1256.

https://doi.org/10.1182/blood-2018-99-119159

Published: 2018

Journal Articles

Identification of Potent BH3-Mimetic Combinations Targeting Pro-Survival Pathways in Human B-Cell Acute Lymphoblastic Leukemia

Donia M Moujalled, PhD, Diane T Hanna, Giovanna Pomilio, Veronique Litalien, Shaun Fleming, Marie Chanrion, Ana-Leticia Maragno, Laurence Kraus-Berthier, Seong Lin Khaw, Guillaume Lessene, David Huang, Andrew W. Roberts, MBBS, PhD, Olivier Geneste, Paul G Ekert, Ashley P Ng, Andrew H Wei, MBBS,PhD

Blood (2018) 132 (Supplement 1): 567.

https://doi.org/10.1182/blood-2018-99-114051

Published: 2018

Journal Articles

The 3-Drug Combination Treatment ART838, ABT199 Plus Sorafenib Is Effective Against AML Xenografts, Possibly Via Cooperative Targeting of MCL1

Blake S Moses, PhD, Jennifer Fox, PhD, Xiaochun Chen, PhD, Samantha McCullough, BS, Sang Ngoc Tran, BA, Allison Kirkpatrick, BS, Kalyani Kumar, BS, Jeffrey W. Tyner, PhD, Gary H. Posner, PhD, Curt I. Civin, MD

Blood (2018) 132 (Supplement 1): 4044.

https://doi.org/10.1182/blood-2018-99-113040

Published: 2018

Journal Articles

Deubiquitinase Inhibitor WP1130 Blocks FLT3-ITD to Induce Apoptosis in Leukemic Cells

Hiroki Akiyama, MD, Yoshihiro Umezawa, MD, Keigo Okada, MD, Shinya Ishida, MD, Ayako Nogami, MD, PhD, Osamu Miura, MD, PhD

Blood (2017) 130 (Supplement 1): 2531.

https://doi.org/10.1182/blood.V130.Suppl_1.2531.2531

Published: 2017

Journal Articles

Artemisinins Synergize with BCL2 Inhibitors By Reducing MCL1 Protein Levels in Leukemia Cells

Blake S Moses, PhD, Jennifer Fox, PhD, Xiaochun Chen, PhD, Samantha McCullough, BS, Allison Kirkpatrick, BS, Kalyani Kumar, BS, Jeffrey W. Tyner, PhD, Gary H. Posner, PhD, Curt I. Civin, MD

Blood (2017) 130 (Supplement 1): 3827.

https://doi.org/10.1182/blood.V130.Suppl_1.3827.3827

Published: 2017

Journal Articles

Galectin 3 Protein Network Analysis By Reverse Protein Arrays Demonstrates Regulation of MCL-1, PKC Delta and CD74 Associated with Poor Survival in Patients with AML

Peter P. Ruvolo, PhD, Chenyue Hu, Yihua Qiu, Vivian Ruvolo, PhD, Kevin R Coombes, Amina Qutub, Michael Andreeff, MD PhD, Steven Kornblau, MD

Blood (2017) 130 (Supplement 1): 1395.

https://doi.org/10.1182/blood.V130.Suppl_1.1395.1395

Published: 2017

Journal Articles

Bone marrow microenvironment–derived signals induce Mcl-1 dependence in multiple myeloma

Vikas A. Gupta, Shannon M. Matulis, Jason E. Conage-Pough, Ajay K. Nooka, Jonathan L. Kaufman, Sagar Lonial, Lawrence H. Boise

Blood (2017) 129 (14): 1969–1979.

https://doi.org/10.1182/blood-2016-10-745059

Published: 2017

Includes: Supplemental data

Journal Articles

BCL-2, a Therapeutic Target for High Risk Hypodiploid B-Cell Acute Lymphoblastic Leukemia

