Page 1 | Search Results | Blood | American Society of Hematology

1-20 of 20

Sort by

Sort Order Select

Journal Articles

Small Molecular Modulators of Histone Demethylases Selectively Inhibits Growth of Hematopoietic Malignancies

Xin Xu, PhD, Wilhelm G Dirks, PhD, Hans G. Drexler, MD PhD, Zhenbo Hu, MD PhD

Blood (2018) 132 (Supplement 1): 3941.

https://doi.org/10.1182/blood-2018-99-112376

Published: 2018

Journal Articles

A Small Molecular Agonist of Histone Demethylase KDM3B Selectively Represses MLL -Rearranged Acute Leukemia

Xin Xu, PhD, Wilhelm G Dirks, PhD, Hans G. Drexler, MD PhD, Zhenbo Hu, MD PhD

Blood (2018) 132 (Supplement 1): 4682.

https://doi.org/10.1182/blood-2018-99-112018

Published: 2018

Journal Articles

The Mechanisms By Which Mutant-NPM1 Uncouples Differentiation from Proliferation Are Reversed By Several Drugs, Enabling Rational Multi-Component Non-Cytotoxic Differentiation Therapy

Xiaorong Gu, PhD, Quteba Ebrahem, MD, Reda Z. Mahfouz, MD PhD, Metis Hasipek, PhD, Francis Enane, PhD, Tomas Radivoyevitch, Nicolas Rapin, PhDMSc, Bartlomiej P. Przychodzen, MSc, Ramesh Balusu, PhD, Claudiu V Cotta, David Wald, MD PhD, Zhenbo Hu, MD PhD, Yosef Landesman, PhD, Maria Paola Martelli, MD PhD, Brunangelo Falini, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Babal K Jha, PhD, Yogenthiran Saunthararajah, MD

Blood (2017) 130 (Supplement 1): 878.

https://doi.org/10.1182/blood.V130.Suppl_1.878.878

Published: 2017

Journal Articles

The Mechanism By Which Mutant Nucleophosmin (NPM1) Creates Leukemic Self-Renewal Is Readily Reversed

Xiaorong Gu, PhD, Reda Z. Mahfouz, MD, PhD, Quteba Ebrahem, Francis Enane, Tomas Radivoyevitch, PhD, Michael J. Clemente, M.S., Bartlomiej P Przychodzen, MSc, Zhenbo Hu, MD PhD, Ramesh Balusu, PhD, Claudiu V. Cotta, MD, David N. Wald, MDPhD, Yosef Landesman, PhD, Maria Paola Martelli, MD PhD, Brunangelo Falini, Jaroslaw P Maciejewski, MD PhD FACP, Yogenthiran Saunthararajah, MD

Blood (2016) 128 (22): 444.

https://doi.org/10.1182/blood.V128.22.444.444

Published: 2016

Journal Articles

A Specific Mechanism By Which NPM1 mutations Impede Myeloid Differentiation Also Explains The Link With DNMT3A Mutation

Xiaorong Gu, PhD, Reda Z Mahfouz, MD/PhD, Francis Enane, MS, Zhenbo Hu, MD, PhD, Michael J. Clemente, Bartlomiej P Przychodzen, PhD, Mikkael A. Sekeres, MD, MS, Anjali S. Advani, MD, Matt Kalaycio, MD, Jaroslaw P. Maciejewski, MD, PhD, Yogen Saunthararajah, M.D.

Blood (2013) 122 (21): 1254.

https://doi.org/10.1182/blood.V122.21.1254.1254

Published: 2013

Journal Articles

Extra-Nuclear Dislocation of PU.1 but Not CEBPA by Mutated NPM1 in AML Explains Lineage-Associations, ATRA Therapeutic Potential and DNMT3A Secondary Mutation.

Xiaorong Gu, PhD, Reda Z Mahfouz, MD/PhD, Zhenbo Hu, MD, PhD, Yogenthiran Saunthararajah, MD

Blood (2012) 120 (21): 2427.

https://doi.org/10.1182/blood.V120.21.2427.2427

Published: 2012

Journal Articles

CEBPE activation in PML-RARA cells by arsenic

Zhenbo Hu, Yogen Saunthararajah

Blood (2012) 119 (9): 2177–2179.

https://doi.org/10.1182/blood-2011-12-395350

Published: 2012

Includes: Supplemental data

Journal Articles

Runx1 Haploinsufficiency Permits Lineage-Commitment but Impairs Activation of a Key Late Differentiation Gene

Zhenbo Hu, MD, Kwok Peng Ng, PhD, Quteba Ebrahem, MD, Yogen Saunthararajah, MD

Blood (2011) 118 (21): 2442.

