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Journal Articles

Less-deformable erythrocyte subpopulations biomechanically induce endothelial inflammation in sickle cell disease

Christina Caruso, Xiaopo Cheng, Marina E. Michaud, Hannah M. Szafraniec, Beena E. Thomas, Meredith E. Fay, Robert G. Mannino, Xiao Zhang, Yumiko Sakurai, Wei Li, David R. Myers, Clinton H. Joiner, David K. Wood, Manoj Bhasin, Michael D. Graham, Wilbur A. Lam

Blood (2024) 144 (19): 2050–2062.

https://doi.org/10.1182/blood.2024024608

Published: 2024

Includes: Supplemental data

Journal Articles

“Endothelialized” Hemostasis-on-a-Chip Reveals Rapid Platelet Recruitment By Locally Concentrated Ultra-Large Von Willebrand Factor (VWF) Release from Endothelial Cells Surpasses Plasma and Platelet VWF in Initiating Hemostasis

Theodora T. Alese, Yumiko Sakurai, Elaissa L. Hardy, Wilbur Lam

Blood (2024) 144 (Supplement 1): 1226.

https://doi.org/10.1182/blood-2024-211451

Published: 2024

Journal Articles

Disturbed Arterial Flow As a Driver of Perturbed RBC Physiology and Thromboembolic Events in Sickle Cell Disease

Anshu Dendukuri, Eudorah Vital, Alice Liu, Christina Caruso, Yumiko Sakurai, Cheryl L Maier, David Bark, Wilbur Lam

Blood (2024) 144 (Supplement 1): 5294.

https://doi.org/10.1182/blood-2024-212077

Published: 2024

Journal Articles

Quantitative Platelet Adhesion and Platelet Geometry-Sensing Assays for Evaluating Mild Bleeding Disorders

Sally Azer, Oluwamayokun Oshinowo, Meredith E. Fay, Yumiko Sakurai, Megan C. Brown, Carolyn Bennett, Shannon L. Meeks, Wilbur A. Lam

Blood (2022) 140 (Supplement 1): 5538–5539.

https://doi.org/10.1182/blood-2022-162598

Published: 2022

Journal Articles

Redefining Hyperviscosity in Acute Leukemia: Implications for Red Cell Transfusions

Jamie Oakley, Evelyn Kendall Williams, Dan Y. Zhang, Christina Caruso, Yumiko Sakurai, Reginald Tran, Melissa L. Kemp, Glen Lew, Ross M. Fasano, Wilbur A. Lam

Blood (2021) 138 (Supplement 1): 3253.

https://doi.org/10.1182/blood-2021-146577

Published: 2021

Journal Articles

Introducing a Novel Biophysical Platelet Function Panel to Investigate Disorders of Primary Hemostasis and Bleeding of Unknown Cause

Sally Azer, Oluwamayokun Oshinowo, Meredith E. Fay, Yumiko Sakurai, Yongzhi Qiu, Carolyn M. Bennett, Shannon Meeks, Megan C. Brown, David R. Myers, Wilbur A. Lam

Blood (2021) 138 (Supplement 1): 2072.

https://doi.org/10.1182/blood-2021-153324

Published: 2021

Journal Articles

Incorporating Hemoglobin Levels to Map Leukostasis Risk in Acute Leukemia Using Microvasculature-on-Chip Technologies

Jamie Oakley, MD, Evelyn K. Williams, BS, Christina Caruso, MD, Yumiko Sakurai, MSc, Reginald Tran, PhD, Glen Lew, MD, Wilbur A. Lam, MDPhD

Blood (2020) 136 (Supplement 1): 9–10.

https://doi.org/10.1182/blood-2020-137804

Published: 2020

Journal Articles

Monitoring the "Lifetime" of a Thrombus over Long Timescales By Leveraging a Novel Microvasculature-on-Chip Thrombosis Resolution Assay

Yongzhi Qiu, PhD, Yumiko Sakurai, MSc, Wilbur A. Lam, MD PhD

Blood (2019) 134 (Supplement_1): 441.

https://doi.org/10.1182/blood-2019-128718

Published: 2019

Journal Articles

Stiff Erythrocyte Subpopulations Biomechanically Induce Endothelial Inflammation in Sickle Cell Disease

