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David K. Wood
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Journal Articles

Less-deformable erythrocyte subpopulations biomechanically induce endothelial inflammation in sickle cell disease

Available to Purchase
Christina Caruso, Xiaopo Cheng, Marina E. Michaud, Hannah M. Szafraniec, Beena E. Thomas, Meredith E. Fay, Robert G. Mannino, Xiao Zhang, Yumiko Sakurai, Wei Li, David R. Myers, Clinton H. Joiner, David K. Wood, Manoj Bhasin, Michael D. Graham, Wilbur A. Lam
Journal: Blood
Blood (2024) 144 (19): 2050–2062.
https://doi.org/10.1182/blood.2024024608
Published: 2024
Includes: Supplemental data
Journal Articles

Model-Predicted Clinical Factors Impacting Patient-Specific Response of Sickle Cells to Voxelotor in a Microfluidic Platform

Free
Dan Y. Zhang, Melissa Azul, Wilbur A. Lam, David K. Wood, Melissa L. Kemp
Journal: Blood
Blood (2021) 138 (Supplement 1): 2033.
https://doi.org/10.1182/blood-2021-148026
Published: 2021
Journal Articles

Effects of BCL11A Shmir-Induced Post-Transcriptional Silencing on Hemoglobin Polymer Inhibition in Single Red Blood Cells at Physiologic Oxygen Tension

Free
Daniel C. De Souza, Erica B. Esrick, Nicolas Hebert, Giuseppe Di Caprio, Marioara Ciuculescu, Emily Morris, Myriam Armant, Bronner P. Gonçalves, Ethan Schonbrun, Christian Brendel, David K. Wood, Pablo Bartolucci, David A. Williams, John M. Higgins
Journal: Blood
Blood (2021) 138 (Supplement 1): 964.
https://doi.org/10.1182/blood-2021-147314
Published: 2021
Journal Articles

Visualizing Sickle Cell Disease Whole Blood Flow and Viscosity through Modifications to Hemoglobin Levels from a Simple Blood Transfusion

Free
Kirby S. Fibben, Wilbur A. Lam, Dan Y. Zhang, Melissa L. Kemp, David K. Wood, Elizabeth Eiffrig
Journal: Blood
Blood (2021) 138 (Supplement 1): 3244.
https://doi.org/10.1182/blood-2021-153386
Published: 2021
Journal Articles

Voxelotor Improves Sickle Red Blood Cell Flow Under Hypoxia in a Microfluidic Venule

Free
Melissa Azul, DO, David K. Wood, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-139529
Published: 2020
Journal Articles

Ruxolitinib Reduces Endothelial Pro-Adhesive Interactions: Implications for JAK2 V617+ MPN Thrombosis

Free
Angelica DaSilva, BS, Elena Aronovich, PhD, Aithanh Nguyen, Julia Nguyen, David Reynolds, Geneva D. Doak, B.S., PhD, Gregory M. Vercellotti, MD, David K. Wood, PhD, Joan D. Beckman, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-140116
Published: 2020
Journal Articles

Robust Pre-Clinical Results and Large-Scale Manufacturing Process for Edit-301: An Autologous Cell Therapy for the Potential Treatment of SCD

Free
Edouard De Dreuzy, PhD, Jack Heath, Patricia Sousa, Tusneem Janoudi, Harry An, PhD, Scott Hansen, David K. Wood, PhD, Charles F Albright, PhD, Sandra Teixeira, PhD, Tamara Monesmith, Kate Zhang, PhD, Kai-Hsin Chang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–46.
https://doi.org/10.1182/blood-2020-140073
Published: 2020
Journal Articles

Validation of BCL11A As Therapeutic Target in Sickle Cell Disease: Results from the Adult Cohort of a Pilot/Feasibility Gene Therapy Trial Inducing Sustained Expression of Fetal Hemoglobin Using Post-Transcriptional Gene Silencing

Free
Erica B. Esrick, MD, Maureen Achebe, MD MPH, Myriam Armant, PhD, Pablo Bartolucci, MD PhD, Marioara Felicia Ciuculescu, MD, Heather Daley, Colleen Dansereau, MSN, RN, CPN, Giuseppe Di Caprio, PhD, Bronner Goncalves, MD PhD, Nicolas Hebert, Matthew M Heeney, MD, John M. Higgins, MD PhD, Leslie E. Lehmann, MD, John P Manis, MD, Olivier Negre, PhD, Sarah Nikiforow, MD PhD, Ethan Schonbrun, PhD, David K. Wood, PhD, David A. Williams, MD
Journal: Blood
Blood (2019) 134 (Supplement_2): LBA-5.
https://doi.org/10.1182/blood-2019-132745
Published: 2019
Journal Articles

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Free
Melanie Demers, PhD, Sarah Sturtevant, BSc, Kevin Guertin, PhD, Dipti Gupta, Kunal Desai, MS, Benjamin Vieira, BS, Alexandra Hicks, PhD, Ayman Ismail, PhD, Yukio Nakamura, MD PhD, Bronner Goncalves, MD PhD, Giuseppe Di Caprio, PhD, Ethan Schonbrun, PhD, Scott Hansen, BS, Martin K. Safo, PhD, David K. Wood, PhD, John M. Higgins, MD PhD, David R. Light, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2260.
https://doi.org/10.1182/blood-2019-128727
Published: 2019
Journal Articles

Extracellular fluid tonicity impacts sickle red blood cell deformability and adhesion

Free
Marcus A. Carden, Meredith E. Fay, Xinran Lu, Robert G. Mannino, Yumiko Sakurai, Jordan C. Ciciliano, Caroline E. Hansen, Satheesh Chonat, Clinton H. Joiner, David K. Wood, Wilbur A. Lam
Journal: Blood
Blood (2017) 130 (24): 2654–2663.
https://doi.org/10.1182/blood-2017-04-780635
Published: 2017
Includes: Multimedia, Supplemental data