https://doi.org/10.1182/blood.V118.21.2442.2442

Published: 2011

Journal Articles

Runx1 Regulates Pu.1 Coactivator/Corepressor Exchange

Xiaorong Gu, PhD, Zhenbo Hu, MD, Quteba Ebrahem, MD, Kwok Peng Ng, PhD, Jack S Crabb, MS, John W Crabb, PhD, Yogen Saunthararajah, MD

Blood (2011) 118 (21): 2372.

https://doi.org/10.1182/blood.V118.21.2372.2372

Published: 2011

Journal Articles

Consequences of UTX Dysfunction in Myelodysplastic Syndrome

Anna M Jankowska, PhD, Hadrian Szpurka, PhD, Venugopalan Cheriyath, PhD, Kwok Peng Ng, PhD, Zhenbo Hu, MD, Michael A McDevitt, MD, Yogen Saunthararajah, MD, Jaroslaw P. Maciejewski, MD, PhD

Blood (2011) 118 (21): 2427.

https://doi.org/10.1182/blood.V118.21.2427.2427

Published: 2011

Journal Articles

Evaluation of a-Catenin(CTNNA1) As a Tumor Suppressor Gene in Acute Myeloid Leukemis

Xianwei Zeng, MD, PHD, Ya Liu, MD, Cui Lv, MD, Zhenbo Hu, MD

Blood (2011) 118 (21): 5240.

https://doi.org/10.1182/blood.V118.21.5240.5240

Published: 2011

Journal Articles

Gender Is A Major Determinant of Cytidine Analogue Metabolism and May Contribute to Differences in Treatment Outcomes

Reda Z Mahfouz, MD, Ania Jankowska, PhD, Quteba Ebrahem, MD, Zhenbo Hu, MD, Kenneth K. Chan, Ph.D, Donald Lavelle, Ph.D., Joseph DeSimone, PhD, Mikkael A. Sekeres, MD, MS, Ramon V. Tiu, MD, BS, Jaroslaw P. Maciejewski, MD, PhD, Yogen Saunthararajah, M.D.

Blood (2011) 118 (21): 1434.

https://doi.org/10.1182/blood.V118.21.1434.1434

Published: 2011

Journal Articles

EZH2 Is Either Mutated or Downregulated in Patients with Loss of Heterozygosity of Chromosome 7/7q and Leads to Epigenetic Dysregulation Via Histone H3K27.

Hideki Makishima, MD, PhD, Shahper N Khan, PhD, Anna M Jankowska, PhD, Yuka Sugimoto, MD, Zhenbo Hu, MD, Venugopalan Cheriyath, PhD, Reda Mahfouz, MD, Quteba Ebrahem, MD, Sergei Vatolin, PhD, Yogen Saunthararajah, MD, Mikkael A. Sekeres, MD, MS, Jaroslaw P Maciejewski, MD, PhD, FACP

Blood (2011) 118 (21): 228.

https://doi.org/10.1182/blood.V118.21.228.228

Published: 2011

Journal Articles

RUNX1 regulates corepressor interactions of PU.1

Zhenbo Hu, Xiaorong Gu, Kristine Baraoidan, Vinzon Ibanez, Arun Sharma, ShriHari Kadkol, Reinhold Munker, Steven Ackerman, Giuseppina Nucifora, Yogen Saunthararajah

Blood (2011) 117 (24): 6498–6508.

https://doi.org/10.1182/blood-2010-10-312512

Published: 2011

Includes: Supplemental data

Journal Articles

Effective and Non-Cytotoxic p53 Independent Epigenetic-Differentiation Therapy In Xeno-Transplant Models of Human Acute Myeloid Leukemia

Kwok Peng Ng, PhD, Quteba Ebrahem, MD, Soledad Negrotto, PhD, Reda Mahfouz, MD, Kevin Link, PhD, Zhenbo Hu, MD, Xiaorong Gu, PhD, Anjali Advani, MD, Matt Kalaycio, MD, Mikkael A. Sekeres, MD, MS, Edward A. Copelan, MD, Jaroslaw P Maciejewski, MD, PhD, FACP, James C. Mulloy, PhD, Yogenthiran Saunthararajah, MD

Blood (2010) 116 (21): 3309.

https://doi.org/10.1182/blood.V116.21.3309.3309

Published: 2010

Journal Articles

Identification of Oncogenic EZH2 Mutations In Myelodysplastic Syndromes and Related Myeloid Malignancies

Hideki Makishima, MD, PhD, Ania Jankowska, MSC, Ramon V. Tiu, MD, Hadrian Szpurka, PhD, MSC, Yuka Sugimoto, MD, PhD, Quteba Ebrahem, MD, Zhenbo Hu, MD, Reda Mahfouz, MD, Yogen Saunthararajah, MD, Kathryn Guinta, Mehdi Keddache, MSC, Christine L. O'Keefe, PhD, Mikkael A. Sekeres, MD, MS, Alan F. List, Michael A McDevitt, MD, PhD, Jaroslaw P Maciejewski, MD, PhD, FACP

Blood (2010) 116 (21): 607.