Christina Caruso, MD, Xiao Zhang, BS, Yumiko Sakurai, MSc, Wei Li, MD, Meredith E. Fay, BS, Marcus A. Carden, MD, David R. Myers, PhD, Robert G. Mannino, PhD, Clinton H. Joiner, MD PhD, Michael D. Graham, PhD, Wilbur A. Lam, MD PhD

Blood (2019) 134 (Supplement_1): 3560.

https://doi.org/10.1182/blood-2019-125408

Published: 2019

Journal Articles

Mitochondrial Uncoupling Prevents Procoagulant Platelet Formation Resulting in Decreased Thrombus Stability

Andaleb Kholmukhamedov, MD, Yumiko Sakurai, MSc, Elaissa L. Hardy, PhD, Wilbur A Lam, MD PhD, Shawn M. Jobe, MD PhD

Blood (2018) 132 (Supplement 1): 2421.

https://doi.org/10.1182/blood-2018-99-117004

Published: 2018

Journal Articles

A Comparative Medicine Study of Platelet Biophysics Among Hemostasis Models of Different Species

Renee Copeland, BS, Oluwamayokun T. Oshinowo, Yumiko Sakurai, MSc, Meredith Ellen Fay, BS, Brian G. Petrich, PhD, Benjamin Brainard, VMD, Dipl ACVAA, ACVECC, Wilbur A Lam, MD PhD, David R. Myers, PhD

Blood (2018) 132 (Supplement 1): 869.

https://doi.org/10.1182/blood-2018-99-113107

Published: 2018

Journal Articles

Extracellular fluid tonicity impacts sickle red blood cell deformability and adhesion

Marcus A. Carden, Meredith E. Fay, Xinran Lu, Robert G. Mannino, Yumiko Sakurai, Jordan C. Ciciliano, Caroline E. Hansen, Satheesh Chonat, Clinton H. Joiner, David K. Wood, Wilbur A. Lam

Blood (2017) 130 (24): 2654–2663.

https://doi.org/10.1182/blood-2017-04-780635

Published: 2017

Includes: Multimedia, Supplemental data

Journal Articles

Leveraging the Contractile Force of Platelets for Targeted Factor VIII Delivery in Hemophilia with Inhibitors

Caroline E. Hansen, BS, David R Myers, PhD, Yumiko Sakurai, MSc, Wallace Hunter Baldwin, BS, Shannon L. Meeks, MD, L. Andrew Lyon, PhD, Wilbur A Lam, MD PhD

Blood (2016) 128 (22): 81.

https://doi.org/10.1182/blood.V128.22.81.81

Published: 2016

Journal Articles

Improving Lentiviral Transduction Efficiency with Microfluidic Systems

Reginald Tran, BS, David R Myers, PhD, Jordan E Shields, MS, Byungwook Ahn, PhD, Yongzhi Qiu, PhD, Caroline Hansen, BS, Yumiko Sakurai, MSc, Robert Moot, BS, H. Trent Spencer, PhD, Christopher B Doering, PhD, Wilbur A Lam, MD PhD

Blood (2015) 126 (23): 4415.

https://doi.org/10.1182/blood.V126.23.4415.4415

Published: 2015

Journal Articles

Commonly Used Clinical Intravenous Fluid Formulations Differentially Affect Sickle Red Blood Cell Stiffness and Transit Time

Marcus A Carden, MD, Meredith Ellen Fay, BS, Yumiko Sakurai, MSc, Robert G Mannino, BS, Jordan Ciciliano, BS, Reginald Tran, BS, Wilbur A Lam, MD PhD

Blood (2015) 126 (23): 2164.

https://doi.org/10.1182/blood.V126.23.2164.2164

Published: 2015

Journal Articles

Characterizing Cellular Interactions Contributing to Vaso-Occlusion in Patients with Sickle Cell Disease Utilizing a Novel Endothelialized Microfluidic Device

Margo Renee Rollins, MD, Byungwook Ahn, PhD, Yumiko Sakurai, MSc, Wilbur A Lam, MD PhD

Blood (2015) 126 (23): 3381.

https://doi.org/10.1182/blood.V126.23.3381.3381

Published: 2015

Journal Articles

Engineering a "Self-Healing" Hydrogel-Based Microvasculature-on-a-Chip for Investigating the Effects of Cellular and Biomolecular Interactions on Endothelial Permeability in Sickle Cell Disease

Yongzhi Qiu, PhD, Byungwook Ahn, PhD, Yumiko Sakurai, MSc, Caroline Hansen, BS, Clinton H. Joiner, MD PhD, Solomon Fiifi Ofori-Acquah, PhD, Wilbur A Lam, MD PhD