Ernesto Diaz-Flores, PhD, Evan Q. Comeaux, PhD, Kailyn Kim, Kyle Beckman, BS, Kara L. Davis, DO, Kevin Wu, Jon Akutagawa, Linda Holmfeldt, PhD, Benjamin S. Braun, MD PhD, Charles Mullighan, MBBS, MSc, MD, Mignon L. Loh, MD

Blood (2016) 128 (22): 280.

https://doi.org/10.1182/blood.V128.22.280.280

Published: 2016

Journal Articles

Effects of Platelet Circulatory Age on Platelet Function

Moritz Stolla, MD, Renata Grozovsky, PhD, Melissa M Lee-Sundlov, PhD, Herve Falet, PhD, Karin M. Hoffmeister, MD

Blood (2016) 128 (22): 413.

https://doi.org/10.1182/blood.V128.22.413.413

Published: 2016

Journal Articles

Extended Platelet In Vivo Survival Results in Exhausted Platelets

Irina Pleines, Marion Lebois, Amanda E.-L. Au, Rachael M. Lane, Katya J. Henley, Jason Corbin, Ping Cannon, Kate E Jarman, Sarah Ellis, Shaun P Jackson, Simone M. Schoenwaelder, Benjamin T. Kile, Emma C. Josefsson

Blood (2015) 126 (23): 416.

https://doi.org/10.1182/blood.V126.23.416.416

Published: 2015

NARROW

Selective Targeting BET Family Bdii Bromodomain with Abbv-744 and BCL-2 with Venetoclax (ABT-199) Is Synergistic in Primary Acute Myeloid Leukemia Models

Desialylation and Apoptosis Crosstalk to Modulate Platelet Clearance

An Oral Combination Study of Novel Nucleoside Analogue Sapacitabine and BCL2 Inhibitor Venetoclax to Treat Patients with Relapsed or Refractory AML or MDS

Novel Genetic Mechanism of Venetoclax Resistance in AML: BAX Deletion

Ex Vivo Co-Culture of AML Blasts and Bone Marrow Mesenchymal Stromal Cells to Accurately Predict the Clinical Efficacy of Cytarabine-Daunorubicin Treatment

Necrotic but Not Apoptotic Platelets Are Functionally Procoagulant

Identifying Combination Therapies Targeting Apoptosis Pathways in Pediatric Acute Myeloid Leukemia (CAuSAL Study)

Drug Combinations Co-Targeting Myeloid Cell Leukemia-1 (Mcl-1) Protein Can Overcome Microenvironmentally-Induced Multi-Drug Tolerance in Non-Hodgkin Lymphomas

Preclinical Activity of Novel MCL1 Inhibitor AZD5991 in Multiple Myeloma

In-Vitro Drug Sensitivity Screening in Chronic Lymphocytic Leukemia (CLL) Primary Patient Samples Identifies Drug Candidates for Precision Cancer Therapy

Cofilin-1 Activation in Stored Platelets

Identification of Potent BH3-Mimetic Combinations Targeting Pro-Survival Pathways in Human B-Cell Acute Lymphoblastic Leukemia

The 3-Drug Combination Treatment ART838, ABT199 Plus Sorafenib Is Effective Against AML Xenografts, Possibly Via Cooperative Targeting of MCL1

Deubiquitinase Inhibitor WP1130 Blocks FLT3-ITD to Induce Apoptosis in Leukemic Cells

Artemisinins Synergize with BCL2 Inhibitors By Reducing MCL1 Protein Levels in Leukemia Cells

Galectin 3 Protein Network Analysis By Reverse Protein Arrays Demonstrates Regulation of MCL-1, PKC Delta and CD74 Associated with Poor Survival in Patients with AML

Bone marrow microenvironment–derived signals induce Mcl-1 dependence in multiple myeloma

BCL-2, a Therapeutic Target for High Risk Hypodiploid B-Cell Acute Lymphoblastic Leukemia

Effects of Platelet Circulatory Age on Platelet Function

Extended Platelet In Vivo Survival Results in Exhausted Platelets

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American Society of Hematology

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ASH Publications

American Society of Hematology

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