https://doi.org/10.1182/blood.V116.21.607.607

Published: 2010

Journal Articles

UTX Mutations and Epigenetic Changes In MDS/MPN and Related Myeloid Malignancies

Hadrian Szpurka, PhD, MSc, Anna M Jankowska, MSc, Bartlomiej Przychodzen, BSc, Zhenbo Hu, MD, PhD, Yogen Saunthararajah, MD, Michael A McDevitt, MD, PhD, Jaroslaw P Maciejewski, MD, PhD

Blood (2010) 116 (21): 121.

https://doi.org/10.1182/blood.V116.21.121.121

Published: 2010

Journal Articles

Non-p53 Dependent, Leukemia Initiating-Cell Selective, Therapy.

Kwok Peng Ng, Soledad Negrotto, Zhenbo Hu, Kevin A Link, Santosh L Saraf, MD, Anjali Advani, M.D., Mikkael A. Sekeres, MD, MS, Jaroslaw P. Maciejewski, MD, PhD, James C. Mulloy, PhD, Yogenthiran Saunthararajah, M.D.

Blood (2009) 114 (22): 2077.

https://doi.org/10.1182/blood.V114.22.2077.2077

Published: 2009

Journal Articles

Runx1 Deficiency Produces Aberrant Progenitor Self-Renewal through Selective Compromise of Pu.1 Mediated Transactivation but Not Transrepression.

Zhenbo Hu, Soledad Negrotto, Kristine Marie Baraoidan, Vinzon Ibanez, Aron Shama, Fariborz Mortazavi, Steven Ackerman, Shrihari Kadkol, Giuseppina Nucifora, Yogen Saunthararajah

Blood (2008) 112 (11): 1351.

https://doi.org/10.1182/blood.V112.11.1351.1351

Published: 2008

Journal Articles

Differentiation-Chronology Specific Function of DNMT1 and Selective Anti-Leukemia Stem-Cell Therapy

Soledad Negrotto, Zhenbo Hu, Kevin A Link, Hien Duong, Andrew E. Schade, MD, PhD, Jaroslaw P. Maciejewski, MD, PhD, James C. Mulloy, PhD, Yogenthiran Saunthararajah

Blood (2008) 112 (11): 201.

https://doi.org/10.1182/blood.V112.11.201.201

Published: 2008

NARROW

Small Molecular Modulators of Histone Demethylases Selectively Inhibits Growth of Hematopoietic Malignancies

A Small Molecular Agonist of Histone Demethylase KDM3B Selectively Represses MLL -Rearranged Acute Leukemia

The Mechanisms By Which Mutant-NPM1 Uncouples Differentiation from Proliferation Are Reversed By Several Drugs, Enabling Rational Multi-Component Non-Cytotoxic Differentiation Therapy

The Mechanism By Which Mutant Nucleophosmin (NPM1) Creates Leukemic Self-Renewal Is Readily Reversed

A Specific Mechanism By Which NPM1 mutations Impede Myeloid Differentiation Also Explains The Link With DNMT3A Mutation

Extra-Nuclear Dislocation of PU.1 but Not CEBPA by Mutated NPM1 in AML Explains Lineage-Associations, ATRA Therapeutic Potential and DNMT3A Secondary Mutation.

CEBPE activation in PML-RARA cells by arsenic

Runx1 Haploinsufficiency Permits Lineage-Commitment but Impairs Activation of a Key Late Differentiation Gene

Runx1 Regulates Pu.1 Coactivator/Corepressor Exchange

Consequences of UTX Dysfunction in Myelodysplastic Syndrome

Evaluation of a-Catenin(CTNNA1) As a Tumor Suppressor Gene in Acute Myeloid Leukemis

Gender Is A Major Determinant of Cytidine Analogue Metabolism and May Contribute to Differences in Treatment Outcomes

EZH2 Is Either Mutated or Downregulated in Patients with Loss of Heterozygosity of Chromosome 7/7q and Leads to Epigenetic Dysregulation Via Histone H3K27.

RUNX1 regulates corepressor interactions of PU.1

Effective and Non-Cytotoxic p53 Independent Epigenetic-Differentiation Therapy In Xeno-Transplant Models of Human Acute Myeloid Leukemia

Identification of Oncogenic EZH2 Mutations In Myelodysplastic Syndromes and Related Myeloid Malignancies

UTX Mutations and Epigenetic Changes In MDS/MPN and Related Myeloid Malignancies

Non-p53 Dependent, Leukemia Initiating-Cell Selective, Therapy.

Runx1 Deficiency Produces Aberrant Progenitor Self-Renewal through Selective Compromise of Pu.1 Mediated Transactivation but Not Transrepression.

Differentiation-Chronology Specific Function of DNMT1 and Selective Anti-Leukemia Stem-Cell Therapy

Email alerts

ASH Publications

American Society of Hematology

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only