Blood (2015) 126 (23): 240.

https://doi.org/10.1182/blood.V126.23.240.240

Published: 2015

Journal Articles

Engineering a Valve-Regulated Endothelialized Microfluidic Device As an " in Vitro " Bleeding Time for Assessing Global Hemostasis

Yumiko Sakurai, MSc, Elaissa T. Hardy, PhD, Byungwook Ahn, PhD, Shannon L. Meeks, MD, W. Hunter Baldwin, BS, Shawn M Jobe, MD PhD, Wilbur A Lam, MD PhD

Blood (2015) 126 (23): 3485.

https://doi.org/10.1182/blood.V126.23.3485.3485

Published: 2015

Journal Articles

Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach

Jordan C. Ciciliano, Yumiko Sakurai, David R. Myers, Meredith E. Fay, Beatrice Hechler, Shannon Meeks, Renhao Li, J. Brandon Dixon, L. Andrew Lyon, Christian Gachet, Wilbur A. Lam

Blood (2015) 126 (6): 817–824.

https://doi.org/10.1182/blood-2015-02-628594

Published: 2015

Includes: Multimedia, Supplemental data

Journal Articles

Platelet geometry sensing spatially regulates α-granule secretion to enable matrix self-deposition

Yumiko Sakurai, Jennifer L. Fitch-Tewfik, Yongzhi Qiu, Byungwook Ahn, David R. Myers, Reginald Tran, Meredith E. Fay, Lingmei Ding, Paul W. Spearman, Alan D. Michelson, Robert Flaumenhaft, Wilbur A. Lam

Blood (2015) 126 (4): 531–538.

https://doi.org/10.1182/blood-2014-11-607614

Published: 2015

Includes: Supplemental data

NARROW

Less-deformable erythrocyte subpopulations biomechanically induce endothelial inflammation in sickle cell disease

“Endothelialized” Hemostasis-on-a-Chip Reveals Rapid Platelet Recruitment By Locally Concentrated Ultra-Large Von Willebrand Factor (VWF) Release from Endothelial Cells Surpasses Plasma and Platelet VWF in Initiating Hemostasis

Disturbed Arterial Flow As a Driver of Perturbed RBC Physiology and Thromboembolic Events in Sickle Cell Disease

Quantitative Platelet Adhesion and Platelet Geometry-Sensing Assays for Evaluating Mild Bleeding Disorders

Redefining Hyperviscosity in Acute Leukemia: Implications for Red Cell Transfusions

Introducing a Novel Biophysical Platelet Function Panel to Investigate Disorders of Primary Hemostasis and Bleeding of Unknown Cause

Incorporating Hemoglobin Levels to Map Leukostasis Risk in Acute Leukemia Using Microvasculature-on-Chip Technologies

Monitoring the "Lifetime" of a Thrombus over Long Timescales By Leveraging a Novel Microvasculature-on-Chip Thrombosis Resolution Assay

Stiff Erythrocyte Subpopulations Biomechanically Induce Endothelial Inflammation in Sickle Cell Disease

Mitochondrial Uncoupling Prevents Procoagulant Platelet Formation Resulting in Decreased Thrombus Stability

A Comparative Medicine Study of Platelet Biophysics Among Hemostasis Models of Different Species

Extracellular fluid tonicity impacts sickle red blood cell deformability and adhesion

Leveraging the Contractile Force of Platelets for Targeted Factor VIII Delivery in Hemophilia with Inhibitors

Improving Lentiviral Transduction Efficiency with Microfluidic Systems

Commonly Used Clinical Intravenous Fluid Formulations Differentially Affect Sickle Red Blood Cell Stiffness and Transit Time

Characterizing Cellular Interactions Contributing to Vaso-Occlusion in Patients with Sickle Cell Disease Utilizing a Novel Endothelialized Microfluidic Device

Engineering a "Self-Healing" Hydrogel-Based Microvasculature-on-a-Chip for Investigating the Effects of Cellular and Biomolecular Interactions on Endothelial Permeability in Sickle Cell Disease

Engineering a Valve-Regulated Endothelialized Microfluidic Device As an " in Vitro " Bleeding Time for Assessing Global Hemostasis

Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach

Platelet geometry sensing spatially regulates α-granule secretion to enable matrix self-deposition

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American Society of Hematology

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ASH Publications

American Society of Hematology

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